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Hinklin, R.J.1
Aicher, T.D.2
Boyd, S.A.3
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237
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77949360528
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Early clinical studies to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy volunteers and subjects with Type 2 diabetes mellitus
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Chicago, IL, USA 22-27 June
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Hussey EK, Clark RV, Amin DM et al. Early clinical studies to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy volunteers and subjects with Type 2 diabetes mellitus. Presented at: 67th Scientifc Sessions of the American Diabetes Association. Chicago, IL, USA, 22-27 June 2007.
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Hussey, E.K.1
Clark, R.V.2
Amin, D.M.3
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238
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77949388811
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A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects
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Chicago, IL, USA 22-27 June
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Hussey EK, Dobbins RL, Stolz RR et al. A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects. Presented at: 67th Scientifc Sessions of the American Diabetes Association. Chicago, IL, USA, 22-27 June 2007.
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(2007)
Presented At: 67th Scientifc Sessions of the American Diabetes Association
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Hussey, E.K.1
Dobbins, R.L.2
Stolz, R.R.3
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239
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77949376565
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Safety pharmokinetics and pharmacodynamics of remoglifozzin etabonate (SGLT2 inhibitor) and metformin when co-administered in Type 2 diabetes mellitus (T2DM) patients
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New Orleans LA USA 5-9 June
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Hussey EK, Kapur A, O'Conner-Semmes RL et al. Safety, pharmokinetics and pharmacodynamics of remoglifozzin etabonate (SGLT2 inhibitor) and metformin when co-administered in Type 2 diabetes mellitus (T2DM) patients. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Presented At: 69th Scientifc Sessions of the American Diabetes Association
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Hussey, E.K.1
Kapur, A.2
O'Conner-Semmes, R.L.3
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240
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77949420924
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Remoglifozzin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), reduces serum glucose in Type 2 diabetes mellitus (T2DM) patients
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New Orleans, LA, USA 5-9 June
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Dobbins RL, Kapur A, Kapitza C et al. Remoglifozzin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), reduces serum glucose in Type 2 diabetes mellitus (T2DM) patients. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Presented At: 69th Scientifc Sessions of the American Diabetes Association
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Dobbins, R.L.1
Kapur, A.2
Kapitza, C.3
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242
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In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2 inhibitor
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New Orleans, LA, USA 5-9 June
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Grempler R, Thomas L, Eckhardt M et al. In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2 inhibitor. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Grempler, R.1
Thomas, L.2
Eckhardt, M.3
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243
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Effcacy and tolerability of rimonabant in overweight or obese patients with Type 2 diabetes: A randomised controlled study
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Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF. Effcacy and tolerability of rimonabant in overweight or obese patients with Type 2 diabetes: a randomised controlled study. Lancet 368(9548), 1660-1672 (2006).
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Naltrexone + bupropion combination causes signifcant weight loss: A 56-week Phase 3 study
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New Orleans, LA, USA 5-9 June
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Wadden, T.1
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Naltrexone + bupropion combination causes signifcant weight loss without worsening psychiatric symptoms
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New Orleans, LA, USA 5-9 June
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Klein S, Wadden T, Erickson J et al. Naltrexone + bupropion combination causes signifcant weight loss without worsening psychiatric symptoms. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Klein, S.1
Wadden, T.2
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Naltrexone + bupropion combination causes weight loss and improves quality of life
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New Orleans, LA, USA 5-9 June
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Wadden T, Pi-Sunyer FX, Erickson J et al. Naltrexone + bupropion combination causes weight loss and improves quality of life. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Wadden, T.1
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One-year treatment with VI-0521 in Type 2 diabetes demonstrates continued glycemic improvement and weight loss
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New Orleans, LA, USA 5-9 June
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Garvey W T, Troupin B, Tam P et al. One-year treatment with VI-0521 in Type 2 diabetes demonstrates continued glycemic improvement and weight loss. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
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Garvey, W.T.1
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248
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Discovery of PF-04620110: A selective DGAT-1 inhibitor for the treatment of Type 2 diabetes
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Half Moon Bay, CA, USA 22-23 September
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Dow R. Discovery of PF-04620110: a selective DGAT-1 inhibitor for the treatment of Type 2 diabetes. Presented at: Metabolic Diseases Drug Discovery & Development. Half Moon Bay, CA, USA, 22-23 September 2009.
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Presented At: Metabolic Diseases Drug Discovery & Development
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Dow, R.1
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249
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Discovery of AMG 221: An 11b-HSD1 inhibitor in the clinic for Type 2 diabetes
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Washington, DC, USA 16-20 August
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Fotsch C, Adams J, Bartberger M et al. Discovery of AMG 221: an 11b-HSD1 inhibitor in the clinic for Type 2 diabetes. Presented at: 238th ACS National Meeting and Exposition. Washington, DC, USA, 16-20 August 2009.
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Fotsch, C.1
Adams, J.2
Bartberger, M.3
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250
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Two asymmetric syntheses of AMG 221, an inhibitor of 11b-hydroxysteroid dehydrogenase Type 1
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Caille S, Cui S, Hwang TL, Wang X, Faul MM. Two asymmetric syntheses of AMG 221, an inhibitor of 11b-hydroxysteroid dehydrogenase Type 1. J. Org. Chem. 74(10), 3833-3842 (2009).
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Modulation of 11b-hydroxysteroid dehydrogenase (11bHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11bHSD1 inhibitor
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Courtney R, Stewart PM, Toh M, Ndongo MN, Calle RA, Hirshberg B. Modulation of 11b-hydroxysteroid dehydrogenase (11bHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11bHSD1 inhibitor. J. Clin. Endocrinol. Metab. 93(2), 550-556 (2008).
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