mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats

Neuropsychopharmacology

Volumn 34, Issue 4, 2009, Pages 820-833

  Gass, Justin T ^a   Osborne, Megan P H ^a   Watson, Noreen L ^a   Brown, Jordan L ^a   Olive, M Foster ^a  

^a MUSC Center for Drug and Alcohol Programs   (United States)

Author keywords

Methamphetamine; mGluR5; MTEP; Progressive ratio; Reinstatement; Self administration

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; METABOTROPIC RECEPTOR 5; METHAMPHETAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; FEEDING; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; SPRAGUE DAWLEY RAT;

AMPHETAMINE-RELATED DISORDERS; ANALYSIS OF VARIANCE; ANIMALS; APPETITIVE BEHAVIOR; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; CUES; EXCITATORY AMINO ACID ANTAGONISTS; FOOD; MALE; METHAMPHETAMINE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; THIAZOLES;

EID: 59949088634     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.140     Document Type: Article

References (78)

1. Abekawa T, Ohmori T, Koyama T (1994). Effects of repeated administration of a high dose of methamphetamine on dopamine and glutamate release in rat striatum and nucleus accumbens. Brain Res 643: 276-281.
2. 3H]-methoxy-5-(pyridin-2- ylethynyl)pyridine). Eur J Pharmacol 473: 35-40.
3. Backstrom P, Hyytia P (2006). Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31: 778-786.
4. Backstrom P, Hyytia P (2007). Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology 192: 571-580.
5. Backstrom P, Bachteler D, Koch S, Hyytia P, Spanagel R (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928.
6. Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S et al (2003). Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6: 743-749.
7. Barr AM, Panenka WJ, MacEwan GW, Thornton AE, Lang DJ, Honer WG et al (2006). The need for speed: an update on methamphetamine addiction. J Psychiatry Neurosci 31: 301-313.
8. Besheer J, Faccidomo S, Grondin JJ, Hodge CW (2008). Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcohol Clin Exp Res 32: 209-221.
9. Bespalov AY, Dravolina OA, Sukhanov I, Zakharova E, Blokhina E, Zvartau E et al (2005). Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 49: 167-178.
10. Bossert JM, Poles GC, Sheffler-Collins SI, Ghitza UE (2006). The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats. Behav Brain Res 173: 148-152.
11. Bradbury MJ, Campbell U, Giracello D, Chapman D, King C, Tehrani L et al (2005). Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J Pharmacol Exp Ther 313: 395-402.
12. Bustamante D, You ZB, Castel MN, Johansson S, Goiny M, Terenius L et al (2002). Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat. J Neurochem 83: 645-654.
13. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S et al (2001). Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4: 873-874.
14. Collett VJ, Collingridge GL (2004). Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells. Br J Pharmacol 142: 991-1001.
15. Cornish JL, Kalivas PW (2000). Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. J Neurosci 20: RC89.
16. Cornish JL, Duffy P, Kalivas PW (1999). A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior. Neuroscience 92: 1359-1367.
17. Cosford ND, Tehrani L, Roppe J, Schwieger E, Smith ND, Anderson J et al (2003). 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46: 204-206.
18. Cowen MS, Djouma E, Lawrence AJ (2005). The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl)-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp Ther 315: 590-600.
19. Cowen MS, Krstew E, Lawrence AJ (2007). Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/ 6J mice under operant conditions: regulation by mGlu5 receptor antagonism. Psychopharmacology 190: 21-29.
20. Darke S, Kaye S, McKetin R, Duflou J (2008). Major physical and psychological harms of methamphetamine use. Drug Alcohol Rev 27: 253-262.
21. Dews PB (1977). Rate-dependency hypothesis. Science 198: 1182-1183.
22. Di Ciano P, Cardinal RN, Cowell RA, Little SJ, Everitt BJ (2001). Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior. J Neurosci 21: 9471-9477.
