Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients

Experimental Neurology

Volumn 159, Issue 2, 1999, Pages 559-564

  Battaini, Fiorenzo ^a   Pascale, Alessia ^b   Lucchi, Laura ^b   Pasinetti, Giulio M ^c   Govoni, Stefano ^d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Alzheimer's disease; Anchoring proteins; Brain cortex; PKC activation; PKC II; RACK1

Indexed keywords

PROTEIN KINASE C;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREACTIVITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0032865258     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7151     Document Type: Article

References (49)

1. Battaini F., Garbillo G., Bergamaschi S., Parenti M., Wetsel W. C., Govoni S., Trabucchi M. Regulation of protein kinase C in NG108-15 cell differentiation. Biochem. Biophys. Res. Commun. 201:1994;135-142.
2. Battaini F., Elkabes S., Bergamaschi S., Ladisa V., Lucchi L., De Graan P. N. E., Schuurman T., Wetsel W. C., Trabucchi M., Govoni S. Protein kinase C activity, translocation and conventional isoforms in aging rat brain. Neurobiol. Aging. 16:1995;137-148.
3. Battaini F., Govoni S., Trabucchi M. Protein kinase C signal transmission during aging. Macieira-Coelho A. Molecular Basis of Aging. 1995;269-291 CRC Press, Boca Raton.
4. Battaini F., Pascale A., Paoletti R., Govoni S. The role of anchoring protein RACK1 in PKC activation in the ageing rat brain. Trends Neurosci. 20:1997;410-415.
5. Bergamaschi S., Binetti G., Govoni S., Wetsel W. C., Battaini F., Trabucchi M., Racchi M. Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts. Neurosci. Lett. 201:1995;1-4.
6. Bixby J. L., Jhabvala P. Tyrosine phosphorylation in early embryonic growth cones. J. Neurosci. 13:1993;3421-3432.
7. Blobe G., Stribling S., Fabbro D., Stabel S., Hannum Y. Protein kinase βII specifically binds to and is activated by F-actin. J. Biol. Chem. 271:1996;15823-15830.
8. Bothmer J., Jolles J. Phosphoinositide metabolism, aging and Alzheimer's disease. Biochim. Biophys. Acta. 1225:1994;111-124.
9. Bradford M. M. A rapid and sensitive method for the quantitation of micrograms quantities of proteins utilizing the principle of protein dye binding. Anal. Biochem. 72:1976;248-254.
10. Chang B. Y., Conroy K. B., Machleder E. M., Cartwright C. A. RACK1, a receptor for activated C kinase and a homolog of the β subunit of G proteins, inhibits activity of Src tyrosine kinases and growth of NIH 3T3 cells. Mol. Cell Biol. 18:1998;3245-3256.
11. Checler F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65:1995;1431-1444.
12. Csukai M., Mochly-Rosen D. Pharmacologic modulation of protein kinase C isozymes: The role of RACKs and subcellular localization. Pharmacol. Res. 39:1999;253-259.
13. Faux M. C., Scott J. D. More on target with protein phosphorylation: Conferring specificity by location. Trends Biochem. Sci. 21:1996;312-315.
14. Friedman E., Wang H.-Y. Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release. J. Neurochem. 52:1989;187-192.
15. Govoni S., Bergamaschi S., Racchi M., Battaini F., Binetti G., Bianchetti A., Trabucchi M. Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients. Neurology. 43:1993;2581-2586.
16. Greenwood A. F., Powers R. E., Jope R. S. Phosphoinositide hydrolysis, Gαp, phospholipase C and protein kinase C in post mortem human brain: Effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience. 69:1995;125-138.
17. Horsburgh K., Mackay K. B., McCulloch J. Intracortical glutamate perfusion in vivo induces cellular alterations in specific protein kinase C isoforms and amyloid precursor protein. Exp. Neurol. 143:1997;207-218.
18. Imai Y., Suzuki Y., Tohyama M., Wanaka A., Takagi T. Cloning and expression of a neural differentiation-associated gene, p205, in the embrional carcinoma cell line P19 and in the developing mouse. Mol. Brain Res. 24:1994;313-319.
19. Jin L.-W., Saitoh T. Changes in protein kinases in brain aging and Alzheimer's disease. Drugs Aging. 6:1995;136-149.
20. Khachaturian Z. S. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1985;1097-1105.
21. Kurumatani T., Fastbom J., Bonkale W. L., Bogdanovic N., Winblad B., Ohm T. G., Cowburn R. Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology. Brain Res. 796:1998;209-221.
22. Ladner C. J., Lee J. M. Pharmacological drug treatment of Alzheimer disease: The cholinergic hypothesis revisited. J. Neuropathol. Exp. Neurol. 57:1998;719-731.
23. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
24. LeBlanc A. C., Koutroumanis M., Goodyer C. G. Protein kinase C activation increases release of secreted amyloid precursor protein without decreasing Aβ production in human primary neuron cultures. J. Neurosci. 18:1998;2907-29013.
25. Masliah E., Cole G., Shimohama S., Hansen L. A., De Teresa L., Terry R. D., Saitoh T. Differential involvement of protein kinase C isozymes in Alzheimer's disease. J. Neurosci. 10:1991;2113-2124.
26. 2+-independent protein kinase C changes in the brains of patients with Alzheimer's disease. J. Neurochem. 67:1996;317-323.
27. Mattson M. P. Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons. Exp. Neurol. 112:1991;95-103.
28. Mattson M. P. Cellular actions of beta amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77:1997;1081-1132.
29. Meyer M., Judkins J. H., Momol A. E., Hardvik E. O. Effect of peroxidation and aging on rat neocortical Ach release and protein kinase C. Neurobiol. Aging. 15:1994;63-67.
30. Mirra S. S., Heyman A., McKeel D., Sumi S. M., Crain B. J., Brownlee L. M., Vogel F. S., Hugues J. P., van Belle G., Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
31. Mochly-Rosen D., Khaner H., Lopez J. Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA. 88:1991;3997-4000.
32. Mochly-Rosen D. Compartmentalization of protein kinases by intracellular receptor proteins: A theme in signal transduction. Science. 268:1995;247-251.
33. Mochly-Rosen D., Gordon A. S. Anchoring proteins for protein kinase C: A means for isozyme selectivity. FASEB J. 12:1998;35-42.
34. Padanilam B. J., Hammermann M. R. Ischemia-induced receptor for activated C kinase (RACK1) expression in rat kidneys. Am. J. Physiol. 272:1997;F160-F166.
35. Pascale A., Fortino I., Govoni S., Trabucchi M., Wetsel W. C., Battaini F. Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. J. Neurochem. 67:1996;2471-2477.
36. Pascale A., Govoni S., Battaini F. Age-related alteration of PKC, a key enzyme in memory processes. Physiological and pathological examples. Mol. Neurobiol. 16:1998;49-62.
37. Pettegrew J. W. Molecular insights into Alzheimer's disease. Ann. N. Y. Acad. Sci. 568:1989;5-28.
38. Ron D., Chen C.-H., Caldwell J., Jamieson L., Orr E., Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C: A homolog of the β subunit of G proteins. Proc. Natl. Acad. Sci. USA. 91:1994;839-843.
39. Ron D., Luo J., Mochly-Rosen D. C2 region-derived peptides inhibit translocation and function of β protein kinase C in vivo. J. Biol. Chem. 270:1995;24180-24187.
40. Roth G. S., Joseph J. A., Mason R. P. Membrane alteration as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci. 18:1995;203-206.
41. Shapiro I. P., Masliah E., Saitoh T. Altered protein tyrosine phosphorylation in Alzheimer's disease. J. Neurochem. 56:1991;1154-1162.
42. Shimohama S., Narita M., Matsushima H., Kimura J., Kameyama M., Hagiwara M., Hidaka H., Tabiguchi T. Assessment of protein kinase C isozymes by two site enzyme immunoassay in human brains and changes in Alzheimer's disease. Neurology. 43:1993;1407-1413.
43. Solerte S. B., Fioravanti M., Pascale A., Ferrari E., Govoni S., Battaini F. Increased natural killer cell citotoxicity in Alzheimer's disease may involve protein kinase C dysregulation. Neurobiol. Aging. 19:1998;191-199.
44. Souroujon M. C., Mochly-Rosen D. Peptide modulators of protein-protein interactions in intracellular signaling. Nat. Biotechnol. 16:1998;919-924.
45. Tanaka C., Nishizuka Y. The protein kinase C family for neuronal signaling. Annu. Rev. Neurosci. 17:1994;551-567.
46. Undie A. S., Wang H.-Y., Friedman E. Decreased phospholipase C beta immunoreactivity, phosphoinositide metabolism and protein kinase C activation in senescent F-344 rat brain. Neurobiol. Aging. 16:1995;19-28.
47. Wang H.-Y., Pisano M. R., Friedman E. Attenuated protein kinase C activity and translocation in Alzheimer's disease brain. Neurobiol. Aging. 15:1994;293-298.
48. Wetsel W. C., Khan W. A., Merchenthaler I., Rivera H., Phung A. H. M., Negro-Vilar A., Hannun Y. A. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J. Cell. Biol. 117:1992;121-123.
49. Wood J. G., Zinsmeister P. Tyrosine phosphorylation systems in Alzheimer's disease pathology. Neurosci. Lett. 121:1991;12-16.