Effects of the mGlu2/3 Agonist LY379268 and the mGlu5 Antagonist MTEP on Ethanol Seeking and Reinforcement Are Differentially Altered in Rats with a History of Ethanol Dependence

Biological Psychiatry

Volumn 67, Issue 9, 2010, Pages 804-811

  Sidhpura, Nimish ^a   Weiss, Friedbert ^a   Martin Fardon, Rémi ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Ethanol dependence; LY379268; metabotropic glutamate receptor; MTEP; relapse; self administration

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; ALCOHOL; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5;

ALCOHOL BLOOD LEVEL; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOTSHOCK; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ALCOHOLISM; AMINO ACIDS; ANALYSIS OF VARIANCE; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXCITATORY AMINO ACID AGENTS; MALE; PYRIDINES; RATS; RATS, WISTAR; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; STRESS, PSYCHOLOGICAL; THIAZOLES;

EID: 77950357306     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.01.005     Document Type: Article

References (73)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Publishing, Washington, DC
2. Koob G.F., and Le Moal M. Addiction and the brain antireward system. Annu Rev Psychol 59 (2008) 29-53
3. Tsai G., and Coyle J.T. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49 (1998) 173-184
4. Melendez R.I., Hicks M.P., Cagle S.S., and Kalivas P.W. Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res 29 (2005) 326-333
5. Vengeliene V., Bilbao A., Molander A., and Spanagel R. Neuropharmacology of alcohol addiction. Br J Pharmacol 154 (2008) 299-315
6. Chiamulera C., Epping-Jordan M.P., Zocchi A., Marcon C., Cottiny C., Tacconi S., et al. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4 (2001) 873-874
7. Kenny P.J., Gasparini F., and Markou A. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/ kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. J Pharmacol Exp Ther 306 (2003) 1068-1076
8. Paterson N.E., Semenova S., Gasparini F., and Markou A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology 167 (2003) 257-264
9. Rasmussen K., Martin H., Berger J.E., and Seager M.A. The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats. Neuropharmacology 48 (2005) 173-180
10. Lominac K.D., Kapasova Z., Hannun R.A., Patterson C., Middaugh L.D., and Szumlinski K.K. Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: Potential insight into their anti-addictive properties. Drug Alcohol Depend 85 (2006) 142-156
11. Knackstedt L.A., and Kalivas P.W. Glutamate and reinstatement. Curr Opin Pharmacol 9 (2009) 59-64
12. Spooren W., Ballard T., Gasparini F., Amalric M., Mutel V., and Schreiber R. Insight into the function of group I and group II metabotropic glutamate (mGlu) receptors: Behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol 14 (2003) 257-277
13. Schoepp D.D., and Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14 (1993) 13-20
14. Kenny P.J., and Markou A. The ups and downs of addiction: Role of metabotropic glutamate receptors. Trends Pharmacol Sci 25 (2004) 265-272
15. Heilig M., and Egli M. Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms. Pharmacol Ther 111 (2006) 855-876
16. Gass J.T., and Olive M.F. Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75 (2008) 218-265
17. Conn P.J., and Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37 (1997) 205-237
18. Schoepp D.D. Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299 (2001) 12-20
19. Cowen M.S., Djouma E., and Lawrence A.J. The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315 (2005) 590-600
20. Olive M.F., McGeehan A.J., Kinder J.R., McMahon T., Hodge C.W., Janak P.H., et al. The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol 67 (2005) 349-355
21. Schroeder J.P., Overstreet D.H., and Hodge C.W. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology 179 (2005) 262-270
22. Hodge C.W., Miles M.F., Sharko A.C., Stevenson R.A., Hillmann J.R., Lepoutre V., et al. The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology 183 (2006) 429-438
