메뉴 건너뛰기




Volumn 654, Issue , 2010, Pages 627-640

In vivo regeneration of insulin-producing β-cells

Author keywords

cell; Differentiation; Growth factor; Regeneration; Transcription factor

Indexed keywords

ACTIVIN A; ADENOVIRUS VECTOR; BETACELLULIN; EPIDERMAL GROWTH FACTOR; EXENDIN 4; GASTRIN; GLUCAGON LIKE PEPTIDE 1; HERBACEOUS AGENT; LECTIN; MOMORDICA CHARANTIA EXTRACT; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; NYMPHAEA STELLATA EXTRACT; PROTEIN REG; RECOMBINANT PROTEIN; SCATTER FACTOR; STREPTOZOCIN; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; INSULIN; TRANSCRIPTION FACTOR;

EID: 77950226098     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-3271-3_27     Document Type: Article
Times cited : (10)

References (97)
  • 1
    • 0036137987 scopus 로고    scopus 로고
    • Understanding autoimmune diabetes: Insights from mouse models
    • DOI 10.1016/S1471-4914(01)02193-1, PII S1471491401021931
    • Adorini L, Gregori S, Harrison LC. Understanding autoimmune diabetes: insights from mouse models. Trends Mol Med 2002;8:31-8. (Pubitemid 34044676)
    • (2002) Trends in Molecular Medicine , vol.8 , Issue.1 , pp. 31-38
    • Adorini, L.1    Gregori, S.2    Harrison, L.C.3
  • 4
    • 1942489373 scopus 로고    scopus 로고
    • Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes
    • DOI 10.1016/j.ydbio.2004.01.040, PII S0012160604000910
    • Ashery-Padan R, Zhou X, Marquardt T, Herrera P, Toube L, Berry A, Gruss P. Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol 2004;269:479-88. (Pubitemid 38521112)
    • (2004) Developmental Biology , vol.269 , Issue.2 , pp. 479-488
    • Ashery-Padan, R.1    Zhou, X.2    Marquardt, T.3    Herrera, P.4    Toube, L.5    Berry, A.6    Gruss, P.7
  • 6
    • 0036968693 scopus 로고    scopus 로고
    • Pharmacological treatment of chronic diabetes by stimulating pancreatic β-cell regeneration with systemic co-administration of EGF and gastrin
    • DOI 10.1034/j.1600-0773.2002.910621.x
    • Brand SJ, Tagerud S, Lambert P, Magil SG, Tatarkiewicz K, Doiron K, Yan Y. Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin. Pharmacol Toxicol 2002;91:414-20. (Pubitemid 36132447)
    • (2002) Pharmacology and Toxicology , vol.91 , Issue.6 , pp. 414-420
    • Brand, S.J.1    Tagerud, S.2    Lambert, P.3    Magil, S.G.4    Tatarkiewicz, K.5    Doiron, K.6    Yan, Y.7
  • 7
    • 0037219411 scopus 로고    scopus 로고
    • β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52: 102-10. (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 8
    • 34447100368 scopus 로고    scopus 로고
    • Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1
    • DOI 10.1038/sj.gt.3302963, PII 3302963
    • Chen S, Ding J, Yu C, Yang B, Wood DR, Grayburn PA. Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1. Gene Ther 2007;14:1102-10. (Pubitemid 47029493)
    • (2007) Gene Therapy , vol.14 , Issue.14 , pp. 1102-1110
    • Chen, S.1    Ding, J.2    Yu, C.3    Yang, B.4    Wood, D.R.5    Grayburn, P.A.6
  • 9
    • 33645226291 scopus 로고    scopus 로고
    • Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration
    • Chong AS, Shen J, Tao J, Yin D, Kuznetsov A, Hara M, Philipson LH. Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 2006;311:1774-5.
