Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib

Leukemia and Lymphoma

Volumn 45, Issue 11, 2004, Pages 2197-2203

  Loriaux, Marc ^a   Deininger, Michael ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Chronic myelogenous leukemia; Clonal evolution; Imatinib mesylate; Philadelphia negative hematopoiesis

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; HYDROXYUREA; IMATINIB;

BONE MARROW TRANSPLANTATION; CARCINOGENESIS; CHROMOSOME 1; CHROMOSOME 20; CHROMOSOME 3; CHROMOSOME 5; CHROMOSOME 6; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHROMOSOME DELETION 5; CHROMOSOME DUPLICATION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION 22; CHROMOSOME TRANSLOCATION 9; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; CYTOGENETICS; DISEASE COURSE; HEMATOPOIESIS; HUMAN; KARYOTYPING; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; PATIENT CARE; PHILADELPHIA CHROMOSOME NEGATIVE CELL; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; REVIEW; STRUCTURAL CHROMOSOME ABERRATION; TREATMENT OUTCOME; TRISOMY 8; Y CHROMOSOME;

BONE MARROW TRANSPLANTATION; CHROMOSOME ABERRATIONS; COHORT STUDIES; DISEASE PROGRESSION; HEMATOPOIESIS; HUMANS; INTERFERON-ALPHA; KARYOTYPING; LEUKEMIA, MYELOID, PHILADELPHIA-NEGATIVE; MYELODYSPLASTIC SYNDROMES; PIPERAZINES; PROGNOSIS; PYRIMIDINES; TREATMENT OUTCOME;

EID: 8644286697     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190410001723278     Document Type: Review

References (63)