23. Dravolina OA, Zakharova ES, Shekunova EV, Zvartau EE, Danysz W, Bespalov AY (2007). mGlu1 receptor blockade attenuates cue- and nicotine-induced reinstatement of extinguished nicotine self-administration behavior in rats. Neuropharmacology 52: 263-269.
24. Gass JT, Olive MF (2008). Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol 75: 218-265.
25. Glick SD, Maisonneuve IM, Dickinson HA, Kitchen BA (2001). Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats. Eur J Pharmacol 422: 87-90.
26. Green MD, Yang X, Cramer M, King CD (2006). In vitro metabolic studies on the selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP). Neurosci Lett 391: 91-95.
27. Hodge CW, Miles MF, Sharko AC, Stevenson RA, Hillmann JR, Lepoutre V et al (2006). The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology 183: 429-438.
28. Homayoun H, Stefani MR, Adams BW, Tamagan GD, Moghaddam B (2004). Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 29: 1259-1269.
29. Iso Y, Grajkowska E, Wroblewski JT, Davis J, Goeders NE, Johnson KM et al (2006). Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. J Med Chem 49: 1080-1100.
30. Jun JH, Schindler CW (2000). Dextromethorphan alters methamphetamine self-administration in the rat. Pharmacol Biochem Behav 67: 405-409.
31. Kalivas PW (2000). A role for glutamate transmission in addiction to psychostimulants. Addict Biol 5: 325-329.
32. Kalivas PW (2007). Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity. Dialogues Clin Neurosci 9: 389-397.
33. Kenny PJ, Markou A (2004). The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol Sci 25: 265-272.
34. Kenny PJ, Paterson NE, Boutrel B, Semenova S, Harrison AA, Gasparini F et al (2003). Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann NY Acad Sci 1003: 415-418.
35. Kim HS, Jang CG (1997). MK-801 inhibits methamphetamine-induced conditioned place preference and behavioral sensitization to apomorphine in mice. Brain Res Bull 44: 221-227.
36. Lea PM, Faden AI (2006). Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev 12: 149-166.
37. Lee B, Platt DM, Rowlett JK, Adewale AS, Spealman RD (2005). Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J Pharmacol Exp Ther 312: 1232-1240.
38. Lee NK, Rawson RA (2008). A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev 27: 309-317.
39. Liechti ME, Lhuillier L, Kaupmann K, Markou A (2007). Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. J Neurosci 27: 9077-9085.
40. Lineberry TW, Bostwick JM (2006). Methamphetamine abuse: a perfect storm of complications. Mayo Clin Proc 81: 77-84.
41. Ling W, Rawson R, Shoptaw S, Ling W (2006). Management of methamphetamine abuse and dependence. Curr Psychiatry Rep 8: 345-354.
42. Liu X, Caggiula AR, Yee SK, Nobuta H, Sved AF, Pechnick RN et al (2007). Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats. Neuropsychopharmacology 32: 710-718.
43. Lominac KD, Kapasova Z, Hannun RA, Patterson C, Middaugh LD, Szumlinski KK (2006). Behavioral and neurochemical interactions between group I mGluR antagonists and ethanol: potential insight into their anti-addictive properties. Drug Alcohol Depend 85: 142-156.
44. Marshall JF, O'Dell SJ, Weihmuller FB (1993). Dopamine-glutamate interactions in methamphetamine-induced neurotoxicity. J Neural Transm Gen Sect 91: 241-254.
45. Maxwell JC, Rutkowski BA (2008). The prevalence of methamphetamine and amphetamine abuse in North America: a review of the indicators, 1992-2007. Drug Alcohol Rev 27: 229-235.
46. McFarland K, Lapish CC, Kalivas PW (2003). Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 23: 3531-3537.
47. McLaughlin RJ, Floresco SB (2007). The role of different subregions of the basolateral amygdala in cue-induced reinstatement and extinction of food-seeking behavior. Neuroscience 146: 1484-1494.
48. Meredith CW, Jaffe C, Ang-Lee K, Saxon AJ (2005). Implications of chronic methamphetamine use: a literature review. Harv Rev Psychiatry 13: 141-154.
49. Nash JF, Maickel RP (1999). The role of the hypothalamic-pituitary- adrenocortical axis in post-stress induced ethanol consumption by rats. Prog Neuropsychopharmacol Biol Psychiatry 12: 653-671.
