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Volumn 1, Issue 4, 2007, Pages 433-448

Imatinib-resistant chronic myeloid leukemia (CML): Current concepts on pathogenesis and new emerging pharmacologic approaches

Author keywords

BCR ABL mutations; CML; Drug resistance; Imatinib; Stem cells

Indexed keywords


EID: 77949767699     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (37)

References (180)
  • 1
    • 0642347553 scopus 로고    scopus 로고
    • CNS and cutaneous involvement in patients with chronic myeloid leukemia treated with imatinib in hematologic complete remission: Two case reports
    • Abruzzese E, Cantonetti M, Morino L, et al. 2003. CNS and cutaneous involvement in patients with chronic myeloid leukemia treated with imatinib in hematologic complete remission: two case reports. J Clin Oncol, 21:4256-8.
    • (2003) J Clin Oncol , vol.21 , pp. 4256-4258
    • Abruzzese, E.1    Cantonetti, M.2    Morino, L.3
  • 2
    • 34547427247 scopus 로고    scopus 로고
    • Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy
    • Abdelhalim A, Barcos M, Block AW, et al. 2007. Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. Leuk Lymphoma, 48:1053-6.
    • (2007) Leuk Lymphoma , vol.48 , pp. 1053-1056
    • Abdelhalim, A.1    Barcos, M.2    Block, A.W.3
  • 3
    • 2542613623 scopus 로고    scopus 로고
    • Detection of trisomy 8 in donor-derived Phcells in a patient with Ph+ chronic myeloid leukemia successfully treated with Imatinib (STI571) in relapse after allogeneic transplantation
    • Agis H, Mannhalter C, Sperr WR, et al. 2004. Detection of trisomy 8 in donor-derived Phcells in a patient with Ph+ chronic myeloid leukemia successfully treated with Imatinib (STI571) in relapse after allogeneic transplantation. Leuk Lymphoma, 45:1453-8.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1453-1458
    • Agis, H.1    Mannhalter, C.2    Sperr, W.R.3
  • 4
    • 24944450475 scopus 로고    scopus 로고
    • Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors
    • Angstreich GR, Matsui W, Huff CA, et al. 2005. Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors. Br J Haematol, 130:373-81.
    • (2005) Br J Haematol , vol.130 , pp. 373-381
    • Angstreich, G.R.1    Matsui, W.2    Huff, C.A.3
  • 5
    • 34748923568 scopus 로고    scopus 로고
    • Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukemia occurring during imatinib therapy
    • Aichberger KJ, Herndlhofer S, Agis H, et al. 2007. Liposomal cytarabine for treatment of myeloid central nervous system relapse in chronic myeloid leukemia occurring during imatinib therapy. Eur J Clin Invest, 37:808-13.
    • (2007) Eur J Clin Invest , vol.37 , pp. 808-813
    • Aichberger, K.J.1    Herndlhofer, S.2    Agis, H.3
  • 6
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam M, Latek RR, Daley GQ. 2003. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, 112:831-43.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 7
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
    • Baccarani M, Saglio G, Goldman J, et al. 2006. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood, 108:1809-20.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 8
    • 0037103411 scopus 로고    scopus 로고
    • Complete molecular remission in chronic myelogenous leukemia after imatinib therapy
    • Swedish CML Group
    • Barbany G, Hoglund M, Simonsson B; Swedish CML Group. 2002. Complete molecular remission in chronic myelogenous leukemia after imatinib therapy. N Engl J Med, 347:539-40.
    • (2002) N Engl J Med , vol.347 , pp. 539-540
    • Barbany, G.1    Hoglund, M.2    Simonsson, B.3
  • 9
    • 33845664398 scopus 로고    scopus 로고
    • Primitive, quiescent and difficult to kill: The role of non-proliferating stem cells in chronic myeloid leukemia
    • Barnes DJ, Melo JV. 2006. Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia. Cell Cycle, 5:2862-6.
    • (2006) Cell Cycle , vol.5 , pp. 2862-2866
    • Barnes, D.J.1    Melo, J.V.2
  • 10
    • 0036398414 scopus 로고    scopus 로고
    • Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571
    • Barthe C, Gharbi MJ, Lagarde V, et al. 2002. Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571. Br J Haematol, 119:109-11.
    • (2002) Br J Haematol , vol.119 , pp. 109-111
    • Barthe, C.1    Gharbi, M.J.2    Lagarde, V.3
  • 11
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N, et al. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood, 101:4701-7.
    • Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3
  • 12
    • 0028786297 scopus 로고
    • Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
    • Biernaux C, Loos M, Sels A, et al. 1995. Huez G, Stryckmans P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood, 86:3118-22.
    • (1995) Blood , vol.86 , pp. 3118-3122
    • Biernaux, C.1    Loos, M.2    Sels, A.3    Huez, G.4    Stryckmans, P.5
  • 13
    • 0442313672 scopus 로고    scopus 로고
    • Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects
    • Bolton AE, Peng B, Hubert M, et al. 2004. Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects. Cancer Chemother Pharmacol, 53:102-6.
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 102-106
    • Bolton, A.E.1    Peng, B.2    Hubert, M.3
  • 14
    • 2542439701 scopus 로고    scopus 로고
    • CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid
    • Bornhäuser M, Jenke A, Freiberg-Richter J, et al. 2004. CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid. Ann Hematol, 83:401-2.
    • (2004) Ann Hematol , vol.83 , pp. 401-402
    • Bornhäuser, M.1    Jenke, A.2    Freiberg-Richter, J.3
  • 15
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
    • Bose S, Deininger M, Gora-Tybor J, et al. 1998. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood, 92:3362-7.
    • (1998) Blood , vol.92 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3
  • 16
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S, Rudzki Z, Walsh S, et al. 2002. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood, 99:3472-5.
    • (2002) Blood , vol.99 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 17
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, et al. 2003. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood, 102:276-83.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 18
    • 30344487254 scopus 로고    scopus 로고
    • Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
    • Breedveld P, Beijnen JH, Schellens JH. 2006. Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs. Trends Pharmacol Sci, 27:17-24.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 17-24
    • Breedveld, P.1    Beijnen, J.H.2    Schellens, J.H.3
  • 19
    • 16844384057 scopus 로고    scopus 로고
    • The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients
    • Breedveld P, Pluim D, Cipriani G, et al. 2005. The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res, 65:2577-82.
    • (2005) Cancer Res , vol.65 , pp. 2577-2582
    • Breedveld, P.1    Pluim, D.2    Cipriani, G.3
  • 20
    • 33749987744 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achievement of complete molecular response in a Ph(+) CML patient treated while in long lasting complete cytogenetic remission (CCR) induced by interferon
    • Breccia M, Diverio D, Pane F, et al. 2006. Discontinuation of imatinib therapy after achievement of complete molecular response in a Ph(+) CML patient treated while in long lasting complete cytogenetic remission (CCR) induced by interferon. Leuk Res, 30:1577-9.
    • (2006) Leuk Res , vol.30 , pp. 1577-1579
    • Breccia, M.1    Diverio, D.2    Pane, F.3
  • 21
    • 34249669336 scopus 로고    scopus 로고
    • Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells
    • Brendel C, Scharenberg C, Dohse M, et al. 2007. Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells. Leukemia, 2007; 21:1267-75.
    • (2007) Leukemia , vol.21 , pp. 1267-1275
    • Brendel, C.1    Scharenberg, C.2    Dohse, M.3
  • 22
    • 17144381630 scopus 로고    scopus 로고
    • Pharmacokinetic resistance to imatinib mesylate: Role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib
    • Burger H, Nooter K. 2004. Pharmacokinetic resistance to imatinib mesylate: role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib. Cell Cycle, 3:1502-5.