1. Shtivelman, E., Lifshitz, B., Gale, R.P. and Canaani, E. (1985) "Fused transcript of abl and bcr genes in chronic myelogenous leukaemia", Nature, 315, 550-554.
2. Bartram, C.R., de Klein, A., Hagemeijer, A., van Agthoven, T., Geurts van Kessel, A., Bootsma, D., et al. (1983) "Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia", Nature, 306, 277-280.
3. Nowell, P.C. and Hungerford, D.A. (1960) "A minute chromosome in human chronic ganulocytic leukemia", Science, 132 1497. Abstract.
4. Rowley, J.D. (1973) "Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining", Nature, 243, 290-293.
5. Daley, G.Q., Van Etten, R.A. and Baltimore, D. (1990) "Induction of chronic myelogenous leukemia in mice by the P210bcr /abl gene of the Philadelphia chromosome", Science, 247, 824-830.
6. Cervantes, F. (2003) "Durability of responses to Imatinib in newly diagnosed Chronic-Phase Chronic Myeloid Leukemia (CML): 24-Month Update from the IRIS Study", Blood, 102, 181a. Abstract.
7. Kantarjian, H., Sawyers, C., Hochhaus, A., Guilhot, F., Schiffer, C., Gambacorti-Passcrini, C., et al. (2002) " Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia", N. Engl. J. Med., 346, 645-652.
8. O'Brien, S.G., Guilhot, F., Larson, R.A., Gathmann, I., Baccarani, M., Cervantes, F., et al. (2003) "Imatimb compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia", N. Engl. J. Med., 348, 994-1004.
9. Mitelman, F., Levan, G., Nilsson, P.G. and Brandt, L. (1976) "Non-random karyotypic evolution in chronic myeloid leukemia", Int. J. Cancer, 18, 24-30.
10. Lawler, S.D., O'Malley, F. and Lobb, D.S. (1976) "Chromosome banding studies in Philadelphia chromosome positive myeloid leukaemia", Scand. J. Haematol., 17, 17-28.
11. Johansson, B., Fioretos, T., Billstrom, R. and Mitelman, F. (1996) "Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha", Leukemia, 10, 1134-1138.
12. Nanjangud, G., Kadam, P.R., Saikia, T., Bhisey, A.N., Kumar, A., Gopal, R., et al. (1994) "Karyotypic findings as an independent prognostic marker in chronic myeloid leukaemia blast crisis", Leuk. Res., 18, 385-392.
13. Swolin, B., Weinfeld, A., Westin, J., Waldenstrom, J. and Magnusson, B. (1985) "Karyotypic evolution in Ph-positive chronic myeloid leukemia in relation to management and disease progression", Cancer Genet. Cytogenet., 18, 65-79.
14. Hild, F., Freund, M. and Fonatsch, C. (1991) "Chromosomal aberrations during interferon therapy for chronic myelogenous leukemia", N. Engl. J. Med., 325, 132. Letter.
15. Maloisel, F., Uettwiller, F., Laplace, A., Lioure, B., Herbrecht, R., Mark, M., et al. (1999) "Emergence of unusual cytogenetic abnormalities under interferon-alpha therapy in patients with chronic myelogenous leukemia", Cancer Genet. Cytogenet., 113 172-176.
16. Chase, A., Pickard, J., Szydlo, R., Coulthard, S., Goldman, J.M. and Cross, N.C. (2000) "Non-random involvement of chromosome 13 in patients with persistent or relapsed disease after bone-marrow transplantation for chronic myeloid leukemia", Genes Chromosomes Cancer, 27, 278-284.
17. Bilhou-Nabera, C., Bernard, P., Marit, G., Viard, F., Gharbi, M.J., Wen, Z., et al. (1992) "Serial cytogenetic studies in allografted patients with chronic myeloid leukemia", Bone Marrow Transplant, 9, 263-268.
18. Sessarego, M., Frassoni, F., Defferrari, R., Bacigalupo, A., Fugazza, G., Mareni, C., et al. (1991) "Karyotype evolution of Ph positive chronic myelogenous leukemia patients relapsed in advanced phases of the disease after allogeneic bone marrow transplantation", Cancer Genet. Cytogenet., 57, 69-78.
19. Marktel, S., Marin, D., Foot, N., Szydlo, R., Bua, M., Karadimitris, A., et al. (2003) "Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression", Haematologica, 88, 260-267.
20. Mohamed, A.N., Pemberton, P., Zonder, J. and Schiffer, C.A. (2003) "The effect of imatinib mesylate on patients with Philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations", Clin Cancer Res., 9, 1333-1337.
21. Bilhou-Nabera, C., Marit, G., Devianne, I., Viard, F., Salzes, S., Montastruc, M., et al. (1993) "A second case of trisomy 8 in Philadelphia chromosome (Ph)-negative cells during the course of Ph-positive chronic myelocytic leukemia", Genes Chromosomes Cancer, 6, 255-226.
