Electrophysiological remodeling in heart failure

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 4, 2010, Pages 619-632

  Wang, Yanggan ^a   Hill, Joseph A ^b,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arrhythmia; Electrophysiology; Heart failure; Ion channel; Remodeling

Indexed keywords

EXCITATION; GAP JUNCTION; HEART ARRHYTHMIA; HEART ATRIOVENTRICULAR NODE; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE REMODELING; HUMAN; NONHUMAN; PATHOLOGICAL ANATOMY; PATHOPHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; PURKINJE CELL; REVIEW; SARCOPLASMIC RETICULUM; SINUS NODE; SODIUM CURRENT;

ANIMALS; ANISOTROPY; ARRHYTHMIAS, CARDIAC; ATRIOVENTRICULAR NODE; ELECTROPHYSIOLOGY; GAP JUNCTIONS; HEART; HEART FAILURE; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; POTASSIUM; PURKINJE CELLS; RATS;

EID: 77649342262     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.01.009     Document Type: Review

References (257)

1. Lloyd-Jones D., Adams R., Carnethon M., De Simone G., Ferguson T.B., Flegal K., et al. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119 3 (2009 Jan 27) 480-486
2. Hill J.A., and Olson E.N. Cardiac plasticity. N. Engl. J. Med. 358 13 (2008) 1370-1380
3. Tomaselli G.F., and Zipes D.P. What causes sudden death in heart failure?. Circ. Res. 95 8 (2004 Oct 15) 754-763
4. Nattel S., Maguy A., Le Bouter S., and Yeh Y.H. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol. Rev. 87 2 (2007 Apr) 425-456
5. Nass R.D., Aiba T., Tomaselli G.F., and Akar F.G. Mechanisms of disease: ion channel remodeling in the failing ventricle. Nat. Clin. Pract. Cardiovasc. Med. 5 4 (2008 Apr) 196-207
6. Bleeker W.K., Mackaay A.J., Masson-Pevet M., Bouman L.N., and Becker A.E. Functional and morphological organization of the rabbit sinus node. Circ. Res. 46 1 (1980 Jan) 11-22
7. Boyett M.R., Honjo H., and Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc. Res. 47 4 (2000 Sep) 658-687
8. Noma A., Morad M., and Irisawa H. Does the "pacemaker current" generate the diastolic depolarization in the rabbit SA node cells?. Pflugers Arch. 397 3 (1983 May) 190-194
9. DiFrancesco D. The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J. Physiol. 434 (1991 Mar) 23-40
10. Jalife J. Mutual entrainment and electrical coupling as mechanisms for synchronous firing of rabbit sino-atrial pace-maker cells. J. Physiol. 356 (1984 Nov) 221-243
11. Wu J., Schuessler R.B., Rodefeld M.D., Saffitz J.E., and Boineau J.P. Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node. Am. J. Physiol. Heart Circ. Physiol. 280 3 (2001 Mar) H1232-1240
12. Accili E.A., Robinson R.B., and DiFrancesco D. Properties and modulation of If in newborn versus adult cardiac SA node. Am. J. Physiol. 272 3 Pt 2 (1997 Mar) H1549-1552
13. Boyett M.R., Dobrzynski H., Lancaster M.K., Jones S.A., Honjo H., and Kodama I. Sophisticated architecture is required for the sinoatrial node to perform its normal pacemaker function. J. Cardiovasc. Electrophysiol. 14 1 (2003 Jan) 104-106
14. Dokos S., Celler B., and Lovell N. Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model. J. Theor. Biol. 181 3 (1996 Aug 7) 245-272
15. Hagiwara N., Irisawa H., and Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J. Physiol. 395 (1988 Jan) 233-253
16. Doerr T., Denger R., and Trautwein W. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflugers Arch. 413 6 (1989 Apr) 599-603
17. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol. Rev. 83 1 (2003 Jan) 117-161
18. Opthof T., Coronel R., Rademaker H.M., Vermeulen J.T., Wilms-Schopman F.J., and Janse M.J. Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death. Circulation 101 25 (2000 Jun 27) 2975-2980
19. Sanders P., Kistler P.M., Morton J.B., Spence S.J., and Kalman J.M. Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. Circulation 110 8 (2004 Aug 24) 897-903
20. Jose A.D., and Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc. Res. 4 2 (1970 Apr) 160-167