    • (2006) Science , vol.311 , pp. 1774-1775
    • Chong, A.S.1    Shen, J.2    Tao, J.3    Yin, D.4    Kuznetsov, A.5    Hara, M.6    Philipson, L.H.7
  • 10
    • 0037428479 scopus 로고    scopus 로고
    • Transcription factor occupancy of the insulin gene in vivo: Evidence for direct regulation by Nkx2.2
    • DOI 10.1074/jbc.M205905200
    • Cissell MA, Zhao L, Sussel L, Henderson E, Stein R. Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem 2003;278:751-6. (Pubitemid 36790746)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.2 , pp. 751-756
    • Cissell, M.A.1    Zhao, L.2    Sussel, L.3    Henderson, E.4    Stein, R.5
  • 11
    • 0038711652 scopus 로고    scopus 로고
    • Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice
    • Dai C, Li Y, Yang J, Liu Y. Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice. J Biol Chem 2003;278:27080-7.
    • (2003) J Biol Chem , vol.278 , pp. 27080-17087
    • Dai, C.1    Li, Y.2    Yang, J.3    Liu, Y.4
  • 12
    • 0024458020 scopus 로고
    • Pancreatic beta cell proliferation in rabbits demonstrated by bromodeoxyuridine labeling
    • Davidson PM, Campbell IL, Oxbrow L, Hutson JM, Harrison LC. Pancreatic beta cell proliferation in rabbits demonstrated by bromodeoxyuridine labeling. Pancreas 1989;4:594-600. (Pubitemid 19261028)
    • (1989) Pancreas , vol.4 , Issue.5 , pp. 594-600
    • Davidson, P.M.1    Campbell, I.L.2    Oxbrow, L.3    Hutson, J.M.4    Harrison, L.C.5
  • 13
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 1995;80: 952-7.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 14
    • 29744461931 scopus 로고    scopus 로고
    • FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo
    • DOI 10.1016/j.mod.2005.10.001, PII S0925477305001656
    • Dessimoz J, Opoka R, Kordich JJ, Grapin-Botton A, Wells JM. FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mech Dev 2006;123:42-55. (Pubitemid 43031356)
    • (2006) Mechanisms of Development , vol.123 , Issue.1 , pp. 42-55
    • Dessimoz, J.1    Opoka, R.2    Kordich, J.J.3    Grapin-Botton, A.4    Wells, J.M.5
  • 15
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
    • DOI 10.1038/nature02520
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by selfduplication rather than stem-cell differentiation. Nature 2004;429:41-6. (Pubitemid 38620543)
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 16
    • 0345257136 scopus 로고    scopus 로고
    • Glucagon-Like Peptide-1 and the Islet β-Cell: Augmentation of Cell Proliferation and Inhibition of Apoptosis
    • DOI 10.1210/en.2003-1147
    • Drucker DJ. Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 2003;144:5145-8. (Pubitemid 37476039)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5145-5148
    • Drucker, D.J.1
  • 17
    • 0037357951 scopus 로고    scopus 로고
    • GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
    • DOI 10.1002/dmrr.357
    • Egan JM, Bulotta A, Hui H, Perfetti R. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev 2003;19: 115-23. (Pubitemid 36417195)
    • (2003) Diabetes/Metabolism Research and Reviews , vol.19 , Issue.2 , pp. 115-123
    • Egan, J.M.1    Bulotta, A.2    Hui, H.3    Perfetti, R.4
  • 19
    • 0028987251 scopus 로고
    • Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995;44: 249-56.
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 20
    • 57749171125 scopus 로고    scopus 로고
    • Prospects and challenges for islet regeneration as a treatment for diabetes: A review of islet neogenesis associated protein
    • Fleming A, Rosenberg L. Prospects and challenges for islet regeneration as a treatment for diabetes: A review of islet neogenesis associated protein. J Diabetes Sci Technol 2007;1: 231-44.
