메뉴 건너뛰기




Volumn 3, Issue 2, 2010, Pages 209-229

Novel therapeutics and targets for the treatment of diabetes

Author keywords

cell; Diabetes; Therapy; Weight loss

Indexed keywords

ANTIDIABETIC AGENT; COLESEVELAM; DAPAGLIFLOZIN; EXENDIN 4; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOKINASE; GLUCOSE; INSULIN; MBX 2982; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIOGLITAZONE; PIRAGLIATIN; PLACEBO; PRAMLINTIDE; REMOGLIFLOZIN ETABONATE; RIMONABANT; RO 28 1675; ROSIGLITAZONE; SAXAGLIPTIN; SERGLIFLOZIN ETABONATE; SITAGLIPTIN; SULFONYLUREA; TOLBUTAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN;

EID: 77949355634     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/ecp.10.1     Document Type: Review
Times cited : (17)

References (251)
  • 1
    • 0030861943 scopus 로고    scopus 로고
    • Management of diabetes mellitus from a public health perspective
    • Roman SH, Harris ML. Management of diabetes mellitus from a public health perspective. Endocrinol. Metab. Clin. North. Am. 26(3), 443-474 (1997).
    • (1997) Endocrinol. Metab. Clin. North. Am. , vol.26 , Issue.3 , pp. 443-474
    • Roman, S.H.1    Harris, M.L.2
  • 2
    • 0242300698 scopus 로고    scopus 로고
    • Follow-up report on the diagnosis of diabetes mellitus
    • Genuth S, Alberti KG, Bennett P et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26(11), 3160-3167 (2003).
    • (2003) Diabetes Care , vol.26 , Issue.11 , pp. 3160-3167
    • Genuth, S.1    Alberti, K.G.2    Bennett, P.3
  • 3
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27(5), 1047-1053 (2004).
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 4
    • 33847645068 scopus 로고    scopus 로고
    • Impaired fasting glucose and impaired glucose tolerance: Implications for care
    • Nathan DM, Davidson MB, DeFronzo RA et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30(3), 753-759 (2007).
    • (2007) Diabetes Care , vol.30 , Issue.3 , pp. 753-759
    • Nathan, D.M.1    Davidson, M.B.2    Defronzo, R.A.3
  • 5
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world-a growing challenge
    • Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N. Engl. J. Med. 356(3), 213-215 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , Issue.3 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El Nahas, M.3
  • 7
    • 50249114066 scopus 로고    scopus 로고
    • Hepatic dysfunction and insulin insensitivity in Type 2 diabetes mellitus: A critical target for insulin-sensitizing agents
    • Home PD, Pacini G. Hepatic dysfunction and insulin insensitivity in Type 2 diabetes mellitus: a critical target for insulin-sensitizing agents. Diabetes Obes. Metab. 10(9), 699-718 (2008).
    • (2008) Diabetes Obes. Metab. , vol.10 , Issue.9 , pp. 699-718
    • Home, P.D.1    Pacini, G.2
  • 8
    • 0024026298 scopus 로고
    • Lilly lecture 1987. the triumvirate: B-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: b-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37(6), 667-687 (1988).
    • (1988) Diabetes , vol.37 , Issue.6 , pp. 667-687
    • Defronzo, R.A.1
  • 10
    • 64649104158 scopus 로고    scopus 로고
    • Banting lecture. from the triumvirate to the ominous octet: A new paradigm for the treatment of Type 2 diabetes mellitus
    • DeFronzo RA. Banting lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of Type 2 diabetes mellitus. Diabetes 58(4), 773-795 (2009)
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 773-795
    • Defronzo, R.A.1
  • 11
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The diabetes control and complications trial research group
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The diabetes control and complications trial research group. N. Engl. J. Med. 329(14), 977-986 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , Issue.14 , pp. 977-986
  • 12
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with Type 1 diabetes four years after a trial of intensive therapy the Diabetes Control and Retinopathy and nephropathy in patients with Type 1 diabetes four years after a trial of intensive therapy. the Diabetes Control and
    • Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N. Engl. J. Med. 342(6), 381-389 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , Issue.6 , pp. 381-389
  • 13
    • 33645700675 scopus 로고    scopus 로고
    • Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion
    • Martin CL, Albers J, Herman WH et al. Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care 29(2), 340-344 (2006).
    • (2006) Diabetes Care , vol.29 , Issue.2 , pp. 340-344
    • Martin, C.L.1    Albers, J.2    Herman, W.H.3
  • 14
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM, Adler AL, Neil HA et al. Association of glycaemia with macrovascular and microvascular complications of Type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321(7258), 405-412 (2000).
    • (2000) BMJ , vol.321 , Issue.7258 , pp. 405-412
    • Stratton, I.M.1    Adler, A.L.2    Neil, H.A.3
  • 15
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo Y, Kishikawa H, Araki E et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res. Clin. Pract. 28(2), 103-117 (1995).
    • (1995) Diabetes Res. Clin. Pract. , vol.28 , Issue.2 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 16
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34)
    • UK prospective diabetes study (UKPDS) group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with Type 2 diabetes (UKPDS 34). UK prospective diabetes study (UKPDS) group. Lancet 352(9131), 854-865 (1998).
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 854-865
  • 17
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33)
    • UK prospective diabetes study (UKPDS) group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33). UK prospective diabetes study (UKPDS) group. Lancet 352(9131), 837-853 (1998).
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 18
    • 0023136556 scopus 로고
    • Mortality and survival in Type 2 (non-insulin-dependent) diabetes mellitus
    • Panzram G. Mortality and survival in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30(3), 123-131 (1987).
    • (1987) Diabetologia , vol.30 , Issue.3 , pp. 123-131
    • Panzram, G.1
  • 19
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. the Framingham study
    • Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA 241(19), 2035-2038 (1979).
    • (1979) JAMA , vol.241 , Issue.19 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 20
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285(19), 2486-2497 (2001).
    • (2001) JAMA , vol.285 , Issue.19 , pp. 2486-2497
  • 22
    • 0030050623 scopus 로고    scopus 로고
    • Microalbuminuria in patients with NIDDM: An overview
    • Alzaid AA. Microalbuminuria in patients with NIDDM: an overview. Diabetes Care 19(1), 79-89 (1996).
    • (1996) Diabetes Care , vol.19 , Issue.1 , pp. 79-89
    • Alzaid, A.A.1
  • 25
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with Type diabetes
    • Nathan DM, Cleary PA, Backlund JY et al. Intensive diabetes treatment and cardiovascular disease in patients with Type diabetes. N. Engl. J. Med. 353(25), 2643-2653 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , Issue.25 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 27
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with Type 2 diabetes
    • Duckworth W, Abraira C, Moritz T et al. Glucose control and vascular complications in veterans with Type 2 diabetes. N. Engl. J. Med. 360(2), 129-139 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 28
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in Type 2 diabetes
    • Gerstein HC, Miller ME, Byington RP et al. Effects of intensive glucose lowering in Type 2 diabetes. N. Engl. J. Med. 358(24), 2545-2559 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3
  • 29
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356(24), 2457-2471 (2007).
    • (2007) N. Engl. J. Med. , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 30
    • 35848930559 scopus 로고    scopus 로고
    • Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death
    • Diamond GA, Bax L, Kaul S. Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death. Ann. Intern. Med. 147(8), 578-581 (2007).
    • (2007) Ann. Intern. Med. , vol.147 , Issue.8 , pp. 578-581
    • Diamond, G.A.1    Bax, L.2    Kaul, S.3
  • 31
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in Type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB et al. Medical management of hyperglycemia in Type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32(1), 193-203 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 32
    • 63149173251 scopus 로고    scopus 로고
    • Standards of medical care in diabetes-2009
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes-2009. Diabetes Care 32(Suppl. 1), S13-S61 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 1
  • 33
    • 0031690490 scopus 로고    scopus 로고
    • Insulin degradation: Progress and potential
    • Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr. Rev. 19(5), 608-624 (1998).
    • (1998) Endocr. Rev. , vol.19 , Issue.5 , pp. 608-624
    • Duckworth, W.C.1    Bennett, R.G.2    Hamel, F.G.3
  • 34
    • 35048841093 scopus 로고    scopus 로고
    • Insulin-associated weight gain in diabetes-causes, effects and coping strategies
    • Russell-Jones D, Khan R. Insulin-associated weight gain in diabetes-causes, effects and coping strategies. Diabetes Obes. Metab. 9(6), 799-812 (2007).
    • (2007) Diabetes Obes. Metab. , vol.9 , Issue.6 , pp. 799-812
    • Russell-Jones, D.1    Khan, R.2
  • 35
    • 0036021746 scopus 로고    scopus 로고
    • Breaking the barriers to optimal glycaemic control-what physicians need to know from patients' perspectives
    • Snoek FJ. Breaking the barriers to optimal glycaemic control-what physicians need to know from patients' perspectives. Int. J. Clin. Pract. Suppl. 129, 80-84 (2002).
    • (2002) Int. J. Clin. Pract. Suppl. , vol.129 , pp. 80-84
    • Snoek, F.J.1
  • 37
    • 0037768213 scopus 로고    scopus 로고
    • Metformin as an adjunct therapy in adolescents with Type 1 diabetes and insulin resistance: A randomized controlled trial
    • Hamilton J, Cummings E, Zdravkovic V, Finegood D, Daneman D. Metformin as an adjunct therapy in adolescents with Type 1 diabetes and insulin resistance: a randomized controlled trial. Diabetes Care 26(1), 138-143 (2003).
    • (2003) Diabetes Care , vol.26 , Issue.1 , pp. 138-143
    • Hamilton, J.1    Cummings, E.2    Zdravkovic, V.3    Finegood, D.4    Daneman, D.5
  • 38
    • 8144228619 scopus 로고    scopus 로고
    • Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: A 1-year, randomized controlled trial
    • Ratner RE, Dickey R, Fineman M et al. Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. Diabet. Med. 21(11), 1204-1212 (2004).
    • (2004) Diabet. Med. , vol.21 , Issue.11 , pp. 1204-1212
    • Ratner, R.E.1    Dickey, R.2    Fineman, M.3
  • 39
    • 18844376324 scopus 로고    scopus 로고
    • 1c without concomitant weight gain and increased risk of severe hypoglycemia in patients with Type 1 diabetes approaching glycemic targets
    • 1c without concomitant weight gain and increased risk of severe hypoglycemia in patients with Type 1 diabetes approaching glycemic targets. Exp. Clin. Endocrinol. Diabetes 113(4), 199-204 (2005).
    • (2005) Exp. Clin. Endocrinol. Diabetes , vol.113 , Issue.4 , pp. 199-204
    • Ratner, R.1    Whitehouse, F.2    Fineman, M.S.3
  • 41
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108(8), 1167-1174 (2001).
