메뉴 건너뛰기




Volumn 18, Issue 3, 2004, Pages 753-774

Accelerated and blastic phases of chronic myelogenous leukemia

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 5 AZA 2' DEOXYCYTIDINE; AP 23573; ARSENIC TRIOXIDE; ARYLBUTYRIC ACID DERIVATIVE; BEVACIZUMAB; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; EVEROLIMUS; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; IDARUBICIN; IMATINIB; LBH 589; LONAFARNIB; MITOXANTRONE; NUCLEOSIDE ANALOG; PEGINTERFERON; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAPAMYCIN DERIVATIVE; RECOMBINANT ALPHA INTERFERON; RETINOID DERIVATIVE; SEMAXANIB; TEMSIROLIMUS; TIPIFARNIB; TROXACITABINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR; VATALANIB; VINCRISTINE;

EID: 3242748217     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2004.03.005     Document Type: Review
Times cited : (38)

References (177)
  • 1
    • 0033520092 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: Biology and therapy
    • Faderl S., Talpaz M., Estrov Z., et al. Chronic myelogenous leukemia: biology and therapy. Ann Intern Med. 131(3):1999;207-219
    • (1999) Ann Intern Med , vol.131 , Issue.3 , pp. 207-219
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 2
    • 0033565561 scopus 로고    scopus 로고
    • The biology of chronic myeloid leukemia
    • Faderl S., Talpaz M., Estrov Z., et al. The biology of chronic myeloid leukemia. N Engl J Med. 341(3):1999;164-172
    • (1999) N Engl J Med , vol.341 , Issue.3 , pp. 164-172
    • Faderl, S.1    Talpaz, M.2    Estrov, Z.3
  • 3
    • 0021344640 scopus 로고
    • Allogeneic bone-marrow transplantation for chronic myelogenous leukaemia
    • Speck B., Bortin M.M., Champlin R., et al. Allogeneic bone-marrow transplantation for chronic myelogenous leukaemia. Lancet. 1(8378):1984;665-668
    • (1984) Lancet , vol.1 , Issue.8378 , pp. 665-668
    • Speck, B.1    Bortin, M.M.2    Champlin, R.3
  • 4
    • 0027992614 scopus 로고
    • Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia
    • Clift R.A., Buckner C.D., Thomas E.D., et al. Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia. Blood. 84(12):1994;4368-4373
    • (1994) Blood , vol.84 , Issue.12 , pp. 4368-4373
    • Clift, R.A.1    Buckner, C.D.2    Thomas, E.D.3
  • 5
    • 0023841366 scopus 로고
    • Characteristics of accelerated disease in chronic myelogenous leukemia
    • Kantarjian H.M., Dixon D., Keating M.J., et al. Characteristics of accelerated disease in chronic myelogenous leukemia. Cancer. 61(7):1988;1441-1446
    • (1988) Cancer , vol.61 , Issue.7 , pp. 1441-1446
    • Kantarjian, H.M.1    Dixon, D.2    Keating, M.J.3
  • 6
    • 0030831669 scopus 로고    scopus 로고
    • Bone marrow transplantation for chronic myeloid leukaemia: The effects of differing criteria for defining chronic phase on probabilities of survival and relapse
    • Savage D.G., Szydlo R.M., Chase A., et al. Bone marrow transplantation for chronic myeloid leukaemia: the effects of differing criteria for defining chronic phase on probabilities of survival and relapse. Br J Haematol. 99(1):1997;30-35
    • (1997) Br J Haematol , vol.99 , Issue.1 , pp. 30-35
    • Savage, D.G.1    Szydlo, R.M.2    Chase, A.3
  • 7
    • 0023806919 scopus 로고
    • Prognostic significance of additional cytogenetic abnormalities at diagnosis of Philadelphia chromosome-positive chronic granulocytic leukemia
    • Sokal J.E., Gomez G.A., Baccarani M., et al. Prognostic significance of additional cytogenetic abnormalities at diagnosis of Philadelphia chromosome-positive chronic granulocytic leukemia. Blood. 72(1):1988;294-298
    • (1988) Blood , vol.72 , Issue.1 , pp. 294-298
    • Sokal, J.E.1    Gomez, G.A.2    Baccarani, M.3
  • 8
    • 0027235886 scopus 로고
    • The cytogenetic scenario of chronic myeloid leukemia
    • Mitelman F. The cytogenetic scenario of chronic myeloid leukemia. Leuk Lymphoma. 11(Suppl 1):1993;11-15
    • (1993) Leuk Lymphoma , vol.11 , Issue.SUPPL. 1 , pp. 11-15
    • Mitelman, F.1
  • 9
    • 0030061157 scopus 로고    scopus 로고
    • Significance of cytogenetic clonal evolution in chronic myelogenous leukemia
    • Majlis A., Smith T.L., Talpaz M., et al. Significance of cytogenetic clonal evolution in chronic myelogenous leukemia. J Clin Oncol. 14(1):1996;196-203
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 196-203
    • Majlis, A.1    Smith, T.L.2    Talpaz, M.3
  • 10
    • 0031785825 scopus 로고    scopus 로고
    • Suppression of cytogenetic clonal evolution with interferon alfa therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Cortes J., Talpaz M., O'Brien S., et al. Suppression of cytogenetic clonal evolution with interferon alfa therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. J Clin Oncol. 16(10):1998;3279-3285
    • (1998) J Clin Oncol , vol.16 , Issue.10 , pp. 3279-3285
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 11
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M., Silver R.T., Druker B.J., et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 99(6):2002;1928-1937
    • (2002) Blood , vol.99 , Issue.6 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 12
    • 0026550269 scopus 로고
    • Treatment of chronic myelogenous leukemia in accelerated and blastic phases with daunorubicin, high-dose cytarabine, and granulocyte-macrophage colony-stimulating factor
    • Kantarjian H.M., Talpaz M., Kontoyiannis D., et al. Treatment of chronic myelogenous leukemia in accelerated and blastic phases with daunorubicin, high-dose cytarabine, and granulocyte-macrophage colony-stimulating factor. J Clin Oncol. 10(3):1992;398-405
    • (1992) J Clin Oncol , vol.10 , Issue.3 , pp. 398-405
    • Kantarjian, H.M.1    Talpaz, M.2    Kontoyiannis, D.3
  • 13
    • 0032941216 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome-positive early chronic phase chronic myelogenous leukemia with daily doses of interferon alpha and low-dose cytarabine
    • Kantarjian H.M., O'Brien S., Smith T.L., et al. Treatment of Philadelphia chromosome-positive early chronic phase chronic myelogenous leukemia with daily doses of interferon alpha and low-dose cytarabine. J Clin Oncol. 17(1):1999;284-292
    • (1999) J Clin Oncol , vol.17 , Issue.1 , pp. 284-292
    • Kantarjian, H.M.1    O'Brien, S.2    Smith, T.L.3
  • 14
    • 0034668122 scopus 로고    scopus 로고
    • Therapeutic choices in younger patients with chronic myelogenous leukemia
    • Kantarjian H.M., Giles F.J., O'Brien S, et al. Therapeutic choices in younger patients with chronic myelogenous leukemia. Cancer. 89(8):2000;1647-1658
    • (2000) Cancer , vol.89 , Issue.8 , pp. 1647-1658
    • Kantarjian, H.M.1    Giles, F.J.2    O'Brien, S.3
  • 15
    • 0028813711 scopus 로고
    • Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy
    • Kantarjian H.M., Smith T.L., O'Brien S., et al. Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy. Ann Intern Med. 122(4):1995;254-261
    • (1995) Ann Intern Med , vol.122 , Issue.4 , pp. 254-261
    • Kantarjian, H.M.1    Smith, T.L.2    O'Brien, S.3
  • 16
    • 0026647320 scopus 로고
    • Treatment of advanced stages of Philadelphia chromosome-positive chronic myelogenous leukemia with interferon-alpha and low-dose cytarabine
    • Kantarjian H.M., Keating M.J., Estey E.H., et al. Treatment of advanced stages of Philadelphia chromosome-positive chronic myelogenous leukemia with interferon-alpha and low-dose cytarabine. J Clin Oncol. 10(5):1992;772-778
    • (1992) J Clin Oncol , vol.10 , Issue.5 , pp. 772-778
    • Kantarjian, H.M.1    Keating, M.J.2    Estey, E.H.3
  • 17
    • 0037300895 scopus 로고    scopus 로고
    • Pegylated interferons
    • Karnam U.S., Reddy K.R. Pegylated interferons. Clin Liver Dis. 7(1):2003;139-148
    • (2003) Clin Liver Dis , vol.7 , Issue.1 , pp. 139-148
    • Karnam, U.S.1    Reddy, K.R.2
  • 18
    • 0347589393 scopus 로고    scopus 로고
    • Evolving role of pegylated interferons in metastatic renal cell carcinoma
    • Choueiri T.K., Hutson T.E., Bukowski R.M. Evolving role of pegylated interferons in metastatic renal cell carcinoma. Expert Rev Anticancer Ther. 3(6):2003;823-829
    • (2003) Expert Rev Anticancer Ther , vol.3 , Issue.6 , pp. 823-829
    • Choueiri, T.K.1    Hutson, T.E.2    Bukowski, R.M.3
  • 19
    • 10744221948 scopus 로고    scopus 로고
    • Pegylated recombinant interferon alpha-2b vs recombinant interferon alpha-2b for the initial treatment of chronic-phase chronic myelogenous leukemia: A phase III study
