The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison

Neuropharmacology

Volumn 51, Issue 7-8, 2006, Pages 1146-1155

  Gravius, A ^a   Barberi, C ^a   Schafer D ^a   Schmidt, W J ^b   Danysz, W ^a  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Acquisition; Auditory fear conditioning; Contextual fear conditioning; Expression; mGluR1; mGluR5; NMDA receptor

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; CITALOPRAM; DIAZEPAM; DIZOCILPINE; JNJ 16567083; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEAR; LEARNING DISORDER; LONG TERM MEMORY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACOUSTIC STIMULATION; ANIMALS; AVOIDANCE LEARNING; CITALOPRAM; CONDITIONING, CLASSICAL; DIAZEPAM; DIZOCILPINE MALEATE; ELECTROSHOCK; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEAR; FREEZING REACTION, CATALEPTIC; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; PYRIDINES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SCOPOLAMINE; THIAZOLES;

EID: 33750802463     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.07.008     Document Type: Article

References (58)

1. Aiba A., Chen C., Herrup K., Rosenmund C., Stevens C.F., and Tonegawa S. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell 79 (1994) 365-375
2. Anagnostaras S.G., Maren S., Sage J.R., Goodrich S., and Fanselow M.S. Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis. Neuropsychopharmacology 21 (1999) 731-744
3. Balschun D., and Wetzel W. Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. Pharmacol. Biochem. Behav. 73 (2002) 375-380
4. Barros D.M., Izquierdo L.A., Mello e, Souza T., Ardenghi P.G., Pereira P., Medina J.H., and Izquierdo I. Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats. Behav. Brain Res. 114 (2000) 183-192
5. Bashir Z.I., Bortolotto Z.A., Davies C.H., Berretta N., Irving A.J., Seal A.J., Henley J.M., Jane D.E., Watkins J.C., and Collingridge G.L. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature 363 (1993) 347-350
6. Blanchard R.J., and Blanchard D.C. Crouching as an index of fear. J. Comp. Physiol. Psychol. 67 (1969) 370-375
7. Brodkin J., Busse C., Sukoff S.J., and Varney M.A. Anxiolytic-like activity of the mGluR5 antagonist MPEP - a comparison with diazepam and buspirone. Pharmacol. Biochem. Behav. 73 (2002) 359-366
8. Burghardt N.S., Sullivan G.M., McEwen B.S., Gorman J.M., and LeDoux J.E. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Biol. Psychiatry 55 (2004) 1171-1178
9. Busse C.S., Brodkin J., Tattersall D., Anderson J.J., Warren N., Tehrani L., Bristow L.J., Varney M.A., and Cosford N.D. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety. Neuropsychopharmacology 29 (2004) 1971-1979
10. Campbell U.C., Lalwani K., Hernandez L., Kinney G.G., Conn P.J., and Bristow L.J. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology (Berl) 175 (2004) 310-318
11. Campeau S., Miserendino M.J., and Davis M. Intra-amygdala infusion of the N-methyl-d-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav. Neurosci. 106 (1992) 569-574
12. Car H., Nadlewska A., and Wisniewski K. 3,5-DHPG influences behavioral effects of baclofen in rats. Pol. J. Pharmacol. 52 (2000) 247-254
13. Collingridge G. Synaptic plasticity. The role of NMDA receptors in learning and memory. Nature 330 (1987) 604-605
14. Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37 (1997) 205-237
15. Coulibaly A.P., Shelat P.B., Dopheide M.M., Serfozo P., Schachtman T.R., and Simonyi A. Hippocampal Metabotropic Glutamate Receptor 5 in Inhibitory Avoidance Learning (2005), Society for Neuroscience, Washington, DC Program No. 998.14. Abstract Viewer/Itinerary Planner
16. Danysz W., Zajaczkowski W., and Parsons C.G. Modulation of learning processes by ionotropic glutamate receptor ligands. Behav. Pharmacol. 6 (1995) 455-474