    • (2001) J. Clin. Invest. , vol.108 , Issue.8 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 42
    • 0036299982 scopus 로고    scopus 로고
    • Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with Type 2 diabetes
    • Musi N, Hirshman MF, Nygren J et al. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with Type 2 diabetes. Diabetes 51(7), 2074-2081 (2002).
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2074-2081
    • Musi, N.1    Hirshman, M.F.2    Nygren, J.3
  • 43
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: A review of its metabolic effects
    • Cusi K, DeFronzo RA. Metformin: a review of its metabolic effects. Diabetes Rev. 6, 89-131 (1998).
    • (1998) Diabetes Rev. , vol.6 , pp. 89-131
    • Cusi, K.1    Defronzo, R.A.2
  • 44
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with Type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • UK prospective diabetes study (UKPDS) group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with Type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK prospective diabetes study (UKPDS) group. JAMA 281(21), 2005-2012 (1999).
    • (1999) JAMA , vol.281 , Issue.21 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 45
    • 35748947212 scopus 로고    scopus 로고
    • Novel selective estrogen receptor modulators (SERMs)
    • Macor JE (Ed.). Academic Press, NY, USA
    • Dodge JA, Richardson TL. Novel selective estrogen receptor modulators (SERMs). In: Annual Reports in Medicinal Chemistry (Volume 42). Macor JE (Ed.). Academic Press, NY, USA 147-160 (2007).
    • (2007) Annual Reports in Medicinal Chemistry , vol.42 , pp. 147-160
    • Dodge, J.A.1    Richardson, T.L.2
  • 46
    • 13844262924 scopus 로고    scopus 로고
    • Corepressors selectively control the transcriptional activity of PPARg in adipocytes
    • Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA. Corepressors selectively control the transcriptional activity of PPARg in adipocytes. Genes Dev. 19(4), 453-461 (2005).
    • (2005) Genes Dev. , vol.19 , Issue.4 , pp. 453-461
    • Guan, H.P.1    Ishizuka, T.2    Chui, P.C.3    Lehrke, M.4    Lazar, M.A.5
  • 47
    • 33746080426 scopus 로고    scopus 로고
    • Genome-wide identifcation of peroxisome proliferator response elements using integrated computational genomics
    • Lemay DG, Hwang DH. Genome-wide identifcation of peroxisome proliferator response elements using integrated computational genomics. J. Lipid Res. 47(7), 1583-1587 (2006).
    • (2006) J. Lipid Res. , vol.47 , Issue.7 , pp. 1583-1587
    • Lemay, D.G.1    Hwang, D.H.2
  • 48
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 298(10), 1189-1195 (2007).
    • (2007) JAMA , vol.298 , Issue.10 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 49
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with Type 2 diabetes in the PROactive study (Prospective Pioglitazone Clinical Trial in Macrovascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ et al. Secondary prevention of macrovascular events in patients with Type 2 diabetes in the PROactive study (Prospective Pioglitazone Clinical Trial in Macrovascular Events): a randomised controlled trial. Lancet 366(9493), 1279-1289 (2005).
    • (2005) Lancet , vol.366 , Issue.9493 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3
  • 50
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with Type 2 diabetes mellitus: A meta-analysis of randomized trials
    • Lincoff AM, Wolski K, Nicholls SJ, Nissen SE. Pioglitazone and risk of cardiovascular events in patients with Type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 298(10), 1180-1188 (2007).
    • (2007) JAMA , vol.298 , Issue.10 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 53
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione use, fuid retention, and congestive heart failure: A consensus statement from the American Heart Association and American Diabetes Association
    • Nesto RW, Bell D, Bonow RO et al. Thiazolidinedione use, fuid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 27(1), 256-263 (2004).
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3
  • 54
    • 36448968168 scopus 로고    scopus 로고
    • Bodyweight changes associated with antihyperglycaemic agents in Type 2 diabetes mellitus
    • Hermansen K, Mortensen LS. Bodyweight changes associated with antihyperglycaemic agents in Type 2 diabetes mellitus. Drug Saf. 30(12), 1127-1142 (2007).
    • (2007) Drug Saf. , vol.30 , Issue.12 , pp. 1127-1142
    • Hermansen, K.1    Mortensen, L.S.2
  • 55
    • 34250865768 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis
    • Home PD, Pocock SJ, Beck-Nielsen H et al. Rosiglitazone evaluated for cardiovascular outcomes-an interim analysis. N. Engl. J. Med. 357(1), 28-38 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , Issue.1 , pp. 28-38
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 56
    • 34547700735 scopus 로고    scopus 로고
    • Thiazolidinediones and heart failure: A teleo-analysis
    • Singh S, Loke YK, Furberg CD. Thiazolidinediones and heart failure: a teleo-analysis. Diabetes Care 30(8), 2148-2153 (2007).
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 2148-2153
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 57
    • 49849083531 scopus 로고    scopus 로고
    • Pharmacological differences of glitazones: Does peroxisome proliferator-activated receptor-g activation make the difference?
    • Kintscher U. Pharmacological differences of glitazones: does peroxisome proliferator-activated receptor-g activation make the difference? J. Am. Coll. Cardiol. 52(10), 882-884 (2008).
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.10 , pp. 882-884
    • Kintscher, U.1
  • 58
    • 59149084957 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor g agonists as insulin sensitizers: From the discovery to recent progress
    • Cho N, Momose Y. Peroxisome proliferator-activated receptor g agonists as insulin sensitizers: from the discovery to recent progress. Curr. Top. Med. Chem. 8(17), 1483-1507 (2008).
    • (2008) Curr. Top. Med. Chem. , vol.8 , Issue.17 , pp. 1483-1507
    • Cho, N.1    Momose, Y.2
  • 59
    • 33646045898 scopus 로고    scopus 로고
    • Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
    • Balint BL, Nagy L. Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocr. Metab. Immune Disord. Drug Targets 6(1), 33-43 (2006).
    • (2006) Endocr. Metab. Immune Disord. Drug Targets , vol.6 , Issue.1 , pp. 33-43
    • Balint, B.L.1    Nagy, L.2
  • 60
    • 49449087092 scopus 로고    scopus 로고
    • Effcacy and safety of colesevelam in patients with Type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy
    • Goldberg RB, Fonseca VA, Truitt KE, Jones MR. Effcacy and safety of colesevelam in patients with Type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy. Arch. Intern. Med. 168(14), 1531-1540 (2008).
    • (2008) Arch. Intern. Med. , vol.168 , Issue.14 , pp. 1531-1540
    • Goldberg, R.B.1    Fonseca, V.A.2    Truitt, K.E.3    Jones, M.R.4
  • 61
    • 49649095014 scopus 로고    scopus 로고
    • Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled Type 2 diabetes on sulfonylurea-based therapy
    • Fonseca VA, Rosenstock J, Wang AC, Truitt KE, Jones MR. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled Type 2 diabetes on sulfonylurea-based therapy. Diabetes Care 31(8), 1479-1484 (2008).
    • (2008) Diabetes Care , vol.31 , Issue.8 , pp. 1479-1484
    • Fonseca, V.A.1    Rosenstock, J.2    Wang, A.C.3    Truitt, K.E.4    Jones, M.R.5
  • 62
    • 54049103635 scopus 로고    scopus 로고
    • Colesevelam hydrochloride therapy in patients with Type 2 diabetes mellitus treated with metformin: Glucose and lipid effects
    • Bays HE, Goldberg RB, Truitt KE, Jones MR. Colesevelam hydrochloride therapy in patients with Type 2 diabetes mellitus treated with metformin: glucose and lipid effects. Arch. Intern. Med. 168(18), 1975-1983 (2008).
    • (2008) Arch. Intern. Med. , vol.168 , Issue.18 , pp. 1975-1983
    • Bays, H.E.1    Goldberg, R.B.2    Truitt, K.E.3    Jones, M.R.4
  • 63
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of welchol study (GLOWS): A randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with Type 2 diabetes
    • Zieve FJ, Kalin MF, Schwartz SL, Jones MR, Bailey WL. Results of the glucose-lowering effect of welchol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with Type 2 diabetes. Clin. Ther. 29(1), 74-83 (2007).
    • (2007) Clin. Ther. , vol.29 , Issue.1 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5
  • 65
    • 69849083064 scopus 로고    scopus 로고
    • Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as frst-line therapy in Type 2 diabetes and colesevelam HCl in prediabetes
    • Jones MR, Mudaliar S, Hernandez-Triana E et al. Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as frst-line therapy in Type 2 diabetes and colesevelam HCl in prediabetes. Curr. Med. Res. Opin. 25(9), 2239-2249 (2009).
    • (2009) Curr. Med. Res. Opin. , vol.25 , Issue.9 , pp. 2239-2249
    • Jones, M.R.1    Mudaliar, S.2    Hernandez-Triana, E.3
  • 66
    • 33645997712 scopus 로고    scopus 로고
    • Meglitinide analogues: A review of clinical data focused on recent trials
    • Blickle JF. Meglitinide analogues: a review of clinical data focused on recent trials. Diabetes Metab. 32(2), 113-120 (2006).
    • (2006) Diabetes Metab. , vol.32 , Issue.2 , pp. 113-120
    • Blickle, J.F.1
  • 67
    • 0029024314 scopus 로고
    • Cloning of the b cell high-affnity sulfonylurea receptor: A regulator of insulin secretion
    • Aguilar-Bryan L, Nichols CG, Wechsler SW et al. Cloning of the b cell high-affnity sulfonylurea receptor: a regulator of insulin secretion. Science 268(5209), 423-426 (1995).
    • (1995) Science , vol.268 , Issue.5209 , pp. 423-426
    • Aguilar-Bryan, L.1    Nichols, C.G.2    Wechsler, S.W.3
  • 68
    • 0029658824 scopus 로고    scopus 로고
    • Mechanisms of the glycaemic effects of sulfonylureas
    • Ashcroft FM. Mechanisms of the glycaemic effects of sulfonylureas. Horm. Metab. Res. 28(9), 456-463 (1996).
    • (1996) Horm. Metab. Res. , vol.28 , Issue.9 , pp. 456-463
    • Ashcroft, F.M.1
  • 69
    • 9444242168 scopus 로고    scopus 로고
    • Desensitization of insulin secretion by depolarizing insulin secretagogues
    • Rustenbeck I, Wienbergen A, Bleck C, Jorns A. Desensitization of insulin secretion by depolarizing insulin secretagogues. Diabetes 53(Suppl. 3), S140-S150 (2004).