    • (2007) J Diabetes Sci Technol , vol.1 , pp. 231-244
    • Fleming, A.1    Rosenberg, L.2
  • 21
    • 71749096644 scopus 로고    scopus 로고
    • Antidiabetic effect of orally administered conophyllinecontaining plant extract on streptozotocin-treated and Goto-Kakizaki rats
    • Epub ahead of print
    • Fujii M, Takei I, Umezawa K. Antidiabetic effect of orally administered conophyllinecontaining plant extract on streptozotocin-treated and Goto-Kakizaki rats. Biomed Pharmacother 2009;[Epub ahead of print].
    • (2009) Biomed Pharmacother
    • Fujii, M.1    Takei, I.2    Umezawa, K.3
  • 22
    • 0037414812 scopus 로고    scopus 로고
    • Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death
    • DOI 10.1074/jbc.M207848200
    • Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 2003;278:343-51. (Pubitemid 36043582)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 343-351
    • Garcia-Ocana, A.1    Takane, K.K.2    Reddy, V.T.3    Lopez-Talavera, J.-C.4    Vasavada, R.C.5    Stewart, A.F.6
  • 23
    • 9644266753 scopus 로고    scopus 로고
    • β cell replication is the primary mechanism for maintaining postnatal β cell mass
    • DOI 10.1172/JCI200422098
    • Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 2004;114:963-8. (Pubitemid 39578724)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.7 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 24
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965;14:619-33.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 26
    • 0031792577 scopus 로고    scopus 로고
    • Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment
    • Gross DJ, Weiss L, Reibstein I, van den Brand J, Okamoto H, Clark A, Slavin S. Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment. Endocrinology 1998;139:2369-74. (Pubitemid 28513761)
    • (1998) Endocrinology , vol.139 , Issue.5 , pp. 2369-2374
    • Gross, D.J.1    Weiss, L.2    Reibstein, I.3    Van Den Brand, J.4    Okamoto, H.5    Clark, A.6    Slavin, S.7
  • 27
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-57. (Pubitemid 34863851)
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 28
    • 0042665560 scopus 로고    scopus 로고
    • Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
    • DOI 10.1016/S0012-1606(03)00326-9
    • Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J. Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol 2003;260:426-37. (Pubitemid 36966084)
    • (2003) Developmental Biology , vol.260 , Issue.2 , pp. 426-437
    • Hald, J.1    Hjorth, J.P.2    German, M.S.3    Madsen, O.D.4    Serup, P.5    Jensen, J.6
  • 29
    • 24644435613 scopus 로고    scopus 로고
    • Islet transplantation: Current status and future directions
    • Hatipoglu B, Benedetti E, Oberholzer J. Islet transplantation: current status and future directions. Curr Diab Rep 2005;5:311-6. (Pubitemid 41269597)
    • (2005) Current Diabetes Reports , vol.5 , Issue.4 , pp. 311-316
    • Hatipoglu, B.1    Benedetti, E.2    Oberholzer, J.3
  • 31
    • 14044264798 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus
    • DOI 10.1016/j.coph.2004.08.005, PII S1471489204001705
    • Holst JJ, Deacon CF. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus. Curr Opin Pharmacol 2004;4: 589-96. (Pubitemid 40276776)
    • (2004) Current Opinion in Pharmacology , vol.4 , Issue.6 , pp. 589-596
    • Holst, J.J.1    Deacon, C.F.2
  • 32
    • 0031763478 scopus 로고    scopus 로고
    • Growth factor-mediated proliferation and differentiation of insulin- producing INS-1 and RINm5F cells: Identification of betacellulin as a novel β-cell mitogen
    • Huotari MA, Palgi J, Otonkoski T. Growth factor-mediated proliferation and differentiation of insulin-producing INS-1 and RINm5F cells: identification of betacellulin as a novel beta-cell mitogen. Endocrinology 1998;139:1494-9. (Pubitemid 28513801)
    • (1998) Endocrinology , vol.139 , Issue.4 , pp. 1494-1499