    • (2004) Cell Cycle , vol.3 , pp. 1502-1505
    • Burger, H.1    Nooter, K.2
  • 23
    • 25144450089 scopus 로고    scopus 로고
    • Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps
    • Burger H, van Tol H, Brok M, et al. 2005. Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol Ther, 4:747-52.
    • (2005) Cancer Biol Ther , vol.4 , pp. 747-752
    • Burger, H.1    van Tol, H.2    Brok, M.3
  • 24
    • 2542500611 scopus 로고    scopus 로고
    • The biology of CML blast crisis
    • Calabretta B, Perrotti D. 2004. The biology of CML blast crisis. Blood, 103:4010-22.
    • (2004) Blood , vol.103 , pp. 4010-4022
    • Calabretta, B.1    Perrotti, D.2
  • 25
    • 0036874198 scopus 로고    scopus 로고
    • BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration
    • Campbell LJ, Patsouris C, Rayeroux KC, et al. 2002. BCR/ABL amplification in chronic myelocytic leukemia blast crisis following imatinib mesylate administration. Cancer Genet Cytogenet, 139:30-3.
    • (2002) Cancer Genet Cytogenet , vol.139 , pp. 30-33
    • Campbell, L.J.1    Patsouris, C.2    Rayeroux, K.C.3
  • 26
    • 23344440655 scopus 로고    scopus 로고
    • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    • Carter TA, Wodicka LM, Shah NP, et al. 2005. Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci USA, 102:11011-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11011-11016
    • Carter, T.A.1    Wodicka, L.M.2    Shah, N.P.3
  • 27
    • 34247615972 scopus 로고    scopus 로고
    • Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680
    • Cheetham GM, Charlton PA, Golec JM, et al. 2007. Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680. Cancer Lett, 251:323-9.
    • (2007) Cancer Lett , vol.251 , pp. 323-329
    • Cheetham, G.M.1    Charlton, P.A.2    Golec, J.M.3
  • 28
    • 0036094117 scopus 로고    scopus 로고
    • Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia
    • Cohen MH, Williams G, Johnson JR, et al. 2002. Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia. Clin Cancer Res, 8:935-42.
    • (2002) Clin Cancer Res , vol.8 , pp. 935-942
    • Cohen, M.H.1    Williams, G.2    Johnson, J.R.3
  • 29
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M, Hamilton A, Elrick LJ, et al. 2006. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood, 107:4532-9.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 30
    • 29244461485 scopus 로고    scopus 로고
    • Evolving molecular therapy for chronic myeloid leukaemia are we on target?
    • Copland M, Jorgensen HG, Holyoake TL. 2005. Evolving molecular therapy for chronic myeloid leukaemia are we on target? Hematology, 10:349-59.
    • (2005) HematolOgy , vol.10 , pp. 349-359
    • Copland, M.1    Jorgensen, H.G.2    Holyoake, T.L.3
  • 31
    • 0037255947 scopus 로고    scopus 로고
    • Advanced-phase chronic myeloid leukemia
    • Cortes J, Kantarjian H. 2003. Advanced-phase chronic myeloid leukemia. Semin Hematol, 40:79-86.
    • (2003) Semin Hematol , vol.40 , pp. 79-86
    • Cortes, J.1    Kantarjian, H.2
  • 32
    • 0012906888 scopus 로고    scopus 로고
    • Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy
    • Cortes JE, Talpaz M, Giles F, et al. 2003. Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood, 101:3794-800.
    • (2003) Blood , vol.101 , pp. 3794-3800
    • Cortes, J.E.1    Talpaz, M.2    Giles, F.3
  • 33
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinibresistant or -intolerant chronic myeloid leukemia in blast crisis
    • Cortes J, Rousselot P, Kim DW, et al. 2007. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinibresistant or -intolerant chronic myeloid leukemia in blast crisis. Blood, 109:3207-13.
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3
  • 34
    • 33644833353 scopus 로고    scopus 로고
    • Staging of chronic myeloid leukemia in the imatinib era: An evaluation of the World Health Organization proposal
    • Cortes JE, Talpaz M, O'Brien S, et al. 2006. Staging of chronic myeloid leukemia in the imatinib era: an evaluation of the World Health Organization proposal. Cancer, 106:1306-15.
    • (2006) Cancer , vol.106 , pp. 1306-1315
    • Cortes, J.E.1    Talpaz, M.2    O'Brien, S.3
  • 35
    • 2342629325 scopus 로고    scopus 로고
    • Imatinib (STI571) resistance in chronic myelogenous leukemia: Molecular basis of the underlying mechanisms and potential strategies for treatment
    • Cowan-Jacob SW, Guez V, Fendrich G, et al. 2004. Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment. Mini Rev Med Chem, 4:285-99.
    • (2004) Mini Rev Med Chem , vol.4 , pp. 285-299
    • Cowan-Jacob, S.W.1    Guez, V.2    Fendrich, G.3
  • 36
    • 0025117392 scopus 로고
    • Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
    • Daley GQ, Van Etten RA, Baltimore D. 1990. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science, 247:824-30.
    • (1990) Science , vol.247 , pp. 824-830
    • Daley, G.Q.1    van Etten, R.A.2    Baltimore, D.3
  • 37
    • 0020333906 scopus 로고
    • A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
    • de Klein A, van Kessel AG, Grosveld G, et al. 1982. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature, 300:765-7.
    • (1982) Nature , vol.300 , pp. 765-767
    • de Klein, A.1    van Kessel, A.G.2    Grosveld, G.3
  • 38
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux
    • Dai H, Marbach P, Lemaire M, et al. 2003. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J Pharmacol Exp Ther, 304:1085-92.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1085-1092
    • Dai, H.1    Marbach, P.2    Lemaire, M.3
  • 39
    • 33947266607 scopus 로고    scopus 로고
    • Optimizing therapy of chronic myeloid leukemia
    • Deininger MW. 2007. Optimizing therapy of chronic myeloid leukemia. Exp Hematol, 35(S1):144-54.
    • (2007) Exp Hematol , vol.35 , Issue.S1 , pp. 144-154
    • Deininger, M.W.1
  • 40
    • 29244492306 scopus 로고    scopus 로고
    • A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    • Devireddy LR, Gazin C, Zhu X, Green MR. 2005. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell, 123:1293-305.
    • (2005) Cell , vol.123 , pp. 1293-1305
    • Devireddy, L.R.1    Gazin, C.2    Zhu, X.3    Green, M.R.4
  • 41
    • 33847230958 scopus 로고    scopus 로고
    • Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase
    • Diaz-Blanco E, Bruns I, Neumann F, et al. 2007. Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase. Leukemia, 21:494-504.
    • (2007) Leukemia , vol.21 , pp. 494-504
    • Diaz-Blanco, E.1    Bruns, I.2    Neumann, F.3
  • 42
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, et al. 2006. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med, 355:2408-17.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 43
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, et al. 2001. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med, 344:1038-42.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 44
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. 2001. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med, 344:1031-7.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 45
    • 0034174927 scopus 로고    scopus 로고
    • Accelerated and blastic phase of chronic myeloid leukemia
    • Dutcher JP, Wiernik PH. 2000. Accelerated and blastic phase of chronic myeloid leukemia. Curr Treat Options Oncol, 1:51-62.
