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Volumn 56, Issue 2, 1999, Pages 185-192

In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; CREATINE PHOSPHATE;

EID: 0033001444     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.56.2.185     Document Type: Article
Times cited : (120)

References (83)
  • 7
    • 0027932872 scopus 로고
    • Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory
    • Soininen HS, Partanen K, Pitkanen A, Vainio P, Hanninen T, Hallikainen M, Koivisto K, Riekkinen PJ. Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: correlation to visual and verbal memory. Neurology. 1994;44:1660-1668.
    • (1994) Neurology , vol.44 , pp. 1660-1668
    • Soininen, H.S.1    Partanen, K.2    Pitkanen, A.3    Vainio, P.4    Hanninen, T.5    Hallikainen, M.6    Koivisto, K.7    Riekkinen, P.J.8
  • 9
    • 0027316077 scopus 로고
    • Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes
    • Bouras C, Hof PR, Morrison JH. Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changes. Neurosci Lett. 1993;153:131-135.
    • (1993) Neurosci Lett , vol.153 , pp. 131-135
    • Bouras, C.1    Hof, P.R.2    Morrison, J.H.3
  • 10
    • 0001804233 scopus 로고
    • Neuroanatomical and neuropathological changes during aging and dementia
    • Albert, ML, Knoefel, JE, eds. New York, NY: Oxford University Press
    • Kemper TL. Neuroanatomical and neuropathological changes during aging and dementia. In: Albert, ML, Knoefel, JE, eds. Clinical Neurology of Aging. New York, NY: Oxford University Press; 1994.
    • (1994) Clinical Neurology of Aging
    • Kemper, T.L.1
  • 11
    • 0019440757 scopus 로고
    • The pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading
    • Brun A, Englund E. The pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading. Histopathology. 1981;5:549-564.
    • (1981) Histopathology , vol.5 , pp. 549-564
    • Brun, A.1    Englund, E.2
  • 13
    • 0025968532 scopus 로고
    • Alzheimer's disease affects limbic nuclei ot the thalamus
    • Braak H, Braak E. Alzheimer's disease affects limbic nuclei ot the thalamus. Acta Neuropathol (Berl). 1991;81:261-268.
    • (1991) Acta Neuropathol (Berl) , vol.81 , pp. 261-268
    • Braak, H.1    Braak, E.2
  • 14
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl). 1991;82:239-259.
    • (1991) Acta Neuropathol (Berl) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 15
    • 0031046727 scopus 로고    scopus 로고
    • Morphology and neurochemical characteristics of the vulnerable neurons in brain aging and Alzheimer's disease
    • Hof PR. Morphology and neurochemical characteristics of the vulnerable neurons in brain aging and Alzheimer's disease. Eur Neurol. 1997;37:71-81.
    • (1997) Eur Neurol. , vol.37 , pp. 71-81
    • Hof, P.R.1
  • 16
    • 0027979695 scopus 로고
    • Neuropathological changes of the temporal pole in Alzheimer's disease and Pick's disease
    • Arnold SE, Hyman BT, Van Hoesen G. Neuropathological changes of the temporal pole in Alzheimer's disease and Pick's disease. Arch Neurol 1994;51:145-150.
    • (1994) Arch Neurol , vol.51 , pp. 145-150
    • Arnold, S.E.1    Hyman, B.T.2    Van Hoesen, G.3
  • 17
    • 0028177487 scopus 로고
    • Lack of neocortical nerve cell loss in Alzheimer's disease: Reality or methodological artifact
    • Mufson EJ. Lack of neocortical nerve cell loss in Alzheimer's disease: reality or methodological artifact. Neurobiol Aging. 1994;15:361-362.
    • (1994) Neurobiol Aging , vol.15 , pp. 361-362
    • Mufson, E.J.1
  • 18
    • 0028234124 scopus 로고
    • Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder
    • Braak H, Braak E. Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder. Neurobiol Aging. 1994;15:355-356.
    • (1994) Neurobiol Aging , vol.15 , pp. 355-356
    • Braak, H.1    Braak, E.2
  • 19
    • 0028337668 scopus 로고
    • No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type
    • Regeur L, Jensen GB, Pakkenberg H, Evans SM, Pakkenberg B. No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type. Neurobiol Aging. 1994;15:347-352.
    • (1994) Neurobiol Aging , vol.15 , pp. 347-352
    • Regeur, L.1    Jensen, G.B.2    Pakkenberg, H.3    Evans, S.M.4    Pakkenberg, B.5
  • 21
    • 0028017540 scopus 로고
    • A quantitative magnetic resonance imaging study of changes in Drain morphology from infancy to late adulthood
    • Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO. A quantitative magnetic resonance imaging study of changes in Drain morphology from infancy to late adulthood. Arch Neurol. 1994;51:874-887.