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Rustenbeck, I.1    Wienbergen, A.2    Bleck, C.3    Jorns, A.4
  • 70
    • 14644404951 scopus 로고    scopus 로고
    • Comparison of pioglitazone and gliclazide in sustaining glycemic control over 2 years in patients with Type 2 diabetes
    • Tan MH, Baksi A, Krahulec B et al. Comparison of pioglitazone and gliclazide in sustaining glycemic control over 2 years in patients with Type 2 diabetes. Diabetes Care 28(3), 544-550 (2005).
    • (2005) Diabetes Care , vol.28 , Issue.3 , pp. 544-550
    • Tan, M.H.1    Baksi, A.2    Krahulec, B.3
  • 71
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N. Engl. J. Med. 355(23), 2427-2443 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , Issue.23 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 72
    • 33745700035 scopus 로고    scopus 로고
    • Glycemic control and treatment failure with pioglitazone versus glibenclamide in Type 2 diabetes mellitus: A 42-month, open-label, observational, primary care study
    • Hanefeld M, Pfutzner A, Forst T, Lubben G. Glycemic control and treatment failure with pioglitazone versus glibenclamide in Type 2 diabetes mellitus: a 42-month, open-label, observational, primary care study. Curr. Med. Res. Opin. 22(6), 1211-1215 (2006).
    • (2006) Curr. Med. Res. Opin. , vol.22 , Issue.6 , pp. 1211-1215
    • Hanefeld, M.1    Pfutzner, A.2    Forst, T.3    Lubben, G.4
  • 74
    • 34547658090 scopus 로고    scopus 로고
    • Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic b-cell death in the chronic phase
    • Takahashi A, Nagashima K, Hamasaki A et al. Sulfonylurea and glinide reduce insulin content, functional expression of K(ATP) channels, and accelerate apoptotic b-cell death in the chronic phase. Diabetes Res. Clin. Pract. 77(3), 343-350 (2007).
    • (2007) Diabetes Res. Clin. Pract. , vol.77 , Issue.3 , pp. 343-350
    • Takahashi, A.1    Nagashima, K.2    Hamasaki, A.3
  • 75
    • 53949097376 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in b cells: Latent mechanism of secondary sulfonylurea failure in Type 2 diabetes? Med
    • Qian L, Zhang S, Xu L, Peng Y. Endoplasmic reticulum stress in b cells: latent mechanism of secondary sulfonylurea failure in Type 2 diabetes? Med. Hypotheses 71(6), 889-891 (2008).
    • (2008) Hypotheses , vol.71 , Issue.6 , pp. 889-891
    • Qian, L.1    Zhang, S.2    Xu, L.3    Peng, Y.4
  • 76
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr. Rev. 29(1), 42-61 (2008).
    • (2008) Endocr. Rev. , vol.29 , Issue.1 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 77
    • 33745202552 scopus 로고    scopus 로고
    • WFS1-defciency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifcally in pancreatic b-cells
    • Yamada T, Ishihara H, Tamura A et al. WFS1-defciency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifcally in pancreatic b-cells. Hum. Mol. Genet. 15(10), 1600-1609 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , Issue.10 , pp. 1600-1609
    • Yamada, T.1    Ishihara, H.2    Tamura, A.3
  • 78
    • 28244435870 scopus 로고    scopus 로고
    • WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic b-cells
    • Fonseca SG, Fukuma M, Lipson KL et al. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic b-cells. J. Biol. Chem. 280(47), 39609-39615 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.47 , pp. 39609-39615
    • Fonseca, S.G.1    Fukuma, M.2    Lipson, K.L.3
  • 79
    • 67349176115 scopus 로고    scopus 로고
    • Protein-coupled receptors as potential targets for treatment of Type 2 diabetes
    • Ahren B. Islet G protein-coupled receptors as potential targets for treatment of Type 2 diabetes. Nat. Rev. Drug Discov. 8(5), 369-385 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.5 , pp. 369-385
    • Ahren, B.1    Islet, G.2
  • 80
    • 0033304603 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr. Rev. 20(6), 876-913 (1999).
    • (1999) Endocr. Rev. , vol.20 , Issue.6 , pp. 876-913
    • Kieffer, T.J.1    Habener, J.F.2
  • 81
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak M, Orskov C, Holst JJ, Ahren B, Efendic S. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326(20), 1316-1322 (1992).
    • (1992) N. Engl. J. Med. , vol.326 , Issue.20 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3    Ahren, B.4    Efendic, S.5
  • 82
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379(6560), 69-72 (1996).
    • (1996) Nature , vol.379 , Issue.6560 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 83
    • 0022617246 scopus 로고
    • Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes. Diabetologia 29(1), 46-52 (1986).
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 84
    • 34547702501 scopus 로고    scopus 로고
    • Mechanisms by which common variants in the TCF7L2 gene increase risk of Type 2 diabetes
    • Lyssenko V, Lupi R, Marchetti P et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of Type 2 diabetes. J. Clin. Invest. 117(8), 2155-2163 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.8 , pp. 2155-2163
    • Lyssenko, V.1    Lupi, R.2    Marchetti, P.3
  • 85
    • 65549124145 scopus 로고    scopus 로고
    • Exenatide: Clinical aspects of the frst incretin-mimetic for the treatment of Type 2 diabetes mellitus
    • Wajcberg E, Tavaria A. Exenatide: clinical aspects of the frst incretin-mimetic for the treatment of Type 2 diabetes mellitus. Expert Opin. Pharmacother. 10(1), 135-142 (2009).
    • (2009) Expert Opin. Pharmacother. , vol.10 , Issue.1 , pp. 135-142
    • Wajcberg, E.1    Tavaria, A.2
  • 87
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for Type 2 diabetes (lead-3 mono): A randomised, 52-week, Phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R et al. Liraglutide versus glimepiride monotherapy for Type 2 diabetes (lead-3 mono): a randomised, 52-week, Phase III, double-blind, parallel-treatment trial. Lancet 373(9662), 473-481 (2009).
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 89
    • 68849092593 scopus 로고    scopus 로고
    • Taspoglutide: A long acting human glucagon-like polypeptide-1 analogue
    • Retterstol K. Taspoglutide: a long acting human glucagon-like polypeptide-1 analogue. Expert Opin. Investig. Drugs 18(9), 1405-1411 (2009).
    • (2009) Expert Opin. Investig. Drugs , vol.18 , Issue.9 , pp. 1405-1411
    • Retterstol, K.1
  • 90
    • 57349168543 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with Type 2 diabetes
    • Matthews JE, Stewart MW, de Boever EH et al. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with Type 2 diabetes. J. Clin. Endocrinol. Metab. 93(12), 4810-4817 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.12 , pp. 4810-4817
    • Matthews, J.E.1    Stewart, M.W.2    De Boever, E.H.3
  • 91
    • 38049065376 scopus 로고    scopus 로고
    • Sitagliptin phosphate: A DPP-4 inhibitor for the treatment of Type 2 diabetes mellitus
    • Zerilli T, Pyon EY. Sitagliptin phosphate: a DPP-4 inhibitor for the treatment of Type 2 diabetes mellitus. Clin. Ther. 29(12), 2614-2634 (2007).
    • (2007) Clin. Ther. , vol.29 , Issue.12 , pp. 2614-2634
    • Zerilli, T.1    Pyon, E.Y.2
  • 92
    • 57349125875 scopus 로고    scopus 로고
    • Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of Type 2 diabetes
    • Gallwitz B. Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of Type 2 diabetes. IDrugs 11(12), 906-917 (2008).
    • (2008) IDrugs , vol.11 , Issue.12 , pp. 906-917
    • Gallwitz, B.1
  • 93
    • 55049090992 scopus 로고    scopus 로고
    • Vildagliptin: A review of its use in the management of Type 2 diabetes mellitus
    • Croxtall JD, Keam SJ. Vildagliptin: a review of its use in the management of Type 2 diabetes mellitus. Drugs 68(16), 2387-2409 (2008).
    • (2008) Drugs , vol.68 , Issue.16 , pp. 2387-2409
    • Croxtall, J.D.1    Keam, S.J.2
  • 94
    • 63049125578 scopus 로고    scopus 로고
    • Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 diabetes
    • Gupta R, Walunj SS, Tokala RK, Parsa K V, Singh SK, Pal M. Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 diabetes. Curr. Drug Targets 10(1), 71-87 (2009).
    • (2009) Curr. Drug Targets , vol.10 , Issue.1 , pp. 71-87
    • Gupta, R.1    Walunj, S.S.2    Tokala, R.K.3    Parsa, K.V.4    Singh, S.K.5    Pal, M.6
  • 95
    • 58149265313 scopus 로고    scopus 로고
    • Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes
    • Ahren B. Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes. Expert Opin. Emerg. Drugs 13(4), 593-607 (2008).
    • (2008) Expert Opin. Emerg. Drugs , vol.13 , Issue.4 , pp. 593-607
    • Ahren, B.1
  • 96
    • 40749157994 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide-mediated up-regulation of b-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2
    • Kim SJ, Nian C, Widenmaier S, McIntosh CH. Glucose-dependent insulinotropic polypeptide-mediated up-regulation of b-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol. Cell. Biol. 28(5), 1644-1656 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.5 , pp. 1644-1656
    • Kim, S.J.1    Nian, C.2    Widenmaier, S.3    McIntosh, C.H.4
  • 97
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both b-cell replication and neogenesis, resulting in increased b-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both b-cell replication and neogenesis, resulting in increased b-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48(12), 2270-2276 (1999).
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 98
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA et al. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49(5), 741-748 (2000).
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3
  • 99
    • 0036312680 scopus 로고    scopus 로고
    • Persistent improvement of Type 2 diabetes in the Goto-Kakizaki rat model by expansion of the b-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4
    • Tourrel C, Bailbe D, Lacorne M, Meile MJ, Kergoat M, Portha B. Persistent improvement of Type 2 diabetes in the Goto-Kakizaki rat model by expansion of the b-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes 51(5), 1443-1452 (2002).
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1443-1452
    • Tourrel, C.1    Bailbe, D.2    Lacorne, M.3    Meile, M.J.4    Kergoat, M.5    Portha, B.6
  • 100
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic b-cell mass and function in a rodent model of Type 2 diabetes
    • Mu J, Woods J, Zhou YP et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic b-cell mass and function in a rodent model of Type 2 diabetes. Diabetes 55(6), 1695-1704 (2006).
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3
  • 101
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates b-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik JA, Martin J, Doty T et al. Dipeptidyl peptidase IV inhibitor treatment stimulates b-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52(3), 741-750 (2003).