17. Fanselow M.S., Kim J.J., Yipp J., and De Oca B. Differential effects of the N-methyl-d-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav. Neurosci. 108 (1994) 235-240
18. Fendt M., and Schmid S. Metabotropic glutamate receptors are involved in amygdaloid plasticity. Eur. J. Neurosci. 15 (2002) 1535-1541
19. Gould T.J., McCarthy M.M., and Keith R.A. MK-801 disrupts acquisition of contextual fear conditioning but enhances memory consolidation of cued fear conditioning. Behav. Pharmacol. 13 (2002) 287-294
20. Gravius A., Pietraszek M., Schafer D., Schmidt W.J., and Danysz W. Effects of mGlu1 and mGlu5 receptor antagonists on negatively reinforced learning. Behav. Pharmacol. 16 (2005) 113-121
21. Gravius A., Pietraszek M., Schmidt W.J., and Danysz W. Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats. Psychopharmacology (Berl) 185 (2006) 58-65
22. Gravius, A., More, L., Schmidt, W.J., Danysz, W., 2006b. The role of group I glutamate receptors in acquisition and expression of contextual an auditory fear conditioning. EBPS meeting Krakow 2006, Program No. P40.
23. Gravius A., More L., Schmidt W.J., and Danysz W. The role of group I glutamate receptors in acquisition and expression of contextual an auditory fear conditioning (2006), Society for Neuroscience, Washington, DC Abstract, sumitted. (Poster presentation number not allocated so far).
24. Hashimoto S., Inoue T., and Koyama T. Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats. Psychopharmacology (Berl) 123 (1996) 182-186
25. Helton D.R., Tizzano J.P., Monn J.A., Schoepp D.D., and Kallman M.J. Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J. Pharmacol. Exp. Ther. 284 (1998) 651-660
26. Inoue T., Hashimoto S., Tsuchiya K., Izumi T., Ohmori T., and Koyama T. Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing. Eur. J. Pharmacol. 311 (1996) 1-6
27. Inoue T., Tsuchiya K., and Koyama T. Serotonergic activation reduces defensive freezing in the conditioned fear paradigm. Pharmacol. Biochem. Behav. 53 (1996) 825-831
28. Izquierdo L.A., Barros D.M., Ardenghi P.G., Pereira P., Rodrigues C., Choi H., Medina J.H., and Izquierdo I. Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning. Behav. Brain Res. 111 (2000) 93-98
29. Izumi T., Inoue T., Kitaichi Y., Nakagawa S., and Koyama T. Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor. Eur. J. Pharmacol. 534 (2006) 129-132
30. Kim J.J., and Fanselow M.S. Modality-specific retrograde amnesia of fear. Science 256 (1992) 675-677
31. Kim M., and McGaugh J.L. Effects of intra-amygdala injections of NMDA receptor antagonists on acquisition and retention of inhibitory avoidance. Brain Res. 585 (1992) 35-48
32. Klodzinska A., Tatarczynska E., Chojnacka-Wojcik E., Nowak G., Cosford N.D., and Pilc A. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology 47 (2004) 342-350
33. Klodzinska A., Tatarczynska E., Stachowicz K., and Chojnacka-Wojcik E. The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. J. Physiol. Pharmacol. 55 (2004) 113-126
34. Lavreysen H., Wouters R., Bischoff F., Nobrega Pereira S., Langlois X., Blokland S., Somers M., Dillen L., and Lesage A.S.J. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology 47 (2004) 961-972
35. Lu Y.M., Jia Z., Janus C., Henderson J.T., Gerlai R., Wojtowicz J.M., and Roder J.C. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17 (1997) 5196-5205
36. Maciejak P., Taracha E., Lehner M., Szyndler J., Bidzinski A., Skorzewska A., Wislowska A., Zienowicz M., and Plaznik A. Hippocampal mGluR1 and consolidation of contextual fear conditioning. Brain Res. Bull. 62 (2003) 39-45