    • Michallet M., Maloisel F., Delain M., et al. Pegylated recombinant interferon alpha-2b vs recombinant interferon alpha-2b for the initial treatment of chronic-phase chronic myelogenous leukemia: a phase III study. Leukemia. 18(2):2004;309-315
    • (2004) Leukemia , vol.18 , Issue.2 , pp. 309-315
    • Michallet, M.1    Maloisel, F.2    Delain, M.3
  • 20
    • 20844461361 scopus 로고    scopus 로고
    • Risk and early cytogenetic response to imatinib and interferon in chronic myeloid leukemia
    • Rosti G., Trabacchi E., Bassi S., et al. Risk and early cytogenetic response to imatinib and interferon in chronic myeloid leukemia. Haematologica. 88(3):2003;256-259
    • (2003) Haematologica , vol.88 , Issue.3 , pp. 256-259
    • Rosti, G.1    Trabacchi, E.2    Bassi, S.3
  • 21
    • 0037099637 scopus 로고    scopus 로고
    • Treating cancer with PEG Intron: Pharmacokinetic profile and dosing guidelines for an improved interferon-alpha-2b formulation
    • Bukowski R.M., Tendler C., Cutler D., et al. Treating cancer with PEG Intron: pharmacokinetic profile and dosing guidelines for an improved interferon-alpha-2b formulation. Cancer. 95(2):2002;389-396
    • (2002) Cancer , vol.95 , Issue.2 , pp. 389-396
    • Bukowski, R.M.1    Tendler, C.2    Cutler, D.3
  • 22
    • 0036044951 scopus 로고    scopus 로고
    • Perspectives of pegylated interferon use in dermatological oncology
    • Pehamberger H. Perspectives of pegylated interferon use in dermatological oncology. Recent Results Cancer Res. 160:2002;158-164
    • (2002) Recent Results Cancer Res , vol.160 , pp. 158-164
    • Pehamberger, H.1
  • 24
    • 0034868065 scopus 로고    scopus 로고
    • Interferon-alfa-based treatment of chronic myeloid leukemia and implications of signal transduction inhibition
    • Talpaz M. Interferon-alfa-based treatment of chronic myeloid leukemia and implications of signal transduction inhibition. Semin Hematol. 38(3 Suppl 8):2001;22-27
    • (2001) Semin Hematol , vol.38 , Issue.3 SUPPL. 8 , pp. 22-27
    • Talpaz, M.1
  • 25
    • 0034609586 scopus 로고    scopus 로고
    • Identification of the major positional isomer of pegylated interferon alpha-2b
    • Wang Y.S., Youngster S., Bausch J., et al. Identification of the major positional isomer of pegylated interferon alpha-2b. Biochemistry. 39(35):2000;10634-10640
    • (2000) Biochemistry , vol.39 , Issue.35 , pp. 10634-10640
    • Wang, Y.S.1    Youngster, S.2    Bausch, J.3
  • 26
    • 0034619980 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis
    • Heathcote E.J., Shiffman M.L., Cooksley W.G., et al. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med. 343(23):2000;1673-1680
    • (2000) N Engl J Med , vol.343 , Issue.23 , pp. 1673-1680
    • Heathcote, E.J.1    Shiffman, M.L.2    Cooksley, W.G.3
  • 27
    • 0034619946 scopus 로고    scopus 로고
    • Peginterferon alfa-2a in patients with chronic hepatitis C
    • Zeuzem S., Feinman S.V., Rasenack J., et al. Peginterferon alfa-2a in patients with chronic hepatitis C. N Engl J Med. 343(23):2000;1666-1672
    • (2000) N Engl J Med , vol.343 , Issue.23 , pp. 1666-1672
    • Zeuzem, S.1    Feinman, S.V.2    Rasenack, J.3
  • 28
    • 0035885964 scopus 로고    scopus 로고
    • Phase 1 study of polyethylene glycol formulation of interferon alpha-2B (Schering 54031) in Philadelphia chromosome-positive chronic myelogenous leukemia
    • Talpaz M., O'Brien S., Rose E., et al. Phase 1 study of polyethylene glycol formulation of interferon alpha-2B (Schering 54031) in Philadelphia chromosome-positive chronic myelogenous leukemia. Blood. 98(6):2001;1708-1713
    • (2001) Blood , vol.98 , Issue.6 , pp. 1708-1713
    • Talpaz, M.1    O'Brien, S.2    Rose, E.3
  • 29
    • 0035992318 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
    • Kantarjian H., O'Brien S., Cortes J., et al. Treatment of Philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate. Clin Cancer Res. 8(7):2002;2167-2176
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2167-2176
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 30
    • 0037092980 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase
    • Kantarjian H.M., Cortes J., O'Brien S., et al. Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase. Blood. 99(10):2002;3547-3553
    • (2002) Blood , vol.99 , Issue.10 , pp. 3547-3553
    • Kantarjian, H.M.1    Cortes, J.2    O'Brien, S.3
  • 31
    • 0003285566 scopus 로고    scopus 로고
    • Combination of Hyper-CVAD with imatinib mesylate for Philadelphia- positive adult acute lymphoblastic leukemia or chronic myelogenous leukemia in lymphoid blast phase
    • Abstract 3340
    • Thomas D., Cortes J., Giles F.J., et al. Combination of Hyper-CVAD with imatinib mesylate for Philadelphia-positive adult acute lymphoblastic leukemia or chronic myelogenous leukemia in lymphoid blast phase. Blood. 98(11):2001;803a. Abstract 3340
    • (2001) Blood , vol.98 , Issue.11
    • Thomas, D.1    Cortes, J.2    Giles, F.J.3
  • 32
    • 11144357159 scopus 로고    scopus 로고
    • Results of imatinib mesylate therapy in chronic myelogenous leukemia with variant Philadelphia chromosome
    • El-Zimaity M.M., Kantarjian H., Talpaz M., et al. Results of imatinib mesylate therapy in chronic myelogenous leukemia with variant Philadelphia chromosome. Br J Haematol. 125(2):2004;187-195
    • (2004) Br J Haematol , vol.125 , Issue.2 , pp. 187-195
    • El-Zimaity, M.M.1    Kantarjian, H.2    Talpaz, M.3
  • 33
    • 1642453610 scopus 로고    scopus 로고
    • New agents in acute myeloid leukemia and other myeloid disorders
    • Ravandi F., Kantarjian H., Giles F., et al. New agents in acute myeloid leukemia and other myeloid disorders. Cancer. 100(3):2004;441-454
    • (2004) Cancer , vol.100 , Issue.3 , pp. 441-454
    • Ravandi, F.1    Kantarjian, H.2    Giles, F.3
  • 34
    • 9144234689 scopus 로고    scopus 로고
    • Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia
    • Donato N.J., Wu J.Y., Stapley J., et al. Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia. Cancer Res. 64(2):2004;672-677
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 672-677
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3
  • 35
    • 85044560776 scopus 로고    scopus 로고
    • Periorbital oedema and epiphora as ocular side effects of imatinib mesylate (Gleevec)
    • in press
    • Esmaeli B., Diba R., Ahmadi M.A., et al. Periorbital oedema and epiphora as ocular side effects of imatinib mesylate (Gleevec). Eye. 2004;. in press
    • (2004) Eye
    • Esmaeli, B.1    Diba, R.2    Ahmadi, M.A.3
  • 36
    • 9144265432 scopus 로고    scopus 로고
    • Survival advantage with imatinib mesylate therapy in chronic-phase chronic myelogenous leukemia (CML-CP) after IFN-alpha failure and in late CML-CP, comparison with historical controls
    • Kantarjian H., O'Brien S., Cortes J., et al. Survival advantage with imatinib mesylate therapy in chronic-phase chronic myelogenous leukemia (CML-CP) after IFN-alpha failure and in late CML-CP, comparison with historical controls. Clin Cancer Res. 10(1):2004;68-75
    • (2004) Clin Cancer Res , vol.10 , Issue.1 , pp. 68-75
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 37
    • 11144354274 scopus 로고    scopus 로고
    • High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia
    • Kantarjian H., Talpaz M., O'Brien S., et al. High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia. Blood. 103(8):2004;2873-2878
    • (2004) Blood , vol.103 , Issue.8 , pp. 2873-2878
    • Kantarjian, H.1    Talpaz, M.2    O'Brien, S.3
  • 38
    • 10744230175 scopus 로고    scopus 로고
    • The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase
    • Sneed T.B., Kantarjian H.M., Talpaz M., et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer. 100(1):2004;116-121
    • (2004) Cancer , vol.100 , Issue.1 , pp. 116-121
    • Sneed, T.B.1    Kantarjian, H.M.2    Talpaz, M.3
  • 39
    • 10744225099 scopus 로고    scopus 로고
    • Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in the chronic phase: Comparison with historic data
    • Kantarjian H.M., O'Brien S., Cortes J., et al. Imatinib mesylate therapy improves survival in patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in the chronic phase: comparison with historic data. Cancer. 98(12):2003;2636-2642
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2636-2642
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 40
    • 0344412948 scopus 로고    scopus 로고
    • Imatinib mesylate causes hypopigmentation in the skin