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3
  • 102
    • 43749120731 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic b-cell proliferation
    • Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic b-cell proliferation. J. Biol. Chem. 283(13), 8723-8735 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.13 , pp. 8723-8735
    • Liu, Z.1    Habener, J.F.2
  • 103
    • 53549129604 scopus 로고    scopus 로고
    • Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with Type 2 diabetes and mild hyperglycaemia
    • Scherbaum WA, Schweizer A, Mari A et al. Evidence that vildagliptin attenuates deterioration of glycaemic control during 2-year treatment of patients with Type 2 diabetes and mild hyperglycaemia. Diabetes Obes. Metab. 10(11), 1114-1124 (2008).
    • (2008) Diabetes Obes. Metab. , vol.10 , Issue.11 , pp. 1114-1124
    • Scherbaum, W.A.1    Schweizer, A.2    Mari, A.3
  • 104
    • 34248527678 scopus 로고    scopus 로고
    • A role for b-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release
    • Chu ZL, Jones RM, He H et al. A role for b-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 148(6), 2601-2609 (2007).
    • (2007) Endocrinology , vol.148 , Issue.6 , pp. 2601-2609
    • Chu, Z.L.1    Jones, R.M.2    He, H.3
  • 105
    • 42449126696 scopus 로고    scopus 로고
    • A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide release
    • Chu ZL, Carroll C, Alfonso J et al. A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide release. Endocrinology 149(5), 2038-2047 (2008).
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2038-2047
    • Chu, Z.L.1    Carroll, C.2    Alfonso, J.3
  • 106
    • 10644275303 scopus 로고    scopus 로고
    • Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor
    • Soga T, Ohishi T, Matsui T et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem. Biophys. Res. Commun. 326(4), 744-751 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.326 , Issue.4 , pp. 744-751
    • Soga, T.1    Ohishi, T.2    Matsui, T.3
  • 107
    • 65549142522 scopus 로고    scopus 로고
    • Gpr119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell
    • Lauffer LM, Iakoubov R, Brubaker PL. Gpr119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes 58(5), 1058-1066 (2009).
    • (2009) Diabetes , vol.58 , Issue.5 , pp. 1058-1066
    • Lauffer, L.M.1    Iakoubov, R.2    Brubaker, P.L.3
  • 108
    • 58149464981 scopus 로고    scopus 로고
    • Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
    • Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 52(2), 289-298 (2009).
    • (2009) Diabetologia , vol.52 , Issue.2 , pp. 289-298
    • Parker, H.E.1    Habib, A.M.2    Rogers, G.J.3    Gribble, F.M.4    Reimann, F.5
  • 109
    • 0242710648 scopus 로고    scopus 로고
    • Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives
    • Fredriksson R, Hoglund PJ, Gloriam DE et al. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554(3), 381-388 (2003).
    • (2003) FEBS Lett. , vol.554 , Issue.3 , pp. 381-388
    • Fredriksson, R.1    Hoglund, P.J.2    Gloriam, D.E.3
  • 110
    • 33644627958 scopus 로고    scopus 로고
    • Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
    • Overton HA, Babbs AJ, Doel SM et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3(3), 167-175 (2006).
    • (2006) Cell Metab. , vol.3 , Issue.3 , pp. 167-175
    • Overton, H.A.1    Babbs, A.J.2    Doel, S.M.3
  • 114
    • 51849099001 scopus 로고    scopus 로고
    • Discovery of the frst potent and orally effcacious agonist of the orphan G-protein coupled receptor 119
    • Semple G, Fioravanti B, Pereira G et al. Discovery of the frst potent and orally effcacious agonist of the orphan G-protein coupled receptor 119. J. Med. Chem. 51(17), 5172-5175 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.17 , pp. 5172-5175
    • Semple, G.1    Fioravanti, B.2    Pereira, G.3
  • 115
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of Type 2 diabetes and obesity
    • Overton HA, Fyfe MC, Reynet C. GPR119, a novel G protein-coupled receptor target for the treatment of Type 2 diabetes and obesity. Br. J. Pharmacol. 153(Suppl. 1), S76-S81 (2008).
    • (2008) Br. J. Pharmacol. , vol.153 , Issue.SUPPL. 1
    • Overton, H.A.1    Fyfe, M.C.2    Reynet, C.3
  • 118
    • 77949368048 scopus 로고    scopus 로고
    • GPR119 agonists acutely improve glycemia in rodents by delaying gastric emptying, increasing incretin levels and directly stimulating insulin secretion, and delay diabetes onset in female ZDF rats during chronic treatment
    • Banff, AB, Canada 20-25 January
    • Wilson M, Gregoire F, Pandey B et al. GPR119 agonists acutely improve glycemia in rodents by delaying gastric emptying, increasing incretin levels and directly stimulating insulin secretion, and delay diabetes onset in female ZDF rats during chronic treatment. Presented at: Keystone Symposium: Type 2 Diabetes and Insulin Resistance. Banff, AB, Canada, 20-25 January 2009.
    • (2009) Presented At: Keystone Symposium: Type 2 Diabetes and Insulin Resistance
    • Wilson, M.1    Gregoire, F.2    Pandey, B.3
  • 119
    • 70350292362 scopus 로고    scopus 로고
    • Bile-acid-activated receptors: Targeting TGR and farnesoid-X-receptor in lipid and glucose disorders
    • DOI: 10.1016/j.plipres.2009.11.001 Epub ahead of print
    • Fiorucci S, Mencarelli A, Palladino G, Cipriani S. Bile-acid-activated receptors: targeting TGR and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol. Sci. DOI: 10.1016/j.plipres.2009.11.001 (2009) (Epub ahead of print).
    • (2009) Trends Pharmacol. Sci.
    • Fiorucci, S.1    Mencarelli, A.2    Palladino, G.3    Cipriani, S.4
  • 120
    • 56449093424 scopus 로고    scopus 로고
    • Glucose sensing in L cells: A primary cell study
    • Reimann F, Habib AM, Tolhurst G et al. Glucose sensing in L cells: a primary cell study. Cell Metab. 8(6), 532-539 (2008).
    • (2008) Cell Metab. , vol.8 , Issue.6 , pp. 532-539
    • Reimann, F.1    Habib, A.M.2    Tolhurst, G.3
  • 121
    • 13844299425 scopus 로고    scopus 로고
    • Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
    • Katsuma S, Hirasawa A, Tsujimoto G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem. Biophys. Res. Commun. 329(1), 386-390 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , Issue.1 , pp. 386-390
    • Katsuma, S.1    Hirasawa, A.2    Tsujimoto, G.3
  • 122
    • 0003269455 scopus 로고    scopus 로고
    • A G protein-coupled receptor responsive to bile acids
    • Kawamata Y, Fujii R, Hosoya M et al. A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278(11), 9435-9440 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.11 , pp. 9435-9440
    • Kawamata, Y.1    Fujii, R.2    Hosoya, M.3
  • 123
    • 33749431724 scopus 로고    scopus 로고
    • Deiodinases: Implications of the local control of thyroid hormone action
    • Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J. Clin. Invest. 116(10), 2571-2579 (2006).
    • (2006) J. Clin. Invest. , vol.116 , Issue.10 , pp. 2571-2579
    • Bianco, A.C.1    Kim, B.W.2
  • 124
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439(7075), 484-489 (2006).
    • (2006) Nature , vol.439 , Issue.7075 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 125
    • 5744227334 scopus 로고    scopus 로고
    • Thyroid hormone ligands and metabolic diseases
    • Malm J. Thyroid hormone ligands and metabolic diseases. Curr. Pharm. Des. 10(28), 3525-3532 (2004).
    • (2004) Curr. Pharm. Des. , vol.10 , Issue.28 , pp. 3525-3532
    • Malm, J.1
  • 126
    • 0029044699 scopus 로고
    • Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine
    • Yokoyama N, Walker GN, Main AJ et al. Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. J. Med. Chem. 38(4), 695-707 (1995).
    • (1995) J. Med. Chem. , vol.38 , Issue.4 , pp. 695-707
    • Yokoyama, N.1    Walker, G.N.2    Main, A.J.3
  • 127
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10(3), 167-177 (2009).
    • (2009) Cell Metab. , vol.10 , Issue.3 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 128
    • 0036191639 scopus 로고    scopus 로고
    • Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases
    • Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr. Rev. 23(1), 38-89 (2002).
    • (2002) Endocr. Rev. , vol.23 , Issue.1 , pp. 38-89
    • Bianco, A.C.1    Salvatore, D.2    Gereben, B.3    Berry, M.J.4    Larsen, P.R.5
  • 129
    • 36148996843 scopus 로고    scopus 로고
    • G-protein-coupled receptors and islet function-implications for treatment of Type 2 diabetes
    • Winzell MS, Ahren B. G-protein-coupled receptors and islet function-implications for treatment of Type 2 diabetes. Pharmacol. Ther. 116(3), 437-448 (2007).
    • (2007) Pharmacol. Ther. , vol.116 , Issue.3 , pp. 437-448
    • Winzell, M.S.1    Ahren, B.2
  • 131
    • 47749128507 scopus 로고    scopus 로고
    • Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: Pharmacological, phylogenetic, and drug discovery aspects
    • Costanzi S, Neumann S, Gershengorn MC. Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects. J. Biol. Chem. 283(24), 16269-16273 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.24 , pp. 16269-16273
    • Costanzi, S.1    Neumann, S.2    Gershengorn, M.C.3
  • 132
    • 67649331670 scopus 로고    scopus 로고
    • Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): An emerging target for Type 2 diabetes
    • Bharate SB, Nemmani KV, Vishwakarma RA. Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for Type 2 diabetes. Expert Opin. Ther. Pat. 19(2), 237-264 (2009).
    • (2009) Expert Opin. Ther. Pat. , vol.19 , Issue.2 , pp. 237-264
    • Bharate, S.B.1    Nemmani, K.V.2    Vishwakarma, R.A.3
  • 133
    • 0037838892 scopus 로고    scopus 로고
    • The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
    • Briscoe CP, Tadayyon M, Andrews JL et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J. Biol. Chem. 278(13), 11303-11311 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.13 , pp. 11303-11311
    • Briscoe, C.P.1    Tadayyon, M.2    Andrews, J.L.3
  • 135
    • 65549114432 scopus 로고    scopus 로고
    • Overexpression of GPR40 in pancreatic b-cells augments GSIS and improves glucose tolerance in normal and diabetic mice
    • Nagasumi K, Esaki R, Iwachidow K et al. Overexpression of GPR40 in pancreatic b-cells augments GSIS and improves glucose tolerance in normal and diabetic mice. Diabetes 58(5), 1067-1076 (2009).
    • (2009) Diabetes , vol.58 , Issue.5 , pp. 1067-1076
    • Nagasumi, K.1    Esaki, R.2    Iwachidow, K.3
  • 136
    • 65549096659 scopus 로고    scopus 로고
    • GPR40: Good cop bad cop?
