The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal

Neuropharmacology

Volumn 38, Issue 2, 1999, Pages 217-222

  Vandergriff, Jim ^a   Rasmussen, Kurt ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Locus coeruleus; Metabotropic glutamate receptors; Morphine; Opiates; Withdrawal

Indexed keywords

AMPA RECEPTOR; EGLUMETAD; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; METABOTROPIC RECEPTOR; MORPHINE; NALTREXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; LOCUS CERULEUS; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; BICYCLO COMPOUNDS; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; LOCUS COERULEUS; MALE; MEMBRANE POTENTIALS; MORPHINE; MORPHINE DEPENDENCE; NALTREXONE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0032968641     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00196-8     Document Type: Article

References (44)

1. Aceto, M.D., Dewey, W.L., Portoghese, P.S., Takemori, A.E., 1986. Effects of β-flu-naltrexamine (β-FNA) on morphine dependence in rats and monkeys. Eur. J. Pharmacol. 123, 387-393.
2. Aghajanian, G.K., 1978. Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine. Nature 276, 186-187.
3. Aghajanian, G.K., Kogan, J.H., Moghaddam, B., 1994. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res. 636, 126-130.
4. Akaoka, H., Aston-Jones, G.A., 1991. Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input. J. Neurosci. 11, 3830-3839.
5. Battaglia, G., Monn, J.A., Schoepp, D.D., 1997. In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats. Neurosci. Lett. 229, 161-164.
6. Blasig, J., Herz, A., Reinhold, K., Stieglgansberger, S., 1973. Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia 33, 19-33.
7. Breakwell, N.A., Huang, L., Rowan, M.J., Anwyl, R., 1997. DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus. Eur. J. Pharmacol. 322, 173-178.
8. Conn, P.J., Pin, J.-P., 1997. Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. 37, 205-237.
9. Dahlstrom, A., Fuxe, K., 1965. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiol. Scand. Suppl. 232, 1-55.
10. Dube, G.R., Marshall, K.C., 1997. Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors. Neuroscience 80, 511-521.
11. Ennis, M., Aston-Jones, G., 1988. Activation of locus coeruleus from nucleus paragigantocellularis: a new excitatory amino acid pathway in brain. J. Neurosci. 8, 3644-3657.
12. Ennis, M., Aston-Jones, G., 1989. Potent inhibitory input to locus coeruleus from the nucleus prepositus hypoglossi. Brain Res. Bull. 22, 793-803.
13. Fundytus, M.E., Coderre, T.J., 1997. Attenuation of precipitated morphine withdrawal symptoms by acute i.c.v. administration of a group II mGluR agonist. Br. J. Pharmacol. 121, 511-514.
14. Gereau, R.W., Conn, P.J., 1995. Multiple presynaptic metabotropic glutamate receptors modulate excititory and inhibitory synaptic transmission in hippocampal area CAl. J. Neurosci. 15, 6879-6889.
15. Helton, D.R., Tizzano, J.P., Monn, J.A., Schoepp, D.D., Kallman, M.J., 1997. Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J. Pharm. Exp. Ther. 284, 251-260.
16. Helton, D.R., Tizzano, J.P., Monn, J.A., Schoepp, D.D., Kallman, M.J., 1998. LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats. Neuropharmacology 36, 1511-1516.
17. Herrero, I., Miras-Portugal, T., Sanchez-Prieto, J., 1992. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature 360, 163-166.
18. Himmelsbach, C.K., Gerlach, G.H., Stanton, E.J., 1935. A method for testing addiction, tolerance, and abstinence in the rat. J. Pharmacol. Exp. Ther. 53, 179-188.
19. Jones, B.E., Moore, R.Y., 1977. Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study. Brain Res. 127, 23-53.
20. Lane-Ladd, S.B., Pineda, J., Boundy, V.A., Pfeuffer, T., Krupinski, J., Aghajanian, G.K., Nestler, E.J., 1997. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17, 7890-7901.
21. Maldonado, R., Stinus, L., Gold, L.H., Koob, G.F., 1992. Role of different brain structures in the expression of the physical morphine withdrawal syndrome. J. Pharm. Exp. Ther. 261, 669-677.
22. Maldonado, R., Koob, G.F., 1993. Destruction of the locus coeruleus decreases physical signs of opiate withdrawal. Brain Res. 605, 128-138.
23. Monn, J.A., Valli, M.J., Massey, S.M., et al., 1997. Design, synthesis, and pharmacological characterization of (+) - 2 - aminobicyclo -[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. J. Med. Chem. 40, 528-537.
24. Nakanishi, S., 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597-603.
25. Nestler, E.J., 1996. Under siege: the brain on opiates. Neuron 16, 897-900.
26. Nestler, E.J., Aghajanian, G.K., 1997. Molecular and cellular basis of addiction. Science 278, 58-63.
27. Ohishi, H., Shigemoto, R., Nakanishi, S., Mizuno, N., 1993. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study. J. Comp. Neurol. 335, 252-266.
28. Ohishi, H., Shigemoto, R., Nakanishi, S., Mizuno, N., 1993. Distribution of the mRNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat. Neuroscience 53, 1009-1018.
29. O'Leary, D.M., Cassidy, E.M., O'Connor, J.J., 1997. Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro. Eur. J. Pharmacol. 340, 35-44.
30. Pin, J.-P., Duvoisin, R., 1994. The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34, 1-26.
31. Petralia, R.S., Wang, Y.X., Niedzielski, A.S., Wenthold, R.J., 1995. The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience 71, 949-976.
32. Punch, L.J., Self, D.W., Nestler, E.J., Taylor, J.R., 1997. Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray. J. Neurosci. 17, 8520-8527.
33. Rasmussen, K., Aghajanian, G.K., 1989. Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Res. 505, 346-350.
34. Rasmussen, K., Beitner, D.B., Krystal, J.H., Aghajanian, G.K., Nestler, E.J., 1990. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological and biochemical correlates. J. Neurosci. 10, 2308-2317.
35. Rasmussen, K., Fuller, R.W., Stockton, M.E., Perry, K.W., Swinford, R.M., Ornstein, P.L., 1991. NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal. Eur. J. Pharmacol. 117, 9-16.
36. Rasmussen, K., 1995. The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal. Neuropsychopharmacology 13, 195-200.
37. Rasmussen, K., Kendrick, W.T., Kogan, J.H., Aghajanian, G.K., 1996. A selective AMPA antagonist, LY293558, antagonizes morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology 15, 497-505.
38. Salt, T.E., Eaton, S.A., 1995. Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on gabaergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists. MAP4 and MCCG, in the rat thalamus in vivo. Neuroscience 65, 5-13.
39. Schaffhauser, H., Cartmell, J., Jakob-Rotne, R., Mutel, V., 1997. Pharmacological characterization of metabotropic glutamate receptors linked to the inhibition of adenylate cyclase activity in rat striatal slices. Neuropharmacology 36, 933-940.
40. Schoepp, D.D., Conn, J.P., 1993. Metabotropic glutamate receptors in brain function and pathology. Trends Pharm. Sci. 14, 13-20.
41. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Mayne, N.G., Wu, S., Cockerman, S.L., Burnett, J.P., Belegaje, R., Bleakman, D., Monn, J.A., 1997. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharm. 36, 1-11.
42. Uyama, Y., Ishida, M., Shinozaki, H., 1997. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 752, 327-330.
43. Way, E.L., Loh, H.H., Shen, F.-H., 1969. Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167, 1-8.
44. Wei, E., 1973. Assessment of precipitated abstinence in morphine-dependent rats. Psychopharmacologia (Berl) 28, 35-44.