23. Besheer J., Faccidomo S., Grondin J.J., and Hodge C.W. Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol Clin Exp Res 32 (2008) 209-221
24. Kenny P.J., Paterson N.E., Boutrel B., Semenova S., Harrison A.A., Gasparini F., et al. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann NY Acad Sci 1003 (2003) 415-418
25. Tessari M., Pilla M., Andreoli M., Hutcheson D.M., and Heidbreder C.A. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur J Pharmacol 499 (2004) 121-133
26. Lee B., Platt D.M., Rowlett J.K., Adewale A.S., and Spealman R.D. Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: Comparison with dizocilpine. J Pharmacol Exp Ther 312 (2005) 1232-1240
27. Liechti M.E., and Markou A. Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. Eur J Pharmacol 554 (2007) 164-174
28. Popik P., and Wrobel M. Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 43 (2002) 1210-1217
29. Backstrom P., and Hyytia P. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 (2006) 778-786
30. Bespalov A.Y., Dravolina O.A., Sukhanov I., Zakharova E., Blokhina E., Zvartau E., et al. Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 49 suppl 1 (2005) 167-178
31. Backstrom P., Bachteler D., Koch S., Hyytia P., and Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29 (2004) 921-928
32. Ferraguti F., and Shigemoto R. Metabotropic glutamate receptors. Cell Tissue Res 326 (2006) 483-504
33. Pinheiro P.S., and Mulle C. Presynaptic glutamate receptors: Physiological functions and mechanisms of action. Nat Rev Neurosci 9 (2008) 423-436
34. Moghaddam B., and Adams B.W. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281 (1998) 1349-1352
35. Vandergriff J., and Rasmussen K. The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropharmacology 38 (1999) 217-222
36. Cartmell J., Monn J.A., and Schoepp D.D. The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing. Eur J Pharmacol 400 (2000) 221-224
37. Baptista M.A., Martin-Fardon R., and Weiss F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent conventional reinforcer. J Neurosci 24 (2004) 4723-4727
38. Bossert J.M., Liu S.Y., Lu L., and Shaham Y. A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking. J Neurosci 24 (2004) 10726-10730
39. Adewale A.S., Platt D.M., and Spealman R.D. Pharmacological stimulation of group II metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys. J Pharmacol Exp Ther 318 (2006) 922-931
40. Lu L., Uejima J.L., Gray S.M., Bossert J.M., and Shaham Y. Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. Biol Psychiatry 61 (2007) 591-598
41. Zhao Y., Dayas C.V., Aujla H., Baptista M.A., Martin-Fardon R., and Weiss F. Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-Fos expression in the hippocampus and amygdala. J Neurosci 26 (2006) 9967-9974
42. Backstrom P., and Hyytia P. Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG. Eur J Pharmacol 528 (2005) 110-118
43. Le A., and Shaham Y. Neurobiology of relapse to alcohol in rats. Pharmacol Ther 94 (2002) 137-156
44. Swanson C.J., Bures M., Johnson M.P., Linden A.M., Monn J.A., and Schoepp D.D. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov 4 (2005) 131-144
45. Martin-Fardon R., Ciccocioppo R., Massi M., and Weiss F. Nociceptin prevents stress-induced ethanol- but not cocaine-seeking behavior in rats. Neuroreport 11 (2000) 1939-1943
46. Ciccocioppo R., Martin-Fardon R., Weiss F., and Massi M. Nociceptin/orphaning FQ inhibits stress- and CRF-induced anorexia in rats. Neuroreport 12 (2001) 1145-1149
47. Martin-Fardon R., Baptista M.A., Dayas C.V., and Weiss F. Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: Comparison between cocaine and a conventional reinforcer. J Pharmacol Exp Ther 329 (2009) 1084-1090
48. Cartmell J., Monn J.A., and Schoepp D.D. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J Pharmacol Exp Ther 291 (1999) 161-170
49. Cartmell J., Monn J.A., and Schoepp D.D. Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine. Psychopharmacology 148 (2000) 423-429
50. Varty G.B., Grilli M., Forlani A., Fredduzzi S., Grzelak M.E., Guthrie D.H., et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: A comparison of efficacy and side-effect profiles. Psychopharmacology 179 (2005) 207-217