    • (2000) Curr Treat Options Oncol , vol.1 , pp. 51-62
    • Dutcher, J.P.1    Wiernik, P.H.2
  • 46
    • 4644287353 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects
    • Dutreix C, Peng B, Mehring G, et al. 2004. Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects. Cancer Chemother Pharmacol, 54:290-4.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 290-294
    • Dutreix, C.1    Peng, B.2    Mehring, G.3
  • 47
    • 0032227733 scopus 로고    scopus 로고
    • Differences between normal and CML stem cells: Potential targets for clinical exploitation
    • Eaves AC, Barnett MJ, Ponchio L, et al. 1998. Cashman JD, Petzer AL, Eaves CJ. Differences between normal and CML stem cells: potential targets for clinical exploitation. Stem Cells, 16(S1):77-83.
    • (1998) Stem Cells , vol.16 , Issue.S1 , pp. 77-83
    • Eaves, A.C.1    Barnett, M.J.2    Ponchio, L.3    Cashman, J.D.4    Petzer, A.L.5    Eaves, C.J.6
  • 48
    • 0027163397 scopus 로고
    • The biology of normal and neoplastic stem cells in CML
    • Eaves C, Udomsakdi C, Cashman J, et al. 1993. The biology of normal and neoplastic stem cells in CML. Leuk Lymphoma, 11S1:245-53.
    • (1993) Leuk Lymphoma , vol.11 S1 , pp. 245-253
    • Eaves, C.1    Udomsakdi, C.2    Cashman, J.3
  • 49
    • 29144474459 scopus 로고    scopus 로고
    • Pharmacokinetic and clinical phase II trial of imatinib in patients with impaired liver function and advanced hepatocellular carcinoma
    • Eckel F, von Delius S, Mayr M, et al. 2005. Pharmacokinetic and clinical phase II trial of imatinib in patients with impaired liver function and advanced hepatocellular carcinoma. Oncology, 69:363-71.
    • (2005) Oncology , vol.69 , pp. 363-371
    • Eckel, F.1    von Delius, S.2    Mayr, M.3
  • 50
    • 20144374544 scopus 로고    scopus 로고
    • Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease
    • Eisterer W, Jiang X, Christ O, et al. 2005. Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease. Leukemia, 19:435-41.
    • (2005) Leukemia , vol.19 , pp. 435-441
    • Eisterer, W.1    Jiang, X.2    Christ, O.3
  • 52
    • 4744338886 scopus 로고    scopus 로고
    • Effect of St John's wort on imatinib mesylate pharmacokinetics
    • Frye RF, Fitzgerald SM, Lagattuta TF, et al. 2004. Effect of St John's wort on imatinib mesylate pharmacokinetics. Clin Pharmacol Ther, 76:323-9.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 323-329
    • Frye, R.F.1    Fitzgerald, S.M.2    Lagattuta, T.F.3
  • 53
    • 19344364557 scopus 로고    scopus 로고
    • BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinib
    • Gadzicki D, von Neuhoff N, Steinemann D, et al. 2005. BCR-ABL gene amplification and overexpression in a patient with chronic myeloid leukemia treated with imatinib. Cancer Genet Cytogenet, 159:164-7.
    • (2005) Cancer Genet Cytogenet , vol.159 , pp. 164-167
    • Gadzicki, D.1    von Neuhoff, N.2    Steinemann, D.3
  • 54
    • 0037716675 scopus 로고    scopus 로고
    • Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia
    • Gargallo PM, Cuello MT, Aranguren PN, et al. 2003. Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia. Cancer Genet Cytogenet, 143:140-4.
    • (2003) Cancer Genet Cytogenet , vol.143 , pp. 140-144
    • Gargallo, P.M.1    Cuello, M.T.2    Aranguren, P.N.3
  • 56
    • 33846240316 scopus 로고    scopus 로고
    • MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
    • Giles FJ, Cortes J, Jones D, et al. 2007. MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. Blood, 109:500-2.
    • (2007) Blood , vol.109 , pp. 500-502
    • Giles, F.J.1    Cortes, J.2    Jones, D.3
  • 57
    • 34247863611 scopus 로고    scopus 로고
    • Impact of imatinib therapy on the use of allogeneic haematopoietic progenitor cell transplantation for the treatment of chronic myeloid leukaemia
    • Giralt SA, Arora M, Goldman JM, et al. 2007. Impact of imatinib therapy on the use of allogeneic haematopoietic progenitor cell transplantation for the treatment of chronic myeloid leukaemia. Br J Haematol, 137:461-7
    • (2007) Br J Haematol , vol.137 , pp. 461-467
    • Giralt, S.A.1    Arora, M.2    Goldman, J.M.3
  • 58
    • 0026608119 scopus 로고
    • Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro
    • Gishizky ML, Witte ON. 1992. Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro. Science, 256:836-9.
    • (1992) Science , vol.256 , pp. 836-839
    • Gishizky, M.L.1    Witte, O.N.2
  • 59
    • 30844457497 scopus 로고    scopus 로고
    • Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: Does it really matter?
    • Goldman J, Gordon M. 2006. Why do chronic myelogenous leukemia stem cells survive allogeneic stem cell transplantation or imatinib: does it really matter? Leuk Lymphoma, 47:1-7.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1-7
    • Goldman, J.1    Gordon, M.2
  • 60
    • 0022643765 scopus 로고
    • Bone marrow transplantation for patients with chronic myeloid leukemia
    • Goldman JM, Apperley JF, Jones L, et al. 1986. Bone marrow transplantation for patients with chronic myeloid leukemia. N Engl J Med, 314:202-7.
    • (1986) N Engl J Med , vol.314 , pp. 202-207
    • Goldman, J.M.1    Apperley, J.F.2    Jones, L.3
  • 61
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. 2001. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science, 293:876-80.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 62
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, et al. 2002. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood, 99:319-25.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3
  • 63
    • 0032480589 scopus 로고    scopus 로고
    • Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    • Gratwohl A, Hermans J, Goldman JM, et al. 1998. Risk assessment for patients with chronic myeloid leukaemia before allogeneic blood or marrow transplantation. Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Lancet, 352:1087-92.
    • (1998) Lancet , vol.352 , pp. 1087-1092
    • Gratwohl, A.1    Hermans, J.2    Goldman, J.M.3
  • 64
    • 33746934638 scopus 로고    scopus 로고
    • Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib
    • Griswold IJ, MacPartlin M, Bumm T, et al. 2006. Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib. Mol Cell Biol, 26:6082-93.
    • (2006) Mol Cell Biol , vol.26 , pp. 6082-6093
    • Griswold, I.J.1    Macpartlin, M.2    Bumm, T.3
  • 66
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinibresistant or -intolerant chronic myeloid leukemia in accelerated phase
    • Guilhot F, Apperley J, Kim DW, et al. 2007. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinibresistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood, 109:4143-50.
    • (2007) Blood , vol.109 , pp. 4143-4150
    • Guilhot, F.1    Apperley, J.2    Kim, D.W.3
  • 67
    • 13844261144 scopus 로고    scopus 로고
    • A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
    • Gumireddy K, Baker SJ, Cosenza SC, et al. 2005. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc Natl Acad Sci USA, 102:1992-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1992-1997
    • Gumireddy, K.1    Baker, S.J.2    Cosenza, S.C.3
  • 68
    • 0025341341 scopus 로고
    • Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine
    • Herweijer H, Sonneveld P, Baas F, Nooter K. 1990. Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine. J Natl Cancer Inst, 82:1133-40.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1133-1140
    • Herweijer, H.1    Sonneveld, P.2    Baas, F.3    Nooter, K.4
  • 69
    • 33846847772 scopus 로고    scopus 로고
    • Resistance to targeted therapy in chronic myelogenous leukemia
    • Hochhaus A, Erben P, Ernst T, Mueller MC. 2007. Resistance to targeted therapy in chronic myelogenous leukemia. Semin Hematol, 44: S15-24.
