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"Lysophosphatidic acid: G-protein signalling and cellular responses": W. H. Moolenaar, O. Kranenburg, F. R. Postma, G. C. M. Zondag, Curr. Opin. Cell Biol. 1997, 9, 168-173.
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2
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Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells: D. A. Fishman, Y. Y. Liu, S. M. Ellerbroek, M. S. Stack, Cancer Res. 2001, 61, 3194-3199.
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"Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells": D. A. Fishman, Y. Y. Liu, S. M. Ellerbroek, M. S. Stack, Cancer Res. 2001, 61, 3194-3199.
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Lysophosphatidic acid is a bioactive mediator in ovarian cancer: X. Fang, M. Schummer, M. Mao, S. Yu, F. H. Tabassam, R. Swaby, Y. Hasegawa, J. L. Tanyi, R. LaPushin, A. Eder, R. Jaffe, J. Erickson, G. B. Mills, Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2002, 1582, 257-264.
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"Lysophosphatidic acid is a bioactive mediator in ovarian cancer": X. Fang, M. Schummer, M. Mao, S. Yu, F. H. Tabassam, R. Swaby, Y. Hasegawa, J. L. Tanyi, R. LaPushin, A. Eder, R. Jaffe, J. Erickson, G. B. Mills, Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2002, 1582, 257-264.
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4
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Unfolding the pathophysiological role of bioactive lysophospholipids: Y. Xu, Y.-J. Xiao, K. Zhu, L. M. Baudhuin, J. Lu, G. Hong, K.-S. Kim, K. L. Cristina, L. Song, F. S. Williams, P. Elson, M. Markman, J. Belinson, Curr. Drug Targets Immune Endocr. Metab. Disord. 2003, 3, 23-32.
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"Unfolding the pathophysiological role of bioactive lysophospholipids": Y. Xu, Y.-J. Xiao, K. Zhu, L. M. Baudhuin, J. Lu, G. Hong, K.-S. Kim, K. L. Cristina, L. Song, F. S. Williams, P. Elson, M. Markman, J. Belinson, Curr. Drug Targets Immune Endocr. Metab. Disord. 2003, 3, 23-32.
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5
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0034668925
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Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase: X. Fang, S. Yu, R. LaPushin, Y. Lu, T. Furui, L. Z. Penn, D. Stokoe, J. R. Erickson, R. C. Bast, Jr., G. B. Mills, Biochem. J. 2000, 352, 135-143.
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"Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase": X. Fang, S. Yu, R. LaPushin, Y. Lu, T. Furui, L. Z. Penn, D. Stokoe, J. R. Erickson, R. C. Bast, Jr., G. B. Mills, Biochem. J. 2000, 352, 135-143.
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6
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17144460494
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Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer: G. B. Mills, A. Eder, X. Fang, Y. Hasegawa, M. Mao, Y. Lu, J. Tanyi, F. H. Tabassam, J. Wiener, R. Lapushin, S. Yu, J. A. Parrott, T. Compton, W. Tribley, D. Fishman, M. S. Stack, D. Gaudette, R. Jaffe, T. Furui, J. Aoki, J. R. Erickson, Cancer Treat. Res. 2002, 107, 259-283.
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"Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer": G. B. Mills, A. Eder, X. Fang, Y. Hasegawa, M. Mao, Y. Lu, J. Tanyi, F. H. Tabassam, J. Wiener, R. Lapushin, S. Yu, J. A. Parrott, T. Compton, W. Tribley, D. Fishman, M. S. Stack, D. Gaudette, R. Jaffe, T. Furui, J. Aoki, J. R. Erickson, Cancer Treat. Res. 2002, 107, 259-283.
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The emerging role of lysophosphatidic acid in cancer: G. B. Mills, W. H. Moolenaar, Nat. Rev. Cancer 2003, 3, 582-591.
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"The emerging role of lysophosphatidic acid in cancer": G. B. Mills, W. H. Moolenaar, Nat. Rev. Cancer 2003, 3, 582-591.