    • (1994) Arch Neurol. , vol.51 , pp. 874-887
    • Pfefferbaum, A.1    Mathalon, D.H.2    Sullivan, E.V.3    Rawles, J.M.4    Zipursky, R.B.5    Lim, K.O.6
  • 26
    • 0031457783 scopus 로고    scopus 로고
    • Age-induced white-matter changes in the human brain: A stereological investigation
    • Tang Y, Nyengaard JR, Pakkenberg B, Gundersen HJG. Age-induced white-matter changes in the human brain: a stereological investigation. Neurobiol Aging. 1997;18:609-615.
    • (1997) Neurobiol Aging , vol.18 , pp. 609-615
    • Tang, Y.1    Nyengaard, J.R.2    Pakkenberg, B.3    Gundersen, H.J.G.4
  • 27
    • 0025281641 scopus 로고
    • Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease
    • Storm-Mathisen J, Zimmer J, Otterson OP, eds. Amsterdam, the Netherlands: Elsevier Science Publishers
    • Flood DG, Coleman PD. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. In: Storm-Mathisen J, Zimmer J, Otterson OP, eds. Progress in Brain Research: Understanding the Brain Through the Hippocampus. Amsterdam, the Netherlands: Elsevier Science Publishers; 1990;83: 435-443.
    • (1990) Progress in Brain Research: Understanding the Brain Through the Hippocampus , vol.83 , pp. 435-443
    • Flood, D.G.1    Coleman, P.D.2
  • 28
    • 0026032513 scopus 로고
    • Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease, II: Subiculum
    • Flood DG. Region-specific stability of dendritic extent in normal human aging and regression in Alzheimer's disease, II: subiculum. Brain Res. 1991;540:83-95.
    • (1991) Brain Res. , vol.540 , pp. 83-95
    • Flood, D.G.1
  • 29
    • 0027490565 scopus 로고
    • Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents
    • Flood DG. Critical issues in the analysis of dendritic extent in aging humans, primates, and rodents. Neurobiol Aging. 1993;14:649-654.
    • (1993) Neurobiol Aging , vol.14 , pp. 649-654
    • Flood, D.G.1
  • 30
    • 0000356642 scopus 로고
    • Studies on the distribution of N-acetyl-l-aspartate acid in brain
    • Tallan HH. Studies on the distribution of N-acetyl-L-aspartate acid in brain. J Biol Chem. 1956;224:41-45.
    • (1956) J Biol Chem. , vol.224 , pp. 41-45
    • Tallan, H.H.1
  • 31
    • 0030915132 scopus 로고    scopus 로고
    • Frontotemporal dementia and early Alzheimer disease: Differentiation with frontal lobe H-f NTR spectroscopy
    • Ernst T, Chang L, Melchor R, Mehringer CM. Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-f NTR spectroscopy. Radiology. 1997;203:829-836.
    • (1997) Radiology , vol.203 , pp. 829-836
    • Ernst, T.1    Chang, L.2    Melchor, R.3    Mehringer, C.M.4
  • 33
    • 0026726198 scopus 로고
    • N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer s disease brain: A preliminary proton nuclear magnetic resonance study
    • Klunk WE, Panchalingam K, Moossy J, McClure RJ, Pettegrew JW. N-acetyl-L-aspartate and other amino acid metabolites in Alzheimer s disease brain: a preliminary proton nuclear magnetic resonance study. Neurology. 1992;42:1578-1585.
    • (1992) Neurology , vol.42 , pp. 1578-1585
    • Klunk, W.E.1    Panchalingam, K.2    Moossy, J.3    McClure, R.J.4    Pettegrew, J.W.5
  • 34
    • 0031033130 scopus 로고    scopus 로고
    • Estimating NAA in cortical gray matter with applications for measuring changes due to aging
    • Lim KO, Spielman DM. Estimating NAA in cortical gray matter with applications for measuring changes due to aging. Magn Reson Med. 1997;37:372-377.
    • (1997) Magn Reson Med. , vol.37 , pp. 372-377
    • Lim, K.O.1    Spielman, D.M.2
  • 37
    • 0027169607 scopus 로고
    • The concentration of N-acetyl aspartate, creatine+phosphocreatine, and choline in different parts of the brain in adulthood and senium
    • Christiansen P, Toft P, Larsson HBW, Stubgaard M, Henriksen O. The concentration of N-acetyl aspartate, creatine+phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn Reson Imaging. 1993;11:799-806.