22. Ariyama, T., Inazawa, J., Uemura, Y., Kakazu, N., Maekawa, T., Urase, F., et al. (1995) "Clonal origin of Philadelphia chromosome negative cells with trisomy 8 appearing during the course of alpha-interferon therapy for Ph positive chronic myelocytic leukemia", Cancer Genet. Cytogenet., 81, 20-23.
23. Casali, M., Truglio, F., Milone, G., Di Raimondo, F., Parrinello, G., Maserati, E., et al. (1992) "Trisomy 8 in Philadelphia chromosome (Ph1)-negative cells in the course of Ph1-positive chronic myelocytic leukemia", Genes Chromosomes Cancer 4, 269-270.
24. Izumi, T., Imagawa, S., Hatake, K., Miura, Y., Ariyama, T., Inazawa, J., et al. (1996) "Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph1-positive chronic myelogenous leukemia", Int. J. Hematol., 64, 73-77.
25. Fayad, L., Kantarjian, H., O'Brien, S., Seong, D., Albitar, M., Keating, M., et al. (1997) "Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases", Leukemia, 11, 767-771.
26. Shepherd, P., Brito-Babapulle, F., Duncombe, A., Parker, A., Parry, H., Winfield, D., et al. (1996) "Acute blast transformation in CML patients still showing cytogenetic response to IFN-n1 and the presence of cytogenetic abnormalities in Ph negative cells", Br. J. Haematol., 93, 72. Abstract 282.
27. Alimena, G., Breccia, M., Mancini, M., Ferranti, G., De Felice, L., Gallucei, C., et al. (2004) "Clonal evolution in Philadelphia chromosome negative cells following successful treatment with Imatinib of a CML patient: clinical and biological features of a myelodysplastic syndrome", Leukemia, 18, 361-362.
28. Goldberg, S.L., Madan, R.A., Rowley, S.D., Pecora, A.L., Hsu, J.W. and Tantravahi, R. (2003) "Myelodysplastic subclones in chronic myeloid leukemia: implications for imatinib mesylate therapy", Blood 101, 781.
29. Andersen, M.K., Pedersen-Bjergaard, J., Kjeldsen, L., Dufva, I.H. and Brondum-Nielsen, K. (2002) "Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8", Leukemia, 16, 1390-1393.
30. Besalduch, J., Gutierrez, A., Rosell, J., Bernues, M. and Sampol, A. (2002) "Abnormal cytogenetic evolution in a case of CML treated by imatinib mesylate", Blood, 100, 331b.
31. Bumm, T., Muller, C., Al Ali, H.K., Krohn, K., Shepherd, P., Schmidt, E., et al. (2003) "Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority", Blood, 101, 1941-1949.
32. Cervetti, G., Galimberti, S., Fazzi, R., Papineschi, F., Azzara, A., Simi, P., et al. (2004) "Adjunctive chromosomal abnormalities in Philadelphia-negative cells of CML patients treated with Imatinib", Eur. J. Clin. Invest., 34, 243-244.
33. Herens, C., Baron, F., Croisiau, C., Tassin, F. and Bours, V. (2003) "Clonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases", Cancer Genet. Cytogenet., 147, 78-80.
34. Feldman, E., Najfeld, V., Schuster, M., Roboz, G., Chadburn, A. and Silver, R.T. (2003) "The emergence of Ph-, trisomy-8 + cells in patients with chronic myeloid leukemia treated with imatinib mesylate", Experimental Hematology, 31, 702-707.
35. Gozzetti, A., Tozzuoli, D., Crupi, R., Gentili, S., Bocchia, M., Raspadori, D., et al. (2003) "Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI)", European Journal of Haematology, 71, 313-314.
36. Gambacorti-Passerini, C., Giudici, G., le Coutre, P., Bungaro, S., Pogliani, E., Kreuzer, K.A., et al. (2001) "Non random chromosomal abnormalities in Ph-negative bone marrow (BM) cells from CML patients achieving major cytogenetic responses (MCR) with STI571 (GleevecTM)", Blood, 98, 257b.
37. Meeus, P., Demuynck, H., Martiat, P., Michaux, L., Wouters, E. and Hagemeijer, A. (2003) "Sustained, clonal karyotype abnormalities in the Philadelphia chromosome negative cells of CML patients successfully treated with Imatinib", Leukemia, 17, 465-467.
38. Medina, J., Kantarjian, H., Talpaz, M., O'Brien, S., Garcia-Manero, G., Faderl, S., et al. (2002) "Chromosomal abnormalities in Philadelphia chromosome (Ph) negative metaphases appearing during treatment with imatinib mesylate in patients (pts) with Ph positive chronic myeloid leukemia (CML) in chronic phase (CP)", Blood, 100, 368a.
39. McMullin, M.F., Humphreys, M., Byrne, J., Russell, N.H., Cuthbert, R.J. and O'Dwyer, M.E. (2003) "Chromosomal abnormalities in Ph- cells of patients on imatinib", Blood, 102, 2700-2701; author reply 2701.
40. O'Dwyer, M.E., Gatter, K.M., Loriaux, M., Druker, B.J., Olson, S.B., Magenis, R.E., et al. (2003) "Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate", Leukemia, 17, 481-487.
