A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice

Annals of Surgery

Volumn 240, Issue 5, 2004, Pages 875-884

  Rosenberg, Lawrence ^a,e   Lipsett, Mark ^a   Yoon, Ji Won ^b   Prentki, Marc ^c   Wang, Rennian ^a   Jun, Hee Sook ^b   Pittenger, Gary L ^d   Taylor Fishwick, David ^d   Vinik, Aaron I ^d  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF MONTREAL   (Canada)

^d EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^e MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; ISLET NEOGENESIS ASSOCIATED PROTEIN; PEPTIDE FRAGMENT; SODIUM CHLORIDE; STREPTOZOCIN; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ACINAR CELL; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; HAMSTER; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULITIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL DIVISION; CRICETINAE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INSULIN; ISLETS OF LANGERHANS; MALE; MESOCRICETUS; MICE; MICE, INBRED C57BL; PANCREAS; PEPTIDE FRAGMENTS; PROTEINS;

EID: 7044241260     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sla.0000143270.99191.10     Document Type: Article

References (49)

1. Cerasi E, Boitard C, Efendic S, et al. The islet in type 2 diabetes: back to center stage. Diabetes. 2001;50(suppl 1):S1-S3.
2. Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52: 102-110.
3. UK Prospective Diabetes Study Group. UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes. 1995;44:1249-1258.
4. Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech. 1998;43:332-336.
5. Hellerstrom C, Swenne I. Growth patterns of pancreatic islets in animals. In: Volk B, Arquillo E, eds. The Diabetic Pancreas. New York: Plenum Medical; 1985:53-80.
6. Rosenberg L. Neogenesis of beta cells from pancreatic ductal cells. Cell Transplant. 1995;4:371-384.
7. Rosenberg L, Duguid WP, Brown RA. Effect of experimental nesidioblastosis on streptozotocin-induced diabetes. Surg Forum. 1983;34:48-51.
8. Rosenberg L, Brown RA, Duguid WP. A new model for the development of duct epithelial hyperplasia and the initiation of nesidioblastosis. J Surg Res. 1983;35:63-72.
9. Rosenberg L, Clas D, Duguid WP. Trophic stimulation of the ductular-islet cell axis: a new approach to the treatment of diabetes. Surgery. 1990;108:191-197.
10. Rosenberg L. Induction of islet cell neogenesis in the adult pancreas-The partial duct obstruction model. Microsc Res Tech. 1998;43:337-346.
11. Rosenberg L, Duguid WP, Brown RA, et al. Induction of islet cell proliferation will reverse diabetes in the Syrian golden hamster. Diabetes. 1988;37:334-341.
12. Rosenberg L, Kahlenberg M, Vinik AI, et al. Paracrine/autocrine regulation of pancreatic islet cell proliferation and differentiation in the hamster-studies using parabiosis. Clin Invest Med. 1996;9:3-12.
13. Pittenger GL, Rosenberg L, Vinik AI. Partial purification and characterization of ilotropin, a pancreatic-islet specific growth factor. J Cell Biol. 1991;115:270A.
14. Pittenger GL, Vinik AI, Rosenberg L. The partial isolation and characterization of ilotropin, a novel islet-specific growth factor. In: Vinik A, ed. Pancreatic Islet Cell Regeneration and Growth. New York: Plenum Press; 1992:123-132.
15. Rosenberg L, Thomas D, Dafoe D, et al. Stimulation of pancreatic growth by a cytosol extract derived from the cellophane wrapped pancreas. Surg Forum. 1986;37:168-169.
16. Vinik AI, Rafaeloff R, Pittenger GL, et al. Induction of pancreatic islet neogenesis-an approach towards a cure for diabetes. Horm Metab Res. 1997;29:278-293.
17. Rosenberg L, Vinik AI, Pittenger GL, et al. Islet cell regeneration in the diabetic hamster pancreas with restoration of normoglycemia can be induced by a local growth factor(s). Diabetologia. 1996;39:256-262.
18. Rafaeloff R, Qin XF, Barlow SW, et al. Identification of differentially expressed genes induced in pancreatic islet neogenesis. FEBS Lett. 1996;378:219-223.
19. Rafaeloff R, Pittenger GL, Barlow SW, et al. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest. 1997;99:2100-2109.