    • (2007) Semin Hematol , vol.44
    • Hochhaus, A.1    Erben, P.2    Ernst, T.3    Mueller, M.C.4
  • 70
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Hochhaus A, Kantarjian HM, Baccarani M, et al. 2007. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood, 109:2303-9.
    • (2007) Blood , vol.109 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3
  • 71
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, et al. 2002. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia, 16:2190-6.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 72
    • 0034480563 scopus 로고    scopus 로고
    • Cell separation improves the sensitivity of detecting rare human normal and leukemic hematopoietic cells in vivo in NOD/SCID mice
    • Holyoake TL, Horrocks C, Thomas T, et al. 2000. Cell separation improves the sensitivity of detecting rare human normal and leukemic hematopoietic cells in vivo in NOD/SCID mice. Cytotherapy, 2:411-21.
    • (2000) Cytotherapy , vol.2 , pp. 411-421
    • Holyoake, T.L.1    Horrocks, C.2    Thomas, T.3
  • 73
    • 85014195943 scopus 로고    scopus 로고
    • Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia
    • Holyoake TL, Jiang X, Drummond MW, et al. 2002. Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia. Leukemia, 16:549-58.
    • (2002) Leukemia , vol.16 , pp. 549-558
    • Holyoake, T.L.1    Jiang, X.2    Drummond, M.W.3
  • 74
    • 0035254540 scopus 로고    scopus 로고
    • Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3
    • Holyoake TL, Jiang X, Jorgensen HG, et al. 2001. Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3. Blood, 97:720-8.
    • (2001) Blood , vol.97 , pp. 720-728
    • Holyoake, T.L.1    Jiang, X.2    Jorgensen, H.G.3
  • 75
    • 0035855648 scopus 로고    scopus 로고
    • Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells
    • Hoover RR, Gerlach MJ, Koh EY, Daley GQ. 2001. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene, 20:5826-35.
    • (2001) Oncogene , vol.20 , pp. 5826-5835
    • Hoover, R.R.1    Gerlach, M.J.2    Koh, E.Y.3    Daley, G.Q.4
  • 76
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S, et al. 2003. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med, 349:1423-32.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 77
    • 1542713480 scopus 로고    scopus 로고
    • P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    • Illmer T, Schaich M, Platzbecker U, et al. 2004. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia, 18:401-8.
    • (2004) Leukemia , vol.18 , pp. 401-408
    • Illmer, T.1    Schaich, M.2    Platzbecker, U.3
  • 78
    • 33747156914 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure
    • Jabbour E, Cortes J, Kantarjian HM, et al. 2006. Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure. Blood, 108:1421-3.
    • (2006) Blood , vol.108 , pp. 1421-1423
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.M.3
  • 79
    • 34547178987 scopus 로고    scopus 로고
    • Novel tyrosine kinase inhibitor therapy before allogeneic stem cell transplantation in patients with chronic myeloid leukemia: No evidence for increased transplant-related toxicity
    • Jabbour E, Cortes J, Kantarjian H, et al. 2007. Novel tyrosine kinase inhibitor therapy before allogeneic stem cell transplantation in patients with chronic myeloid leukemia: no evidence for increased transplant-related toxicity. Cancer, 110:340-44.
    • (2007) Cancer , vol.110 , pp. 340-344
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.3
  • 80
    • 33846849302 scopus 로고    scopus 로고
    • New targeted therapies for chronic myelogenous leukemia: Opportunities to overcome imatinib resistance
    • Jabbour E, Cortes J, O'Brien S, et al. 2007. New targeted therapies for chronic myelogenous leukemia: opportunities to overcome imatinib resistance. Semin Hematol, 44(S1):S25-31.
    • (2007) Semin Hematol , vol.44 , Issue.S1
    • Jabbour, E.1    Cortes, J.2    O'Brien, S.3
  • 81
    • 35548971639 scopus 로고    scopus 로고
    • Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • in press
    • Jabbour E, Kantarjian HM, Abruzzo L, et al. 2007. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood, in press.
    • (2007) Blood
    • Jabbour, E.1    Kantarjian, H.M.2    Abruzzo, L.3
  • 82
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E, Kantarjian H, Jones D, et al. 2006. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia, 20:1767-73.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 83
    • 34249693090 scopus 로고    scopus 로고
    • Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells
    • Jiang X, Saw KM, Eaves A, Eaves C. 2007. Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells. J Natl Cancer Inst, 99:680-93.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 680-693
    • Jiang, X.1    Saw, K.M.2    Eaves, A.3    Eaves, C.4
  • 84
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • Jiang X, Zhao Y, Smith C, et al. 2007. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia, 21:926-35.
    • (2007) Leukemia , vol.21 , pp. 926-935
    • Jiang, X.1    Zhao, Y.2    Smith, C.3
  • 85
    • 0037092980 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
    • Kantarjian HM, Cortes J, O'Brien S, et al. 2002. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood, 99:3547-53.
    • (2002) Blood , vol.99 , pp. 3547-3553
    • Kantarjian, H.M.1    Cortes, J.2    O'Brien, S.3
  • 86
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. 2006. Nilotinib in imatinibresistant CML and Philadelphia chromosome-positive ALL. N Engl J Med, 354:2542-51.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 87
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, et al. 2002. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med, 346:645-52.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 88
    • 33947224197 scopus 로고    scopus 로고
    • New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance
    • Kantarjian HM, Talpaz M, Giles F, et al. 2006. New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance. Ann Intern Med, 145:913-23.
    • (2006) Ann Intern Med , vol.145 , pp. 913-923
    • Kantarjian, H.M.1    Talpaz, M.2    Giles, F.3
  • 89
    • 0037438467 scopus 로고    scopus 로고
    • Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
    • Kantarjian HM, Talpaz M, O'Brien S, et al. 2003. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood, 101:473-5.
    • (2003) Blood , vol.101 , pp. 473-475
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 90
    • 33646483941 scopus 로고    scopus 로고
    • The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib
    • Khorashad JS, Anand M, Marin D, et al. 2006. The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib. Leukemia, 20:658-63.
    • (2006) Leukemia , vol.20 , pp. 658-663
    • Khorashad, J.S.1    Anand, M.2    Marin, D.3
  • 91
    • 33748450738 scopus 로고    scopus 로고
    • Isolated blast crisis in CNS in a patient with chronic myelogenous leukaemia maintaining major cytogenetic response after imatinib
    • Kim HJ, Jung CW, Kim K, et al. 2006. Isolated blast crisis in CNS in a patient with chronic myelogenous leukaemia maintaining major cytogenetic response after imatinib. J Clin Oncol, 24:4028-29.
    • (2006) J Clin Oncol , vol.24 , pp. 4028-4029
    • Kim, H.J.1    Jung, C.W.2    Kim, K.3
  • 92
    • 28444479480 scopus 로고    scopus 로고
    • NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinibresistant leukemia
    • Kimura S, Naito H, Segawa H, et al. 2005. NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinibresistant leukemia. Blood, 106:3948-54.
    • (2005) Blood , vol.106 , pp. 3948-3954
    • Kimura, S.1    Naito, H.2    Segawa, H.3
  • 93
    • 0038514851 scopus 로고    scopus 로고
    • Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique
    • Kreuzer KA, Le Coutre P, Landt O, et al. 2003. Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique. Ann Hematol, 82:284-9.