37. Manahan-Vaughan D. Group 1 and 2 metabotropic glutamate receptors play differential roles in hippocampal long-term depression and long-term potentiation in freely moving rats. J. Neurosci. 17 (1997) 3303-3311
38. Miserendino M.J., Sananes C.B., Melia K.R., and Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345 (1990) 716-718
39. Morris R.G., Anderson E., Lynch G.S., and Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5. Nature 319 (1986) 774-776
40. Naie K., and Manahan-Vaughan D. Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cereb. Cortex 14 (2004) 189-198
41. Pérez de la Mora M., Lara-Garci{dotless}a D., Jacobsen K.X., Vazquez-Garci{dotless}a M., Crespo-Rami{dotless}rez M., Flores-Gracia C., Escamilla-Marvan E., and Fuxe K. Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety. Eur. J. Pharmacol. 23 (2006) 2749-2759
42. Petersen S., Bomme C., Baastrup C., Kemp A., and Christoffersen G.R.J. Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats. Pharmacol. Biochem. Behav. 73 (2002) 381-389
43. Phillips R.G., and LeDoux J.E. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav. Neurosci. 106 (1992) 274-285
44. Pietraszek M., Sukhanov I., Maciejak P., Szyndler J., Gravius A., Wislowska A., Plaznik A., Bespalov A.Y., and Danysz W. Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats. Eur. J. Pharmacol. 514 (2005) 25-34
45. Quinn J.J., Loya F., Ma Q.D., and Fanselow M.S. Dorsal hippocampus NMDA receptors differentially mediate trace and contextual fear conditioning. Hippocampus 15 (2005) 665-674
46. Rodrigues S.M., Bauer E.P., Farb C.R., Schafe G.E., and LeDoux J.E. The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J. Neurosci. 22 (2002) 5219-5229
47. Rudy J.W. Scopolamine administered before and after training impairs both contextual and auditory-cue fear conditioning. Neurobiol. Learn. Mem. 65 (1996) 73-81
48. Schachtman T.R., Bills C., Ghinescu R., Murch K., Serfozo P., and Simonyi A. MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. Behav. Brain Res. 141 (2003) 177-182
49. Schenberg E.E., Soares J.C., and Oliveira M.G. Effects of pre- or post-training entorhinal cortex AP5 injection on fear conditioning. Physiol. Behav. 86 (2005) 508-515
50. Schulz B., Fendt M., Gasparini F., Lingenhohl K., Kuhn R., and Koch M. The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats. Neuropharmacology 41 (2001) 1-7
51. Sevostianova, N., Danysz, W. Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test. Neuropharmacology, in press. doi:10.1016/j.neuropharm.2006.05.004.
52. Sienkiewicz-Jarosz H., Szyndler J., Czlonkowska A.I., Siemiatkowski M., Maciejak P., Wislowska A., Zienowicz M., Lehner M., Turzynska D., Bidzinski A., and Plaznik A. Rat behavior in two models of anxiety and brain. Behav. Brain Res. 145 (2003) 17-22
53. Simonyi A., Schachtman T.R., and Christoffersen G.R. The role of metabotropic glutamate receptor 5 in learning and memory processes. Drug News Perspect 18 (2005) 353-361
54. Spooren W., Ballard T., Gasparini F., Amalric M., Mutel V., and Schreiber R. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav. Pharmacol. 14 (2003) 257-277
55. Steckler T., Oliveira A.F., Van Dyck C., Van Craenendonck H., Mateus A.M., Langlois X., Lesage A.S., and Prickaerts J. Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Behav. Brain Res. 164 (2005) 52-60
56. Steckler T., Lavreysen H., Oliveira A.M., Aerts N., Van Craenendonck H., Prickaerts J., Megens A., and Lesage A.S. Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test. Psychopharmacology (Berl) 179 (2005) 198-206
57. Tizzano J.P., Griffey K.I., and Schoepp D.D. The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam. Pharmacol. Biochem. Behav. 73 (2002) 367-374
58. Zajaczkowski W., Frankiewicz T., Parsons C.G., and Danysz W. Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 (1997) 961-971