20. Edlund H. Developmental biology of the pancreas. Diabetes. 2001; 50(suppl 1):S5-S9.
21. Gold G, Broderick C, Carfagna M, et al. INGAP treatment improves glycemic control in SZ diabetes hamsters. Diabetes 1998;47(suppl 1):A253.
22. Young AA, Gedulin BR, Bhavsar S, et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes. 1999;48:1026-1034.
23. Xu G, Stoffers DA, Habener JF, et al. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999; 48:2270-2276.
24. Wang RN, Bouwens L, Klöppel G. Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity. Diabetologia. 1994;37:1088-1096.
25. Wang RN, Rosenberg L. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J Endocrinol. 1999;163:181-190.
26. Bouwens L, Pipeleers DG. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia. 1998;41: 629-633.
27. Bouwens L, Lu WG, De Krijger R. Proliferation and differentiation in the human fetal endocrine pancreas. Diabetologia. 1997;40:398-404.
28. Bouwens L, Klöppel G. Islet cell neogenesis in the pancreas. Virchows Arch. 1996;427:553-560.
29. Lipsett M, Finegood DT. Beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes. 2002;51:1834-1841.
30. Li Y, Hansotia T, Yusta B, et al. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem. 2003;278:471-478.
31. Lipsett M, Hanley S, Radzioch D, et al. INGAP: a critical mediator of islet neogenesis? Diabetes 2003;52(suppl 1):A360.
32. Larsen J, Hylleberg B, Ng K, et al. Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulfonylurea treatment. Diabetes Care. 2001;24:1416-1421.
33. Pridal L, Deacon CF, Kirk O, et al. Glucagon-like peptide-1(7-37) has a larger volume of distribution than glucagon-like peptide-1(7-36)amide in dogs and is degraded more quickly in vitro by dog plasma. Eur J Drug Metab Pharmacokinet. 1996;21:51-59.
34. Kaneto H, Miyagawa J, Kajimoto Y, et al. Expression of heparin-binding epidermal growth factor-like growth factor during pancreas development: a potential role of PDX-1 in transcriptional activation. J Biol Chem. 1997;272:29137-29143.
35. Habener JF, Stoffers DA. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Phys. 1998;110:12-21.
36. De Takats G, Cuthbert FP. Surgical attempts at increasing sugar tolerance. Arch Surg. 1933;26:750-764.
37. De Takats G, Wilder RM. Isolation of tail of pancreas in a diabetic child. JAMA. 1929;93:606-610.
38. De Takats G. Ligation of the tail of the pancreas in juvenile diabetes. Endocrinology. 1930;14:255-264.
39. De Takats G. The effect of ligating the tail of the pancreas in juvenile diabetes. Surg Gynecol Obstet. 1931;53:45-53.
40. Sarvetnick N. Transgeneic mouse models for growth factor studies. Methods Enzymol. 1991;198:519-525.
41. Rafaeloff-Phail R, Schmitt E, Sandusky G, et al. INGAP is a human cytokine expressed only in the presence of islet neogenesis. Diabetes 1998;47(suppl 1):259A.
42. Yoon JW, Jun HS. Cellular and molecular roles of beta cell autoantigens, macrophages and T cells in the pathogenesis of autoimmune diabetes. Arch Pharmacol Res. 1999;22:437-447.
43. Leiter EH, Simon D, Cherry M, et al. Induction in C57BL/KsJ mice of complement-dependent antibody cytotoxic to cultured beta cells. Diabetes. 1981;30:30-39.
44. Rossini AA, Like AA, Chick WL, et al. Studies of streptozotocin-induced insulitis and diabetes. Proc Natl Acad Sci U S A. 1977;74:2485-2489.
45. Leiter EH. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: influence of inbred background, sex and thymus. Proc Natl Acad Sci U S A. 1982;79:630-634.
46. Rafaeloff R, Barlow SW, Rosenberg L, et al. Expression of REG gene in the Syrian golden hamster pancreatic islet regeneration model. Diabetologia. 1995;38:906-913.
47. Gurr W, Yavari R, Wen L, et al. A reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice. Diabetes. 2002;51:339-346.
48. Wong FS, Janeway CA Jr. Insulin-dependent diabetes mellitus and its animal models. Curr Opin Immunol. 1999;11:643-647.
49. Raz I, Elias D, Avron A, et al. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet. 2001; 358:1749-1753.