    • Alquier T, Poitout V. GPR40: good cop, bad cop? Diabetes 58(5), 1035-1036 (2009).
    • (2009) Diabetes , vol.58 , Issue.5 , pp. 1035-1036
    • Alquier, T.1    Poitout, V.2
  • 138
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    • Hirasawa A, Tsumaya K, Awaji T et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat. Med. 11(1), 90-94 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.1 , pp. 90-94
    • Hirasawa, A.1    Tsumaya, K.2    Awaji, T.3
  • 139
    • 54349086815 scopus 로고    scopus 로고
    • Modulation of osteoclastogenesis by fatty acids
    • Cornish J, MacGibbon A, Lin JM et al. Modulation of osteoclastogenesis by fatty acids. Endocrinology 149(11), 5688-5695 (2008).
    • (2008) Endocrinology , vol.149 , Issue.11 , pp. 5688-5695
    • Cornish, J.1    MacGibbon, A.2    Lin, J.M.3
  • 140
    • 57349135245 scopus 로고    scopus 로고
    • Identifcation of G protein-coupled receptor 120-selective agonists derived from PPAR-g agonists
    • Suzuki T, Igari S, Hirasawa A et al. Identifcation of G protein-coupled receptor 120-selective agonists derived from PPAR-g agonists. J. Med. Chem. 51(23), 7640-7644 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.23 , pp. 7640-7644
    • Suzuki, T.1    Igari, S.2    Hirasawa, A.3
  • 141
    • 68349086914 scopus 로고    scopus 로고
    • Novel selective ligands for free fatty acid receptors GPR120 and GPR40
    • Hara T, Hirasawa A, Sun Q et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch. Pharmacol. 380(3), 247-255 (2009).
    • (2009) Naunyn Schmiedebergs Arch. Pharmacol. , vol.380 , Issue.3 , pp. 247-255
    • Hara, T.1    Hirasawa, A.2    Sun, Q.3
  • 142
    • 67349139275 scopus 로고    scopus 로고
    • Assessing the potential of glucokinase activators in diabetes therapy
    • Matschinsky FM. Assessing the potential of glucokinase activators in diabetes therapy. Nat. Rev. Drug Discov. 8(5), 399-416 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.5 , pp. 399-416
    • Matschinsky, F.M.1
  • 143
    • 39049086785 scopus 로고    scopus 로고
    • Glucokinase activators in diabetes management
    • Coghlan M, Leighton B. Glucokinase activators in diabetes management. Expert Opin. Investig. Drugs 17(2), 145-167 (2008).
    • (2008) Expert Opin. Investig. Drugs , vol.17 , Issue.2 , pp. 145-167
    • Coghlan, M.1    Leighton, B.2
  • 144
    • 67651213750 scopus 로고    scopus 로고
    • Recent advances in glucokinase activators for the treatment of Type 2 diabetes
    • Pal M. Recent advances in glucokinase activators for the treatment of Type 2 diabetes. Drug Discov. Today 14(15-16), 784-792 (2009).
    • (2009) Drug Discov. Today , vol.14 , Issue.15-16 , pp. 784-792
    • Pal, M.1
  • 146
    • 59149101384 scopus 로고    scopus 로고
    • Glucokinase activators for the potential treatment of Type 2 diabetes
    • Grimsby J, Berthel SJ, Sarabu R. Glucokinase activators for the potential treatment of Type 2 diabetes. Curr. Top. Med. Chem. 8(17), 1524-1532 (2008).
    • (2008) Curr. Top. Med. Chem. , vol.8 , Issue.17 , pp. 1524-1532
    • Grimsby, J.1    Berthel, S.J.2    Sarabu, R.3
  • 147
    • 1542791635 scopus 로고    scopus 로고
    • Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
    • Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure 12(3), 429-438 (2004).
    • (2004) Structure , vol.12 , Issue.3 , pp. 429-438
    • Kamata, K.1    Mitsuya, M.2    Nishimura, T.3    Eiki, J.4    Nagata, Y.5
  • 148
    • 0037624071 scopus 로고    scopus 로고
    • Allosteric activators of glucokinase: Potential role in diabetes therapy
    • Grimsby J, Sarabu R, Corbett WL et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301(5631), 370-373 (2003).
    • (2003) Science , vol.301 , Issue.5631 , pp. 370-373
    • Grimsby, J.1    Sarabu, R.2    Corbett, W.L.3
  • 149
    • 20144389644 scopus 로고    scopus 로고
    • Discovery, synthesis and biological evaluation of novel glucokinase activators
    • McKerrecher D, Allen JV, Bowker SS et al. Discovery, synthesis and biological evaluation of novel glucokinase activators. Bioorg. Med. Chem. Lett. 15(8), 2103-2106 (2005).
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , Issue.8 , pp. 2103-2106
    • McKerrecher, D.1    Allen, J.V.2    Bowker, S.S.3
  • 150
    • 33748989539 scopus 로고    scopus 로고
    • Predictive blood glucose lowering effcacy by glucokinase activators in high fat fed female Zucker rats
    • Coope GJ, Atkinson AM, Allott C et al. Predictive blood glucose lowering effcacy by glucokinase activators in high fat fed female Zucker rats. Br. J. Pharmacol. 149(3), 328-335 (2006).
    • (2006) Br. J. Pharmacol. , vol.149 , Issue.3 , pp. 328-335
    • Coope, G.J.1    Atkinson, A.M.2    Allott, C.3
  • 151
    • 34249683855 scopus 로고    scopus 로고
    • Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator
    • Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Diabetes 56(6), 1694-1702 (2007).
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1694-1702
    • Johnson, D.1    Shepherd, R.M.2    Gill, D.3    Gorman, T.4    Smith, D.M.5    Dunne, M.J.6
  • 153
    • 23844550012 scopus 로고    scopus 로고
    • A novel glucokinase activator modulates pancreatic islet and hepatocyte function
    • Efanov AM, Barrett DG, Brenner MB et al. A novel glucokinase activator modulates pancreatic islet and hepatocyte function. Endocrinology 146(9), 3696-3701 (2005).
    • (2005) Endocrinology , vol.146 , Issue.9 , pp. 3696-3701
    • Efanov, A.M.1    Barrett, D.G.2    Brenner, M.B.3
  • 155
    • 34247862169 scopus 로고    scopus 로고
    • Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions
    • Fyfe MC, White JR, Taylor A et al. Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions. Diabetologia 50(6), 1277-1287 (2007).
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1277-1287
    • Fyfe, M.C.1    White, J.R.2    Taylor, A.3
  • 156
    • 47749124955 scopus 로고    scopus 로고
    • SAR, pharmacokinetics, safety, and effcacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: Discovery of PSN-GK1
    • Bertram LS, Black D, Briner PH et al. SAR, pharmacokinetics, safety, and effcacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1. J. Med. Chem. 51(14), 4340-4345 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.14 , pp. 4340-4345
    • Bertram, L.S.1    Black, D.2    Briner, P.H.3
  • 157
    • 33845979134 scopus 로고    scopus 로고
    • An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism
    • Futamura M, Hosaka H, Kadotani A et al. An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism. J. Biol. Chem. 281(49), 37668-37674 (2006).
    • (2006) J. Biol. Chem. , vol.281 , Issue.49 , pp. 37668-37674
    • Futamura, M.1    Hosaka, H.2    Kadotani, A.3
  • 158
    • 69949100799 scopus 로고    scopus 로고
    • Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators
    • Iino T, Sasaki Y, Bamba M et al. Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators. Bioorg. Med. Chem. Lett. 19(19), 5531-5538 (2009).
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.19 , pp. 5531-5538
    • Iino, T.1    Sasaki, Y.2    Bamba, M.3
  • 159
    • 69949164182 scopus 로고    scopus 로고
    • The design and optimization of a series of 2-(pyridin-2-yl)-1H- benzimidazole compounds as allosteric glucokinase activators
    • Takahashi K, Hashimoto N, Nakama C et al. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg. Med. Chem. 17(19), 7042-7051 (2009).
    • (2009) Bioorg. Med. Chem. , vol.17 , Issue.19 , pp. 7042-7051
    • Takahashi, K.1    Hashimoto, N.2    Nakama, C.3
  • 160
    • 67651203155 scopus 로고    scopus 로고
    • ARRY-588 and ARRY-403: Novel glucokinase activators with potent glucose-lowering activity in animal models of Type 2 diabetes mellitus
    • London UK 26 September
    • Boyd SA. ARRY-588 and ARRY-403: novel glucokinase activators with potent glucose-lowering activity in animal models of Type 2 diabetes mellitus. Presented at: SMI Metabolic Diseases Conference. London, UK, 26 September 2008.
    • (2008) Presented At: SMI Metabolic Diseases Conference
    • Boyd, S.A.1
  • 161
    • 77949419493 scopus 로고    scopus 로고
    • ARRY-403, a novel glucokinase activator with potent glucose-dependent anti-hyperglycemic activity in animal models of Type 2 diabetes mellitus
    • Banff, AB, Canada 20-25 January
    • Aicher TD, Anderson D, Boyd SA et al. ARRY-403, a novel glucokinase activator with potent glucose-dependent anti-hyperglycemic activity in animal models of Type 2 diabetes mellitus. Presented at: Keystone Symposium: Type 2 Diabetes and Insulin Resistance. Banff, AB, Canada, 20-25 January 2009.
    • (2009) Presented At: Keystone Symposium: Type 2 Diabetes and Insulin Resistance
    • Aicher, T.D.1    Anderson, D.2    Boyd, S.A.3
  • 162
    • 77949389859 scopus 로고    scopus 로고
    • Combination therapy of ARRY-403 with metformin, sitagliptin, or pioglitazone results in additive glucose lowering in female ZDF rats
    • Banff, AB, Canada 20-25 January
    • McVean M, Aicher TD, Boyd SA et al. Combination therapy of ARRY-403 with metformin, sitagliptin, or pioglitazone results in additive glucose lowering in female ZDF rats. Presented at: Keystone Symposium: Type 2 Diabetes and Insulin Resistance. Banff, AB, Canada, 20-25 January 2009.
    • (2009) Presented At: Keystone Symposium: Type 2 Diabetes and Insulin Resistance
    • McVean, M.1    Aicher, T.D.2    Boyd, S.A.3
  • 163
    • 70349641037 scopus 로고    scopus 로고
    • Investigation of functionally liver selective glucokinase activators for the treatment of Type 2 diabetes
    • Bebernitz GR, Beaulieu V, Dale BA et al. Investigation of functionally liver selective glucokinase activators for the treatment of Type 2 diabetes. J. Med. Chem. 52(19), 6142-6152 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.19 , pp. 6142-6152
    • Bebernitz, G.R.1    Beaulieu, V.2    Dale, B.A.3
  • 164
    • 34447632817 scopus 로고    scopus 로고
    • Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of Type 2 diabetes
    • Van Poelje PD, Dang Q, Erion MD. Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of Type 2 diabetes. Curr. Opin. Drug Discov. Devel. 10(4), 430-437 (2007).
