Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent conventional reinforcer

Journal of Neuroscience

Volumn 24, Issue 20, 2004, Pages 4723-4727

  Baptista, Marco A S ^a,b   Martin Fardon, Rémi ^a   Weiss, Friedbert ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CVN 15 ^*  (United States)

Author keywords

Addiction; Drug cues; Drug seeking behavior; Group II mGluRs; Relapse; Self administration

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; COCAINE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; PSYCHOSTIMULANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; COCAINE DEPENDENCE; COGNITION; COMPARATIVE STUDY; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SELF ADMINISTRATION; MALE; MILK; MOTIVATION; NEUROPHARMACOLOGY; NEUROPSYCHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE; REWARD; STIMULUS; STRESS; WITHDRAWAL SYNDROME;

AMINO ACIDS; ANIMALS; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS, HETEROCYCLIC; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; MALE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECURRENCE; REINFORCEMENT (PSYCHOLOGY); REWARD; SELF ADMINISTRATION;

EID: 2442672865     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0176-04.2004     Document Type: Article

References (26)

1. Baker DA, McFarland K, Lake RW, Shen H, Tang X, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743-749.
2. Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515-532.
3. Bond A, Jones NM, Hicks CA, Whiffin GM, Ward MA, O'Neill MF, Kingston AE, Monn JA, Ornstein PL, Schoepp DD, Lodge D, O'Neill MJ (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J Pharmacol Exp Ther 294:800-809.
4. Caine SB, Koob GF (1993) Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science 260:1814-1816.
5. Carelli RM, Wondolowski J (2003) Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure. J Neurosci 23:11214-11223.
6. Carelli RM, Ijames SG, Crumling AJ (2000) Evidence that separate neural circuits in the nucleus accumbens encode cocaine versus "natural" (water and food) reward. J Neurosci 20:4255-4266.
7. Cartmell J, Monn JA, Schoepp DD (1999) The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus D-amphetamine motor behaviors in rats. J Pharmacol Exp Ther 291:161-170.
8. Cartmell J, Monn JA, Schoepp DD (2000a) The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing. Eur J Pharmacol 400:221-224.
9. Cartmell J, Monn JA, Schoepp DD (2000b) Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268, and comparison with the atypical antipsychotic, clozapine. Psychopharmacology (Berl) 148:423-429.
10. Clark M, Johnson BG, Wright RA, Monn JA, Schoepp DD (2002) Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats. Pharmacol Biochem Behav 73:339-346.
11. Cornish JL, Duffy P, Kalivas PW (1999) A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 93:1359-1367.
12. Helton DR, Tizzano JP, Monn JA, Schoepp DD, Kallman MJ (1997) LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats. Neuropharmacology 36:1511-1516.
13. Helton DR, Tizzano JP, Monn JA, Schoepp DD, Kallman MJ (1998) Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. J Pharmacol Exp Ther 284:651-660.
14. Hotsenpiller G, Giorgetti M, Wolf ME (2001) Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure. Eur J Neurosci 14:1843-1855.
15. Hurd YL, McGregor A, Ponten M (1997) In vivo amygdala dopamine levels modulate cocaine self-administration behaviour in the rat: D1 dopamine receptor involvement. Eur J Neurosci 9:2541-2548.
16. Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ (2000) Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. J Neurosci 20:7489-7495.
17. Kim JH, Vezina P (2002) The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine. Pharmacol Biochem Behav 73:333-337.
18. Konieczny J, Ossowska K, Wolfarth S, Pilc A (1998) LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats. Naunyn Schmiedebergs Arch Pharmacol 358:500-502.
19. Martin-Fardon R, Ciccocioppo R, Dayas CV, Weiss F (2003) Comparison of neural activation induced by stimuli conditioned to cocaine versus a conventional reinforcer. Soc Neurosci Abstr 29:854.16.
20. Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:12-20.
21. Ungless MA, Whistler JL, Malenka RC, Bonci A (2001) Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411:583-587.
22. Weiss F, Maldonado-Vlaar CS, Parsons LH, Kerr TM, Smith DL, Ben-Shahar O (2000) Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proc Natl Acad Sci USA 97:4321-4326.
23. Weiss F, Martin-Fardon R, Ciccocioppo R, Kerr TM, Smith DL, Ben-Shahar O (2001) Enduring resistance to extinction of cocaine-seeking behavior induced by drug-related cues. Neuropsychopharmacology 25:361-372.
24. Wigmore MA, Lacey MG (1998) Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro. Br J Pharmacol 123:667-674.
25. Wolf ME (1998) The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.
26. Xi ZX, Ramamoorthy S, Baker D, Shen H, Samuvel DJ, Kalivas PW (2002) Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther 303:608-615.