    • Tsao A.S., Kantarjian H., Cortes J., et al. Imatinib mesylate causes hypopigmentation in the skin. Cancer. 98(11):2003;2483-2487
    • (2003) Cancer , vol.98 , Issue.11 , pp. 2483-2487
    • Tsao, A.S.1    Kantarjian, H.2    Cortes, J.3
  • 41
    • 0142243204 scopus 로고    scopus 로고
    • Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
    • Medina J., Kantarjian H., Talpaz M., et al. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer. 98(9):2003;1905-1911
    • (2003) Cancer , vol.98 , Issue.9 , pp. 1905-1911
    • Medina, J.1    Kantarjian, H.2    Talpaz, M.3
  • 42
    • 2442615975 scopus 로고    scopus 로고
    • Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate
    • in press
    • Thomas D.A., Faderl S., Cortes J., et al. Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. Blood, in press
    • Blood
    • Thomas, D.A.1    Faderl, S.2    Cortes, J.3
  • 43
    • 0141563723 scopus 로고    scopus 로고
    • Analysis of the impact of imatinib mesylate therapy on the prognosis of patients with Philadelphia chromosome-positive chronic myelogenous leukemia treated with interferon-alpha regimens for early chronic phase
    • Kantarjian H., O'Brien S., Cortes J., et al. Analysis of the impact of imatinib mesylate therapy on the prognosis of patients with Philadelphia chromosome-positive chronic myelogenous leukemia treated with interferon-alpha regimens for early chronic phase. Cancer. 98(7):2003;1430-1437
    • (2003) Cancer , vol.98 , Issue.7 , pp. 1430-1437
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 44
    • 0041917185 scopus 로고    scopus 로고
    • Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Cortes J., Talpaz M., O'Brien S., et al. Effects of age on prognosis with imatinib mesylate therapy for patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Cancer. 98(6):2003;1105-1113
    • (2003) Cancer , vol.98 , Issue.6 , pp. 1105-1113
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 45
    • 0041887168 scopus 로고    scopus 로고
    • Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase
    • O'Brien S., Giles F., Talpaz M., et al. Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase. Cancer. 98(5):2003;888-893
    • (2003) Cancer , vol.98 , Issue.5 , pp. 888-893
    • O'Brien, S.1    Giles, F.2    Talpaz, M.3
  • 46
    • 0141761420 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate
    • Gatto S., Scappini B., Pham L., et al. The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate. Haematologica. 88(8):2003;853-863
    • (2003) Haematologica , vol.88 , Issue.8 , pp. 853-863
    • Gatto, S.1    Scappini, B.2    Pham, L.3
  • 47
    • 10744228148 scopus 로고    scopus 로고
    • Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase
    • Giles F.J., Feldman E.J., Roboz G.J., et al. Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. Leuk Res. 27(12):2003;1091-1096
    • (2003) Leuk Res , vol.27 , Issue.12 , pp. 1091-1096
    • Giles, F.J.1    Feldman, E.J.2    Roboz, G.J.3
  • 48
    • 0037962005 scopus 로고    scopus 로고
    • Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S., Cortes J., et al. Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer. 98(3):2003;522-528
    • (2003) Cancer , vol.98 , Issue.3 , pp. 522-528
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 49
    • 10744223441 scopus 로고    scopus 로고
    • Sudden onset of the blastic phase of chronic myelogenous leukemia: Patterns and implications
    • Kantarjian H., O'Brien S., Cortes J., et al. Sudden onset of the blastic phase of chronic myelogenous leukemia: patterns and implications. Cancer. 98(1):2003;81-85
    • (2003) Cancer , vol.98 , Issue.1 , pp. 81-85
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3
  • 50
    • 0141675092 scopus 로고    scopus 로고
    • Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders
    • Tsimberidou A.M., Colburn D.E., Welch M.A., et al. Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders. Cancer Chemother Pharmacol. 52(3):2003;229-234
    • (2003) Cancer Chemother Pharmacol , vol.52 , Issue.3 , pp. 229-234
    • Tsimberidou, A.M.1    Colburn, D.E.2    Welch, M.A.3
  • 51
    • 10744229862 scopus 로고    scopus 로고
    • Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders
    • Cortes J., Giles F., O'Brien S., et al. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer. 97(11):2003;2760-2766
    • (2003) Cancer , vol.97 , Issue.11 , pp. 2760-2766
    • Cortes, J.1    Giles, F.2    O'Brien, S.3
  • 52
    • 0037672877 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics
    • Kurzrock R., Kantarjian H.M., Druker B.J., et al. Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics. Ann Intern Med. 138(10):2003;819-830
    • (2003) Ann Intern Med , vol.138 , Issue.10 , pp. 819-830
    • Kurzrock, R.1    Kantarjian, H.M.2    Druker, B.J.3
  • 53
    • 19244365122 scopus 로고    scopus 로고
    • Prediction of initial cytogenetic response for subsequent major and complete cytogenetic response to imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Kantarjian H., Talpaz M., O'Brien S., et al. Prediction of initial cytogenetic response for subsequent major and complete cytogenetic response to imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Cancer. 97(9):2003;2225-2228
    • (2003) Cancer , vol.97 , Issue.9 , pp. 2225-2228
    • Kantarjian, H.1    Talpaz, M.2    O'Brien, S.3
  • 54
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J., DeAngelo D.J., Gotlib J., et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 348(13):2003;1201-1214
    • (2003) N Engl J Med , vol.348 , Issue.13 , pp. 1201-1214
    • Cools, J.1    Deangelo, D.J.2    Gotlib, J.3
  • 55
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien S.G., Guilhot F., Larson R.A., et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 348(11):2003;994-1004
    • (2003) N Engl J Med , vol.348 , Issue.11 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 56
    • 10744231480 scopus 로고    scopus 로고
    • Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha
    • Cortes J., Giles F., O'Brien S., et al. Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha. Blood. 102(1):2003;83-86
    • (2003) Blood , vol.102 , Issue.1 , pp. 83-86
    • Cortes, J.1    Giles, F.2    O'Brien, S.3
  • 57
    • 0037341414 scopus 로고    scopus 로고
    • Development of varicella-zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate
    • Mattiuzzi G.N., Cortes J.E., Talpaz M., et al. Development of varicella-zoster virus infection in patients with chronic myelogenous leukemia treated with imatinib mesylate. Clin Cancer Res. 9(3):2003;976-980
    • (2003) Clin Cancer Res , vol.9 , Issue.3 , pp. 976-980
    • Mattiuzzi, G.N.1    Cortes, J.E.2    Talpaz, M.3
  • 58
    • 10744228476 scopus 로고    scopus 로고
    • Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome
    • Cortes J., Ault P., Koller C., et al. Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome. Blood. 101(12):2003;4714-4716
    • (2003) Blood , vol.101 , Issue.12 , pp. 4714-4716
    • Cortes, J.1    Ault, P.2    Koller, C.3
  • 59
    • 0037441629 scopus 로고    scopus 로고
    • Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis
    • Kantarjian H.M., O'Brien S., Cortes J.E., et al. Complete cytogenetic and molecular responses to interferon-alpha-based therapy for chronic myelogenous leukemia are associated with excellent long-term prognosis. Cancer. 97(4):2003;1033-1041
    • (2003) Cancer , vol.97 , Issue.4 , pp. 1033-1041
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.E.3
  • 60
    • 0037255947 scopus 로고    scopus 로고
    • Advanced-phase chronic myeloid leukemia
    • Cortes J., Kantarjian H. Advanced-phase chronic myeloid leukemia. Semin Hematol. 40(1):2003;79-86
    • (2003) Semin Hematol , vol.40 , Issue.1 , pp. 79-86
    • Cortes, J.1    Kantarjian, H.2
  • 61
    • 0012906888 scopus 로고    scopus 로고
    • Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy
    • Cortes J.E., Talpaz M., Giles F., et al. Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Blood. 101(10):2003;3794-3800
    • (2003) Blood , vol.101 , Issue.10 , pp. 3794-3800
    • Cortes, J.E.1    Talpaz, M.2    Giles, F.3
  • 62
    • 0346756405 scopus 로고    scopus 로고
    • Quantitative polymerase chain reaction monitoring of BCR-ABL during therapy with imatinib mesylate (STI571; Gleevec) in chronic-phase chronic myelogenous leukemia
    • Kantarjian H.M., Talpaz M., Cortes J., et al. Quantitative polymerase chain reaction monitoring of BCR-ABL during therapy with imatinib mesylate (STI571; gleevec) in chronic-phase chronic myelogenous leukemia. Clin Cancer Res. 9(1):2003;160-166