    • (2003) Ann Hematol , vol.82 , pp. 284-289
    • Kreuzer, K.A.1    le Coutre, P.2    Landt, O.3
  • 94
    • 12144290456 scopus 로고    scopus 로고
    • Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588
    • le Coutre P, Kreuzer KA, Pursche S, et al. 2004. Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588. Cancer Chemother Pharmacol, 53:313-23.
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 313-323
    • le Coutre, P.1    Kreuzer, K.A.2    Pursche, S.3
  • 95
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M, et al. 2000. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood, 95:1758-66.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 96
    • 1342330066 scopus 로고    scopus 로고
    • Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI-571)
    • Leis JF, Stepan DE, Curtin PT, et al. 2004. Central nervous system failure in patients with chronic myelogenous leukemia lymphoid blast crisis and Philadelphia chromosome positive acute lymphoblastic leukemia treated with imatinib (STI-571). Leuk Lymphoma, 45:695-8.
    • (2004) Leuk Lymphoma , vol.45 , pp. 695-698
    • Leis, J.F.1    Stepan, D.E.2    Curtin, P.T.3
  • 97
    • 20444448873 scopus 로고    scopus 로고
    • Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia
    • Li Z, Qiao Y, Liu B, et al. 2005. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res, 11:4460-8.
    • (2005) Clin Cancer Res , vol.11 , pp. 4460-4468
    • Li, Z.1    Qiao, Y.2    Liu, B.3
  • 98
    • 18844397295 scopus 로고    scopus 로고
    • Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia
    • Lin H, Monaco G, Sun T, et al. 2005. Bcr-Abl-mediated suppression of normal hematopoiesis in leukemia. Oncogene, 24:3246-56.
    • (2005) Oncogene , vol.24 , pp. 3246-3256
    • Lin, H.1    Monaco, G.2    Sun, T.3
  • 99
    • 33748474783 scopus 로고    scopus 로고
    • Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: A report of nine cases and analysis of predictive factors
    • Lin Y, Bruyere H, Horsman DE, et al. 2006. Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors. Cancer Genet Cytogenet, 170:16-23.
    • (2006) Cancer Genet Cytogenet , vol.170 , pp. 16-23
    • Lin, Y.1    Bruyere, H.2    Horsman, D.E.3
  • 100
    • 8644286697 scopus 로고    scopus 로고
    • Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib
    • Loriaux M, Deininger M. 2004. Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. Leuk Lymphoma, 45:2197-203.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2197-2203
    • Loriaux, M.1    Deininger, M.2
  • 101
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo TG, Pendergast AM, Muller AJ, Witte ON. 1990. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, 247:1079-82.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 102
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon FX, Belloc F, Lagarde V, et al. 2003. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood, 101:2368-73.
    • (2003) Blood , vol.101 , pp. 2368-2373
    • Mahon, F.X.1    Belloc, F.2    Lagarde, V.3
  • 103
    • 0037346124 scopus 로고    scopus 로고
    • Chronic myeloid leukemia in chronic phase responding to imatinib: The occurrence of additional cytogenetic abnormalities predicts disease progression
    • Marktel S, Marin D, Foot N, et al. 2003. Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression. Haematologica, 88:260-7.
    • (2003) Haematologica , vol.88 , pp. 260-267
    • Marktel, S.1    Marin, D.2    Foot, N.3
  • 104
    • 17844389113 scopus 로고    scopus 로고
    • New tyrosine kinase inhibitors in chronic myeloid leukemia
    • Martinelli G, Soverini S, Rosti G, et al. 2005. New tyrosine kinase inhibitors in chronic myeloid leukemia. Haematologica, 90:534-41.
    • (2005) Haematologica , vol.90 , pp. 534-541
    • Martinelli, G.1    Soverini, S.2    Rosti, G.3
  • 105
    • 22844448054 scopus 로고    scopus 로고
    • Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate
    • Matsuda M, Morita Y, Shimada T, et al. 2005. Extramedullary blast crisis derived from 2 different clones in the central nervous system and neck during complete cytogenetic remission of chronic myelogenous leukemia treated with imatinib mesylate. Int J Hematol, 81:307-9.
    • (2005) Int J Hematol , vol.81 , pp. 307-309
    • Matsuda, M.1    Morita, Y.2    Shimada, T.3
  • 106
    • 0142243204 scopus 로고    scopus 로고
    • Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosomepositive chronic myelogenous leukemia in chronic phase
    • Medina J, Kantarjian H, Talpaz M, et al. 2003. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosomepositive chronic myelogenous leukemia in chronic phase. Cancer, 98:1905-11.
    • (2003) Cancer , vol.98 , pp. 1905-1911
    • Medina, J.1    Kantarjian, H.2    Talpaz, M.3
  • 107
    • 34249676964 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia as a model of disease evolution in human cancer
    • Melo JV, Barnes DJ. 2007. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer, 7:441-53.
    • (2007) Nat Rev Cancer , vol.7 , pp. 441-453
    • Melo, J.V.1    Barnes, D.J.2
  • 108
    • 3242804413 scopus 로고    scopus 로고
    • Biology of chronic myelogenous leukemia signaling pathways of initiation and transformation
    • Melo JV, Deininger MW. 2004. Biology of chronic myelogenous leukemia signaling pathways of initiation and transformation. Hematol Oncol Clin North Am, 18:545-68.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 545-568
    • Melo, J.V.1    Deininger, M.W.2
  • 109
    • 34347386254 scopus 로고    scopus 로고
    • Successful allogeneic stem cell transplantation in second chronic-phase CML induced by the tyrosine kinase inhibitor nilotinib (AMN107) after blast crisis under imatinib
    • Menzel H, von Bubnoff N, Hochhaus A, et al. 2007. Successful allogeneic stem cell transplantation in second chronic-phase CML induced by the tyrosine kinase inhibitor nilotinib (AMN107) after blast crisis under imatinib. Bone Marrow Transplant, 40:83-4.
    • (2007) Bone Marrow Transplant , vol.40 , pp. 83-84
    • Menzel, H.1    von Bubnoff, N.2    Hochhaus, A.3
  • 110
    • 21744462100 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukaemia
    • Michor F, Hughes TP, Iwasa Y, et al. 2005. Dynamics of chronic myeloid leukaemia. Nature, 435:1267-70.
    • (2005) Nature , vol.435 , pp. 1267-1270
    • Michor, F.1    Hughes, T.P.2    Iwasa, Y.3
  • 111
    • 0344177196 scopus 로고    scopus 로고
    • Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib
    • Morel F, Bris MJ, Herry A, et al. 2003. Double minutes containing amplified bcr-abl fusion gene in a case of chronic myeloid leukemia treated by imatinib. Eur J Haematol, 70:235-9.
    • (2003) Eur J Haematol , vol.70 , pp. 235-239
    • Morel, F.1    Bris, M.J.2    Herry, A.3
  • 112
    • 35748951338 scopus 로고    scopus 로고
    • Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: Two cases with a different outcome
    • Navarro JT, Feliu E, Grau J, et al. 2007. Monosomy 7 with severe myelodysplasia developing during imatinib treatment of Philadelphia-positive chronic myeloid leukemia: Two cases with a different outcome. Am J Hematol, 82:849-51.
    • (2007) Am J Hematol , vol.82 , pp. 849-851
    • Navarro, J.T.1    Feliu, E.2    Grau, J.3
  • 113
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P, Santhanam R, Trotta R, et al. 2006. The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell, 5:355-68.
    • (2006) Cancer Cell , vol.5 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3
  • 114
    • 18644386761 scopus 로고    scopus 로고
    • Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion
    • Nguyen Khac F, Waill MC, Romana SP, et al. 2002. Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion. Cancer Genet Cytogenet, 138:22-6.