    • Huotari, M.-A.1    Palgi, J.2    Otonkoski, T.3
  • 33
    • 0348047628 scopus 로고    scopus 로고
    • Gene regulatory factors in pancreatic development
    • DOI 10.1002/dvdy.10460
    • Jensen J. Gene regulatory factors in pancreatic development. Dev Dyn 2004;229:176-200. (Pubitemid 38036833)
    • (2004) Developmental Dynamics , vol.229 , Issue.1 , pp. 176-200
    • Jensen, J.1
  • 34
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003;46:3-19. (Pubitemid 36237741)
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kahn, S.E.1
  • 36
    • 15944417831 scopus 로고    scopus 로고
    • PDX-1/VP16 fusion protein, together with neurod or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    • DOI 10.2337/diabetes.54.4.1009
    • Kaneto H, Nakatani Y, Miyatsuka T, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005;54:1009-22. (Pubitemid 40446314)
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 1009-1022
    • Kaneto, H.1    Nakatani, Y.2    Miyatsuka, T.3    Matsuoka, T.-A.4    Matsuhisa, M.5    Hori, M.6    Yamasaki, Y.7
  • 37
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • DOI 10.1038/ng959
    • Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-34. (Pubitemid 34977207)
    • (2002) Nature Genetics , vol.32 , Issue.1 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.E.6
  • 38
    • 0030681247 scopus 로고    scopus 로고
    • Notochord to endoderm signaling is required for pancreas development
    • Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development 1997;124:4243-52. (Pubitemid 27496860)
    • (1997) Development , vol.124 , Issue.21 , pp. 4243-4252
    • Kim, S.K.1    Hebrok, M.2    Melton, D.A.3
  • 39
    • 34249050832 scopus 로고    scopus 로고
    • Conophylline and betacellulin-δ4: An effective combination of differentiation factors for pancreatic β cells
    • DOI 10.1507/endocrj.K06-199
    • Kitamura R, Ogata T, Tanaka Y, Motoyoshi K, Seno M, Takei I, Umezawa K, Kojima I. Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells. Endocr J 2007;54:255-64. (Pubitemid 46798648)
    • (2007) Endocrine Journal , vol.54 , Issue.2 , pp. 255-264
    • Kitamura, R.-I.1    Ogata, T.2    Tanaka, Y.3    Motoyoshi, K.4    Seno, M.5    Takei, I.6    Umezawa, K.7    Kojima, I.8
  • 40
    • 0242582180 scopus 로고    scopus 로고
    • Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    • DOI 10.1126/science.1088949
    • Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 2003;302:1223-7. (Pubitemid 37421029)
    • (2003) Science , vol.302 , Issue.5648 , pp. 1223-1227
    • Kodama, S.1    Kuhtreiber, W.2    Fujimura, S.3    Dale, E.A.4    Faustman, D.L.5
  • 41
    • 33746813578 scopus 로고    scopus 로고
    • Forced expression of PDX-1 induces insulin production in intestinal epithelia
    • DOI 10.1016/j.surg.2006.06.014, PII S0039606006003588
    • Koizumi M, Nagai K, Kida A, Kami K, Ito D, Fujimoto K, Kawaguchi Y, Doi R. Forced expression of PDX-1 induces insulin production in intestinal epithelia. Surgery 2006;140:273-280. (Pubitemid 44176078)
    • (2006) Surgery , vol.140 , Issue.2 , pp. 273-280
    • Koizumi, M.1    Nagai, K.2    Kida, A.3    Kami, K.4    Ito, D.5    Fujimoto, K.6    Kawaguchi, Y.7    Doi, R.8
  • 42
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • DOI 10.1038/nm867
    • Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroDbetacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9:596-603. (Pubitemid 36597107)
    • (2003) Nature Medicine , vol.9 , Issue.5 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3    Younan, P.4    Imaeda, H.5    Maeda, M.6    Chan, L.7
  • 43
    • 40949136580 scopus 로고    scopus 로고
    • Reversal of streptozotocininduced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: A novel protein transduction domain-based therapy
    • Koya V, Lu S, Sun YP, Purich DL, AtkinsonMA, Li SW, Yang LJ. Reversal of streptozotocininduced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy. Diabetes 2008;57:757-69.