    • (2007) Curr. Opin. Drug Discov. Devel. , vol.10 , Issue.4 , pp. 430-437
    • Van Poelje, P.D.1    Dang, Q.2    Erion, M.D.3
  • 165
    • 0020669367 scopus 로고
    • Regulation of fructose-bisphosphatase activity
    • Tejwani GA. Regulation of fructose-bisphosphatase activity. Adv. Enzymol. Relat. Areas Mol. Biol. 54, 121-194 (1983).
    • (1983) Adv. Enzymol. Relat. Areas Mol. Biol. , vol.54 , pp. 121-194
    • Tejwani, G.A.1
  • 166
    • 37849024068 scopus 로고    scopus 로고
    • Discovery of potent and specifc fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of Type 2 diabetes
    • Dang Q, Kasibhatla SR, Reddy KR et al. Discovery of potent and specifc fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of Type 2 diabetes. J. Am. Chem. Soc. 129(50), 15491-15502 (2007).
    • (2007) J. Am. Chem. Soc. , vol.129 , Issue.50 , pp. 15491-15502
    • Dang, Q.1    Kasibhatla, S.R.2    Reddy, K.R.3
  • 167
    • 77949346840 scopus 로고    scopus 로고
    • MB07803, a prodrug of a second generation fructose-1,6-bisphosphatase inhibitor, lowers blood glucose in diabetic rodents and in cynomolgus monkeys
    • San Francisco, CA, USA 6-10 June
    • Van Poelje PD, Potter SC, Fujitaki JM et al. MB07803, a prodrug of a second generation fructose-1,6-bisphosphatase inhibitor, lowers blood glucose in diabetic rodents and in cynomolgus monkeys. Presented at: 68th Scientifc Sessions of the American Diabetes Association. San Francisco, CA, USA, 6-10 June 2008.
    • (2008) Presented At: 68th Scientifc Sessions of the American Diabetes Association
    • Van Poelje, P.D.1    Potter, S.C.2    Fujitaki, J.M.3
  • 168
    • 20344370977 scopus 로고    scopus 로고
    • MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in Type 2 diabetes
    • Erion MD, Van Poelje PD, Dang Q et al. MB06322 (CS-917): a potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in Type 2 diabetes. Proc. Natl Acad. Sci. USA 102(22), 7970-7975 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.22 , pp. 7970-7975
    • Erion, M.D.1    Van Poelje, P.D.2    Dang, Q.3
  • 169
    • 33748286778 scopus 로고    scopus 로고
    • Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in zucker diabetic fatty rats
    • Van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in zucker diabetic fatty rats. Diabetes 55(6), 1747-1754 (2006).
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1747-1754
    • Van Poelje, P.D.1    Potter, S.C.2    Chandramouli, V.C.3    Landau, B.R.4    Dang, Q.5    Erion, M.D.6
  • 170
    • 77949409657 scopus 로고    scopus 로고
    • Pronounced glucose reduction in poorly controlled T2DM with MB07803 a novel fructose-16-bisphosphatase inhibitor (FBPase) with reduced potential for acid-base disturbances vs the 1st generation FBPaseI CS-917
    • New Orleans LA USA 5-9 June
    • Gumbiner B. Pronounced glucose reduction in poorly controlled T2DM with MB07803, a novel fructose-1,6-bisphosphatase inhibitor (FBPase) with reduced potential for acid-base disturbances vs the 1st generation FBPaseI CS-917. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
    • (2009) Presented At: 69th Scientifc Sessions of the American Diabetes Association
    • Gumbiner, B.1
  • 171
    • 64549142812 scopus 로고    scopus 로고
    • Development of the renal glucose reabsorption inhibitors: A new mechanism for the pharmacotherapy of diabetes mellitus Type 2
    • Washburn WN. Development of the renal glucose reabsorption inhibitors: a new mechanism for the pharmacotherapy of diabetes mellitus Type 2. J. Med. Chem. 52(7), 1785-1794 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.7 , pp. 1785-1794
    • Washburn, W.N.1
  • 172
    • 74949093195 scopus 로고    scopus 로고
    • Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents
    • Washburn WN. Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents. Expert Opin. Ther. Pat. 19(11), 1485-1499 (2009).
    • (2009) Expert Opin. Ther. Pat. , vol.19 , Issue.11 , pp. 1485-1499
    • Washburn, W.N.1
  • 173
    • 0028044629 scopus 로고
    • +/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose
    • +/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J. Clin. Invest. 93(1), 397-404 (1994).
    • (1994) J. Clin. Invest. , vol.93 , Issue.1 , pp. 397-404
    • Kanai, Y.1    Lee, W.S.2    You, G.3    Brown, D.4    Hediger, M.A.5
  • 174
    • 0029938022 scopus 로고    scopus 로고
    • Glucose transporters in the regulation of intestinal, renal, and liver glucose fuxes
    • Thorens B. Glucose transporters in the regulation of intestinal, renal, and liver glucose fuxes. Am. J. Physiol. 270(4 Pt 1), G541-G553 (1996).
    • (1996) Am. J. Physiol. , vol.270 , Issue.4 PART 1
    • Thorens, B.1
  • 175
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • Rahmoune H, Thompson PW, Ward JM et al. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 54(12), 3427-3434 (2005).
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3
  • 176
    • 0036937335 scopus 로고    scopus 로고
    • Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)
    • Van Den Heuvel LP, Assink K, Willemsen M, Monnens L. Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). Hum. Genet. 111(6), 544-547 (2002).
    • (2002) Hum. Genet. , vol.111 , Issue.6 , pp. 544-547
    • Van Den Heuvel, L.P.1    Assink, K.2    Willemsen, M.3    Monnens, L.4
  • 177
    • 33845873376 scopus 로고    scopus 로고
    • Serglifozin, a novel selective inhibitor of low-affnity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
    • Katsuno K, Fujimori Y, Takemura Y et al. Serglifozin, a novel selective inhibitor of low-affnity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J. Pharmacol. Exp. Ther. 320(1), 323-330 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , Issue.1 , pp. 323-330
    • Katsuno, K.1    Fujimori, Y.2    Takemura, Y.3
  • 178
    • 64549093267 scopus 로고    scopus 로고
    • Serglifozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats
    • Fujimori Y, Katsuno K, Ojima K et al. Serglifozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats. Eur. J. Pharmacol. 609(1-3), 148-154 (2009).
    • (2009) Eur. J. Pharmacol. , vol.609 , Issue.1-3 , pp. 148-154
    • Fujimori, Y.1    Katsuno, K.2    Ojima, K.3
  • 179
    • 68949186346 scopus 로고    scopus 로고
    • Long-term treatment with serglifozin etabonate improves disturbed glucose metabolism in KK-A(y) mice
    • Katsuno K, Fujimori Y, Ishikawa-Takemura Y, Isaji M. Long-term treatment with serglifozin etabonate improves disturbed glucose metabolism in KK-A(y) mice. Eur. J. Pharmacol. 618(1-3), 98-104 (2009).
    • (2009) Eur. J. Pharmacol. , vol.618 , Issue.1-3 , pp. 98-104
    • Katsuno, K.1    Fujimori, Y.2    Ishikawa-Takemura, Y.3    Isaji, M.4
  • 180
    • 52649083832 scopus 로고    scopus 로고
    • Remoglifozin etabonate, in a novel category of selective low-affnity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic effcacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remoglifozin etabonate, in a novel category of selective low-affnity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic effcacy in rodent models. J. Pharmacol. Exp. Ther. 327(1), 268-276 (2008).
    • (2008) J. Pharmacol. Exp. Ther. , vol.327 , Issue.1 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3    Ishikawa-Takemura, Y.4    Fujikura, H.5    Isaji, M.6
  • 181
    • 41649087328 scopus 로고    scopus 로고
    • Discovery of dapaglifozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of Type 2 diabetes
    • Meng W, Ellsworth BA, Nirschl AA et al. Discovery of dapaglifozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of Type 2 diabetes. J. Med. Chem. 51(5), 1145-1149 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.5 , pp. 1145-1149
    • Meng, W.1    Ellsworth, B.A.2    Nirschl, A.A.3
  • 182
    • 48249146624 scopus 로고    scopus 로고
    • Dapaglifozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S, Hagan DL, Taylor JR et al. Dapaglifozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 57(6), 1723-1729 (2008).
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 183
    • 67349180574 scopus 로고    scopus 로고
    • Dapaglifozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • Komoroski B, Vachharajani N, Boulton D et al. Dapaglifozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin. Pharmacol. Ther. 85(5), 520-526 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , Issue.5 , pp. 520-526
    • Komoroski, B.1    Vachharajani, N.2    Boulton, D.3
  • 184
    • 67349275999 scopus 로고    scopus 로고
    • Dapaglifozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with Type 2 diabetes mellitus
    • Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfster M. Dapaglifozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with Type 2 diabetes mellitus. Clin. Pharmacol. Ther. 85(5), 513-519 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , Issue.5 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfster, M.6
  • 185
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapaglifozin in Type 2 diabetes
    • List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapaglifozin in Type 2 diabetes. Diabetes Care 32(4), 650-657 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.4 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 186
    • 33745089676 scopus 로고    scopus 로고
    • Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria
    • Ribera MC, Pascual R, Orozco D, Perez Barba C, Pedrera V, Gil V. Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria. Eur. J. Clin. Microbiol. Infect. Dis. 25(6), 389-393 (2006).
    • (2006) Eur. J. Clin. Microbiol. Infect. Dis. , vol.25 , Issue.6 , pp. 389-393
    • Ribera, M.C.1    Pascual, R.2    Orozco, D.3    Perez Barba, C.4    Pedrera, V.5    Gil, V.6
  • 187
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapaglifozin in patients with Type 2 diabetes receiving high doses of insulin plus insulin sensitizers: Applicability of a novel insulin-independent treatment
    • Wilding JP, Norwood P, T'joen C, Bastien A, List JF, Fiedorek FT. A study of dapaglifozin in patients with Type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment. Diabetes Care 32(9), 1656-1662 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1656-1662
    • Wilding, J.P.1    Norwood, P.2    T'Joen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 189
    • 61549094077 scopus 로고    scopus 로고
    • Weight and Type 2 diabetes after bariatric surgery: Systematic review and meta-analysis
    • Buchwald H, Estok R, Fahrbach K et al. Weight and Type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am. J. Med. 122(3), 248-256 (2009).