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 160-166
    • Kantarjian, H.M.1    Talpaz, M.2    Cortes, J.3
  • 63
    • 0037222235 scopus 로고    scopus 로고
    • Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: High incidence of early complete and major cytogenetic responses
    • Kantarjian H.M., Cortes J.E., O'Brien S., et al. Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: high incidence of early complete and major cytogenetic responses. Blood. 101(1):2003;97-100
    • (2003) Blood , vol.101 , Issue.1 , pp. 97-100
    • Kantarjian, H.M.1    Cortes, J.E.2    O'Brien, S.3
  • 64
    • 0037438467 scopus 로고    scopus 로고
    • Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
    • Kantarjian H.M., Talpaz M., O'Brien S., et al. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood. 101(2):2003;473-475
    • (2003) Blood , vol.101 , Issue.2 , pp. 473-475
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 65
    • 0037103002 scopus 로고    scopus 로고
    • Severe periorbital edema secondary to STI571 (Gleevec)
    • Esmaeli B., Prieto V.G., Butler C.E., et al. Severe periorbital edema secondary to STI571 (Gleevec). Cancer. 95(4):2002;881-887
    • (2002) Cancer , vol.95 , Issue.4 , pp. 881-887
    • Esmaeli, B.1    Prieto, V.G.2    Butler, C.E.3
  • 66
    • 0036721320 scopus 로고    scopus 로고
    • Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S., Cortes J.E., et al. Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood. 100(5):2002;1590-1595
    • (2002) Blood , vol.100 , Issue.5 , pp. 1590-1595
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.E.3
  • 67
    • 0037094118 scopus 로고    scopus 로고
    • In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells
    • Scappini B., Onida F., Kantarjian H.M., et al. In vitro effects of STI 571-containing drug combinations on the growth of Philadelphia-positive chronic myelogenous leukemia cells. Cancer. 94(10):2002;2653-2662
    • (2002) Cancer , vol.94 , Issue.10 , pp. 2653-2662
    • Scappini, B.1    Onida, F.2    Kantarjian, H.M.3
  • 68
    • 0036063077 scopus 로고    scopus 로고
    • Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate
    • Ault P., Cortes J., Koller C., et al. Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. Leuk Res. 26(9):2002;881-884
    • (2002) Leuk Res , vol.26 , Issue.9 , pp. 881-884
    • Ault, P.1    Cortes, J.2    Koller, C.3
  • 69
    • 0036604263 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia in T cell lymphoid blastic phase achieving durable complete cytogenetic and molecular remission with imatinib mesylate (STI571; Gleevec) therapy
    • Atallah E., Talpaz M., O'Brien S., et al. Chronic myelogenous leukemia in T cell lymphoid blastic phase achieving durable complete cytogenetic and molecular remission with imatinib mesylate (STI571; Gleevec) therapy. Cancer. 94(11):2002;2996-2999
    • (2002) Cancer , vol.94 , Issue.11 , pp. 2996-2999
    • Atallah, E.1    Talpaz, M.2    O'Brien, S.3
  • 70
    • 0035992329 scopus 로고    scopus 로고
    • Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: Follow-up results
    • Kantarjian H.M., Talpaz M., O'Brien S., et al. Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results. Clin Cancer Res. 8(7):2002;2177-2187
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2177-2187
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 71
    • 0035992318 scopus 로고    scopus 로고
    • Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate
    • Kantarjian H.M., O'Brien S., Cortes J.E., et al. Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate. Clin Cancer Res. 8(7):2002;2167-2176
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2167-2176
    • Kantarjian, H.M.1    O'Brien, S.2    Cortes, J.E.3
  • 72
    • 0036245352 scopus 로고    scopus 로고
    • Current therapy of chronic myelogenous leukemia
    • Garcia-Manero G., Talpaz M., Kantarjian H.M. Current therapy of chronic myelogenous leukemia. Intern Med. 41(4):2002;254-264
    • (2002) Intern Med , vol.41 , Issue.4 , pp. 254-264
    • Garcia-Manero, G.1    Talpaz, M.2    Kantarjian, H.M.3
  • 73
    • 0036534203 scopus 로고    scopus 로고
    • Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia
    • O'Brien S., Talpaz M., Cortes J., et al. Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer. 94(7):2002;2024-2032
    • (2002) Cancer , vol.94 , Issue.7 , pp. 2024-2032
    • O'Brien, S.1    Talpaz, M.2    Cortes, J.3
  • 74
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M., Silver R.T., Druker B.J., et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 99(6):2002;1928-1937
    • (2002) Blood , vol.99 , Issue.6 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 75
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H., Sawyers C., Hochhaus A., et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 346(9):2002;645-652
    • (2002) N Engl J Med , vol.346 , Issue.9 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 76
    • 0035210658 scopus 로고    scopus 로고
    • Imatinib mesylate: Clinical results in Philadelphia chromosome-positive leukemias
    • Kantarjian H.M., Talpaz M. Imatinib mesylate: clinical results in Philadelphia chromosome-positive leukemias. Semin Oncol. 28(5 Suppl 17):2001;9-18
    • (2001) Semin Oncol , vol.28 , Issue.5 SUPPL. 17 , pp. 9-18
    • Kantarjian, H.M.1    Talpaz, M.2
  • 77
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker B.J., Tamura S., Buchdunger E., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 2(5):1996;561-566
    • (1996) Nat Med , vol.2 , Issue.5 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 78
    • 0000199137 scopus 로고    scopus 로고
    • Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia
    • Druker B.J., Talpaz M., Resta D., et al. Clinical efficacy and safety of an ABL specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia. Blood. 94(Suppl 1):1999;368a
    • (1999) Blood , vol.94 , Issue.SUPPL. 1
    • Druker, B.J.1    Talpaz, M.2    Resta, D.3
  • 79
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker B.J., Sawyers C.L., Kantarjian H., et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 344(14):2001;1038-1042
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 80
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 344(14):2001;1031-1037
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 81
    • 0017762514 scopus 로고
    • Harringtonine in acute leukemias. Clinical analysis of 31 cases
    • Anonymous Harringtonine in acute leukemias. Clinical analysis of 31 cases. Chinese Med J. 3(5):1977;319-324
    • (1977) Chinese Med J , vol.3 , Issue.5 , pp. 319-324
    • Anonymous1
  • 82
    • 0017764624 scopus 로고
    • The antitumor effects and pharmacologic actions of harringtonine
    • Anonymous The antitumor effects and pharmacologic actions of harringtonine. Chinese Med J. 3(2):1977;131-136
    • (1977) Chinese Med J , vol.3 , Issue.2 , pp. 131-136
    • Anonymous1
  • 83
    • 0030051722 scopus 로고    scopus 로고
    • Homoharringtonine in patients with myelodysplastic syndrome (MDS) and MDS evolving to acute myeloid leukemia
    • Feldman E.J., Seiter K.P., Ahmed T., et al. Homoharringtonine in patients with myelodysplastic syndrome (MDS) and MDS evolving to acute myeloid leukemia. Leukemia. 10(1):1996;40-42
    • (1996) Leukemia , vol.10 , Issue.1 , pp. 40-42
    • Feldman, E.J.1    Seiter, K.P.2    Ahmed, T.3
  • 84
    • 0023820487 scopus 로고
    • Small-dose Harringtonine induces complete remission in patients with acute promyelocytic leukemia
    • Ye J.S., Wang X.H., Feng G.H., et al. Small-dose Harringtonine induces complete remission in patients with acute promyelocytic leukemia. Leukemia. 2(7):1988;427-429
    • (1988) Leukemia , vol.2 , Issue.7 , pp. 427-429
    • Ye, J.S.1    Wang, X.H.2    Feng, G.H.3
  • 85
    • 0034667856 scopus 로고    scopus 로고
    • Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia
    • Kantarjian H.M., Talpaz M., Smith T.L., et al. Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia. J Clin Oncol. 18(20):2000;3513-3521
    • (2000) J Clin Oncol , vol.18 , Issue.20 , pp. 3513-3521
    • Kantarjian, H.M.1    Talpaz, M.2    Smith, T.L.3
  • 86
    • 0028787176 scopus 로고
    • Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase
    • O'Brien S., Kantarjian H., Keating M., et al. Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase. Blood. 86(9):1995;3322-3326