    • (2008) Diabetes , vol.57 , pp. 757-769
    • Koya, V.1    Lu, S.2    Sun, Y.P.3    Purich, D.L.4    Atkinsonma Li, S.W.5    Yang, L.J.6
  • 44
    • 0032417268 scopus 로고    scopus 로고
    • The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
    • Krapp A, Knofler M, Ledermann B, Burki K, Berney C, Zoerkler N, Hagenbuchle O, Wellauer PK. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 1998;12:3752-63. (Pubitemid 29019655)
    • (1998) Genes and Development , vol.12 , Issue.23 , pp. 3752-3763
    • Krapp, A.1    Knofler, M.2    Ledermann, B.3    Burki, K.4    Berney, C.5    Zoerkler, N.6    Hagenbuchle, O.7    Wellauer, P.K.8
  • 45
    • 0037191135 scopus 로고    scopus 로고
    • Beta-cell dysfunction and insulin resistance in type 2 diabetes: Role of metabolic and genetic abnormalities
    • LeRoith D. Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 113 Suppl. 2002;6A:3S-11S.
    • (2002) Am J Med 113 Suppl. , vol.6 A
    • Leroith, D.1
  • 46
    • 0035206953 scopus 로고    scopus 로고
    • Promotion of β-cell regeneration by betacellulin in ninety percent-pancreatectomized rats
    • DOI 10.1210/en.142.12.5379
    • Li L, Seno M, Yamada H, Kojima I (2001) Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats. Endocrinology 142: 5379-85. (Pubitemid 33131971)
    • (2001) Endocrinology , vol.142 , Issue.12 , pp. 5379-5385
    • Li, L.1    Seno, M.2    Yamada, H.3    Kojima, I.4
  • 47
    • 0041965739 scopus 로고    scopus 로고
    • Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to β-cells in streptozotocin-treated mice
    • Li L, Seno M, Yamada H, Kojima I. Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice. Am J Physiol Endocrinol Metab 2003;285:E577-83. (Pubitemid 37010836)
    • (2003) American Journal of Physiology - Endocrinology and Metabolism , vol.285
    • Li, L.1    Seno, M.2    Yamada, H.3    Kojima, I.4
  • 48
    • 1442276960 scopus 로고    scopus 로고
    • Activin A and Betacellulin: Effect on Regeneration of Pancreatic β-Cells in Neonatal Streptozotocin-Treated Rats
    • DOI 10.2337/diabetes.53.3.608
    • Li L, Yi Z, Seno M, Kojima I. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Diabetes 2004;53:608-15. (Pubitemid 38270629)
    • (2004) Diabetes , vol.53 , Issue.3 , pp. 608-615
    • Li, L.1    Yi, Z.2    Seno, M.3    Kojima, I.4
  • 49
    • 12744259876 scopus 로고    scopus 로고
    • Beta-cell pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1
    • Li Y, Cao X, Li LX, Brubaker PL, Edlund H, Drucker DJ. Beta-cell pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 2005;54:482-91.
