Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro

British Journal of Pharmacology

Volumn 123, Issue 4, 1998, Pages 667-674

  Wigmore, Mark A ^a   Lacey, Michael G ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Basal ganglia; Brain slices; Dopamine neurones; e.p.s.p; Glutamate receptor agonists; Glutamate receptor antagonists; Intracellular recording; Metabotropic glutamate receptors; Phenylglycine derivatives; Synaptic potentials

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 1-AMINO-1,3-DICARBOXYCYCLOPENTANE; ALANINE; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; ALPHA METHYL 4 PHOSPHONOPHENYLGLYCINE; ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE; ALPHA-METHYL-4-PHOSPHONOPHENYLGLYCINE; BENZOIC ACID DERIVATIVE; CYCLOLEUCINE; DOPAMINE; DRUG DERIVATIVE; GLUTAMIC ACID DERIVATIVE; GLYCINE; METABOTROPIC RECEPTOR;

ANIMAL; ARTICLE; DRUG EFFECT; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; IN VITRO STUDY; MALE; MESENCEPHALON; METABOLISM; NERVE CELL; PHYSIOLOGY; RAT; WISTAR RAT;

ALANINE; ANIMALS; BENZOATES; CYCLOLEUCINE; DOPAMINE; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMATES; GLYCINE; MALE; MESENCEPHALON; NEURONS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0031992444     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701662     Document Type: Article

References (52)