    • (2002) Cancer Genet Cytogenet , vol.138 , pp. 22-26
    • Nguyen, K.F.1    Waill, M.C.2    Romana, S.P.3
  • 115
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP)
    • Nicolini FE, Corm S, Le QH, et al. 2006. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia, 20:1061-6.
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm, S.2    Le, Q.H.3
  • 116
    • 0000286732 scopus 로고
    • A minute chromosome in human granulocytic leukemia
    • Nowell PC, Hungerford DA. 1960. A minute chromosome in human granulocytic leukemia. Science, 132:1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 117
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. 2003. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med, 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 118
    • 10744231436 scopus 로고    scopus 로고
    • Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia
    • O'Brien SG, Meinhardt P, Bond E, et al. 2003. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer, 89:1855-9.
    • (2003) Br J Cancer , vol.89 , pp. 1855-1859
    • O'Brien, S.G.1    Meinhardt, P.2    Bond, E.3
  • 119
    • 0942287753 scopus 로고    scopus 로고
    • Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate
    • O'Dwyer ME, Mauro MJ, Blasdel C, et al. 2004. Clonal evolution and lack of cytogenetic response are adverse prognostic factors for hematologic relapse of chronic phase CML patients treated with imatinib mesylate. Blood, 103:451-5.
    • (2004) Blood , vol.103 , pp. 451-455
    • O'Dwyer, M.E.1    Mauro, M.J.2    Blasdel, C.3
  • 121
    • 23244433963 scopus 로고    scopus 로고
    • Pharmacokinetics of imatinib mesylate in end stage renal disease. A case study
    • Pappas P, Karavasilis V, Briasoulis E, et al. 2005. Pharmacokinetics of imatinib mesylate in end stage renal disease. A case study. Cancer Chemother Pharmacol, 56:358-60.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 358-360
    • Pappas, P.1    Karavasilis, V.2    Briasoulis, E.3
  • 122
    • 13344279320 scopus 로고    scopus 로고
    • Early blastic transformation with CNS infiltration in a patient with chronic myeloid leukaemia treated with imatinib
    • Pavlu J, Czepulkowski B, Kaczmarski R, Jan-Mohamed R. 2005. Early blastic transformation with CNS infiltration in a patient with chronic myeloid leukaemia treated with imatinib. Lancet Oncol, 6:128.
    • (2005) Lancet Oncol , vol.6 , pp. 128
    • Pavlu, J.1    Czepulkowski, B.2    Kaczmarski, R.3    Jan-Mohamed, R.4
  • 123
    • 0027368352 scopus 로고
    • BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein
    • Pendergast AM, Quilliam LA, Cripe LD, et al. 1993. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell, 75:175-85.
    • (1993) Cell , vol.75 , pp. 175-185
    • Pendergast, A.M.1    Quilliam, L.A.2    Cripe, L.D.3
  • 124
    • 1642494654 scopus 로고    scopus 로고
    • Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion
    • Peng B, Dutreix C, Mehring G, et al. 2004. Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion. J Clin Pharmacol, 44:158-62.
    • (2004) J Clin Pharmacol , vol.44 , pp. 158-162
    • Peng, B.1    Dutreix, C.2    Mehring, G.3
  • 125
    • 1542608328 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
    • Peng B, Hayes M, Resta D, et al. 2004. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol, 22:935-42.
    • (2004) J Clin Oncol , vol.22 , pp. 935-942
    • Peng, B.1    Hayes, M.2    Resta, D.3
  • 126
    • 34547137932 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells
    • Peng C, Brain J, Hu Y, et al. 2007. Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells. Blood, 110:678-85.
    • (2007) Blood , vol.110 , pp. 678-685
    • Peng, C.1    Brain, J.2    Hu, Y.3
  • 127
    • 24344482346 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of imatinib
    • Peng B, Lloyd P, Schran H. 2005. Clinical pharmacokinetics of imatinib. Clin Pharmacokinet, 44:879-94.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 879-894
    • Peng, B.1    Lloyd, P.2    Schran, H.3
  • 128
    • 34147174980 scopus 로고    scopus 로고
    • Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standarddose imatinib in chronic myeloid leukemia
    • Picard S, Titier K, Etienne G, et al. 2007. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standarddose imatinib in chronic myeloid leukemia. Blood, 109:3496-9.
    • (2007) Blood , vol.109 , pp. 3496-3499
    • Picard, S.1    Titier, K.2    Etienne, G.3
  • 129
    • 34247168516 scopus 로고    scopus 로고
    • Complete cytogenetic and molecular response after imatinib treatment for chronic myeloid leukemia in a patient with atypical karyotype and BCR-ABL b2a3 transcript
    • Pienkowska-Grela B, Woroniecka R, Solarska I, et al. 2007. Complete cytogenetic and molecular response after imatinib treatment for chronic myeloid leukemia in a patient with atypical karyotype and BCR-ABL b2a3 transcript. Cancer Genet Cytogenet, 174:111-5.
    • (2007) Cancer Genet Cytogenet , vol.174 , pp. 111-115
    • Pienkowska-Grela, B.1    Woroniecka, R.2    Solarska, I.3
  • 130
    • 0028147448 scopus 로고
    • Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
    • Puil L, Liu J, Gish G, et al. 1994. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J, 13:764-73.
    • (1994) EMBO J , vol.13 , pp. 764-773
    • Puil, L.1    Liu, J.2    Gish, G.3
  • 131
    • 33846200681 scopus 로고    scopus 로고
    • Dasatinib (BMS354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure
    • Quintas-Cardama A, Kantarjian H, Jones D, et al. 2007. Dasatinib (BMS354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure. Blood, 109:497-9.
    • (2007) Blood , vol.109 , pp. 497-499
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3
  • 132
    • 33644525274 scopus 로고    scopus 로고
    • Gene expression changes associated with progression and response in chronic myeloid leukemia
    • Radich JP, Dai H, Mao M, et al. 2006. Gene expression changes associated with progression and response in chronic myeloid leukemia. Proc Natl Acad Sci USA, 103:2794-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2794-2799
    • Radich, J.P.1    Dai, H.2    Mao, M.3
  • 133
    • 34548412863 scopus 로고    scopus 로고
    • The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant BCR/ABL+ human leukemia cells in association with STAT5 inhibition and MCL-1 downregulation
    • Rahmani M, Nguyen TK, Dent P, et al. 2007. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant BCR/ABL+ human leukemia cells in association with STAT5 inhibition and MCL-1 downregulation. Mol Pharmacol, 72:788-95.
    • (2007) Mol Pharmacol , vol.72 , pp. 788-795
    • Rahmani, M.1    Nguyen, T.K.2    Dent, P.3
  • 134
    • 25144484850 scopus 로고    scopus 로고
    • Isolated central nervous system blast crisis in chronic myeloid leukaemia
    • Rajappa S, Uppin SG, Raghunadharao D, et al. 2004. Isolated central nervous system blast crisis in chronic myeloid leukaemia. Hematol Oncol, 22:179-81.
    • (2004) Hematol Oncol , vol.22 , pp. 179-181
    • Rajappa, S.1    Uppin, S.G.2    Raghunadharao, D.3
  • 135
    • 14644425319 scopus 로고    scopus 로고
    • Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
    • Ren R. 2005. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer, 5:172-83.
    • (2005) Nat Rev Cancer , vol.5 , pp. 172-183
    • Ren, R.1
  • 136
    • 0038700992 scopus 로고    scopus 로고
    • Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment
    • Roche-Lestienne C, Preudhomme C. 2003. Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment. Semin Hematol, 40(S2):80-2.
