Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: Involvement of a nonclassical pathway?

Molecular Endocrinology

Volumn 17, Issue 8, 2003, Pages 1593-1606

  Budnik, Lygia T ^a   Brunswig Spickenheier, Bärbel ^a   Mukhopadhyay, Amal K ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PERTUSSIS TOXIN; PROTEIN EDG2; PROTEIN LPA1; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; RECEPTOR PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THECA CELL;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CATTLE; CELL MEMBRANE; CELL NUCLEUS; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; LYSOPHOSPHOLIPIDS; MAP KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PERTUSSIS TOXIN; PHOSPHORYLATION; PROTEIN TRANSPORT; RAS PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOPHOSPHATIDIC ACID; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; THECA CELLS;

ANIMALIA;

EID: 0043268853     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0371     Document Type: Article

References (67)

1. XuY, Xiao YJ, Baudhuin LM, Schwarz BM 2001 The role and clinical applications of bioactive lysolipids in ovarian cancer. J Soc Gynecol Invest 8:1-13
2. Fang X, Gaudette D, Furui T, Mao M, Estrella V, Eder A, Pustilnik T, Sasagawa T, Lapushin R, Yu S, Jaffe RB, Wiener JR, Erickson JR, Mills GB 2000 Lysophospholipid growth factors in the initiation, progression, metastases and management of ovarian cancer. Ann NY Acad Sci 905:188-208
3. Westermann AM, Havik E, Postman FR, Beijnen JH, Dalesio O, Moolenaar WH, Rodenhuis S 1998 Malignant effusions contain lysophosphatidic acid (LPA) like activity. Ann Oncol 9:437-442
4. Baker DL, Morrison P, Miller B, Rieley CA, Tolley B, Westermann AM, Bonfrer JM, Bais E, Moolenaar WH, Tigyi G 2002 Plasma lysophosphatidic acid concentration and ovarian cancer. JAMA 287:3081-3182
5. Gaits F, Fourcade O, Le Baelle F, Gueguen G, Gaige B, Gassama-Diagne A, Fauvel J, Salles JP, Mauco G, Simon MF, Chap H 1997 Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis. FEBS Lett 410:54-58
6. Budnik LT, Mukhopadhyay AK 2002 Lysophosphatidic acid and its role in reproduction. Biol Reprod 66:859-865
7. Reynolds LP, Redmer DA 1999 Growth and development of the corpus luteum. J Reprod Fertil 54:181-191
8. Richards JS, Russell DL, Ochsner S, Hsieh M, Doyle KH, Falender AE, Lo YK, Sharma SC 2002 Novel signaling pathways that control ovarian follicular development, ovulation and luteinization. Recent Prog Horm Res 57:195-220
9. Gräler MH, Goetzl EJ 2002 Lysophospholipids and their G protein-coupled receptors in inflammation and immunity. Biochim Biophys Acta 1582:168-174
10. Tigyi G 2001 Physiological responses to lysophosphatidic acid and related glycerol-phospholipids. Prostaglandins 64:47-62
11. Budnik LT, Mukhopadhyay AK 1997 Functional lysophosphatidic acid receptor in bovine luteal cells. FEBS Lett 419:4-8
12. Budnik LT, Mukhopadhyay AK 2001 Lysophosphatidic acid antagonizes the morphoregulatory effects of the luteinizing hormone on luteal cells: possible role of small Rho-G-proteins. Biol Reprod 65:180-187
13. Budnik LT, Mukhopadhyay AK 2002 Lysophosphatidic acid-induced nuclear localization of protein kinase Cδ in bovine theca cells stimulated with luteinizing hormone. Biol Reprod 67:935-944
14. Moolenaar WH 1999 Bioactive lysolipids and their G protein coupled receptors. Exp Cell Res 253:230-238
15. Goetzl EJ, An S 1998 Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine-1-phosphate. FASEB J 12:1589-1598
16. Takuwa Y, Takuwa N, Sugimoto N 2002 The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. J Biochem (Tokyo) 131:767-771
17. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ 2001 Lysophospholipids-receptor revelations. Science 294:1875-1878
18. Chun J, Contos JJ, Munroe D 1999 A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem Biophys 30:213-242
19. Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G 2002 International Union of Pharmacology, XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54:265-269
20. Contos JJ, Ishii I, Chun J 196 2000 Lysophosphatidic acid receptors. Mol Pharmacol 58:1188-1191
21. Goetzl EJ, Dolezalova H, Kong Y, Hu Y-L, Jaffe RB, Kalli KR, Conover CA 1999 Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res 59:5370-5375
22. Kranenburg O, Moolenaar WH 2001 Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 20:1540-1546
23. Alessi DR, Gornetz N, Moorhead G, Lewis T, Keyse SM, Cohen P 1995 Inactivation of p42 MAP kinase by protein phosphatase 2A and a tyrosine phosphatase, but not CL 100, in various cell lines. Curr Biol 5:283-295
24. Kerkhoff E, Rapp UR 2001 The Ras-Raf relationship: an unfinished puzzle. Adv Enzyme Regul 41:261-267
25. Pearson G, Robinson F, Beers Gibson T, Xu B-E, Karandikar M, Berman K, Cobb MH 2001 Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22:153-183
26. Murga C, Fukuhara S, Gutkind JS 1999 Novel molecular mediators in the pathway connecting G-protein-coupled receptors to MAP kinase cascades. Trends Endocrinol Metab 10:122-127
27. Lopez-Ilasaca M 1998 Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades. Biochem Pharmacol 56:269-277
28. Huang CY, Ferrell Jr J-E 1996 Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci USA 93:10078-10083
29. Gutkind JS 2000 Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE 40 RE1:1-13
30. Renshaw MW, Toksoz D, Schwartz MA 1996 Involvement of small GTPase Rho in integrin-mediated activation of mitogen-activated-kinase. J Biol Chem 271:21691-21694
31. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR 1995 PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494
32. Cheng JJ, Wung BS, Chao YJ, Wang DL 2001 Sequential activation of protein kinase C (PKC)-α and PKC-ε contributes to sustained Raf/Erk 1/2 activation in endothelial cells under mechanical strain. J Biol Chem 276:31368-31375
33. Ciullo I, Diez-Roux G, Di Domenico M, Migliaccio A, Avvedimento EV 192 2001 cAMP signaling selectively influences Ras effectors pathways. Oncogene 20:1186-1191
34. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A 1999 EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-886
35. Carpenter G 1999 Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol 146:697-702
36. Wu J, Cunnick JM 2002 Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors. Biochim Biophys Acta 1582:100-106
37. van Corven EJ, Hordijk PL, Medema RH, Bos JL, Moolenaar WH 1993 Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proc Natl Acad Sci USA 90:1257-1261
38. Tamanoi F 1993 Inhibitors of Ras farnesyltransferases. Trends Biochem Sci 18:349-353
39. Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S, Moolenaar WH 1994 Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP-ribosylation of the small GTP-binding protein Rho. J Cell Biol 126:801-810
40. Schlesinger TK, Fanger GR, Yujiri T, Johnson GL 1998 The TAO of MEKK. Front Biosci 3:D1181-D1186
41. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL 1993 A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319
42. Lu Z, Xu S, Joazero C, Cobb MH, Hunter T 2002 The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of Erk1/2. Mol Cell 9:945-956
43. Hagemann C, Blank JL 2001 The ups and downs of MEK kinase interactions. Cell Signal 13:863-875
44. Contos JJ, Chun J 1998 Complete cDNA sequence, genomic structure and chromosomal localization of the LPA receptor gene, LpA1/vzg-1/Gpcr 26. Genomics 51:364-378
45. Cunnick JM, Dorsey JF, Standley T, Turkson J, Kraker AJ, Fry DW, Jove R, Wu J 1998 Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen activated protein kinase pathway. J Biol Chem 273:14468-14475