    • (2009) Am. J. Med. , vol.122 , Issue.3 , pp. 248-256
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3
  • 190
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the Rio-Europe study
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the Rio-Europe study. Lancet 365(9468), 1389-1397 (2005).
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5
  • 191
    • 38349114737 scopus 로고    scopus 로고
    • 2c receptor agonist for the treatment of obesity
    • 2c receptor agonist for the treatment of obesity. J. Med. Chem. 51(2), 305-313 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.2 , pp. 305-313
    • Smith, B.M.1    Smith, J.M.2    Tsai, J.H.3
  • 192
    • 0036072223 scopus 로고    scopus 로고
    • Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in Type 2 diabetic patients
    • Miyazaki Y, Mahankali A, Matsuda M et al. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in Type 2 diabetic patients. J. Clin. Endocrinol. Metab. 87(6), 2784-2791 (2002).
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.6 , pp. 2784-2791
    • Miyazaki, Y.1    Mahankali, A.2    Matsuda, M.3
  • 193
    • 0035798713 scopus 로고    scopus 로고
    • The mechanisms by which both heterozygous peroxisome proliferator- activated receptor-g (PPARg) defciency and PPARg agonist improve insulin resistance
    • Yamauchi T, Kamon J, Waki H et al. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor-g (PPARg) defciency and PPARg agonist improve insulin resistance. J. Biol. Chem. 276(44), 41245-41254 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.44 , pp. 41245-41254
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 195
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT
    • Smith SJ, Cases S, Jensen DR et al. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT. Nat. Genet. 25(1), 87-90 (2000).
    • (2000) Nat. Genet. , vol.25 , Issue.1 , pp. 87-90
    • Smith, S.J.1    Cases, S.2    Jensen, D.R.3
  • 196
    • 0036228339 scopus 로고    scopus 로고
    • Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
    • Chen HC, Smith SJ, Ladha Z et al. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 109(8), 1049-1055 (2002).
    • (2002) J. Clin. Invest. , vol.109 , Issue.8 , pp. 1049-1055
    • Chen, H.C.1    Smith, S.J.2    Ladha, Z.3
  • 197
    • 39149122218 scopus 로고    scopus 로고
    • Validation of diacyl glycerolacyltransferaseI as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor
    • Zhao G, Souers AJ, Voorbach M et al. Validation of diacyl glycerolacyltransferaseI as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J. Med. Chem. 51(3), 380-383 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.3 , pp. 380-383
    • Zhao, G.1    Souers, A.J.2    Voorbach, M.3
  • 198
    • 64349101065 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally effcacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor
    • Birch AM, Birtles S, Buckett LK et al. Discovery of a potent, selective, and orally effcacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J. Med. Chem. 52(6), 1558-1568 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.6 , pp. 1558-1568
    • Birch, A.M.1    Birtles, S.2    Buckett, L.K.3
  • 199
    • 78650073174 scopus 로고    scopus 로고
    • Discovery, synthesis, and in vivo activity of phenylpiperazine DGAT-1 inhibitors for the treatment of metabolic syndrome
    • Washington, DC, USA 16-20 August
    • Linders JTM, Roevens P, Berwaer M et al. Discovery, synthesis, and in vivo activity of phenylpiperazine DGAT-1 inhibitors for the treatment of metabolic syndrome. Presented at: 238th ACS National Meeting and Exposition. Washington, DC, USA, 16-20 August 2009.
    • (2009) Presented At: 238th ACS National Meeting and Exposition
    • Linders, J.T.M.1    Roevens, P.2    Berwaer, M.3
  • 201
    • 46749139850 scopus 로고    scopus 로고
    • Recent advances in the discovery of 11b-HSD1 inhibitors
    • Boyle CD. Recent advances in the discovery of 11b-HSD1 inhibitors. Curr. Opin. Drug Discov. Devel. 11(4), 495-511 (2008).
    • (2008) Curr. Opin. Drug Discov. Devel. , vol.11 , Issue.4 , pp. 495-511
    • Boyle, C.D.1
  • 202
    • 67649362287 scopus 로고    scopus 로고
    • 11b-hydroxysteroid dehydrogenase Type 1 inhibitors: A review of recent patents
    • Boyle CD, Kowalski TJ. 11b-hydroxysteroid dehydrogenase Type 1 inhibitors: a review of recent patents. Expert Opin. Ther. Pat. 19(6), 801-825 (2009).
    • (2009) Expert Opin. Ther. Pat. , vol.19 , Issue.6 , pp. 801-825
    • Boyle, C.D.1    Kowalski, T.J.2
  • 204
    • 64549162134 scopus 로고    scopus 로고
    • INCB013739, a selective inhibitor of 11b-hydroxysteroid dehydrogenase Type 1 (11bHSD1) improves insulin sensitivity and lowers plasma cholesterol over 28 days in patients with Type 2 diabetes mellitus
    • San Francisco, CA, USA 6-10 June
    • Hawkins M, Hunter D, Kishore P et al. INCB013739, a selective inhibitor of 11b-hydroxysteroid dehydrogenase Type 1 (11bHSD1), improves insulin sensitivity and lowers plasma cholesterol over 28 days in patients with Type 2 diabetes mellitus. Presented at: 68th Scientifc Sessions of the American Diabetes Association. San Francisco, CA, USA, 6-10 June 2008.
    • (2008) Presented At: 68th Scientifc Sessions of the American Diabetes Association
    • Hawkins, M.1    Hunter, D.2    Kishore, P.3
  • 205
  • 206
    • 0034693259 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
    • Osborne TF. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J. Biol. Chem. 275(42), 32379-32382 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.42 , pp. 32379-32382
    • Osborne, T.F.1
  • 207
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • Brown MS, Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89(3), 331-340 (1997).
    • (1997) Cell , vol.89 , Issue.3 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 208
    • 30344473341 scopus 로고    scopus 로고
    • Protein sensors for membrane sterols
    • Goldstein JL, Debose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell 124(1), 35-46 (2006).
    • (2006) Cell , vol.124 , Issue.1 , pp. 35-46
    • Goldstein, J.L.1    Debose-Boyd, R.A.2    Brown, M.S.3
  • 210
    • 69049116165 scopus 로고    scopus 로고
    • A small molecule that blocks fat synthesis by inhibiting the activation of SREBP
    • Kamisuki S, Mao Q, Abu-Elheiga L et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem. Biol. 16(8), 882-892 (2009).
    • (2009) Chem. Biol. , vol.16 , Issue.8 , pp. 882-892
    • Kamisuki, S.1    Mao, Q.2    Abu-Elheiga, L.3
  • 211
    • 34347238724 scopus 로고    scopus 로고
    • Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
    • Nagle CA, An J, Shiota M et al. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J. Biol. Chem. 282(20), 14807-14815 (2007).
    • (2007) J. Biol. Chem. , vol.282 , Issue.20 , pp. 14807-14815
    • Nagle, C.A.1    An, J.2    Shiota, M.3
  • 212
    • 27244440736 scopus 로고    scopus 로고
    • Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
    • Neschen S, Morino K, Hammond LE et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. Cell Metab. 2(1), 55-65 (2005).
    • (2005) Cell Metab. , vol.2 , Issue.1 , pp. 55-65
    • Neschen, S.1    Morino, K.2    Hammond, L.E.3
  • 213
    • 69949176746 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase inhibitors: Update on patented compounds
    • Liu G. Stearoyl-CoA desaturase inhibitors: update on patented compounds. Expert Opin. Ther. Pat. 19(9), 1169-1191 (2009).
    • (2009) Expert Opin. Ther. Pat. , vol.19 , Issue.9 , pp. 1169-1191
    • Liu, G.1
  • 214
    • 64149083743 scopus 로고    scopus 로고
    • Defciency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding
    • Yen CL, Cheong ML, Grueter C et al. Defciency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding. Nat. Med. 15(4), 442-446 (2009).
    • (2009) Nat. Med. , vol.15 , Issue.4 , pp. 442-446
    • Yen, C.L.1    Cheong, M.L.2    Grueter, C.3
  • 216
    • 0026653715 scopus 로고
    • Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men
    • Geary N, Kissileff HR, Pi-Sunyer FX, Hinton V. Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men. Am. J. Physiol. 262(6 Pt 2), R975-R980 (1992).
    • (1992) Am. J. Physiol. , vol.262 , Issue.6 PART 2
    • Geary, N.1    Kissileff, H.R.2    Pi-Sunyer, F.X.3    Hinton, V.4
  • 217
    • 0025148434 scopus 로고
    • Pancreatic glucagon signals postprandial satiety
    • Geary N. Pancreatic glucagon signals postprandial satiety. Neurosci. Biobehav. Rev. 14(3), 323-338 (1990).
    • (1990) Neurosci. Biobehav. Rev. , vol.14 , Issue.3 , pp. 323-338
    • Geary, N.1
  • 218
    • 0002868036 scopus 로고    scopus 로고
    • Glucagon and the control of meal size
    • Smith GP (Ed.). Oxford Press, NY, USA
    • Geary N. Glucagon and the control of meal size. In: Satiation: From Gut to Brain. Smith GP (Ed.). Oxford Press, NY, USA, 164-167 (1998).
    • (1998) Satiation: From Gut to Brain , pp. 164-167
    • Geary, N.1
  • 219
    • 0020608760 scopus 로고
    • Studies of the biological effect and degradation of glucagon in the rat perifused isolated adipose cell
    • Heckemeyer CM, Barker J, Duckworth WC, Solomon SS. Studies of the biological effect and degradation of glucagon in the rat perifused isolated adipose cell. Endocrinology 113(1), 270-276 (1983).
    • (1983) Endocrinology , vol.113 , Issue.1 , pp. 270-276
    • Heckemeyer, C.M.1    Barker, J.2    Duckworth, W.C.3    Solomon, S.S.4
  • 220
    • 0018358387 scopus 로고
    • Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio
    • Holst JJ, Sorensen TL, Andersen AN et al. Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio. Scand. J. Gastroenterol. 14(2), 205-207 (1979).
    • (1979) Scand. J. Gastroenterol. , vol.14 , Issue.2 , pp. 205-207
    • Holst, J.J.1    Sorensen, T.L.2    Andersen, A.N.3
  • 221
    • 23644443678 scopus 로고    scopus 로고
    • Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial
    • Wynne K, Park AJ, Small CJ et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 54(8), 2390-2395 (2005).
