A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking

Journal of Neuroscience

Volumn 24, Issue 47, 2004, Pages 10726-10730

  Bossert, Jennifer M ^a   Liu, Shirley Y ^a   Lu, Lin ^a   Shaham, Yavin ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Drug environment; Extinction; Opiate self administration; Reinstatement; Relapse; Renewal; Substantia nigra

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; DIAMORPHINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR AGONIST; OPIATE;

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; MALE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE; REWARD; VENTRAL TEGMENTUM;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CUES; EXTINCTION, PSYCHOLOGICAL; GLUTAMIC ACID; HEROIN DEPENDENCE; INJECTIONS; MALE; RATS; RATS, LONG-EVANS; RECEPTORS, METABOTROPIC GLUTAMATE; RECURRENCE; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 9344230367     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3207-04.2004     Document Type: Article

References (34)

1. Baptista MA, Martin-Fardon R, Weiss F (2004) Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement comparison between cocaine and a potent conventional reinforcer. J Neurosci 24:4723-4727.
2. Bechara A, Nader K, van der Kooy D (1998) A two-separate-motivational- systems hypothesis of opioid addiction. Pharmacol Biochem Behav 59:1-17.
3. Bouton ME (2002) Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry 52:976-986.
4. Bouton ME, Bolles RC (1979) Contextual control of the extinction of conditioned fear. Learn Motiv 10:445-466.
5. Byrne R, Harris G, Aston-Jones G (2003) Glutamate input to the ventral tegmental area is necessary for both learning and expression of morphine place preference. Soc Neurosci Abstr 29:110.1.
6. Carlezon Jr WA, Boundy VA, Haile CN, Lane SB, Kalb RG, Neve RL, Nestler EJ (1997) Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814.
7. Crombag H, Grimm JW, Shaham Y (2002) Effect of dopamine receptor antagonists on renewal of cocaine seeking by reexposure to drug-associated contextual cues. Neuropsychopharmacology 27:1007-1016.
8. Crombag HS, Shaham Y (2002) Renewal of drug seeking by contextual cues after prolonged extinction in rats. Behav Neurosci 116:169-173.
9. De Vries TJ, Schoffelmeer AN, Binnekade R, Raasø H, Vanderschuren LJ (2002) Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitization. Neuropsychopharmacology 26:18-26.
10. Di Ciano P, Everitt BJ (2004) Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats. Eur J Neurosci 19:1661-1667.
11. Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neural systems perspective. J Neurosci 22:3312-3320.
12. Fuchs RA, See RE (2002) Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats. Psychopharmacology (Berl) 160:425-433.
13. Georges F, Aston-Jones G (2002) Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: a novel excitatory amino acid input to midbrain dopamine neurons. J Neurosci 22:5173-5187.
14. Kalivas PW (2004) Glutamate systems in cocaine addiction. Curr Opin Pharmacol 4:23-29.
15. Kenny PJ, Markou A (2004) The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol 25:265-272.
16. Kenny PJ, Gasparini F, Markou A (2033) Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. J Pharmacol Exp Ther 306:1068-1076.
17. Kim JH, Vezina P (2002) The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine. Pharmacol Biochem Behav 73:333-337.
18. McFarland K, Ettenberg A (1997) Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli. Psychopharmacology 131:86-92.
19. O'Brien CP, Childress AR, McLellan TA, Ehrman R (1992) Classical conditioning in drug dependent humans. Ann NY Acad Sci 654:400-415.
20. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates, Ed 4. San Diego: Academic.
21. Phillips PE, Stuber GD, Heien ML, Wightman RM, Carelli RM (2003) Subsecond dopamine release promotes cocaine seeking. Nature 422:614-618.
22. Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511-1513.
23. Rouse ST, Marino MJ, Bradley SR, Awad H, Wittmann M, Conn PJ (2000) Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders. Pharmacol Ther 88:427-435.
24. Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:12-20.
25. Sesack SR, Carr DB, Omelchenko N, Pinto A (2003) Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions. Ann NY Acad Sci 1003:36-52.
26. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168:3-20.
27. Shalev U, Grimm JW, Shaham Y (2002) Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev 54:1-42.
28. Stewart J, de Wit H, Eikelboom R (1984) Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91:251-268.
29. Vandergriff J, Rasmussen K (1999) The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropharmacology 38:217-222.
30. Vezina P (2004) Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychostimulant drugs. Neurosci Biobehav Rev 27:827-839.
31. Weiss F, Martin-Fardon R, Ciccocioppo R, Kerr TM, Smith DL, Ben Shahar O (2001) Enduring resistance to extincuon of cocaine-seeking behavior induced by drug-related cues. Neuropsychopharmacology 25:361-372.
32. Wise RA (2004) Dopamine, learning and motivation. Nat Rev Neurosci 5:483-494.
33. Xi ZX, Stein EA (2002) Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat. Psychopharmacology 164:144-150.
34. Yun IA, Wakabayashi KT, Fields HL, Nicola SM (2004) The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues. J Neurosci 24:2923-2933.