    • (1995) Blood , vol.86 , Issue.9 , pp. 3322-3326
    • O'Brien, S.1    Kantarjian, H.2    Keating, M.3
  • 87
    • 0033564350 scopus 로고    scopus 로고
    • Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia
    • O'Brien S., Kantarjian H., Koller C., et al. Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia. Blood. 93(12):1999;4149-4153
    • (1999) Blood , vol.93 , Issue.12 , pp. 4149-4153
    • O'Brien, S.1    Kantarjian, H.2    Koller, C.3
  • 88
    • 85112352613 scopus 로고    scopus 로고
    • In vitro effects of STI571-containing drug combinations on growth of Ph-positive myelogenous leukemia-derived cells
    • Scappini B., Onida F., Kantarjian H., et al. In vitro effects of STI571-containing drug combinations on growth of Ph-positive myelogenous leukemia-derived cells. Blood. 96(11):2000;99a
    • (2000) Blood , vol.96 , Issue.11
    • Scappini, B.1    Onida, F.2    Kantarjian, H.3
  • 89
    • 3242771685 scopus 로고    scopus 로고
    • Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells
    • Ye X.J., Lin M.F. Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells. J Zhejiang Univ Sci. 5(2):2004;230-234
    • (2004) J Zhejiang Univ Sci , vol.5 , Issue.2 , pp. 230-234
    • Ye, X.J.1    Lin, M.F.2
  • 90
    • 0030990163 scopus 로고    scopus 로고
    • Decitabine (5-Aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations
    • Schwartsmann G., Fernandes M.S., Schaan M.D., et al. Decitabine (5-Aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations. Leukemia. 11(Suppl 1):1997;S28-S31
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 1 , pp. 28-S31
    • Schwartsmann, G.1    Fernandes, M.S.2    Schaan, M.D.3
  • 91
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P., Lubbert M., Verhoef G., et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol. 18(5):2000;956-962
    • (2000) J Clin Oncol , vol.18 , Issue.5 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3
  • 92
    • 0348149132 scopus 로고    scopus 로고
    • DNA methylation in haematological malignancies: The role of decitabine
    • Hennessy B.T., Garcia-Manero G., Kantarjian H.M., et al. DNA methylation in haematological malignancies: the role of decitabine. Expert Opin Investig Drugs. 12(12):2003;1985-1993
    • (2003) Expert Opin Investig Drugs , vol.12 , Issue.12 , pp. 1985-1993
    • Hennessy, B.T.1    Garcia-Manero, G.2    Kantarjian, H.M.3
  • 93
    • 0036716596 scopus 로고    scopus 로고
    • New drugs in acute myeloid leukemia
    • Giles F.J. New drugs in acute myeloid leukemia. Curr Oncol Rep. 4(5):2002;369-374
    • (2002) Curr Oncol Rep , vol.4 , Issue.5 , pp. 369-374
    • Giles, F.J.1
  • 94
    • 0036147075 scopus 로고    scopus 로고
    • Novel agents for the therapy of acute leukemia
    • Giles F.J. Novel agents for the therapy of acute leukemia. Curr Opin Oncol. 14(1):2002;3-9
    • (2002) Curr Opin Oncol , vol.14 , Issue.1 , pp. 3-9
    • Giles, F.J.1
  • 95
    • 0028035056 scopus 로고
    • Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia
    • Zion M., Ben-Yehuda D., Avraham A., et al. Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia. Proc Natl Acad Sci USA. 91(22):1994;10722-10726
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.22 , pp. 10722-10726
    • Zion, M.1    Ben-Yehuda, D.2    Avraham, A.3
  • 96
    • 0033559955 scopus 로고    scopus 로고
    • Methylation of the ABL1 promoter in chronic myelogenous leukemia: Lack of prognostic significance
    • Issa J.P., Kantarjian H., Mohan A., et al. Methylation of the ABL1 promoter in chronic myelogenous leukemia: lack of prognostic significance. Blood. 93(6):1999;2075-2080
    • (1999) Blood , vol.93 , Issue.6 , pp. 2075-2080
    • Issa, J.P.1    Kantarjian, H.2    Mohan, A.3
  • 97
    • 0031454221 scopus 로고    scopus 로고
    • Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia
    • Ben-Yehuda D., Krichevsky S., Rachmilewitz E.A., et al. Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia. Blood. 90(12):1997;4918-4923
    • (1997) Blood , vol.90 , Issue.12 , pp. 4918-4923
    • Ben-Yehuda, D.1    Krichevsky, S.2    Rachmilewitz, E.A.3
  • 98
    • 16944363756 scopus 로고    scopus 로고
    • Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia
    • Kantarjian H.M., O'Brien S.M., Keating M., et al. Results of decitabine therapy in the accelerated and blastic phases of chronic myelogenous leukemia. Leukemia. 11(10):1997;1617-1620
    • (1997) Leukemia , vol.11 , Issue.10 , pp. 1617-1620
    • Kantarjian, H.M.1    O'Brien, S.M.2    Keating, M.3
  • 99
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa J.P., Garcia-Manero G., Giles F.J., et al. Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood. 103(5):2004;1635-1640
    • (2004) Blood , vol.103 , Issue.5 , pp. 1635-1640
    • Issa, J.P.1    Garcia-Manero, G.2    Giles, F.J.3
  • 100
    • 0037699302 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors in myeloid malignancies
    • Lancet J.E., Karp J.E. Farnesyl transferase inhibitors in myeloid malignancies. Blood Rev. 17(3):2003;123-129
    • (2003) Blood Rev , vol.17 , Issue.3 , pp. 123-129
    • Lancet, J.E.1    Karp, J.E.2
  • 101
    • 0033014304 scopus 로고    scopus 로고
    • RAS and leukemia: From basic mechanisms to gene-directed therapy
    • Beaupre D.M., Kurzrock R. RAS and leukemia: from basic mechanisms to gene-directed therapy. J Clin Oncol. 17(3):1999;1071-1079
    • (1999) J Clin Oncol , vol.17 , Issue.3 , pp. 1071-1079
    • Beaupre, D.M.1    Kurzrock, R.2
  • 102
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
    • Peters D.G., Hoover R.R., Gerlach M.J., et al. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 97(5):2001;1404-1412
    • (2001) Blood , vol.97 , Issue.5 , pp. 1404-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3
  • 103
    • 0003242133 scopus 로고    scopus 로고
    • Overcoming STI571 resistance with the farnesyltransferase inhibitor SCH66336
    • Hoover R.R., Mahon F.-X., Melo J.V., et al. Overcoming STI571 resistance with the farnesyltransferase inhibitor SCH66336. Blood. 98(11):2001;617a
    • (2001) Blood , vol.98 , Issue.11
    • Hoover, R.R.1    Mahon, F.-X.2    Melo, J.V.3
  • 104
    • 79960970722 scopus 로고    scopus 로고
    • R115777, a farnesyl transferase inhibitor (FTI), has significant anti-leukemia activity in patients with chronic myeloid leukemia
    • Thomas D., Cortes J., O'Brien S., et al. R115777, a farnesyl transferase inhibitor (FTI), has significant anti-leukemia activity in patients with chronic myeloid leukemia. Blood. 98(11):2001;727a
    • (2001) Blood , vol.98 , Issue.11
    • Thomas, D.1    Cortes, J.2    O'Brien, S.3
  • 105
    • 0030845501 scopus 로고    scopus 로고
    • A pilot study of all-trans retinoic acid in patients with Philadelphia chromosome-positive chronic myelogenous leukemia
    • Cortes J., Kantarjian H., O'Brien S., et al. A pilot study of all-trans retinoic acid in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Leukemia. 11(7):1997;929-932
    • (1997) Leukemia , vol.11 , Issue.7 , pp. 929-932
    • Cortes, J.1    Kantarjian, H.2    O'Brien, S.3
  • 106
    • 0030914423 scopus 로고    scopus 로고
    • Treatment of chronic myelogenous leukemia with nucleoside analogs deoxycoformycin and fludarabine
    • Cortes J., Kantarjian H., Talpaz M., et al. Treatment of chronic myelogenous leukemia with nucleoside analogs deoxycoformycin and fludarabine. Leukemia. 11(6):1997;788-791
    • (1997) Leukemia , vol.11 , Issue.6 , pp. 788-791
    • Cortes, J.1    Kantarjian, H.2    Talpaz, M.3
  • 107
    • 0025262141 scopus 로고
    • Clinical characteristics of the blast phase of chronic granulocytic leukemia
    • Canellos G.P. Clinical characteristics of the blast phase of chronic granulocytic leukemia. Hematol Oncol Clin N Am. 4(2):1990;359-367
    • (1990) Hematol Oncol Clin N Am , vol.4 , Issue.2 , pp. 359-367
    • Canellos, G.P.1
  • 108
    • 0020697146 scopus 로고
    • Differentiation patterns in the blastic phase of chronic myeloid leukemia
    • Griffin J.D., Todd R.F. III, Ritz J., et al. Differentiation patterns in the blastic phase of chronic myeloid leukemia. Blood. 61(1):1983;85-91
    • (1983) Blood , vol.61 , Issue.1 , pp. 85-91
    • Griffin, J.D.1    Todd III, R.F.2    Ritz, J.3
  • 109
    • 0035889917 scopus 로고    scopus 로고
    • Response to therapy is independently associated with survival prolongation in chronic myelogenous leukemia in the blastic phase
