Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors

Cancer Genetics and Cytogenetics

Volumn 170, Issue 1, 2006, Pages 16-23

  Lin, Yulia ^a   Bruyère, Hélène ^b   Horsman, Douglas E ^b   Pantzar, Tapio ^b   Barnett, Michael J ^a   Hogge, Donna E ^a   Nevill, Thomas J ^a   Nantel, Stephen H ^a   Sutherland, Heather J ^a   Toze, Cynthia L ^a   Shepherd, John D ^a   Lavoie, Julye C ^a   Song, Kevin W ^a   Smith, Clayton A ^a   Forrest, Donna L ^a  

^a Leukemia/BMT Program of British Columbia   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; CYTARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYUREA; IMATINIB; INTERFERON;

ADULT; AGED; ARTICLE; CANADA; CANCER CHEMOTHERAPY; CHROMOSOME 22; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CLONE; FATIGUE; FEMALE; HEMATOPOIESIS; HUMAN; HUMAN CELL; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MONOSOMY 7; MULTIVARIATE ANALYSIS; MYELODYSPLASIA; NEUTROPENIA; PANCYTOPENIA; PHILADELPHIA CHROMOSOME NEGATIVE CELL; PHILADELPHIA CHROMOSOME POSITIVE CELL; PRIORITY JOURNAL; PROGNOSIS; RISK FACTOR; STEM CELL TRANSPLANTATION; SURVIVAL RATE; TRISOMY 8; X CHROMOSOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; FEMALE; HEMATOPOIESIS; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, PHILADELPHIA-NEGATIVE; MALE; MIDDLE AGED; PIPERAZINES; PYRIMIDINES; RISK FACTORS;

EID: 33748474783     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.04.012     Document Type: Article

References (36)