    • (1993) Magn Reson Imaging , vol.11 , pp. 799-806
    • Christiansen, P.1    Toft, P.2    Larsson, H.B.W.3    Stubgaard, M.4    Henriksen, O.5
  • 38
    • 0032966732 scopus 로고    scopus 로고
    • In vivo quantification of N-acetyl aspartate, creatine and choline from large volumes of gray and white matter on magnetic resonance spectroscopic imaging: Application to normal aging
    • Pfefferbaum A, Sullivan E, Adalsteinsson A, Spielman D, Lim KO. In vivo quantification of N-acetyl aspartate, creatine and choline from large volumes of gray and white matter on magnetic resonance spectroscopic imaging: application to normal aging. Magn Reson Med. 1999;41:276-294.
    • (1999) Magn Reson Med. , vol.41 , pp. 276-294
    • Pfefferbaum, A.1    Sullivan, E.2    Adalsteinsson, A.3    Spielman, D.4    Lim, K.O.5
  • 39
    • 0029978560 scopus 로고    scopus 로고
    • In vivo proton magnetic resonance spectroscopy of the normal aging human brain
    • Chang L, Ernst T, Poland RE, Jenden DJ. In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci. 1996;58:2049-2056.
    • (1996) Life Sci. , vol.58 , pp. 2049-2056
    • Chang, L.1    Ernst, T.2    Poland, R.E.3    Jenden, D.J.4
  • 40
    • 0028290204 scopus 로고
    • Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging
    • Meyerhoff DJ, MacKay S, Constans JM, Norman D, Van Dyke C, Fein G, Weiner MW. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol. 1994; 36:40-47.
    • (1994) Ann Neurol. , vol.36 , pp. 40-47
    • Meyerhoff, D.J.1    MacKay, S.2    Constans, J.M.3    Norman, D.4    Van Dyke, C.5    Fein, G.6    Weiner, M.W.7
  • 42
    • 43949163052 scopus 로고
    • Absolute quantitation of water and metabolites in the human brain. II: Metabolite concentrations
    • Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain. II: metabolite concentrations. J Magn Reson. 1993;102:9-19.
    • (1993) J Magn Reson , vol.102 , pp. 9-19
    • Kreis, R.1    Ernst, T.2    Ross, B.D.3
  • 43
    • 0343097864 scopus 로고
    • Aging of the human adult brain: In vivo quantification of metabolic content with proton magnetic resonance spectroscopy
    • Saunders DE, Howe FA, van den Boogaart A, Griffith JR, Brown MM. Aging of the human adult brain: in vivo quantification of metabolic content with proton magnetic resonance spectroscopy [abstract]. Proc Soc Magn Reson. 1995;3: 1804.
    • (1995) Proc Soc Magn Reson , vol.3 , pp. 1804
    • Saunders, D.E.1    Howe, F.A.2    Van Den Boogaart, A.3    Griffith, J.R.4    Brown, M.M.5
  • 45
    • 0343144806 scopus 로고    scopus 로고
    • In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes
    • Frederick BD, Satlin A, Yurgelun-Todd DA, Renshaw PF. In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes. Biol Psychiatry. 1997;42:147-150.
    • (1997) Biol Psychiatry , vol.42 , pp. 147-150
    • Frederick, B.D.1    Satlin, A.2    Yurgelun-Todd, D.A.3    Renshaw, P.F.4
  • 47
    • 0029834577 scopus 로고    scopus 로고
    • Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging
    • Tedeschi G, Bertolino A, Lundbom N, Bonavita S, Patronas NJ, Duyn JH, Metman LV, Chase TN. Di Chiro G. Cortical and subcortical chemical pathology in Alzheimer's disease as assessed by multislice proton magnetic resonance spectroscopic imaging. Neurology. 1996;47:696-704.
    • (1996) Neurology , vol.47 , pp. 696-704
    • Tedeschi, G.1    Bertolino, A.2    Lundbom, N.3    Bonavita, S.4    Patronas, N.J.5    Duyn, J.H.6    Metman, L.V.7    Chase, T.N.8    Di Chiro, G.9
  • 48
    • 0030983951 scopus 로고    scopus 로고
    • Increased choline signal coinciding with malignant degeneration ot cerebral gliomas: A serial proton magnetic resonance spectroscopy imaging study
    • Tedeschi G, Lundbom N, Raman R, Bonavita S, Duyn J, Alger J. Di Chiro G. Increased choline signal coinciding with malignant degeneration ot cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. J Neurosurg. 1997;87:516-524.