    • Kantarjian H.M., Shan J., Smith T., et al. Response to therapy is independently associated with survival prolongation in chronic myelogenous leukemia in the blastic phase. Cancer. 92(10):2001;2501-2507
    • (2001) Cancer , vol.92 , Issue.10 , pp. 2501-2507
    • Kantarjian, H.M.1    Shan, J.2    Smith, T.3
  • 110
    • 0036530228 scopus 로고    scopus 로고
    • Factors affecting duration of survival after onset of blastic transformation of chronic myeloid leukemia
    • Wadhwa J., Szydlo R.M., Apperley J.F., et al. Factors affecting duration of survival after onset of blastic transformation of chronic myeloid leukemia. Blood. 99(7):2002;2304-2309
    • (2002) Blood , vol.99 , Issue.7 , pp. 2304-2309
    • Wadhwa, J.1    Szydlo, R.M.2    Apperley, J.F.3
  • 111
    • 0007712919 scopus 로고    scopus 로고
    • "Sudden" blastic phase (SBP) transformation in the first 2 years (YRS) of interferon-a (IFN) therapy (RX) for chronic phase (CP) chronic myelogenous leukemia (CML)
    • Abstract 1027
    • Thomas D., Kantarjian H., O'Brien S., et al. "Sudden" blastic phase (SBP) transformation in the first 2 years (YRS) of interferon-a (IFN) therapy (RX) for chronic phase (CP) chronic myelogenous leukemia (CML). Blood. 92(Suppl 1):1998;251a. Abstract 1027
    • (1998) Blood , vol.92 , Issue.SUPPL. 1
    • Thomas, D.1    Kantarjian, H.2    O'Brien, S.3
  • 112
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers C.L., Hochhaus A., Feldman E., et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 99(10):2002;3530-3539
    • (2002) Blood , vol.99 , Issue.10 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 113
    • 0033572876 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia in nonlymphoid blastic phase: Analysis of the results of first salvage therapy with three different treatment approaches for 162 patients
    • Sacchi S., Kantarjian H.M., O'Brien S., et al. Chronic myelogenous leukemia in nonlymphoid blastic phase: analysis of the results of first salvage therapy with three different treatment approaches for 162 patients. Cancer. 86(12):1999;2632-2641
    • (1999) Cancer , vol.86 , Issue.12 , pp. 2632-2641
    • Sacchi, S.1    Kantarjian, H.M.2    O'Brien, S.3
  • 114
    • 0027397997 scopus 로고
    • Chronic myelogenous leukemia in the lymphoid blastic phase: Characteristics, treatment response, and prognosis
    • Derderian P.M., Kantarjian H.M., Talpaz M., et al. Chronic myelogenous leukemia in the lymphoid blastic phase: characteristics, treatment response, and prognosis. Am J Med. 94(1):1993;69-74
    • (1993) Am J Med , vol.94 , Issue.1 , pp. 69-74
    • Derderian, P.M.1    Kantarjian, H.M.2    Talpaz, M.3
  • 115
    • 0036566540 scopus 로고    scopus 로고
    • High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
    • Branford S., Rudzki Z., Walsh S., et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 99(9):2002;3472-3475
    • (2002) Blood , vol.99 , Issue.9 , pp. 3472-3475
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 116
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre M.E., Mohammed M., Ellwood K., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 293(5531):2001;876-880
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 117
    • 0036493544 scopus 로고    scopus 로고
    • Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
    • Hofmann W.K., Jones L.C., Lemp N.A., et al. Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 99(5):2002;1860-1862
    • (2002) Blood , vol.99 , Issue.5 , pp. 1860-1862
    • Hofmann, W.K.1    Jones, L.C.2    Lemp, N.A.3
  • 118
    • 0034684075 scopus 로고    scopus 로고
    • Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571
    • Gambacorti-Passerini C., Barni R., le Coutre P., et al. Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571. J Natl Cancer Inst. 92(20):2000;1641-1650
    • (2000) J Natl Cancer Inst , vol.92 , Issue.20 , pp. 1641-1650
    • Gambacorti-Passerini, C.1    Barni, R.2    Le Coutre, P.3
  • 119
    • 0035064790 scopus 로고    scopus 로고
    • Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients
    • Weisberg E., Griffin J.D. Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients. Drug Resistance Updates. 4(1):2001;22-28
    • (2001) Drug Resistance Updates , vol.4 , Issue.1 , pp. 22-28
    • Weisberg, E.1    Griffin, J.D.2
  • 120
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
    • le Coutre P., Tassi E., Varella-Garcia M., et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood. 95(5):2000;1758-1766
    • (2000) Blood , vol.95 , Issue.5 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 121
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon F.X., Deininger M.W., Schultheis B., et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood. 96(3):2000;1070-1079
    • (2000) Blood , vol.96 , Issue.3 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 122
    • 9144271748 scopus 로고    scopus 로고
    • In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines
    • La Rosee P., Johnson K., Corbin A.S., et al. In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines. Blood. 103(1):2004;208-215
    • (2004) Blood , vol.103 , Issue.1 , pp. 208-215
    • La Rosee, P.1    Johnson, K.2    Corbin, A.S.3
  • 123
    • 0042389716 scopus 로고    scopus 로고
    • Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia
    • Inami M., Inokuchi K., Nakayama K., et al. Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia. Int J Hematol. 78(2):2003;173-175
    • (2003) Int J Hematol , vol.78 , Issue.2 , pp. 173-175
    • Inami, M.1    Inokuchi, K.2    Nakayama, K.3
  • 124
    • 85044560585 scopus 로고    scopus 로고
    • Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography
    • in press
    • Deininger M.W., McGreevey L., Willis S., et al. Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography. Leukemia, in press
    • Leukemia
    • Deininger, M.W.1    McGreevey, L.2    Willis, S.3
  • 125
    • 0348140591 scopus 로고    scopus 로고
    • Mechanisms and implications of imatinib resistance mutations in BCR-ABL
    • Nardi V., Azam M., Daley G.Q. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol. 11(1):2004;35-43
    • (2004) Curr Opin Hematol , vol.11 , Issue.1 , pp. 35-43
    • Nardi, V.1    Azam, M.2    Daley, G.Q.3
  • 126
    • 0001275121 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance in CML patients after STI571 (Glivec) therapy
    • Abstract 1823
    • Kreil S., Muller M.C., Lahaye T., et al. Molecular and chromosomal mechanisms of resistance in CML patients after STI571 (Glivec) therapy. Blood. 98(11):2001;435a. Abstract 1823
    • (2001) Blood , vol.98 , Issue.11
    • Kreil, S.1    Muller, M.C.2    Lahaye, T.3
  • 127
    • 0035313251 scopus 로고    scopus 로고
    • In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents
    • Kano Y., Akutsu M., Tsunoda S., et al. In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents. Blood. 97(7):2001;1999-2007
    • (2001) Blood , vol.97 , Issue.7 , pp. 1999-2007
    • Kano, Y.1    Akutsu, M.2    Tsunoda, S.3
  • 128
    • 0034330931 scopus 로고    scopus 로고
    • Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells
    • Thiesing J.T., Ohno-Jones S., Kolibaba K.S., et al. Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells. Blood. 96(9):2000;3195-3199
    • (2000) Blood , vol.96 , Issue.9 , pp. 3195-3199
    • Thiesing, J.T.1    Ohno-Jones, S.2    Kolibaba, K.S.3
  • 129
    • 0035080416 scopus 로고    scopus 로고
    • Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells
    • Topaly J., Zeller W.J., Fruehauf S. Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia. 15(3):2001;342-347
    • (2001) Leukemia , vol.15 , Issue.3 , pp. 342-347
    • Topaly, J.1    Zeller, W.J.2    Fruehauf, S.3
  • 130
    • 0037029731 scopus 로고    scopus 로고
    • The in vitro activity of the tyrosine kinase inhibitor STI571 in BCR-ABL positive chronic myeloid leukaemia cells: Synergistic interactions with anti-leukaemic agents
    • Liu W.M., Stimson L.A., Joel S.P. The in vitro activity of the tyrosine kinase inhibitor STI571 in BCR-ABL positive chronic myeloid leukaemia cells: synergistic interactions with anti-leukaemic agents. Br J Cancer. 86(9):2002;1472-1478
    • (2002) Br J Cancer , vol.86 , Issue.9 , pp. 1472-1478
    • Liu, W.M.1    Stimson, L.A.2    Joel, S.P.3
  • 131
    • 0033964380 scopus 로고    scopus 로고
    • Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
    • Kantarjian H.M., O'Brien S., Smith T.L., et al. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol. 18(3):2000;547-561
    • (2000) J Clin Oncol , vol.18 , Issue.3 , pp. 547-561