    • (2005) Diabetes , vol.54 , pp. 482-491
    • Li, Y.1    Cao, X.2    Li, L.X.3    Brubaker, P.L.4    Edlund, H.5    Drucker, D.J.6
  • 50
    • 33846010782 scopus 로고    scopus 로고
    • Prolonged remission of diabetes by regeneration of β cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1
    • DOI 10.1038/sj.mt.6300005, PII 6300005
    • Liu MJ, Shin S, Li N, Shigihara T, Lee YS, Yoon JW, Jun HS. Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1. Mol Ther 2007;15:86-93. (Pubitemid 46043653)
    • (2007) Molecular Therapy , vol.15 , Issue.1 , pp. 86-93
    • Liu, M.-J.1    Shin, S.2    Li, N.3    Shigihara, T.4    Lee, Y.-S.5    Yoon, J.-W.6    Jun, H.-S.7
  • 52
    • 34347341779 scopus 로고    scopus 로고
    • Repression of Wnt/β-catenin signaling in the anterior endoderm is essential for liver and pancreas development
    • DOI 10.1242/dev.001230
    • McLin VA, Rankin SA, Zorn AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007;134:2207-17. (Pubitemid 47010010)
    • (2007) Development , vol.134 , Issue.12 , pp. 2207-2217
    • McLin, V.A.1    Rankin, S.A.2    Zorn, A.M.3
  • 54
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993;214:829-35. (Pubitemid 23188160)
    • (1993) European Journal of Biochemistry , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 55
    • 36348997093 scopus 로고    scopus 로고
    • Early administration of keratinocyte growth factor improves β-cell regeneration in rat with streptozotocin-induced diabetes
    • DOI 10.1677/JOE-07-0098
    • Movassat J, Portha B. Early administration of keratinocyte growth factor improves beta-cell regeneration in rat with streptozotocin-induced diabetes. J Endocrinol 2007;195:333-40. (Pubitemid 350143113)
    • (2007) Journal of Endocrinology , vol.195 , Issue.2 , pp. 333-340
    • Movassat, J.1    Portha, B.2
  • 57
    • 33847402673 scopus 로고    scopus 로고
    • Pancreas and beta-cell development: From the actual to the possible
    • DOI 10.1242/dev.02770
    • Murtaugh LC. Pancreas and beta-cell development: from the actual to the possible. Development 2007;134:427-38. (Pubitemid 46332480)
    • (2007) Development , vol.134 , Issue.3 , pp. 427-438
    • Murtaugh, L.C.1
  • 58
    • 33645221626 scopus 로고    scopus 로고
    • Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution
    • Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 2006;311:1775-8.
    • (2006) Science , vol.311 , pp. 1775-1778
    • Nishio, J.1    Gaglia, J.L.2    Turvey, S.E.3    Campbell, C.4    Benoist, C.5    Mathis, D.6
  • 60
    • 3042737844 scopus 로고    scopus 로고
    • Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4
    • DOI 10.2337/diabetes.53.7.1700
    • Ogawa N, List JF, Habener JF, Maki T. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes 2004;53: 1700-5. (Pubitemid 38857027)
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1700-1705
    • Ogawa, N.1    List, J.F.2    Habener, J.F.3    Maki, T.4
  • 61
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • DOI 10.1210/en.141.12.4600
    • Perfetti R, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000;141:4600-5. (Pubitemid 32055138)
    • (2000) Endocrinology , vol.141 , Issue.12 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.I.E.2    Doyle, M.E.3    Egan, J.M.4
  • 62
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes - A matter of β-cell life and death?