    • (1997) J Neurosurg , vol.87 , pp. 516-524
    • Tedeschi, G.1    Lundbom, N.2    Raman, R.3    Bonavita, S.4    Duyn, J.5    Alger, J.6    Di Chiro, G.7
  • 50
    • 0005655903 scopus 로고
    • High-spatial resolution MRS and segmented MRI to study NAA in cortical gray matter and white matter of the human brain
    • Moyher SE, Nelson SJ, Wald LL, Henry RG, Kurhanewicz J, Vigneron DB. High-spatial resolution MRS and segmented MRI to study NAA in cortical gray matter and white matter of the human brain [abstract]. Proc Soc Magn Reson. 1995;1:332.
    • (1995) Proc Soc Magn Reson , vol.1 , pp. 332
    • Moyher, S.E.1    Nelson, S.J.2    Wald, L.L.3    Henry, R.G.4    Kurhanewicz, J.5    Vigneron, D.B.6
  • 52
    • 0031964205 scopus 로고    scopus 로고
    • Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy
    • Wang Y, Li S-J. Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy. Magn Reson Med. 1998;39:28-33.
    • (1998) Magn Reson Med. , vol.39 , pp. 28-33
    • Wang, Y.1    Li, S.-J.2
  • 53
    • 0029004591 scopus 로고
    • Relative concentration of proton MR visible neurochemicals in gray and white matter in human brain
    • Doyle TJ, Beddell BJ, Narayana PA. Relative concentration of proton MR visible neurochemicals in gray and white matter in human brain. Magn Reson Med. 1995; 33:755-759.
    • (1995) Magn Reson Med. , vol.33 , pp. 755-759
    • Doyle, T.J.1    Beddell, B.J.2    Narayana, P.A.3
  • 54
    • 0028670516 scopus 로고
    • Brain N-acetyl-L-aspartic acid in Alzheimer's disease: A proton magnetic resonance spectroscopy study
    • Kwo-On-Yuen PF, Newmark RD, Budinger TF, Kaye JA, Ball MJ, Jagust WJ. Brain N-acetyl-L-aspartic acid in Alzheimer's disease: a proton magnetic resonance spectroscopy study. Brain Res. 1994;667:167-174.
    • (1994) Brain Res. , vol.667 , pp. 167-174
    • Kwo-On-Yuen, P.F.1    Newmark, R.D.2    Budinger, T.F.3    Kaye, J.A.4    Ball, M.J.5    Jagust, W.J.6
  • 55
    • 0024467739 scopus 로고
    • High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy
    • Petroff OA, Spencer DD, Alger JR, Pitchard JW. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology. 1989;39:1197-1202.
    • (1989) Neurology , vol.39 , pp. 1197-1202
    • Petroff, O.A.1    Spencer, D.D.2    Alger, J.R.3    Pitchard, J.W.4
  • 56
    • 0029609260 scopus 로고
    • Symbiosis between in vivo and in vitro NMR spectroscopy: The creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain
    • Petroff OAC, Pleban LA, Spencer DD. Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain. Magn Reson Imaging. 1995;13:1197-1211.
    • (1995) Magn Reson Imaging , vol.13 , pp. 1197-1211
    • Petroff, O.A.C.1    Pleban, L.A.2    Spencer, D.D.3
  • 57
    • 0029082581 scopus 로고
    • Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging
    • Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn JH, Moonen CTW. Alger JR, Di Chiro G. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology. 1995;45:1384-1391.
    • (1995) Neurology , vol.45 , pp. 1384-1391
    • Tedeschi, G.1    Bertolino, A.2    Righini, A.3    Campbell, G.4    Raman, R.5    Duyn, J.H.6    Moonen, C.T.W.7    Alger, J.R.8    Di Chiro, G.9
  • 58
    • 0031985750 scopus 로고    scopus 로고
    • Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
    • Pouwels PJW, Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med. 1998;39:53-60.
    • (1998) Magn Reson Med. , vol.39 , pp. 53-60
    • Pouwels, P.J.W.1    Frahm, J.2
  • 60
    • 0345347832 scopus 로고
    • N-Acetyl-aspartate differences between gray and white matter as observed by proton spectroscopic imaging in normal subjects
    • Knufman NMJ, Berkelbach, van der Sprenkel JW, Tulleken CAF. N-Acetyl-aspartate differences between gray and white matter as observed by proton spectroscopic imaging in normal subjects [abstract]. Proc Soc Magn Reson. 1992: 1905.
    • (1992) Proc Soc Magn Reson , pp. 1905
    • Knufman, N.M.J.1    Van Der Sprenkel, J.W.2    Tulleken, C.A.F.3
  • 61
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G, Drachman D, Folstein M, Katzman R. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;37:939-944.