    • Kantarjian, H.M.1    O'Brien, S.2    Smith, T.L.3
  • 132
    • 0035242026 scopus 로고    scopus 로고
    • Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia
    • Giles F.J., Cortes J.E., Baker S.D., et al. Troxacitabine, a novel dioxolane nucleoside analog, has activity in patients with advanced leukemia. J Clin Oncol. 19(3):2001;762-771
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 762-771
    • Giles, F.J.1    Cortes, J.E.2    Baker, S.D.3
  • 133
    • 0036467689 scopus 로고    scopus 로고
    • Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia
    • Giles F.J., Garcia-Manero G., Cortes J.E., et al. Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. J Clin Oncol. 20(3):2002;656-664
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 656-664
    • Giles, F.J.1    Garcia-Manero, G.2    Cortes, J.E.3
  • 134
    • 0037445119 scopus 로고    scopus 로고
    • Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias
    • Giles F.J., Faderl S., Thomas D.A., et al. Randomized phase I/II study of troxacitabine combined with cytarabine, idarubicin, or topotecan in patients with refractory myeloid leukemias. J Clin Oncol. 21(6):2003;1050-1056
    • (2003) J Clin Oncol , vol.21 , Issue.6 , pp. 1050-1056
    • Giles, F.J.1    Faderl, S.2    Thomas, D.A.3
  • 135
    • 0029836284 scopus 로고    scopus 로고
    • Uptake and metabolism of the new anticancer compound beta-L-(-)- dioxolane-cytidine in human prostate carcinoma DU-145 cells
    • Grove K.L., Cheng Y.C. Uptake and metabolism of the new anticancer compound beta-L-(-)-dioxolane-cytidine in human prostate carcinoma DU-145 cells. Cancer Res. 56(18):1996;4187-4191
    • (1996) Cancer Res , vol.56 , Issue.18 , pp. 4187-4191
    • Grove, K.L.1    Cheng, Y.C.2
  • 136
    • 0036467689 scopus 로고    scopus 로고
    • Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia
    • Giles F.J., Garcia-Manero G., Cortes J.E., et al. Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with refractory leukemia. J Clin Oncol. 20(3):2002;656-664
    • (2002) J Clin Oncol , vol.20 , Issue.3 , pp. 656-664
    • Giles, F.J.1    Garcia-Manero, G.2    Cortes, J.E.3
  • 137
    • 1642280989 scopus 로고    scopus 로고
    • Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukemia: Preclinical evaluation
    • in press
    • Orsolic N., Giles F.J., Gourdeau H., et al. Troxacitabine and imatinib mesylate combination therapy of chronic myeloid leukemia: preclinical evaluation. Br J Haematol, in press
    • Br J Haematol
    • Orsolic, N.1    Giles, F.J.2    Gourdeau, H.3
  • 138
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
    • Karp J.E., Lancet J.E., Kaufmann S.H., et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood. 97(11):2001;3361-3369
    • (2001) Blood , vol.97 , Issue.11 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 139
    • 1642453748 scopus 로고    scopus 로고
    • Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma
    • Zangari M., Anaissie E., Stopeck A., et al. Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma. Clin Cancer Res. 10(1 Pt 1):2004;88-95
    • (2004) Clin Cancer Res , vol.10 , Issue.1 PART 1 , pp. 88-95
    • Zangari, M.1    Anaissie, E.2    Stopeck, A.3
  • 140
    • 0242298170 scopus 로고    scopus 로고
    • Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia
    • Thomas D.A., Estey E., Giles F.J., et al. Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia. Br J Haematol. 123(3):2003;436-441
    • (2003) Br J Haematol , vol.123 , Issue.3 , pp. 436-441
    • Thomas, D.A.1    Estey, E.2    Giles, F.J.3
  • 141
    • 0037411266 scopus 로고    scopus 로고
    • Clinical relevance of VEGF receptors 1 and 2 in patients with chronic myelogenous leukemia
    • Verstovsek S., Lunin S., Kantarjian H., et al. Clinical relevance of VEGF receptors 1 and 2 in patients with chronic myelogenous leukemia. Leuk Res. 27(7):2003;661-669
    • (2003) Leuk Res , vol.27 , Issue.7 , pp. 661-669
    • Verstovsek, S.1    Lunin, S.2    Kantarjian, H.3
  • 142
    • 0345270394 scopus 로고    scopus 로고
    • Phase II study of SU5416 - A small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor - In patients with refractory myeloproliferative diseases
    • Giles F.J., Cooper M.A., Silverman L., et al. Phase II study of SU5416 - a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor - in patients with refractory myeloproliferative diseases. Cancer. 97(8):2003;1920-1928
    • (2003) Cancer , vol.97 , Issue.8 , pp. 1920-1928
    • Giles, F.J.1    Cooper, M.A.2    Silverman, L.3
  • 143
    • 0043245991 scopus 로고    scopus 로고
    • SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
    • Giles F.J., Stopeck A.T., Silverman L.R., et al. SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 102(3):2003;795-801
    • (2003) Blood , vol.102 , Issue.3 , pp. 795-801
    • Giles, F.J.1    Stopeck, A.T.2    Silverman, L.R.3
  • 144
    • 0037370702 scopus 로고    scopus 로고
    • A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome
    • Cortes J., Kantarjian H., Albitar M., et al. A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome. Cancer. 97(5):2003;1234-1241
    • (2003) Cancer , vol.97 , Issue.5 , pp. 1234-1241
    • Cortes, J.1    Kantarjian, H.2    Albitar, M.3
  • 145
    • 0037372488 scopus 로고    scopus 로고
    • Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
    • Cortes J., Albitar M., Thomas D., et al. Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood. 101(5):2003;1692-1697
    • (2003) Blood , vol.101 , Issue.5 , pp. 1692-1697
    • Cortes, J.1    Albitar, M.2    Thomas, D.3
  • 146
    • 0036841072 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes
    • Aguayo A., Kantarjian H.M., Estey E.H., et al. Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes. Cancer. 95(9):2002;1923-1930
    • (2002) Cancer , vol.95 , Issue.9 , pp. 1923-1930
    • Aguayo, A.1    Kantarjian, H.M.2    Estey, E.H.3
  • 147
    • 18644386378 scopus 로고    scopus 로고
    • Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival
    • Giles F.J., Kantarjian H.M., Bekele B.N., et al. Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival. Br J Haematol. 119(1):2002;38-45
    • (2002) Br J Haematol , vol.119 , Issue.1 , pp. 38-45
    • Giles, F.J.1    Kantarjian, H.M.2    Bekele, B.N.3
  • 148
    • 0036561385 scopus 로고    scopus 로고
    • The emerging role of angiogenesis inhibitors in hematologic malignancies
    • Giles F.J. The emerging role of angiogenesis inhibitors in hematologic malignancies. Oncology (Huntingt). 16(5 Suppl 4):2002;23-29
    • (2002) Oncology (Huntingt) , vol.16 , Issue.5 SUPPL. 4 , pp. 23-29
    • Giles, F.J.1
  • 149
    • 0036062374 scopus 로고    scopus 로고
    • Clinical relevance of vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukaemia and myelodysplastic syndrome
    • Verstovsek S., Estey E., Manshouri T., et al. Clinical relevance of vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukaemia and myelodysplastic syndrome. Br J Haematol. 118(1):2002;151-156
    • (2002) Br J Haematol , vol.118 , Issue.1 , pp. 151-156
    • Verstovsek, S.1    Estey, E.2    Manshouri, T.3
  • 150
    • 0037085781 scopus 로고    scopus 로고
    • Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia
    • Verstovsek S., Kantarjian H., Manshouri T., et al. Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia. Blood. 99(6):2002;2265-2267
    • (2002) Blood , vol.99 , Issue.6 , pp. 2265-2267
    • Verstovsek, S.1    Kantarjian, H.2    Manshouri, T.3
  • 151
    • 0035168739 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF) signaling pathway: A therapeutic target in patients with hematologic malignancies
    • Giles F.J. The vascular endothelial growth factor (VEGF) signaling pathway: a therapeutic target in patients with hematologic malignancies. Oncologist. 6(Suppl 5):2001;32-39
    • (2001) Oncologist , vol.6 , Issue.SUPPL. 5 , pp. 32-39
    • Giles, F.J.1
  • 152
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • Aguayo A., Estey E., Kantarjian H., et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia. Blood. 94(11):1999;3717-3721
    • (1999) Blood , vol.94 , Issue.11 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3
  • 153
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
    • Benjamin L.E., Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA. 94(16):1997;8761-8766
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.16 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 154
    • 0033637287 scopus 로고    scopus 로고