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8
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0037077199
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Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood: T. Sano, D. Baker, T. Virag, A. Wada, Y. Yatomi, T. Kobayashi, Y. Igarashi, G. Tigyi, J. Biol. Chem. 2002, 277, 21197-21206.
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"Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood": T. Sano, D. Baker, T. Virag, A. Wada, Y. Yatomi, T. Kobayashi, Y. Igarashi, G. Tigyi, J. Biol. Chem. 2002, 277, 21197-21206.
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9
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Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate: L. A. van Meeteren, P. Ruurs, E. Christodoulou, J. W. Goding, H. Takakusa, K. Kikuchi, A. Perrakis, T. Nagano, W. H. Moolenaar, J. Biol. Chem. 2005, 280, 21155-21161.
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"Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate": L. A. van Meeteren, P. Ruurs, E. Christodoulou, J. W. Goding, H. Takakusa, K. Kikuchi, A. Perrakis, T. Nagano, W. H. Moolenaar, J. Biol. Chem. 2005, 280, 21155-21161.
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10
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Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1: K. Hama, J. Aoki, M. Fukaya, Y. Kishi, T. Sakai, R. Suzuki, H. Ohta, T. Yamori, M. Watanabe, J. Chun, H. Arai, J. Biol. Chem. 2004, 279, 17634-17639.
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"Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1": K. Hama, J. Aoki, M. Fukaya, Y. Kishi, T. Sakai, R. Suzuki, H. Ohta, T. Yamori, M. Watanabe, J. Chun, H. Arai, J. Biol. Chem. 2004, 279, 17634-17639.
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11
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0036244390
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Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines: N. Euer, M. Schwirzke, V. Evtimova, H. Burscher, M. Jarsch, D. Tarin, U. H. Weidle, Anticancer Res. 2002, 22, 733-740.
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"Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines": N. Euer, M. Schwirzke, V. Evtimova, H. Burscher, M. Jarsch, D. Tarin, U. H. Weidle, Anticancer Res. 2002, 22, 733-740.
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12
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Lysophosphatidic acid signaling: how a small lipid does big things: C. Luquain, V. A. Sciorra, A. J. Morris, Trends Biochem. Sci. 2003, 28, 377-383.
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"Lysophosphatidic acid signaling: how a small lipid does big things": C. Luquain, V. A. Sciorra, A. J. Morris, Trends Biochem. Sci. 2003, 28, 377-383.
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13
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Lysophosphatidic acid production and action: validated targets in cancer?: M. Umezu-Goto, J. Tanyi, J. Lahad, S. Liu, S. Yu, R. Lapushin, Y. Hasegawa, Y. Lu, R. Trost, T. Bevers, E. Jonasch, K. Aldape, J. Liu, R. D. James, C. G. Ferguson, Y. Xu, G. D. Prestwich, G. B. Mills, J. Cell. Biochem. 2004, 92, 1115-1140.
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"Lysophosphatidic acid production and action: validated targets in cancer?": M. Umezu-Goto, J. Tanyi, J. Lahad, S. Liu, S. Yu, R. Lapushin, Y. Hasegawa, Y. Lu, R. Trost, T. Bevers, E. Jonasch, K. Aldape, J. Liu, R. D. James, C. G. Ferguson, Y. Xu, G. D. Prestwich, G. B. Mills, J. Cell. Biochem. 2004, 92, 1115-1140.
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14
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0038152846
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Identification of p2y9/GPR23 as a novel G-protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family: K. Noguchi, S. Ishii, T. Shimizu, J. Biol. Chem. 2003, 278, 25600-25606.
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"Identification of p2y9/GPR23 as a novel G-protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family": K. Noguchi, S. Ishii, T. Shimizu, J. Biol. Chem. 2003, 278, 25600-25606.