    • (1984) Neurology , vol.37 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4
  • 62
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol. 1985;42:1097-1105.
    • (1985) Arch Neurol. , vol.42 , pp. 1097-1105
    • Khachaturian, Z.S.1
  • 63
    • 0016823810 scopus 로고
    • Mini-mental state: A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12:189-198.
    • (1975) J Psychiatr Res. , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 68
    • 0025881282 scopus 로고
    • Rapid, fully-automatic, arbitrary volume, in-vivo shimming
    • Webb P, Macovski A. Rapid, fully-automatic, arbitrary volume, in-vivo shimming. Magn Reson Med. 1991;20:113-122.
    • (1991) Magn Reson Med. , vol.20 , pp. 113-122
    • Webb, P.1    Macovski, A.2
  • 69
    • 0028839871 scopus 로고
    • The Rician distibution of noisy MRI data
    • Gudbjartsson H, Patz S. The Rician distibution of noisy MRI data. Magn Reson Med. 1995;34:910-914.
    • (1995) Magn Reson Med. , vol.34 , pp. 910-914
    • Gudbjartsson, H.1    Patz, S.2
  • 70
    • 0030059064 scopus 로고    scopus 로고
    • Regional gray and white matter metabolite differences in subjects with AD. With subcortical ischemic vascular dementia, and elderly controls with H-1 magnetic resonance spectroscopic imaging
    • MacKay S, Meyerhoff DJ, Constans JM, Norman D, Fein G, Weiner MW. Regional gray and white matter metabolite differences in subjects with AD. with subcortical ischemic vascular dementia, and elderly controls with H-1 magnetic resonance spectroscopic imaging. Arch Neurol. 1996;53:167-174.
    • (1996) Arch Neurol. , vol.53 , pp. 167-174
    • MacKay, S.1    Meyerhoff, D.J.2    Constans, J.M.3    Norman, D.4    Fein, G.5    Weiner, M.W.6
  • 71
    • 0028244281 scopus 로고
    • Abnormal cerebral metabolite concentrations in patients with probable Alzheimer's disease
    • Moats RA, Ernst T, Shonk TK, Ross BD. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer's disease. Magn Reson Med. 1994; 32:110-115.
    • (1994) Magn Reson Med. , vol.32 , pp. 110-115
    • Moats, R.A.1    Ernst, T.2    Shonk, T.K.3    Ross, B.D.4
  • 73
    • 0028173137 scopus 로고
    • N-acetylaspartate and N-acetyl-aspartylglutamate levels in Alzheimer's disease post-mortem brain tissue
    • Jaarsma D, Veenma van der Duin L, Korf J. N-acetylaspartate and N-acetyl-aspartylglutamate levels in Alzheimer's disease post-mortem brain tissue. J Neurol Sci. 1994;127:230-233.
    • (1994) J Neurol Sci. , vol.127 , pp. 230-233
    • Jaarsma, D.1    Veenma Van Der Duin, L.2    Korf, J.3
  • 80
    • 0029665411 scopus 로고    scopus 로고
    • Quantitative H-1 and P-31 MRS of PCA extracts of postmortem Alzheimer's disease brain
    • Klunk WE, Xu C, Panchalingam K, McClure RJ, Pettegrew JW. Quantitative H-1 and P-31 MRS of PCA extracts of postmortem Alzheimer's disease brain. Neurobiol Aging. 1996;17:349-357.
    • (1996) Neurobiol Aging , vol.17 , pp. 349-357
    • Klunk, W.E.1    Xu, C.2    Panchalingam, K.3    McClure, R.J.4    Pettegrew, J.W.5
  • 81
    • 0029619759 scopus 로고
    • Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia
    • Pettegrew JW, Klunk WE, Kanal E, Panchalingam K, McClure RJ. Changes in brain membrane phospholipid and high-energy phosphate metabolism precede dementia. Neurobiol Aging. 1995;16:973-975.
    • (1995) Neurobiol Aging , vol.16 , pp. 973-975
    • Pettegrew, J.W.1    Klunk, W.E.2    Kanal, E.3    Panchalingam, K.4    McClure, R.J.5
  • 82
    • 0027535032 scopus 로고
    • Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra
    • Michaelis T, Merboldt KD, Bruhn H, Hanicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology. 1993;187:219-227.
    • (1993) Radiology , vol.187 , pp. 219-227
    • Michaelis, T.1    Merboldt, K.D.2    Bruhn, H.3    Hanicke, W.4    Frahm, J.5


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