41. Schoch, C., Haferlach, T., Kern, W., Schnittger, S., Berger, U., Hehlmann, R., et al. (2003) "Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate", Leukemia, 17, 461-463.
42. Sun, G., Boczkowska, B., Tcheurekdjian, L., Lorenzo, M. and Owens, M. (2002) "The emergence of cytogenetically unrelated clones may not be an uncommon finding in imatinib mesylate-treated CML", Blood 100, 326b. Abstract.
43. Snyder, D.S., Slovak, M.L., Bhatia, R. and Arber, D. (2002) "Philadelphia chromosome negative clones in Philadelphia chromosome positive CML: emerging clinical implications in eight cases", Blood 100, 322b. Abstract.
44. Symeonidis, A., Kouraklis-Symeonidis, A., Lambropoulou, V., Giannaloulas, N., Fragopanagou, E., Tinikou, M., et al. (2003) "Emergence of Abnormal Cytogenetic Abnormalities after Treatment of Patients with bcr/abl + Chronic Myelogenous Leukemia with Imatinib", Blood, 102, 318b. Abstract.
45. Meunier, V., Giraudier, S., Van den Aker, J., Perot, C., Jouault, H., Caron-Servan, B., et al. (2001) "Treatment with STI571 (NovartisR) in chronic myeloid leukemia (CML): unexpected hematological findings in a series of 26 patients", Blood, 98 263b.
46. ISCN. (1995) An International System for Human Cytogenetic Nomenclature, edited by F. Mitelman. Basel: S. Karger.
47. Royer-Pokora, B., Hildebrandt, B., Redmann, A., Herold, C., Kronenwett, R., Haas, R., et al. (2003) "Simultaneous occurrence of a t(9;22) (Ph) with a t(2;11) in a patient with CML and emergence of a new clone with the t(2;11) alone after imatinib mesylate treatment", Leukemia, 17, 807-810.
48. Vickers, M. (1996) "Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data", Br. J. Haematol., 94, 1-4.
49. Raskind, W.H., Ferraris, A.M., Najfeld, V., Jacobson, R.J., Moohr, J.W. and Fialkow, P.J. (1993) "Further evidence for the existence of a clonal Ph-negative stage in some cases of Ph-positive chronic myelocytic leukemia", Leukemia, 7, 1163-1167.
50. Fialkow, P.J., Martin, P.J., Najfeld, V., Penfold, G.K., Jacobson, R.J. and Hansen, J.A. (1981) "Evidence for a multistep pathogenesis of chronic myelogenous leukemia", Blood, 58, 158-163.
51. Spencer, A. and Granter, N. (1999) "Leukemia patient-derived lymphoblastoid cell lines exhibit increased induction of leukemia-associated transcripts following high-dose irradiation", Exp. Hematol., 27, 1397-1401.
52. Bergamaschi, G., Podesta, M., Frassoni, F., Rosti, V., Carella, A.M., Saglio, G., et al. (1994) "Restoration of normal polyclonal haemopoiesis in patients with chronic myeloid leukaemia auto-grafted with Ph-negative peripheral stem cells", Br. J. Haematol., 87, 867-870.
53. Mauro, M.J., Loriaux, M. and Deininger, M.W. (2004) "Ph-positive and -negative myeloproliferative syndromes may co-exist", Leukemia.
54. Ganti, A.K., Potti, A. and Mehdi, S.A. (2003) "Chromosomal anomalies in two coexistent myeloproliferative disorders", Cancer Genet. Cytogenet., 145, 172-175.
55. Yuan, Z.M., Shioya, H., Ishiko, T., Sun, X., Gu, J., Huang, Y.Y., et al. (1999) "p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage", Nature, 399, 814-817.
56. Shafman, T., Khanna, K.K., Kedar, P., Spring, K., Kozlov, S., Yen, T., et al. (1997) "Interaction between ATM protein and c-Abl in response to DNA damage", Nature, 387, 520-523.
57. Kharbanda, S., Pandey, P., Jin, S., Inoue, S., Bharti, A., Yuan, Z.M., et al. (1997) "Functional interaction between DNA-PK and c-Abl in response to DNA damage", Nature, 386, 732-735.
58. Heinrich, M.C., Griffith, D.J., Druker, B.J., Wait, C.L., Ott, K.A. and Zigler, A.J. (2000) "Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor", Blood, 96, 925-932.
59. Lowry, P.A., Zsebo, K.M., Deacon, D.H., Eichman, C.E. and Quesenberry, P.J. (1991) "Effects of rrSCF on multiple cytokine responsive HPP-CFC generated from SCA + Lin- murine hematopoietic progenitors", Exp. Hematol., 19, 994-996.
60. Migliaccio, G., Migliaccio, A.R., Valinsky, J., Langley, K., Zsebo, K., Visser, J.W., et al. (1991) "Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells", Proc. Natl. Acad. Sci. USA, 88, 7420-7424.
61. Lyman, S.D. and Jacobsen, S.E. (1998) "c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities", Blood, 91, 1101-1134.
62. Heaney, M.L. and Golde, D.W. (1999) "Myelodysplasia", N. Engl. J. Med., 340, 1649-1660.
63. Olney, H.J. and Le Beau, M.M. (2001) "The cytogenetics of myelodysplastic syndromes", Best Practitioners. Res. Clin. Haematol. 14, 479-495.