    • (2003) Semin Hematol , vol.40 , Issue.S2 , pp. 80-82
    • Roche-Lestienne, C.1    Preudhomme, C.2
  • 137
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Cornu V, Grardel-Duflos N, et al. 2002. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood, 100:1014-8.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Cornu, V.2    Grardel-Duflos, N.3
  • 138
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of imatinib-treated chronic myeloid leukemia: Functional insights and clinical implications
    • Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M. 2006. Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat Med, 12:1181-4.
    • (2006) Nat Med , vol.12 , pp. 1181-1184
    • Roeder, I.1    Horn, M.2    Glauche, I.3    Hochhaus, A.4    Mueller, M.C.5    Loeffler, M.6
  • 139
    • 0036678472 scopus 로고    scopus 로고
    • Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
    • Roumiantsev S, Shah NP, Gorre ME, et al. 2002. Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop. Proc Natl Acad Sci USA, 99:10700-5.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10700-10705
    • Roumiantsev, S.1    Shah, N.P.2    Gorre, M.E.3
  • 140
    • 33846023983 scopus 로고    scopus 로고
    • Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years
    • Rousselot P, Huguet F, Rea D, et al. 2007. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years. Blood, 109:58-60.
    • (2007) Blood , vol.109 , pp. 58-60
    • Rousselot, P.1    Huguet, F.2    Rea, D.3
  • 141
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. 1973. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature, 243:290-3.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 142
    • 3042816939 scopus 로고    scopus 로고
    • Central nervous system relapse in two patients with chronic myelogenous leukemia in myeloid blastic phase on imatinib mesylate therapy
    • Rytting ME, Wierda WG. 2004. Central nervous system relapse in two patients with chronic myelogenous leukemia in myeloid blastic phase on imatinib mesylate therapy. Leuk Lymphoma, 45:1623-6.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1623-1626
    • Rytting, M.E.1    Wierda, W.G.2
  • 143
    • 0038100233 scopus 로고    scopus 로고
    • Molecular mechanisms of transformation by the BCR-ABL oncogene
    • Sattler M, Griffin JD. 2003. Molecular mechanisms of transformation by the BCR-ABL oncogene. Semin Hematol, 40:4-10.
    • (2003) Semin Hematol , vol.40 , pp. 4-10
    • Sattler, M.1    Griffin, J.D.2
  • 144
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, et al. 2002. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood, 99:3530-9.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 145
    • 0037395626 scopus 로고    scopus 로고
    • Gleevec does not cross blood-brain barrier
    • Senior K. 2003. Gleevec does not cross blood-brain barrier. Lancet Oncol, 4:198.
    • (2003) Lancet Oncol , vol.4 , pp. 198
    • Senior, K.1
  • 146
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. 2002. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell, 2:117-25.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 147
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, et al. 2004. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science, 305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 148
    • 0036050013 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: Mechanisms underlying disease progression
    • Shet AS, Jahagirdar BN, Verfaillie CM. 2002. Chronic myelogenous leukemia: mechanisms underlying disease progression. Leukemia, 16:1402-11.
    • (2002) Leukemia , vol.16 , pp. 1402-1411
    • Shet, A.S.1    Jahagirdar, B.N.2    Verfaillie, C.M.3
  • 149
    • 0028116353 scopus 로고
    • Availability and appropriateness of allogeneic bone marrow transplantation for chronic myeloid leukemia in 10 countries
    • Silberman G, Crosse MG, Peterson EA, et al. 1994. Availability and appropriateness of allogeneic bone marrow transplantation for chronic myeloid leukemia in 10 countries. N Engl J Med, 331:1063-7.
    • (1994) N Engl J Med , vol.331 , pp. 1063-1067
    • Silberman, G.1    Crosse, M.G.2    Peterson, E.A.3
  • 150
    • 0034653929 scopus 로고    scopus 로고
    • STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
    • Sillaber C, Gesbert F, Frank DA, et al. 2000. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood, 95:2118-25.
    • (2000) Blood , vol.95 , pp. 2118-2125
    • Sillaber, C.1    Gesbert, F.2    Frank, D.A.3
  • 151
    • 33845893074 scopus 로고    scopus 로고
    • Phosphorylation of the ATPbinding loop directs oncogenicity of drug-resistant BCR-ABL mutants
    • Skaggs BJ, Gorre ME, Ryvkin A, et al. 2006. Phosphorylation of the ATPbinding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci USA, 103:19466-71.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19466-19471
    • Skaggs, B.J.1    Gorre, M.E.2    Ryvkin, A.3
  • 152
    • 0030710188 scopus 로고    scopus 로고
    • Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
    • Skorski T, Bellacosa A, Nieborowska-Skorska M, et al. 1997. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J, 16:6151-61.
    • (1997) EMBO J , vol.16 , pp. 6151-6161
    • Skorski, T.1    Bellacosa, A.2    Nieborowska-Skorska, M.3
  • 153
    • 23044458596 scopus 로고    scopus 로고
    • ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
    • Soverini S, Martinelli G, Rosti G, et al. 2005. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol, 23:4100-9.
    • (2005) J Clin Oncol , vol.23 , pp. 4100-4109
    • Soverini, S.1    Martinelli, G.2    Rosti, G.3
  • 154
    • 0036399992 scopus 로고    scopus 로고
    • Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid
    • Takayama N, Sato N, O'Brien SG, et al. 2002. Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid. Br J Haematol. 119:106-8.
    • (2002) Br J Haematol , vol.119 , pp. 106-108
    • Takayama, N.1    Sato, N.2    O'Brien, S.G.3
  • 155
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. 2006. Dasatinib in imatinibresistant Philadelphia chromosome-positive leukemias. N Engl J Med, 354:2531-41.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 156
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, et al. 2002. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood, 99:1928-37.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 157
    • 0034114155 scopus 로고    scopus 로고
    • Transposition of duplicated chromosomal segment involving fused BCR-ABL gene or ABL oncogene alone in chronic myelocytic leukemia and Ph chromosome-positive acute leukemia with complex karyotypes
    • Tanaka K, Arif M, Kyo T, et al. 2000. Transposition of duplicated chromosomal segment involving fused BCR-ABL gene or ABL oncogene alone in chronic myelocytic leukemia and Ph chromosome-positive acute leukemia with complex karyotypes. Cancer Genet Cytogenet, 119:8-14.
    • (2000) Cancer Genet Cytogenet , vol.119 , pp. 8-14
    • Tanaka, K.1    Arif, M.2    Kyo, T.3
  • 158
    • 33744457928 scopus 로고    scopus 로고
    • The second generation of BCR-ABL tyrosine kinase inhibitors
    • Tauchi T, Ohyashiki K. 2006. The second generation of BCR-ABL tyrosine kinase inhibitors. Int J Hematol, 83:294-300.
    • (2006) Int J Hematol , vol.83 , pp. 294-300
    • Tauchi, T.1    Ohyashiki, K.2
  • 159
    • 4344638050 scopus 로고    scopus 로고
    • Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia
    • Terre C, Eclache V, Rousselot P, et al. 2004. Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia. Leukemia, 18:1340-6.
    • (2004) Leukemia , vol.18 , pp. 1340-1346
    • Terre, C.1    Eclache, V.2    Rousselot, P.3
  • 160
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, Pirmohamed M. 2004. Active transport of imatinib into and out of cells: implications for drug resistance. Blood, 104:3739-45.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3    Pirmohamed, M.4
  • 161
    • 20844434173 scopus 로고    scopus 로고
    • Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance
    • Tseng PH, Lin HP, Zhu J, et al. 2005. Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. Blood, 105:4021-7.