51. Belozertseva I.V., Kos T., Popik P., Danysz W., and Bespalov A.Y. Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. Eur Neuropsychopharmacol 17 (2007) 172-179
52. Roberts A.J., Heyser C.J., Cole M., Griffin P., and Koob G.F. Excessive ethanol drinking following a history of dependence: Animal model of allostasis. Neuropsychopharmacology 22 (2000) 581-594
53. Valdez G.R., Roberts A.J., Chan K., Davis H., Brennan M., Zorrilla E.P., et al. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: Regulation by corticotropin-releasing factor. Alcohol Clin Exp Res 26 (2002) 1494-1501
54. Rodd Z.A., McKinzie D.L., Bell R.L., McQueen V.K., Murphy J.M., Schoepp D.D., et al. The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behav Brain Res 171 (2006) 207-215
55. Smith A.D., and Weiss F. Ethanol exposure differentially alters central monoamine neurotransmission in alcohol-preferring versus -nonpreferring rats. J Pharmacol Exp Ther 288 (1999) 1223-1228
56. McBride W.J., Schultz J.A., Kimpel M.W., McClintick J.N., Wang M., You J., et al. Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: A proteomics study. Pharmacol Biochem Behav 92 (2009) 304-313
57. Cowen M.S., Krstew E., and Lawrence A.J. Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: Regulation by mGlu5 receptor antagonism. Psychopharmacology 190 (2007) 21-29
58. Cozzoli D.K., Goulding S.P., Zhang P.W., Xiao B., Hu J.H., Ary A.W., et al. Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: Functional implications for alcoholism. J Neurosci 29 (2009) 8655-8668
59. Besheer J, Grondin JJ, Cannady R, Sharko AC, Faccidomo S, Hodge CW (2009): Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake [published online ahead of print Nov 6]. Biol Psychiatry.
60. Wigmore M.A., and Lacey M.G. Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro. Br J Pharmacol 123 (1998) 667-674
61. Kalivas P.W., Lalumiere R.T., Knackstedt L., and Shen H. Glutamate transmission in addiction. Neuropharmacology 56 suppl 1 (2009) 169-173
62. Aujla H., Martin-Fardon R., and Weiss F. Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence. Neuropsychopharmacology 33 (2008) 1818-1826
63. Hao Y, Martin-Fardon R, Weiss F (in press): Behavioral and functional evidence of mGlu2/3 and mGlu5 metabotropic glutamate receptor dysregulation in cocaine-escalated rats: Factor in the transition to dependence. Biological Psychiatry.
64. Kim J.H., Austin J.D., Tanabe L., Creekmore E., and Vezina P. Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine. Eur J Neurosci 21 (2005) 295-300 erratum:225:908
65. Simonyi A., Christian M.R., Sun A.Y., and Sun G.Y. Chronic ethanol-induced subtype- and subregion-specific decrease in the mRNA expression of metabotropic glutamate receptors in rat hippocampus. Alcohol Clin Exp Res 28 (2004) 1419-1423
66. Schroeder J.P., Spanos M., Stevenson J.R., Besheer J., Salling M., and Hodge C.W. Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: Blockade by the mGluR5 antagonist MPEP. Neuropharmacology 55 (2008) 546-554
67. Bossert J.M., Gray S.M., Lu L., and Shaham Y. Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking. Neuropsychopharmacology 31 (2006) 2197-2209
68. Liechti M.E., Lhuillier L., Kaupmann K., and Markou A. Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. J Neurosci 27 (2007) 9077-9085
69. Gass J.T., Osborne M.P., Watson N.L., Brown J.L., and Olive M.F. mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology 34 (2009) 820-833
70. Kumaresan V., Yuan M., Yee J., Famous K.R., Anderson S.M., Schmidt H.D., et al. Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. Behav Brain Res 202 (2009) 238-244
71. Peters J., and Kalivas P.W. The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology 186 (2006) 143-149
72. Kenny P.J., Boutrel B., Gasparini F., Koob G.F., and Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology 179 (2005) 247-254
73. Herzig V., Capuani E.M., Kovar K.A., and Schmidt W.J. Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. Addict Biol 10 (2005) 243-249