Metabotropic glutamate 1 receptor distribution and occupancy in the rat brain: A quantitative autoradiographic study using [3H]R214127

Neuropharmacology

Volumn 46, Issue 5, 2004, Pages 609-619

  Lavreysen, Hilde ^a,b   Pereira, Sandrina Nóbrega ^a   Leysen, Joseé E ^b,c   Langlois, Xavier ^a   Lesage, Anne S J ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

3H R214127; Autoradiography; Distribution; MGlu1 receptor; MGlu1 receptor antagonist; Receptor occupancy

Indexed keywords

1 (3,4 DIHYDRO 2H PYRANO[2,3 B]QUINOLIN 7 YL) 2 PHENYL 1 ETHANONE; 6A NAPHTHALAN 2 YLMETHYL 5 METHYLIDENEHEXAHYDROCYCLOPENTA[C]FURAN 1 ON; BAY 36 7620; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; NPS 2390; R 214127; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BASAL GANGLION; BRAIN CORTEX; CENTRAL GRAY MATTER; CEREBELLUM; CONTROLLED STUDY; DENTATE GYRUS; DRUG POTENCY; DRUG RECEPTOR BINDING; HIPPOCAMPUS; INTERPEDUNCULAR NUCLEUS; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR OCCUPANCY; SEPTUM NUCLEUS; THALAMUS; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NAPHTHALENES; PROTEIN BINDING; PYRANS; QUINOLINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; TRITIUM;

EID: 1442275398     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2003.11.014     Document Type: Article

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