    • Molecular biology of the VEGF and the VEGF receptor family
    • Clauss M. Molecular biology of the VEGF and the VEGF receptor family. Semin Thromb Hemost. 26(5):2000;561-569
    • (2000) Semin Thromb Hemost , vol.26 , Issue.5 , pp. 561-569
    • Clauss, M.1
  • 155
    • 0031059348 scopus 로고    scopus 로고
    • Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
    • Perez-Atayde A.R, Sallan S.E., Tedrow U., et al. Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am J Pathol. 150(3):1997;815-821
    • (1997) Am J Pathol , vol.150 , Issue.3 , pp. 815-821
    • Perez-Atayde, A.R.1    Sallan, S.E.2    Tedrow, U.3
  • 156
    • 0030933923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia
    • Fiedler W., Graeven U., Ergun S., et al. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood. 89(6):1997;1870-1875
    • (1997) Blood , vol.89 , Issue.6 , pp. 1870-1875
    • Fiedler, W.1    Graeven, U.2    Ergun, S.3
  • 157
    • 0038714190 scopus 로고    scopus 로고
    • Timed sequential therapy (TST) of relapsed and refractory adult acute myeloid leukemia (AML) with the anti-vascular endothelial growth factor (VEGF) monoclonal antibody Bevacizumab
    • Karp J.E., Gojo I., Gocke C., et al. Timed sequential therapy (TST) of relapsed and refractory adult acute myeloid leukemia (AML) with the anti-vascular endothelial growth factor (VEGF) monoclonal antibody Bevacizumab. Blood. 100(11):2002;198a
    • (2002) Blood , vol.100 , Issue.11
    • Karp, J.E.1    Gojo, I.2    Gocke, C.3
  • 158
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird A.D., Vajkoczy P., Shawver L.K., et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 60(15):2000;4152-4160
    • (2000) Cancer Res , vol.60 , Issue.15 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 159
    • 0033566983 scopus 로고    scopus 로고
    • The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients
    • Thavasu P., Propper D., McDonald A., et al. The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients. Cancer Res. 59(16):1999;3980-3984
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 3980-3984
    • Thavasu, P.1    Propper, D.2    McDonald, A.3
  • 160
    • 0842304369 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
    • Panwalkar A., Verstovsek S., Giles F.J. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer. 100(4):2004;657-666
    • (2004) Cancer , vol.100 , Issue.4 , pp. 657-666
    • Panwalkar, A.1    Verstovsek, S.2    Giles, F.J.3
  • 161
    • 0038066488 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl + human myeloid leukemia cells
    • Yu C., Rahmani M., Almenara J., et al. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl + human myeloid leukemia cells. Cancer Res. 63(9):2003;2118-2126
    • (2003) Cancer Res , vol.63 , Issue.9 , pp. 2118-2126
    • Yu, C.1    Rahmani, M.2    Almenara, J.3
  • 162
    • 1842811645 scopus 로고    scopus 로고
    • Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase-8-mediated apoptosis and downregulation of c-FLIP protein
    • Aron J.L., Parthun M.R., Marcucci G., et al. Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase-8-mediated apoptosis and downregulation of c-FLIP protein. Blood. 20:2003;20
    • (2003) Blood , vol.20 , pp. 20
    • Aron, J.L.1    Parthun, M.R.2    Marcucci, G.3
  • 163
    • 0032941998 scopus 로고    scopus 로고
    • Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes
    • Bandyopadhyay A., Bandyopadhyay J., Chung J., et al. Inhibition of S6 kinase by rapamycin blocks maturation of Rana dybowskii oocytes. Gen Comp Endocrinol. 113(2):1999;230-239
    • (1999) Gen Comp Endocrinol , vol.113 , Issue.2 , pp. 230-239
    • Bandyopadhyay, A.1    Bandyopadhyay, J.2    Chung, J.3
  • 164
    • 0027942560 scopus 로고
    • Partial characterization of a 52 kDa CsA/FK506/rapamycin binding protein
    • Donnelly J.G., Soldin S.J. Partial characterization of a 52 kDa CsA/FK506/rapamycin binding protein. Clin Biochem. 27(5):1994;367-372
    • (1994) Clin Biochem , vol.27 , Issue.5 , pp. 367-372
    • Donnelly, J.G.1    Soldin, S.J.2
  • 165
    • 1642544091 scopus 로고    scopus 로고
    • STAT3 is enriched in nuclear bodies
    • Herrmann A., Sommer U., Pranada A.L., et al. STAT3 is enriched in nuclear bodies. J Cell Sci. 117(Pt 2):2004;339-349
    • (2004) J Cell Sci , vol.117 , Issue.2 PART , pp. 339-349
    • Herrmann, A.1    Sommer, U.2    Pranada, A.L.3
  • 166
    • 0032528434 scopus 로고    scopus 로고
    • Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
    • Inui S., Sanjo H., Maeda K., et al. Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A. Blood. 92(2):1998;539-546
    • (1998) Blood , vol.92 , Issue.2 , pp. 539-546
    • Inui, S.1    Sanjo, H.2    Maeda, K.3
  • 167
    • 0028156740 scopus 로고
    • Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction
    • Kardalinou E., Zhelev N., Hazzalin C.A., et al. Anisomycin and rapamycin
    • (1994) Mol Cell Biol , vol.14 , Issue.2 , pp. 1066-1074
    • Kardalinou, E.1    Zhelev, N.2    Hazzalin, C.A.3
  • 168
    • 0027371861 scopus 로고
    • Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes
    • Morice W.G., Wiederrecht G., Brunn G.J., et al. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes. J Biol Chem. 268(30):1993;22737-22745
    • (1993) J Biol Chem , vol.268 , Issue.30 , pp. 22737-22745
    • Morice, W.G.1    Wiederrecht, G.2    Brunn, G.J.3
  • 169
    • 0043016178 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    • Nimmanapalli R., Fuino L., Bali P., et al. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res. 63(16):2003;5126-5135
    • (2003) Cancer Res , vol.63 , Issue.16 , pp. 5126-5135
    • Nimmanapalli, R.1    Fuino, L.2    Bali, P.3
  • 170
    • 0038620379 scopus 로고    scopus 로고
    • Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells
    • Nimmanapalli R., Fuino L., Stobaugh C., et al. Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Blood. 101(8):2003;3236-3239
    • (2003) Blood , vol.101 , Issue.8 , pp. 3236-3239
    • Nimmanapalli, R.1    Fuino, L.2    Stobaugh, C.3
  • 171
    • 0034142368 scopus 로고    scopus 로고
    • Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L)
    • Perkins C., Kim C.N., Fang G., et al. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). Blood. 95(3):2000;1014-1022
    • (2000) Blood , vol.95 , Issue.3 , pp. 1014-1022
    • Perkins, C.1    Kim, C.N.2    Fang, G.3
  • 172
    • 0037223438 scopus 로고    scopus 로고
    • The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation
    • Rohde J.R., Cardenas M.E. The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol Cell Biol. 23(2):2003;629-635
    • (2003) Mol Cell Biol , vol.23 , Issue.2 , pp. 629-635
    • Rohde, J.R.1    Cardenas, M.E.2
  • 173
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V., Kantarjian H.M., Issa J.P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med. 134(7):2001;573-586
    • (2001) Ann Intern Med , vol.134 , Issue.7 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 174
    • 0344407016 scopus 로고    scopus 로고
    • Histone deacetylases: Unique players in shaping the epigenetic histone code
    • Thiagalingam S., Cheng K.H., Lee H.J., et al. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann N Y Acad Sci. 983:2003;84-100
    • (2003) Ann N Y Acad Sci , vol.983 , pp. 84-100
    • Thiagalingam, S.1    Cheng, K.H.2    Lee, H.J.3
  • 175
    • 0029123838 scopus 로고
    • Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin
    • Wang D.Z., Ray P., Boothby M. Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin. J Biol Chem. 270(39):1995;22924-22932
    • (1995) J Biol Chem , vol.270 , Issue.39 , pp. 22924-22932
    • Wang, D.Z.1    Ray, P.2    Boothby, M.3
  • 176
    • 3643104150 scopus 로고    scopus 로고
    • Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
    • Warrell R.P. Jr., He L.Z., Richon V., et al. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. J Natl Cancer Inst. 90(21):1998;1621-1625
    • (1998) J Natl Cancer Inst , vol.90 , Issue.21 , pp. 1621-1625
    • Warrell Jr., R.P.1    He, L.Z.2    Richon, V.3
  • 177
    • 0037328501 scopus 로고    scopus 로고
    • Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells
    • Klisovic M.I., Maghraby E.A., Parthun M.R., et al. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia. 17(2):2003;350-358
    • (2003) Leukemia , vol.17 , Issue.2 , pp. 350-358
    • Klisovic, M.I.1    Maghraby, E.A.2    Parthun, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.