1. ABBOTT, A., WIGMORE, M.A. & LACEY, M.G. (1997). Excitation of rat subthalamic nucleus neurones in vitro by activation of a group I metabotropic glutamate receptor. Brain Res., 766, 162 - 167.
2. BLANDINI, F., PORTER, R.H.P & GREENAMYRE, J.T. (1996) Glutamate and Parkinson's disease. Mol. Neurobiol., 12, 73 - 94.
3. BUSHELL, T.J., JANE, D.E., TSE, H.-W., WATKINS, J.C., GARTHWAITE, J., COLLINGRIDGE, G.L. & TSE, H.W. (1996). Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br. J. Pharmacol., 117, 1457 - 1462.
4. CALABRESI, P., PISANI, A., MERCURI, N.B. & BERNARDI, G. (1993). Heterogeneity of metabotropic glutamate receptors in the striatum - electrophysiological evidence. Eur. J. Neurosci., 5, 1370 - 1377.
5. CAO, C.Q., EVANS, R.H., HEADLEY, P.M. & UDVARHELYI, P.M. (1995). A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro. Br. J. Pharmacol., 115, 1469 - 1474.
6. CHERGUI, K., AKAOKA, H., CHARLÉTY, P.J., SAUNIER, C.F., BUDA, M. & CHOUVET, G. (1994). Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors. NeuroReport, 5, 1185 - 1188.
7. CHESSELET, M.F. & DELFS, J.M. (1996). Basal ganglia and movement disorders: An update. Trends Neurosci., 19, 417 - 422.
8. CONN, P.J. & PIN, J.P. (1997). Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol., 37, 205 - 237.
9. DAVIES, C.H., CLARKE, V.R.J., JANE, D.E. & COLLINGRIDGE, G.L. (1995). Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. Br. J. Pharmacol., 116, 1859 - 1869.
10. DUNNETT, S.B. & ROBBINS, T.W. (1992). The functional role of mesotelencephalic dopamine systems. Biol. Rev., 67, 491 - 518.
11. DUVOISIN, R., ZHANG, C. & RAMONELL, K. (1995). A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. J. Neurosci., 15, 3075 - 3083.
12. FIBIGER, H.C. & PHILLIPS, A.G. (1986). Reward, motivation, cognition: psychobiology of mesentelencephalic dopamine systems. In Handbook of Physiology. Section 1: The Nervous System. Volume IV, Intrinsic Regulatory Systems of the Brain, ed. Mountcastle, V.B. & Bloom, F.E. pp.647 - 675. Bethesda, Maryland: American Physiological Society.
13. GEREAU, R.W. & CONN, P.J. (1995). Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. J. Neurosci., 15, 6879 - 6889.
14. GERFEN, C.R. (1992). The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu. Rev. Neurosci., 15, 285 - 320.
15. GOLDMAN-RAKIC, P.S. (1995). Cellular basis of working memory. Neuron. 14, 477 - 485.
16. GONZALES, C. & CHESSELET, M.F. (1990). Amygdalo-nigral pathway: an anterograde study in the rat with Phaseolus vulgaris leucoagglutinin (PHA-L). J. Comp. Neurol., 297, 182 - 200.
17. HARVEY, J. & COLLINGRIDGE, G.I., (1993). Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices. Br. J. Pharmacol., 109, 1085 - 1090.
18. HARVEY, J., PALMER, M.J., IRVING, A.J., CLARKE, V.R.J. & COLLINGRIDGE, G.L. (1996). NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus. Br. J. Pharmacol., 119, 1239 - 1247.
19. HYMAN, S.E. (1996). Addiction to cocaine and amphetamine. Neuron, 16, 901 - 904.
20. ISHIDA, M., SAITOH, T., SHIMAMOTO, K., OHFUNE, Y. & SHINOZAKI, H. (1993). A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. Br. J. Pharmacol., 109, 1160 - 1177.
21. JANE, D.E., PITTAWAY, K., SUNTER, D.C., THOMAS, N.K. & WATKINS, J.C. (1995). New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology, 34, 851 - 856.
22. JOHNSON, S.W. & NORTH, R.A. (1992). Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J. Physiol., 450, 455 - 468.
23. KAATZ, K.W. & ALBIN, R.L. (1995). Intrastriatal and intrasubthalamic stimulation of metabotropic glutamate receptors: A behavioural and Fos immunohistochemical study. Neuroscience. 66, 55 - 65.
24. KAMIYA, H., SHINOZAKI, H. & YAMAMOTO, C. (1996). Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses. J. Physiol., 493, 447 - 455.
25. 2+ exchange in rat basolateral amygdala neurones. J. Physiol., 499, 87 - 104.
26. KITA, H. & KITAI, S.T. (1987). Efferent projections of the subthalamic nucleus in the rat: light and electron microscopic analysis with the PHA-L method. J. Comp. Neurol., 260, 435 - 452.
27. KOOB, G.F. (1992). Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci., 13, 177 - 184.
28. LACEY, M.G. (1993). Neurotransmitter receptors and ionic conductances regulating the activity of neurones in substantia nigra pars compacta and ventral tegmental area. Prog. Brain Res., 99, 251 - 276.