46. Pierce KL, Luttrell LM, Lefkowitz RJ 2001 New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539
47. Yan Y, Shirakabe K, Werb Z 2002 The metalloproteinase Kuzbanian (ADAM 10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol 158:221-226
48. Takeda H, Matozaki T, Fujioka Y, Takada T, Noguchi T, Yamao T, Tsuda M, Ochi F, Fukunaga K, Narumiya S, Yamamoto T, Kasuga M 1998 Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: role of RHO, FAK and a SRC family kinase. Oncogene 16:3019-3027
49. Kumagai N, Morii N, Ishizaki T, Watanabe N, Fujisawa K, Saito Y, Narumiya S 1995 Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signaling. FEBS Lett 366:11-16
50. Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH 1996 Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol 16:3707-3713
51. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P 1994 Integrin-mediated signal transduction linked to ras pathway by GRB2 binding to focal adhesion kinase. Nature 372:786-791
52. Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J 2001 Src and Pyk2 mediate G-protein coupled receptor activation of epidermal growth factor receptor (EGF R), but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276:20130-20135
53. Chikumi H, Vazquez-Prado J, Servitja J-M, Miyazaki H, Gutkind JS 2002 Potent activation of RhoA by Gαq and Gq-coupled receptors. J Biol Chem 277:27130-27134
54. Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazernpour R Sternweis PC, Cobb MH 192 2002 p115 Rho GTPase activating protein interacts with MEKK1. J Cell Physiol 192:200-208
55. Blumer KJ, Johnson GL 1994 Diversity in function and regulation of MAP kinase pathways. Trends Biochem Sci 19:236-240
56. Yujiri T, Sather S, Fanger GR, Johnson GL 1998 Role of MEKK1 in cell survival and activation of JNK and Erk pathways defined by targeted gene disruption. Science 282:1911-1914
57. Baumann B, Weber CK, Troppmair J, Whiteside S, Israel A, Rapp UR, Wirth T 2000 Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci USA 97:4615-4620
58. Keel BA, Davis JS 1999 Epidermal growth factor activates extracellular signal regulated kinase (erk) in freshly isolated porcine granulosa cells. Steroids 64:654-658
59. Seger R, Hanoch T, Rosenberg R, Dantes A, Merz WE, Strauss JF, Amsterdam A 2001 The Erk signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J Biol Chem 276:13957-13964
60. Taylor CC 2000 Platelet-derived growth factor activates porcine thecal cell phosphatidyl-inositol-3-kinase Akt/PKB and ras-extracellular signal-regulated kinase-1/2 kinase signaling pathways via the platelet derived growth factor-β receptor. Endocrinology 141:1545-1553
61. Brunswig-Spickenheier B, Mukhopadhyay AK 1993 Effects of tumor necrosis factor-α on luteinizing hormone-stimulated prorenin production by bovine ovarian thecal cells in vitro. Endocrinology 133:2515-2522
62. Bradford MM 1976 A rapid and sensitive method utilizing the principle of protein-dye binding for the quantification of protein. Anal Biochem 72:248-254
63. Chomczynski P, Sacchi N 1987 Single step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159
64. Friedman A, Weiss S, Levy N, Meidan R 2000 Role of tumor necrosis factor α and its type I receptor in luteal regression: induction of programmed cell death in bovine corpus luteum-derived endothelial cells. Biol Reprod 63:1905-1912
65. Tsai SJ, Wiltbank MC, Bodensteiner KJ 1996 Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase, PGE(EP3) receptor and PGF2α receptor in bovine preovulatory follicles. Endocrinology 137:3348-3355
66. Pages C, Daviaud D, An S, Krief S, Lafontan M, Valet P, Saulnier-Blache JS 2001 Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading. J Biol Chem 276:11599-11605
67. Macrae AD, Premont RT, Jaber M, Peterson AS, Lefkowitz RJ 1996 Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Mol Brain Res 42:245-254