Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors

Journal of Medicinal Chemistry

Volumn 49, Issue 17, 2006, Pages 5309-5315

  Xu, Yong ^a   Jiang, Guowei ^a   Tsukahara, Ryoko ^b   Fujiwara, Yuko ^b   Tigyi, Gabor ^b   Prestwich, Glenn D ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUOROHYDROXYL 4 OLEOYLOXYLBUTANE 1,3 CYCLIC PHOSPHONATE; 1,1 DIFLUORO 3 HYDROXYL 4 OLEOYLOXYLBUTANE 1,3 CYCLIC PHOSPHONATE; 3 HYDROXYL 4 OLEOYLOXYLBUTANE 1,3 CYCLIC PHOSPHONOTHIOATE; 3 HYDROXYL 4 PALMITOYLOXYLBUTANE 1,3 CYCLIC PHOSPHONOTHIOATE; AMPHOPHILE; CALCIUM ION; CARBENE; FLUORINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR 1; LYSOPHOSPHATIDIC ACID RECEPTOR 2; LYSOPHOSPHATIDIC ACID RECEPTOR 3; LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST; PHOSPHATIDIC ACID; PHOSPHOLIPID; PHOSPHONIC ACID DERIVATIVE; RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; NONHUMAN; PKA; REACTION ANALYSIS; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; TITRIMETRY;

ANIMALS; CALCIUM; CELL LINE, TUMOR; CYCLIZATION; MOLECULAR STRUCTURE; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHATIDIC ACIDS; PHOSPHONIC ACIDS; RECEPTORS, LYSOPHOSPHATIDIC ACID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747593309     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060351+     Document Type: Article

References (52)

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