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15
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33745957774
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Lysophosphatidic acid binds to and activates GPR92, a G-protein-coupled receptor highly expressed in gastrointestinal lymphocytes: K. Kotarsky, A. Boketoft, J. Bristulf, N. E. Nilsson, A. Norberg, S. Hansson, R. Sillard, C. Owman, F. L. M. Leeb-Lundberg, B. Olde, J. Pharmacol. Exp. Ther. 2006, 318, 619-628.
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"Lysophosphatidic acid binds to and activates GPR92, a G-protein-coupled receptor highly expressed in gastrointestinal lymphocytes": K. Kotarsky, A. Boketoft, J. Bristulf, N. E. Nilsson, A. Norberg, S. Hansson, R. Sillard, C. Owman, F. L. M. Leeb-Lundberg, B. Olde, J. Pharmacol. Exp. Ther. 2006, 318, 619-628.
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16
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33747685338
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GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5: C.-W. Lee, R. Rivera, S. Gardell, A. Dubin, J. Chun, J. Biol. Chem. 2006, 281, 23589-23597.
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"GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5": C.-W. Lee, R. Rivera, S. Gardell, A. Dubin, J. Chun, J. Biol. Chem. 2006, 281, 23589-23597.
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17
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0037134949
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Plasma lysophosphatidic acid concentration and ovarian cancer: D. L. Baker, P. Morrison, B. Miller, C. A. Riely, B. Tolley, A. M. Westermann, J. M. G. Bonfrer, E. Bais, W. H. Moolenaar, G. Tigyi, JAMA J. Am. Med. Assoc. 2002, 287, 3081-3082.
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"Plasma lysophosphatidic acid concentration and ovarian cancer": D. L. Baker, P. Morrison, B. Miller, C. A. Riely, B. Tolley, A. M. Westermann, J. M. G. Bonfrer, E. Bais, W. H. Moolenaar, G. Tigyi, JAMA J. Am. Med. Assoc. 2002, 287, 3081-3082.
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18
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0037422595
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Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist: T. M. McIntyre, A. V. Pontsler, A. R. Silva, A. St Hilaire, Y. Xu, J. C. Hinshaw, G. A. Zimmerman, K. Hama, J. Aoki, H. Arai, G. D. Prestwich, Proc. Natl. Acad. Sci. USA 2003, 100, 131-136.
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"Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist": T. M. McIntyre, A. V. Pontsler, A. R. Silva, A. St Hilaire, Y. Xu, J. C. Hinshaw, G. A. Zimmerman, K. Hama, J. Aoki, H. Arai, G. D. Prestwich, Proc. Natl. Acad. Sci. USA 2003, 100, 131-136.
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19
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12144288490
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Lysophosphatidic acid induces neointima formation through PPARγ activation: C. Zhang, D. L. Baker, S. Yasuda, N. Makarova, L. Balazs, L. R. Johnson, G. K. Marathe, T. M. McIntyre, Y. Xu, G. D. Prestwich, H. S. Byun, R. Bittman, G. Tigyi, J. Exp. Med. 2004, 199, 763-774.
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"Lysophosphatidic acid induces neointima formation through PPARγ activation": C. Zhang, D. L. Baker, S. Yasuda, N. Makarova, L. Balazs, L. R. Johnson, G. K. Marathe, T. M. McIntyre, Y. Xu, G. D. Prestwich, H. S. Byun, R. Bittman, G. Tigyi, J. Exp. Med. 2004, 199, 763-774.
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20
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2942532893
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Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid: W. L. Santos, B. H. Heasley, R. Jarosz, K. M. Carter, K. R. Lynch, T. L. Macdonald, Bioorg. Med. Chem. Lett. 2004, 14, 3473-3476.
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"Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid": W. L. Santos, B. H. Heasley, R. Jarosz, K. M. Carter, K. R. Lynch, T. L. Macdonald, Bioorg. Med. Chem. Lett. 2004, 14, 3473-3476.
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Activity of 2-substituted lysophosphatidic acid (LPA) analogues at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist: C. E. Heise, W. L. Santos, A. M. Schreihofer, B. H. Heasley, Y. V. Mukhin, T. L. Macdonald, K. R. Lynch, Mol. Pharmacol. 2001, 60, 1173-1180.