1. Casali M., Truglio F., Milone G., Di Raimondo F., Parrinello G., Maserati E., and Pasquali F. Trisomy 8 in Philadelphia chromosome (Ph1)-negative cells in the course of Ph1-positive chronic myelocytic leukemia. Genes Chromosomes Cancer 4 (1992) 269-270
2. Bilhou-Nabera C., Marit G., Devianne I., Viard F., Salzes S., Montastruc M., Renoux M., Broustet A., Reiffers J., and Bernard P.h. A second case of trisomy 8 in Philadelphia chromosome (Ph)-negative cells during the course of Ph-positive chronic myelocytic leukemia. Genes Chromosomes Cancer 6 (1993) 255-256
3. Ariyama T., Inazawa J., Uemura Y., Kakazu N., Maekawa T., Urase F., Irimajiri K., Horiuchi A., Nakamura Y., and Abe T. Clonal origin of Philadelphia chromosome negative cells with trisomy 8 appearing during the course of alpha-interferon therapy for Ph positive chronic myelocytic leukemia. Cancer Genet Cytogenet 81 (1995) 20-23
4. Ohtsuka E., Kikuchi H., Abe Y., Moriyama K., Ohno E., Hirota K., Tezono K., and Nasu M. Acute myeloblastic leukaemia without Philadelphia chromosome developing after interferon therapy for chronic myelocytic leukaemia with Philadelphia chromosome. Br J Haematol 90 (1995) 951-953
5. Izumi T., Imagawa S., Hatake K., Miura Y., Ariyama T., Inazawa J., and Abe T. Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph-positive chronic myelogenous leukemia. Int J Hematol 64 (1996) 73-77
6. Shepherd P., Brito-Babapulle F., Duncombe A., Parker A., Parry H., Winfield D., and Allan N. Acute blast transformation in CML patients still showing cytogenetic response to IFN-alpha n1 and the presence of cytogenetic abnormalities in PH negative cells. Br J Haematol 93 Suppl.2 (1996) 72 (Abstract)
7. Fayad L., Kantarjian H., O'Brien S., Seong D., Albitar M., Keating M., and Talpaz M. Emergence of new clonal abnormalities following interferon-alpha induced complete cytogenetic response in patients with chronic myeloid leukemia: report of three cases. Leukemia 11 (1997) 767-771
8. O'Brien S.G., Guilhot F., Larson R.A., Gathmann I., Baccarani M., Cervantes F., Cornelissen J.J., Fischer T., Hochhaus A., Hughes T., Lechner K., Nielsen J.L., Rousselot P., Reiffers J., Saglio G., Shepherd J.D., Simonsson B., Gratwohl A., Goldman J.M., Kantarjian H., Taylor K., Verhoef G., Bolton A.E., Capdeville R., and Druker B.J. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. New Engl J Med 348 (2003) 994-1004
9. Gambacorti-Passeri C., Giudici G., le Coutre P., Bungaro S., Pogliani E.M., Kreuzer K.A., Tornaghi L., Alberti D., Corneo G., and Biondi A. Non random chromosomal abnormalities in Ph-negative bone marrow (BM) cells from CML patients achieving major cytogenetic responses (MCR) with ST1571 (Gleevec). Blood 98 (2001) 257b-258b (Abstract)
10. Meunier V., Giraudier S., van den Akker J., Perot C., Jouault H., Caron-Servan B., Robin V., Tulliez M., and Imbert M. Treatment with STI571 (Novartis R) in chronic myeloid leukemia (CML): unexpected hematological findings in a series of 26 patients. Blood 98 (2001) 253b-263b (Abstract)
11. Feldman E.J., Najfeld V., Schuster M.W., Roboz G.J., Chadburn A., Goodman O., and Silver R.T. The emergence of Philadelphia chromosome (Ph) negative, trisomy 8 positive cells in patients with chronic myelogenous leukemia (CML) treated with imatinib mesylate: clinical evidence for a multistep pathogenesis. Blood 100 (2002) 585a (Abstract)
12. Andersen M.K., Pedersen-Bjergaard J., Kjeldsen L., Dufva I.H., and Brondum-Nielsen K. Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Leukemia 16 (2002) 1390-1393
13. Braziel R.M., Launder T.M., Druker B.J., Olson S.B., Magenis E., Mauro M.J., Sawyers C.L., Paquette R.L., and O'Dwyer M.E. Hematopathologic and cytogenetic findings in imatinib mesylate-treated chronic myelogenous leukemia patients: 14 months' experience. Blood 100 (2002) 435-441
14. Marktel S., Marin D., Foot N., Szydlo R., Bua M., Karadimitris A., De Melo V.A., Kotzampaltiris P., Dazzi F., Rahemtulla A., Olavarria E., Apperley J.F., and Goldman J.M. Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression. Haematologica 88 (2003) 260-267
15. Schoch C., Haferlach T., Kern W., Schnittger S., Berger U., Hehlmann R., Hiddemann W., and Hochhaus A. Occurrence of additional chromosome aberrations in chronic myeloid leukemia patients treated with imatinib mesylate. Leukemia 17 (2003) 461-463
16. Meeus P., Demuynck H., Martiat P.h., Michaux L., Wouters E., and Hagemeijer A. Sustained, clonal karyotype abnormalities in the Philadelphia chromosome negative cells of CML patients successfully treated with imatinib. Leukemia 17 (2003) 465-467
