Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships

Journal of Medicinal Chemistry

Volumn 45, Issue 21, 2002, Pages 4629-4638

  Koide, Yuuki ^a,b   Hasegawa, Takeshi ^a   Takahashi, Atsuo ^a   Endo, Akira ^c   Mochizuki, Naoki ^c   Nakagawa, Masako ^b   Nishida, Atsushi ^b  

^a TOA EIYO LTD   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 HEPTYLPHENYL)THIAZOLIDINE 4 CARBOXYLIC ACID; 2 (4 HEPTYLPHENYL)THIAZOLIDINE 4 CARBOXYLIC ACID; BTB 11545; D 0922; D 9272; DP 00734; ENDOTHELIAL DIFFERENTIATION GENE 3 RECEPTOR ANTAGONIST; G 3751; G PROTEIN COUPLED RECEPTOR; H 0885; H 1390; H 8765; H 87765; K 1250; L 0501; L 3877; NH 00052; P 4509; RECEPTOR BLOCKING AGENT; RH 00666; RH 00669; S 14459; S 341967; S 354384; SB 00761; SPHINGOSINE 1 PHOSPHATE; SQ 5995335; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG SYNTHESIS; HYDROPHOBICITY; MOLECULAR MODEL; REACTION ANALYSIS; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION;

DATABASES, FACTUAL; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; I-KAPPA B PROTEINS; LYSOPHOSPHOLIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, LYSOPHOSPHOLIPID; SPHINGOSINE; STEREOISOMERISM; THIAZINES; THIAZOLES;

EID: 0037057548     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020080c     Document Type: Article

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