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"Activity of 2-substituted lysophosphatidic acid (LPA) analogues at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist": C. E. Heise, W. L. Santos, A. M. Schreihofer, B. H. Heasley, Y. V. Mukhin, T. L. Macdonald, K. R. Lynch, Mol. Pharmacol. 2001, 60, 1173-1180.
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Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors: H. Ohta, K. Sato, N. Murata, A. Damirin, E. Malchinkhuu, J. Kon, T. Kimura, M. Tobo, Y. Yamazaki, T. Watanabe, M. Yagi, M. Sato, R. Suzuki, H. Murooka, T. Sakai, T. Nishitoba, D. S. Im, H. Nochi, K. Tamoto, H. Tomura, F. Okajima, Mol. Pharmacol. 2003, 64, 994-1005.
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"Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors": H. Ohta, K. Sato, N. Murata, A. Damirin, E. Malchinkhuu, J. Kon, T. Kimura, M. Tobo, Y. Yamazaki, T. Watanabe, M. Yagi, M. Sato, R. Suzuki, H. Murooka, T. Sakai, T. Nishitoba, D. S. Im, H. Nochi, K. Tamoto, H. Tomura, F. Okajima, Mol. Pharmacol. 2003, 64, 994-1005.
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23
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Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist: R. H. Heasley, R. Jarosz, K. R. Lynch, T. L. Macdonald, Bioorg. Med. Chem. Lett. 2004, 14, 2735-2740.
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"Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist": R. H. Heasley, R. Jarosz, K. R. Lynch, T. L. Macdonald, Bioorg. Med. Chem. Lett. 2004, 14, 2735-2740.
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24
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Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors: T. Virag, D. B. Elrod, K. Liliom, V. M. Sardar, A. L. Parrill, K. Yokoyama, G. Durgam, W. Deng, D. D. Miller, G. Tigyi, Mol. Pharmacol. 2003, 63, 1032-1042.
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"Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors": T. Virag, D. B. Elrod, K. Liliom, V. M. Sardar, A. L. Parrill, K. Yokoyama, G. Durgam, W. Deng, D. D. Miller, G. Tigyi, Mol. Pharmacol. 2003, 63, 1032-1042.
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25
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0346366461
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3 receptor-selective agonist activity: L. Qian, Y. Xu, Y. Hasegawa, J. Aoki, G. B. Mills, G. D. Prestwich, J. Med. Chem. 2003, 46, 5575-5578.
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3 receptor-selective agonist activity": L. Qian, Y. Xu, Y. Hasegawa, J. Aoki, G. B. Mills, G. D. Prestwich, J. Med. Chem. 2003, 46, 5575-5578.
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Synthesis of α-fluorinated phosphonates from α-fluorovinylphosphonates: a new route to analogues of lysophosphatidic acid: Y. Xu, L. Qian, G. D. Prestwich, Org. Lett. 2003, 5, 2267-2270.
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Structure-activity relationships of fluorinated lysophosphatidic acid analogues: Y. Xu, J. Aoki, K. Shimizu, M. Umezu-Goto, K. Hama, Y. Takanezawa, S. Yu, G. B. Mills, H. Arai, L. Qian, G. D. Prestwich, J. Med. Chem. 2005, 48, 3319-3327.
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Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist: Y. Tamaruya, M. Suzuki, G. Kamura, M. Kanai, K. Hama, K. Shimizu, J. Aoki, H. Arai, M. Shibasaki, Angew. Chem. 2004, 116, 2894-2897;
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Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ and inhibitors of autotaxin: G. G. Durgam, T. Virag, M. D. Walker, R. Tsukahara, S. Yasuda, K. Liliom, L. A. van Meeteren, W. H. Moolenaar, N. Wilke, W. Siess, G. Tigyi, D. D. Miller, J. Med. Chem. 2005, 48, 4919-4930.
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