    • (2005) Blood , vol.105 , pp. 4021-4027
    • Tseng, P.H.1    Lin, H.P.2    Zhu, J.3
  • 162
    • 33947376040 scopus 로고    scopus 로고
    • Oncogenic signaling: New insights and controversies from chronic myeloid leukemia
    • Van Etten RA. 2007. Oncogenic signaling: new insights and controversies from chronic myeloid leukemia. J Exp Med, 204:461-5.
    • (2007) J Exp Med , vol.204 , pp. 461-465
    • van Etten, R.A.1
  • 163
    • 31144446854 scopus 로고    scopus 로고
    • Continuous complete hematological and cytogenetic remission with molecular minimal residual disease 9 years after discontinuation of interferon-alpha in a patient with Philadelphia chromosome-positive chronic myeloid leukemia
    • Verbeek W, Konig H, Boehm J, et al. 2006. Continuous complete hematological and cytogenetic remission with molecular minimal residual disease 9 years after discontinuation of interferon-alpha in a patient with Philadelphia chromosome-positive chronic myeloid leukemia. Acta Haematol, 115:109-12.
    • (2006) Acta Haematol , vol.115 , pp. 109-112
    • Verbeek, W.1    Konig, H.2    Boehm, J.3
  • 164
    • 33744489570 scopus 로고    scopus 로고
    • Identification of genes involved in imatinib resistance in CML: A gene-expression profiling approach
    • Villuendas R, Steegmann JL, Pollan M, et al. 2006. Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach. Leukemia, 20:1047-54.
    • (2006) Leukemia , vol.20 , pp. 1047-1054
    • Villuendas, R.1    Steegmann, J.L.2    Pollan, M.3
  • 165
    • 34347233471 scopus 로고    scopus 로고
    • Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches
    • Volpe G, Cignetti A, Panuzzo C, et al. 2007. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res, 67:5300-7.
    • (2007) Cancer Res , vol.67 , pp. 5300-5307
    • Volpe, G.1    Cignetti, A.2    Panuzzo, C.3
  • 166
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphiachromosome-positive leukaemia to STI571: A prospective study
    • von Bubnoff N, Schneller F, Peschel C, et al. 2002. BCR-ABL gene mutations in relation to clinical resistance of Philadelphiachromosome-positive leukaemia to STI571: a prospective study. Lancet, 359:487-91.
    • (2002) Lancet , vol.359 , pp. 487-491
    • von Bubnoff, N.1    Schneller, F.2    Peschel, C.3
  • 167
    • 38349193809 scopus 로고    scopus 로고
    • Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia
    • doi:10.1038/sj.clpt.6100268
    • Wang L, Giannoudis A, Lane S, et al. 2007. Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin Pharmacol Ther, doi:10.1038/sj.clpt.6100268.
    • (2007) Clin Pharmacol Ther
    • Wang, L.1    Giannoudis, A.2    Lane, S.3
  • 168
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. 2005. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell, 7:129-41.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 169
    • 33745114173 scopus 로고    scopus 로고
    • AMN107 (nilotinib): A novel and selective inhibitor of BCR-ABL
    • Weisberg E, Manley P, Mestan J, et al. 2006. AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. Br J Cancer, 94:1765-9.
    • (2006) Br J Cancer , vol.94 , pp. 1765-1769
    • Weisberg, E.1    Manley, P.2    Mestan, J.3
  • 170
    • 33847379510 scopus 로고    scopus 로고
    • Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias
    • Weisberg E, Catley L, Wright RD, et al. 2007. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood, 109:2112-20.
    • (2007) Blood , vol.109 , pp. 2112-2120
    • Weisberg, E.1    Catley, L.2    Wright, R.D.3
  • 171
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
    • Weisberg E, Griffin JD. 2000. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood, 95:3498-505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 172
    • 34247470836 scopus 로고    scopus 로고
    • Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
    • Weisberg E, Manley PW, Cowan-Jacob SW, et al. 2007. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer, 7:345-56.
    • (2007) Nat Rev Cancer , vol.7 , pp. 345-356
    • Weisberg, E.1    Manley, P.W.2    Cowan-Jacob, S.W.3
  • 173
    • 34247877678 scopus 로고    scopus 로고
    • Allogeneic stem-cell transplantation provides excellent results in advanced stage chronic myeloid leukemia with major cytogenetic response to pre-transplant imatinib therapy
    • Weisser M, Schleuning M, Haferlach C, et al. 2007. Allogeneic stem-cell transplantation provides excellent results in advanced stage chronic myeloid leukemia with major cytogenetic response to pre-transplant imatinib therapy. Leuk Lymphoma, 48:295-301.
    • (2007) Leuk Lymphoma , vol.48 , pp. 295-301
    • Weisser, M.1    Schleuning, M.2    Haferlach, C.3
  • 174
    • 34247474915 scopus 로고    scopus 로고
    • Vaccination with autologous non-irradiated dendritic cells in patients with bcr/abl+ chronic myeloid leukaemia
    • Westermann J, Kopp J, van Lessen A, et al. 2007. Vaccination with autologous non-irradiated dendritic cells in patients with bcr/abl+ chronic myeloid leukaemia. Br J Haematol, 137:297-306.
    • (2007) Br J Haematol , vol.137 , pp. 297-306
    • Westermann, J.1    Kopp, J.2    van Lessen, A.3
  • 175
    • 0027367245 scopus 로고
    • Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation
    • Wetzler M, Talpaz M, Van Etten RA, et al. 1993. Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. J Clin Invest, 92:1925-39.
    • (1993) J Clin Invest , vol.92 , pp. 1925-1939
    • Wetzler, M.1    Talpaz, M.2    van Etten, R.A.3
  • 176
    • 34147107091 scopus 로고    scopus 로고
    • Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs
    • White DL, Saunders VA, Quinn SR, et al. 2007. Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs. Blood, 109:3609-10.
    • (2007) Blood , vol.109 , pp. 3609-3610
    • White, D.L.1    Saunders, V.A.2    Quinn, S.R.3
  • 177
    • 33745203000 scopus 로고    scopus 로고
    • BMS-354825, a dual SRC/ABL kinase inhibitor, displays potent anti-tumor activity in a model of intracranial CML growth
    • Wild R, Castaneda S, Flefleh C, et al. 2004. BMS-354825, a dual SRC/ABL kinase inhibitor, displays potent anti-tumor activity in a model of intracranial CML growth. Blood, 104:549a.
    • (2004) Blood , vol.104
    • Wild, R.1    Castaneda, S.2    Flefleh, C.3
  • 178
    • 0038721475 scopus 로고    scopus 로고
    • The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia
    • Wolff NC, Richardson JA, Egorin M, Ilaria RL. 2003. The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. Blood, 101:5010-3.
    • (2003) Blood , vol.101 , pp. 5010-5013
    • Wolff, N.C.1    Richardson, J.A.2    Egorin, M.3    Ilaria, R.L.4
  • 179
    • 33846018356 scopus 로고    scopus 로고
    • INNO-406, a novel BCRABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity
    • Yokota A, Kimura S, Masuda S, et al. 2007. INNO-406, a novel BCRABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity. Blood, 109:306-14.
    • (2007) Blood , vol.109 , pp. 306-314
    • Yokota, A.1    Kimura, S.2    Masuda, S.3
  • 180
    • 33744466526 scopus 로고    scopus 로고
    • Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis
    • Zheng C, Li L, Haak M, et al. 2006. Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis. Leukemia, 20:1028-34.
    • (2006) Leukemia , vol.20 , pp. 1028-1034
    • Zheng, C.1    Li, L.2    Haak, M.3


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