    • DOI 10.1126/science.1104345
    • Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science 2005;307:380-4. (Pubitemid 40139973)
    • (2005) Science , vol.307 , Issue.5708 , pp. 380-384
    • Rhodes, C.J.1
  • 63
    • 1542284736 scopus 로고    scopus 로고
    • Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57BI6/J mice treated with alloxan
    • DOI 10.1007/s00125-003-1287-1
    • Rooman I, Bouwens L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 2004;47:259-65. (Pubitemid 38315362)
    • (2004) Diabetologia , vol.47 , Issue.2 , pp. 259-265
    • Rooman, I.1    Bouwens, L.2
  • 64
    • 7044241260 scopus 로고    scopus 로고
    • A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice
    • DOI 10.1097/01.sla.0000143270.99191.10
    • Rosenberg L, Lipsett M, Yoon JW, Prentki M, Wang R, Jun HS, Pittenger GL, Taylor- Fishwick D, Vinik AI. A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6 J mice. Ann Surg 2004;240: 875-84. (Pubitemid 39425782)
    • (2004) Annals of Surgery , vol.240 , Issue.5 , pp. 875-884
    • Rosenberg, L.1    Lipsett, M.2    Yoon, J.-W.3    Prentki, M.4    Wang, R.5    Jun, H.-S.6    Pittenger, G.L.7    Taylor-Fishwick, D.8    Vinik, A.I.9
  • 65
    • 9644294263 scopus 로고    scopus 로고
    • Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus
    • DOI 10.1172/JCI200423235
    • Rother KI, Harlan DM. Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. J Clin Invest 2004;114:877-83. (Pubitemid 39578711)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.7 , pp. 877-883
    • Rother, K.I.1    Harlan, D.M.2
  • 69
    • 42549144899 scopus 로고    scopus 로고
    • Remission of diabetes by β-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin
    • DOI 10.1038/mt.2008.22, PII MT200822
    • Shin S, Li N, Kobayashi N, Yoon JW, Jun HS. Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin. Mol Ther 2008;16:854-61. (Pubitemid 351587094)
    • (2008) Molecular Therapy , vol.16 , Issue.5 , pp. 854-861
    • Shin, S.1    Li, N.2    Kobayashi, N.3    Yoon, J.-W.4    Jun, H.-S.5
  • 71
    • 39649125427 scopus 로고    scopus 로고
    • Regeneration of beta cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruits
    • Singh N, Gupta M. Regeneration of beta cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruits. Indian J Exp Biol 2007;45:1055-62.
    • (2007) Indian J Exp Biol , vol.45 , pp. 1055-1062
    • Singh, N.1    Gupta, M.2
  • 72
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: β-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 1997;29:301-7. (Pubitemid 27293660)
    • (1997) Hormone and Metabolic Research , vol.29 , Issue.6 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 73
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas
    • DOI 10.1038/386399a0
    • Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 1997;386:399-402. (Pubitemid 27154480)
    • (1997) Nature , vol.386 , Issue.6623 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 75
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000;49:741-8. (Pubitemid 30339989)
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7
  • 76
    • 21244441973 scopus 로고    scopus 로고
    • Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet β-cells from pancreatic duct cells and an increase in functional β-cell mass
    • DOI 10.1210/jc.2004-0761
    • Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet beta-cells from pancreatic duct cells and an increase in functional beta-cell mass. J Clin Endocrinol Metab 2005;90:3401-9. (Pubitemid 41014304)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.6 , pp. 3401-3409
    • Suarez-Pinzon, W.L.1    Lakey, J.R.T.2    Brand, S.J.3    Rabinovitch, A.4
  • 77
    • 24144446405 scopus 로고    scopus 로고
    • Combination therapy with epidermal growth factor and gastrin increases β-cell mass and reverses hyperglycemia in diabetic NOD mice
    • DOI 10.2337/diabetes.54.9.2596
    • Suarez-Pinzon WL, Yan Y, Power R, Brand SJ, Rabinovitch A. Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice. Diabetes 2005;54: 2596-2601. (Pubitemid 41233580)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2596-2601
    • Suarez-Pinzon, W.L.1    Yan, Y.2    Power, R.3    Brand, S.J.4    Rabinovitch, A.5
  • 78
    • 53749089728 scopus 로고    scopus 로고
    • Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice
    • Suarez-Pinzon WL, Lakey JR, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin induces beta-cell neogenesis from pancreatic duct cells in human islets transplanted in immunodeficient diabetic mice. Cell Transplant 2008;17: 631-40.
    • (2008) Cell Transplant , vol.17 , pp. 631-640
    • Suarez-Pinzon, W.L.1    Lakey, J.R.2    Rabinovitch, A.3
  • 79
    • 58149357117 scopus 로고    scopus 로고
    • Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice
    • Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes 2008;57: 3281-8.