50. Ohmori T, Abekawa T, Koyama T (1996). The role of glutamate in the neurotoxic effects of methamphetamine. Ann NY Acad Sci 801: 315-326.
51. Olive MF (2005). mGlu5 receptors: neuroanatomy, pharmacology, and role in drug addiction. Curr Psychiatry Rev 1: 197-214.
52. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH et al (2005). The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase Ce-dependent mechanism. Mol Pharmacol 67: 349-355.
53. Osborne MPH, Olive MF A role for mGluR5 receptors in intravenous methamphetamine self-administration. Ann NY Acad Sci (in press).
54. Paterson NE, Markou A (2005). The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology 179: 255-261.
55. Paterson NE, Semenova S, Gasparini F, Markou A (2003). The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology 167: 257-264.
56. Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D et al (2001). Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience 106: 579-587.
57. Pulvirenti L, Maldonado-Lopez R, Koob GF (1992). NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat. Brain Res 594: 327-330.
58. Raudensky J, Yamamoto BK (2007). Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Brain Res 1135: 129-135.
59. Richardson NR, Roberts DC (1996). Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Meth 66: 1-11.
60. Rocher C, Gardier AM (2001). Effects of repeated systemic administration of d-Fenfluramine on serotonin and glutamate release in rat ventral hippocampus: comparison with methamphetamine using in vivo microdialysis. Naunyn Schmiedebergs Arch Pharmacol 363: 422-428.
61. Romano C, Sesma MA, McDonald CT, O'Malley K, Van den Pol AN, Olney JW (1995). Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J Comp Neurol 355: 455-469.
62. Sanger DJ, Blackman DE (1976). Rate-dependent effects of drugs: a review of the literature. Pharmacol Biochem Behav 4: 73-83.
63. Schmidt HD, Anderson SM, Famous KR, Kumaresan V, Pierce RC (2005). Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. Eur J Pharmacol 526: 65-76.
64. Schroeder JP, Overstreet DH, Hodge CW (2005). The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology 179: 262-270.
65. Shigemoto R, Mizuno N (2000). Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analysis. In: Ottersen OP, Storm-Mathisen J (eds). Handbook of Chemical Neuroanatomy: Metabotropic Glutamate Receptors: Immunocytochemical and In Situ Hybridization Analyses. Elsevier: London. pp 63-98.
66. Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N (1993). Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163: 53-57.
67. Shoblock JR, Sullivan EB, Maisonneuve IM, Glick SD (2003). Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats. Psychopharmacology 165: 359-369.
68. Srisurapanont M, Jarusuraisin N, Kittirattanapaiboon P (2001). Treatment for amphetamine dependence and abuse. Cochrane Database Syst Rev CD003022.
69. Stafford D, LeSage MG, Glowa JR (1998). Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review. Psychopharmacology 139: 169-184.
70. Stephans SE, Yamamoto BK (1994). Methamphetamine-induced neurotoxicity: roles for glutamate and dopamine efflux. Synapse 17: 203-209.
71. Stephans SE, Yamamoto BY (1995). Effect of repeated methamphetamine administrations on dopamine and glutamate efflux in rat prefrontal cortex. Brain Res 700: 99-106.
72. Sulzer D, Sonders MS, Poulsen NW, Galli A (2005). Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 75: 406-433.
73. Tata DA, Yamamoto BK (2007). Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction. Addiction 102: 49-60.
74. Tessari M, Pilla M, Andreoli M, Hutcheson DM, Heidbreder CA (2004). Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur J Pharmacol 499: 121-133.
75. Tzschentke TM, Schmidt WJ (2003). Glutamatergic mechanisms in addiction. Mol Psychiatry 8: 373-382.
76. Ugolini A, Corsi M, Bordi F (1999). Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons. Neuropharmacology 38: 1569-1576.
77. Vocci FJ, Appel NM (2007). Approaches to the development of medications for the treatment of methamphetamine dependence. Addiction 102: 96-106.
78. Winslow BT, Voorhees KI, Pehl KA (2007). Methamphetamine abuse. Am Fam Physician 76: 1169-1174.