Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5531-5538

  Iino, Tomoharu ^a   Sasaki, Yasuhiro ^a   Bamba, Makoto ^a   Mitsuya, Morihiro ^a   Ohno, Akio ^a   Kamata, Kenji ^a   Hosaka, Hideka ^a   Maruki, Hiroko ^a   Futamura, Mayumi ^a   Yoshimoto, Riki ^a   Ohyama, Sumika ^a   Sasaki, Kaori ^a   Chiba, Masato ^a   Ohtake, Norikazu ^a   Nagata, Yasufumi ^a   Eiki, Jun ichi ^a   Nishimura, Teruyuki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

4,6 Disubstituted quinazoline; Aqueous solubility; Glucokinase; Glucokinase activator; Glucose lowering efficacy; Log D

Indexed keywords

2 AMINOBENZAMIDE; ENZYME ACTIVATOR; GLUCOKINASE; QUINAZOLINE DERIVATIVE; QUINAZOLINE GLUCOKINASE ACTIVATOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANIMALS; BLOOD GLUCOSE; DRUG DISCOVERY; GLUCOKINASE; HYPOGLYCEMIC AGENTS; MICE; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949100799     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.064     Document Type: Article

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