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2390-2395
    • Wynne, K.1    Park, A.J.2    Small, C.J.3
  • 222
    • 63849300305 scopus 로고    scopus 로고
    • Investigation of structure-activity relationships of oxyntomodulin (Oxm) using Oxm analogs
    • Druce MR, Minnion JS, Field BC et al. Investigation of structure-activity relationships of oxyntomodulin (Oxm) using Oxm analogs. Endocrinology 150(4), 1712-1722 (2009).
    • (2009) Endocrinology , vol.150 , Issue.4 , pp. 1712-1722
    • Druce, M.R.1    Minnion, J.S.2    Field, B.C.3
  • 224
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
    • Day J W, Ottaway N, Patterson JT et al. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat. Chem. Biol. 5, 749-757 (2009).
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 749-757
    • Day, J.W.1    Ottaway, N.2    Patterson, J.T.3
  • 225
    • 77949390301 scopus 로고    scopus 로고
    • Discovery of 2-acylindoles as potent, orally active human glucagon receptor antagonists
    • New Orleans, LA, USA 6-10 April
    • Sinz C, Bittner A, Kim A et al. Discovery of 2-acylindoles as potent, orally active human glucagon receptor antagonists. Presented at: 235th ACS National Meeting and Exposition. New Orleans, LA, USA, 6-10 April 2008.
    • (2008) Presented At: 235th ACS National Meeting and Exposition
    • Sinz, C.1    Bittner, A.2    Kim, A.3
  • 226
    • 65649140171 scopus 로고    scopus 로고
    • Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties
    • Madsen P, Kodra JT, Behrens C et al. Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties. J. Med. Chem. 52(9), 2989-3000 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.9 , pp. 2989-3000
    • Madsen, P.1    Kodra, J.T.2    Behrens, C.3
  • 227
    • 32944473560 scopus 로고    scopus 로고
    • Therapeutic approaches to preserve islet mass in Type 2 diabetes
    • Baggio LL, Drucker DJ. Therapeutic approaches to preserve islet mass in Type 2 diabetes. Annu. Rev. Med. 57, 265-281 (2006).
    • (2006) Annu. Rev. Med. , vol.57 , pp. 265-281
    • Baggio, L.L.1    Drucker, D.J.2
  • 228
    • 44749088201 scopus 로고    scopus 로고
    • B-cell replication is the primary mechanism subserving the postnatal expansion of b-cell mass in humans
    • Meier JJ, Butler AE, Saisho Y et al. b-cell replication is the primary mechanism subserving the postnatal expansion of b-cell mass in humans. Diabetes 57(6), 1584-1594 (2008).
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1584-1594
    • Meier, J.J.1    Butler, A.E.2    Saisho, Y.3
  • 229
    • 38449086256 scopus 로고    scopus 로고
    • Partial pancreatectomy in adult humans does not provoke b-cell regeneration
    • Menge BE, Tannapfel A, Belyaev O et al. Partial pancreatectomy in adult humans does not provoke b-cell regeneration. Diabetes 57(1), 142-149 (2008).
    • (2008) Diabetes , vol.57 , Issue.1 , pp. 142-149
    • Menge, B.E.1    Tannapfel, A.2    Belyaev, O.3
  • 230
    • 0024559263 scopus 로고
    • Compensatory adaption to partial pancreatectomy in the rat
    • Lee HC, Bonner-Weir S, Weir GC, Leahy JL. Compensatory adaption to partial pancreatectomy in the rat. Endocrinology 124(3), 1571-1575 (1989).
    • (1989) Endocrinology , vol.124 , Issue.3 , pp. 1571-1575
    • Lee, H.C.1    Bonner-Weir, S.2    Weir, G.C.3    Leahy, J.L.4
  • 231
    • 33845536254 scopus 로고    scopus 로고
    • Regulation of pancreatic b-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse
    • Peshavaria M, Larmie BL, Lausier J et al. Regulation of pancreatic b-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 55(12), 3289-3298 (2006).
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3289-3298
    • Peshavaria, M.1    Larmie, B.L.2    Lausier, J.3
  • 236
    • 77949366276 scopus 로고    scopus 로고
    • ARRY-403 a glucokinase activator with potent glucose-dependent anti-hyperglycemic activity in animal models of Type 2 diabetes mellitus: Frst-in-patient clinical results
    • Vienna, Austria, 29 September-2 October
    • Hinklin RJ, Aicher TD, Boyd SA et al. ARRY-403, a glucokinase activator with potent glucose-dependent anti-hyperglycemic activity in animal models of Type 2 diabetes mellitus: frst-in-patient clinical results. Presented at: 45th Annual Meeting of the European Association for the Study of Diabetes. Vienna, Austria, 29 September-2 October 2009.
    • (2009) Presented At: 45th Annual Meeting of the European Association for the Study of Diabetes
    • Hinklin, R.J.1    Aicher, T.D.2    Boyd, S.A.3
  • 237
    • 77949360528 scopus 로고    scopus 로고
    • Early clinical studies to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy volunteers and subjects with Type 2 diabetes mellitus
    • Chicago, IL, USA 22-27 June
    • Hussey EK, Clark RV, Amin DM et al. Early clinical studies to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy volunteers and subjects with Type 2 diabetes mellitus. Presented at: 67th Scientifc Sessions of the American Diabetes Association. Chicago, IL, USA, 22-27 June 2007.
    • (2007) Presented At: 67th Scientifc Sessions of the American Diabetes Association
    • Hussey, E.K.1    Clark, R.V.2    Amin, D.M.3
  • 238
    • 77949388811 scopus 로고    scopus 로고
    • A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects
    • Chicago, IL, USA 22-27 June
    • Hussey EK, Dobbins RL, Stolz RR et al. A double-blind randomized repeat dose study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of three times daily dosing of serglifozin, a novel inhibitor of renal glucose reabsorption, in healthy overweight and obese subjects. Presented at: 67th Scientifc Sessions of the American Diabetes Association. Chicago, IL, USA, 22-27 June 2007.
    • (2007) Presented At: 67th Scientifc Sessions of the American Diabetes Association
    • Hussey, E.K.1    Dobbins, R.L.2    Stolz, R.R.3
  • 239
    • 77949376565 scopus 로고    scopus 로고
    • Safety pharmokinetics and pharmacodynamics of remoglifozzin etabonate (SGLT2 inhibitor) and metformin when co-administered in Type 2 diabetes mellitus (T2DM) patients
    • New Orleans LA USA 5-9 June
    • Hussey EK, Kapur A, O'Conner-Semmes RL et al. Safety, pharmokinetics and pharmacodynamics of remoglifozzin etabonate (SGLT2 inhibitor) and metformin when co-administered in Type 2 diabetes mellitus (T2DM) patients. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
    • (2009) Presented At: 69th Scientifc Sessions of the American Diabetes Association
    • Hussey, E.K.1    Kapur, A.2    O'Conner-Semmes, R.L.3
  • 240
    • 77949420924 scopus 로고    scopus 로고
    • Remoglifozzin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), reduces serum glucose in Type 2 diabetes mellitus (T2DM) patients
    • New Orleans, LA, USA 5-9 June
    • Dobbins RL, Kapur A, Kapitza C et al. Remoglifozzin etabonate, a selective inhibitor of the sodium-glucose transporter 2 (SGLT2), reduces serum glucose in Type 2 diabetes mellitus (T2DM) patients. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
    • (2009) Presented At: 69th Scientifc Sessions of the American Diabetes Association
    • Dobbins, R.L.1    Kapur, A.2    Kapitza, C.3
  • 242
    • 77957562569 scopus 로고    scopus 로고
    • In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2 inhibitor
    • New Orleans, LA, USA 5-9 June
    • Grempler R, Thomas L, Eckhardt M et al. In vitro properties and in vivo effect on urinary glucose excretion of BI 10773, a novel selective SGLT2 inhibitor. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
    • (2009) Presented At: 69th Scientifc Sessions of the American Diabetes Association
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3
  • 243
    • 33751001942 scopus 로고    scopus 로고
    • Effcacy and tolerability of rimonabant in overweight or obese patients with Type 2 diabetes: A randomised controlled study
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF. Effcacy and tolerability of rimonabant in overweight or obese patients with Type 2 diabetes: a randomised controlled study. Lancet 368(9548), 1660-1672 (2006).
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 247
    • 84962336361 scopus 로고    scopus 로고
    • One-year treatment with VI-0521 in Type 2 diabetes demonstrates continued glycemic improvement and weight loss
    • New Orleans, LA, USA 5-9 June
    • Garvey W T, Troupin B, Tam P et al. One-year treatment with VI-0521 in Type 2 diabetes demonstrates continued glycemic improvement and weight loss. Presented at: 69th Scientifc Sessions of the American Diabetes Association. New Orleans, LA, USA, 5-9 June 2009.
    • (2009) Presented At: 69th Scientifc Sessions of the American Diabetes Association
    • Garvey, W.T.1    Troupin, B.2    Tam, P.3
  • 248
    • 77949399755 scopus 로고    scopus 로고
    • Discovery of PF-04620110: A selective DGAT-1 inhibitor for the treatment of Type 2 diabetes
    • Half Moon Bay, CA, USA 22-23 September
    • Dow R. Discovery of PF-04620110: a selective DGAT-1 inhibitor for the treatment of Type 2 diabetes. Presented at: Metabolic Diseases Drug Discovery & Development. Half Moon Bay, CA, USA, 22-23 September 2009.
    • (2009) Presented At: Metabolic Diseases Drug Discovery & Development
    • Dow, R.1
  • 250
    • 65949101862 scopus 로고    scopus 로고
    • Two asymmetric syntheses of AMG 221, an inhibitor of 11b-hydroxysteroid dehydrogenase Type 1
    • Caille S, Cui S, Hwang TL, Wang X, Faul MM. Two asymmetric syntheses of AMG 221, an inhibitor of 11b-hydroxysteroid dehydrogenase Type 1. J. Org. Chem. 74(10), 3833-3842 (2009).
    • (2009) J. Org. Chem. , vol.74 , Issue.10 , pp. 3833-3842
    • Caille, S.1    Cui, S.2    Hwang, T.L.3    Wang, X.4    Faul, M.M.5
  • 251
    • 39049131253 scopus 로고    scopus 로고
    • Modulation of 11b-hydroxysteroid dehydrogenase (11bHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11bHSD1 inhibitor
    • Courtney R, Stewart PM, Toh M, Ndongo MN, Calle RA, Hirshberg B. Modulation of 11b-hydroxysteroid dehydrogenase (11bHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11bHSD1 inhibitor. J. Clin. Endocrinol. Metab. 93(2), 550-556 (2008).
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.2 , pp. 550-556
    • Courtney, R.1    Stewart, P.M.2    Toh, M.3    Ndongo, M.N.4    Calle, R.A.5    Hirshberg, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.