17. O'Dwyer M.E., Gatter K.M., Loriaux M., Druker B.J., Olson S.B., Magenis R.E., Lawce H., Mauro M.J., Maziarz R.T., and Braziel R.M. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 17 (2003) 481-487
18. Bumm T., Muller C., Al-Ali H., Krohn K., Shepherd P., Schmidt E., Leiblein S., Franke C., Hennig E., Friedrich T., Krahl R., Niederwieser D., and Deininger M.W. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 101 (2003) 1941-1949
19. Gozzetti A., Tozzuoli D., Crupi R., Gentili S., Bocchia M., Raspadori D., and Lauria F. Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI). Eur J Haematol 71 (2003) 313-314
20. Chee Y.L., Vickers M.A., Stevenson D., Holyoake T.L., and Culligan D.J. Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones. Leukemia 17 (2003) 634-635
21. Royer-Pokora B., Hildebrandt B., Redmann A., Herold C., Kronenwett R., Haas R., Drechsler M., and Wieland C. Simultaneous occurrence of a t(9;22) (Ph) with a t(2;11) in a patient with CML and emergence of a new clone with the t(2;11) alone after imatinib mesylate treatment. Leukemia 17 (2003) 807-810
22. McMullin M.F., Humphreys M., Byrne J., Russell N.H., Cuthbert R.J., and O'Dwyer M.E. Chromosomal abnormalities in Ph- cells of patients on imatinib. Blood 102 (2003) 2700-2701
23. Mozziconacci M.J., Cailleres S., Maurice C., Vey N., Sainty D., Blaise D., and Lafage-Pochitaloff M. Myelodysplastic features developing in Philadelphia-negative cells during imatinib mesylate therapy for CML: report of a new case. Leukemia 17 (2003) 1901-1902
24. Medina J., Kantarjian H., Talpaz M., O'Brien S., Garcia-Manero G., Giles F., Rios M.B., Hayes K., and Cortes J. Chromosomal abnormalities in Philadelphia chromosome-negative metaphases appearing during imatinib mesylate therapy in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Cancer 98 (2003) 1905-1911
25. Herens C., Baron F., Croisiau C., Tassin F., and Bours V. Clonal chromosome aberrations in Philadelphia-negative cells from chronic myelocytic leukemia patients treated with imatinib mesylate: report of two cases. Cancer Genet Cytogenet 147 (2003) 78-80
26. Cervetti G., Galimberti S., Fazzi R., Papineschi F., Azzara A., Simi P., and Petrini M. Adjunctive chromosomal abnormalities in Philadelphia-negative cells of CML patients treated with imatinib. Eur J Clin Invest 34 (2004) 243-244
27. Bernardeschi P., Fiorentini G., Rossi S., Dentico P., Simi P., and Guidi S. Trisomy 8 in Philadelphia-negative cells during imatinib therapy. Am J Hematol 77 (2004) 88-89
28. Alimena G., Breccia M., Mancini M., Ferranti G., De Felice L., Gallucci C., and Mandelli F. Clonal evolution in Philadelphia chromosome negative cells following successful treatment with imatinib of a CML patient: clinical and biological features of a myelodysplastic syndrome. Leukemia 18 (2004) 361-362
29. Athanasiadou A., Stavroyianni N., Saloum R., Asteriou O., Anagnostopoulos A., and Fassas A. Novel chromosomal aberrations in Philadelphia negative cells of chronic myelogenous leukemia patients on imatinib: report of three cases. Leukemia 18 (2004) 1029-1031
30. Guilbert-Douet N., Morel F., Le Bris M., Berthou C., Morice P., Bourquard P., and Braekeleer M.D. Clonal chromosomal abnormalities in the Philadelphia chromosome negative cells of chronic myeloid leukemia patients treated with imatinib. Leukemia 18 (2004) 1140-1142
31. Terre C., Eclache V., Rousselot P., Imbert M., Charrin C., Gervais C., Mozziconacci M.J., Maarek O., Mossafa H., Auger N., Dastugue N., Talmant P., Van den Akker J., Leonard C., Khac F.N., Mugneret F., Viguie F., Lafage-Pochitaloff M., Bastie J.N., Roux G.L., Nicolini F., Maloisel F., Vey N., Laurent G., Recher C., Vigier M., Yacouben Y., Giraudier S., Vernant J.P., Salles B., Roussi J., Castaigne S., Leymarie V., Flandrin G., and Lessard M. Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia. Leukemia 18 (2004) 1340-1346
32. Kalbfleisch J.D., and Prentice R.L. The statistical analysis of failure time data (1998), John Wiley & Sons, New York
33. Cox D.R. Regression models and life tables. J R Stat Soc (B) 34 (1972) 187-220
34. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
35. O'Shea D., Crotty G., Carrol P., Conneally E., McCann S., and Neat M.J. Clonal karyotypic abnormalities in Philadelphia negative cells of CML patients treated with imatinib: is it under-reported and does it have any clinical significance. Br J Haematol 127 (2004) 367-369
36. Bose S., Deininger M., Gora-Tybor J., Goldman J.M., and Melo J.V. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood 92 (1998) 3362-3367