    • (2008) Diabetes , vol.57 , pp. 3281-3288
    • Suarez-Pinzon, W.L.1    Power, R.F.2    Yan, Y.3    Wasserfall, C.4    Atkinson, M.5    Rabinovitch, A.6
  • 80
    • 62949091444 scopus 로고    scopus 로고
    • Partial regeneration of beta-cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers
    • Epub ahead of print
    • Subash-Babu P, Ignacimuthu S, Agastian P, Varghese B. Partial regeneration of beta-cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers. Bioorg Med Chem 2009;[Epub ahead of print].
    • (2009) Bioorg Med Chem
    • Subash-Babu, P.1    Ignacimuthu, S.2    Agastian, P.3    Varghese, B.4
  • 81
    • 33645223082 scopus 로고    scopus 로고
    • Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells
    • Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 2006;311:1778-80.
    • (2006) Science , vol.311 , pp. 1778-1780
    • Suri, A.1    Calderon, B.2    Esparza, T.J.3    Frederick, K.4    Bittner, P.5    Unanue, E.R.6
  • 82
    • 0031843386 scopus 로고    scopus 로고
    • Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells
    • Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 1998;125:2213-21. (Pubitemid 28336383)
    • (1998) Development , vol.125 , Issue.12 , pp. 2213-2221
    • Sussel, L.1    Kalamaras, J.2    Hartigan-O'Connor, D.J.3    Meneses, J.J.4    Pedersen, R.A.5    Rubenstein, J.L.R.6    German, M.S.7
  • 83
    • 0037269132 scopus 로고    scopus 로고
    • β-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas
    • DOI 10.1038/sj.gt.3301846
    • Taniguchi H, Yamato E, Tashiro F, Ikegami H, Ogihara T, Miyazaki J. Beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas. Gene Ther 2003;10:15-23. (Pubitemid 36175822)
    • (2003) Gene Therapy , vol.10 , Issue.1 , pp. 15-23
    • Taniguchi, H.1    Yamato, E.2    Ikegami, H.3    Ogihara, T.4    Miyazaki, J.5
  • 84
    • 24144473869 scopus 로고    scopus 로고
    • Very slow turnover of β-cells in aged adult mice
    • DOI 10.2337/diabetes.54.9.2557
    • Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005;54:2557-67. (Pubitemid 41233576)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2557-2567
    • Teta, M.1    Long, S.Y.2    Wartschow, L.M.3    Rankin, M.M.4    Kushner, J.A.5
  • 85
    • 34247644369 scopus 로고    scopus 로고
    • Growth and Regeneration of Adult β Cells Does Not Involve Specialized Progenitors
    • DOI 10.1016/j.devcel.2007.04.011, PII S153458070700158X
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12: 817-26. (Pubitemid 46667754)
    • (2007) Developmental Cell , vol.12 , Issue.5 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 87
    • 27544446435 scopus 로고    scopus 로고
    • E1-INT (Transition Therapeutics/ Novo Nordisk)
    • von Herrath M. E1-INT (Transition Therapeutics/ Novo Nordisk). Curr Opin Investig Drugs 2005;6: 1037-42.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 1037-1042
    • Von Herrath, M.1
  • 90
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999;48:2270-6. (Pubitemid 30395416)
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 93
    • 61749094740 scopus 로고    scopus 로고
    • Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
    • Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell 2009;16: 358-73.
    • (2009) Dev Cell , vol.16 , pp. 358-373
    • Yechoor, V.1    Liu, V.2    Espiritu, C.3    Paul, A.4    Oka, K.5    Kojima, H.6    Chan, L.7
  • 94
    • 28044432292 scopus 로고    scopus 로고
    • Autoimmune destruction of pancreatic beta cells
    • Yoon JW, Jun HS. Autoimmune destruction of pancreatic beta cells. Am J Ther 2005;12: 580-91.
    • (2005) Am J Ther , vol.12 , pp. 580-591
    • Yoon, J.W.1    Jun, H.S.2
  • 96
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J, Wang X, Pineyro MA, Egan JM. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999;48:2358-6.
    • (1999) Diabetes , vol.48 , pp. 2358-2356
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3    Egan, J.M.4
  • 97
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-32.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.