29. LUJAN, R., NUSSER, Z., ROBERTS, J.D.B., SHIGEMOTO, R. & SOMOGYI, P. (1996). Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur. J. Neurosci., 8, 1488 - 1500.
30. MACEK, T.A., WINDER, D.G., GEREAU, R.W., LADD, C.O. & CONN. P.J. (1996). Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses. J. Neurophysiol., 76, 3798 - 3806.
31. MANZONI, O., MICHEL, J.-M. & BOCKAEKT, J. (1997). Metabotropic glutamate receptors in the rat nucleus accumbens. Eur. J. Neurosci., 9, 1514 -1523.
32. MANZONI, O. & BOCKAERT, J. (1995). Metabotropic glutamate receptors inhibiting excitatory synapses in the CA1 area of rat hippocampus. Eur. J. Neurosci., 7, 2518 - 2523.
33. MERCURI, N.B., STRATTA, F., CALABRESI, P., BONCI, A. & BERNARDI, G. (1993). Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons. Neuroscience, 56, 399 - 407.
34. MEREU, G., COSTA, E., ARMSTRONG, D.M. & VICINI, S. (1991). Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices. J. Neurosci. 11, 1359 - 1366.
35. NAITO, A. & KITA, H. (1994). The cortico-nigral projection in the rat: An anterograde tracing study with biotinylated dextran amine. Brain Res., 637, 317 - 322.
36. NAKAJIMA, Y., IWAKABE, H., AKAZAWA, C., NAWA, H., SHIGEMOTO, R., MIZUNO, N. & NAKANISHI, S. (1993). Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J. Biol. Chem., 268, 11868 - 11873.
37. PHILLIPSON, O.T. (1979). Afferent projections to the ventral tegmental area of Tsai and iterfascicular nucleus: a horseradish peroxidase study in the rat. J. Comp. Neurol., 187, 117 - 144.
38. PIN, J.-P. & DUVOISIN, R (1995). The metabotropic glutamate receptors: Structure and functions. Neuropharmacology, 34, 1 - 26.
39. PISANI, A., CALABRESI, P., CENTONZE, D. & BERNARDI, G. (1997). Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones. Br. J. Pharmacol., 120, 1007 - 1014.
40. ROBBINS, T.W. & EVERITT, B.J. (1996). Neurobehavioural mechanisms of reward and motivation. Curr. Opin. Neurobiol., 6, 228 - 236.
41. SACAAN, A.I., BYMASTER, F.P. & SCHOEPP, D.D. (1992). Metabotropic glutamate receptor activation produces extrapyramidal motor system activation that is mediated by striatal dopamine. J. Neurochem., 59, 245 - 251.
42. SCANZIANI, M., SALIN, P.A., VOGT, K.E., MALENKA, R.C. & NICOLL, R.A. (1997). Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature, 385, 630 - 634.
43. SCHOEPP, D.D. & CONN, P.J. (1993). Metabotropic glutamate receptors in brain-relaled function and pathology. Trends Pharmacol. Sci., 14, 13 - 20.
44. SCHOEPP, D.D., GOLDSWORTHY, J., JOHNSON, B.G., SALHOFF, C.R. & BAKER, S.R. (1994). 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic receptors in the rat hippocampus. J. Neurochem., 63, 769 - 771
45. SHEN, K.Z. & JOHNSON, S.W. (1997). A slow excitatory postsynaptic current mediated by G-protein-coupled metabotropic glutamate receptors in rat ventral tegmental dopamine neurons. Eur. J. Neurosci., 9, 48 - 54.
46. SHIGEMOTO, R., KULIK, A., ROBERTS, J.D.B. OHISHI, H., NUSSER, Z., KANEKO, T. & SOMOGYI, P. (1996). Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature, 381, 523 - 525.
47. TAKAHASHI, T., FORSYTHE, I.D. TSUJIMOTO, T., BARNES-DA VIES, M. & ONODERA, K. (1996). Presynaptic calcium current modulation by a metabotropic glutamate receptor. Science, 274, 594 - 597.
48. TESTA, C.M., STANDAERT, D.G., YOUNG, A.B. & PENNEY, J.B., JR (1994). Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J. Neurosci. 14, 3005 - 3018.
49. IROMBLEY, P.G. & WESTBROOCK, G.L. (1992). L-AP4 inhibits calcium currents and synaptic transmission via a G-protein coupled glutamate receptor. J. Neurosci. 12, 2043 - 2050.
50. WIGMORE, M.A. & LACEY, M.G. (1995). Inhibition by metabotropic glutamate receptors of excitatory synaptic input to rat midbrain dopamine neurons in vitro. Soc. Neurosci. Abstr. 21, 1660.
51. WIGMORE, M.A. & LACEY, M.G. (1996). Depression of glutamate input to midbrain dopamine neurones in rat midbrain slices by metabotropic glutamate receptor agonists. Br. J. Pharmacol., 118, 43P.
52. YU, S.P., SENSI, S.L., CANZONIERO, L.M.T., BUISSON, A. & CHOI, D.W. (1997). Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1.5 in cultured mouse cortical neurons. J. Physiol., 499, 721 - 732.