21. Witte K., Hu K., Swiatek J., Mussig C., Ertl G., and Lemmer B. Experimental heart failure in rats: effects on cardiovascular circadian rhythms and on myocardial beta-adrenergic signaling. Cardiovasc. Res. 47 2 (2000 Aug) 350-358
22. Verkerk A.O., Wilders R., Coronel R., Ravesloot J.H., and Verheijck E.E. Ionic remodeling of sinoatrial node cells by heart failure. Circulation 108 6 (2003 Aug 12) 760-766
23. Leoni A.L., Marionneau C., Demolombe S., Le Bouter S., Mangoni M.E., Escande D., et al. Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle. Physiol. Genomics 24 1 (2005 Dec 14) 4-12
24. Elvan A. Sinoatrial remodeling caused by persistent atrial fibrillation: what is the relationship between postcardioversion sinus node dysfunction and increased atrial vulnerability?. J. Cardiovasc. Electrophysiol. 12 7 (2001 Jul) 807-808
25. Hadian D., Zipes D.P., Olgin J.E., and Miller J.M. Short-term rapid atrial pacing produces electrical remodeling of sinus node function in humans. J. Cardiovasc. Electrophysiol. 13 6 (2002 Jun) 584-586
26. Zicha S., Fernandez-Velasco M., Lonardo G., L'Heureux N., and Nattel S. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc. Res. 66 3 (2005 Jun 1) 472-481
27. Manios E.G., Kanoupakis E.M., Mavrakis H.E., Kallergis E.M., Dermitzaki D.N., and Vardas P.E. Sinus pacemaker function after cardioversion of chronic atrial fibrillation: is sinus node remodeling related with recurrence?. J. Cardiovasc. Electrophysiol. 12 7 (2001 Jul) 800-806
28. Meijler F.L., and Janse M.J. Morphology and electrophysiology of the mammalian atrioventricular node. Physiol. Rev. 68 2 (1988 Apr) 608-647
29. Mazgalev T.N., Ho S.Y., and Anderson R.H. Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction. Circulation 103 22 (2001 Jun 5) 2660-2667
30. Tilley D.G., and Rockman H.A. Role of beta-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment. Expert. Rev. Cardiovasc. Ther. 4 3 (2006 May) 417-432
31. Nayebpour M., Talajic M., and Nattel S. Effects of beta-adrenergic receptor stimulation and blockade on rate-dependent atrioventricular nodal properties. Circ. Res. 70 5 (1992 May) 902-911
32. Bristow M.R. beta-adrenergic receptor blockade in chronic heart failure. Circulation 101 5 (2000 Feb 8) 558-569
33. Khoo M.S., Kannankeril P.J., Li J., Zhang R., Kupershmidt S., Zhang W., et al. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm 2 6 (2005 Jun) 634-640
34. Vinogradova T.M., Zhou Y.Y., Bogdanov K.Y., Yang D., Kuschel M., Cheng H., et al. Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activation. Circ. Res. 87 9 (2000 Oct 27) 760-767
35. Rigg L., Mattick P.A., Heath B.M., and Terrar D.A. Modulation of the hyperpolarization-activated current (I(f)) by calcium and calmodulin in the guinea-pig sino-atrial node. Cardiovasc. Res. 57 2 (2003 Feb) 497-504
36. Wu Y., Gao Z., Chen B., Koval O.M., Singh M.V., Guan X., et al. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc. Natl. Acad. Sci. U. S. A. 106 14 (2009 Apr 7) 5972-5977
37. Purkyně J.E. Mikroskopisch-neurologische Beobachtungen. Archf. Anat. Physiol. Wiss. Med. 12 (1845) 281-295
38. El-Sherif N., Chinushi M., Caref E.B., and Restivo M. Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns. Circulation 96 12 (1997 Dec 16) 4392-4399
39. Berenfeld O., and Jalife J. Purkinje-muscle reentry as a mechanism of polymorphic ventricular arrhythmias in a 3-dimensional model of the ventricles. Circ. Res. 82 10 (1998 Jun 1) 1063-1077
40. Boyden P.A., and Pinto J.M. Reduced calcium currents in subendocardial Purkinje myocytes that survive in the 24- and 48-hour infarcted heart. Circulation 89 6 (1994 Jun) 2747-2759
41. Jeck C., Pinto J., and Boyden P. Transient outward currents in subendocardial Purkinje myocytes surviving in the infarcted heart. Circulation 92 3 (1995 Aug 1) 465-473
42. Pinto J.M., and Boyden P.A. Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart. J. Cardiovasc. Electrophysiol. 9 3 (1998 Mar) 299-311
43. Lehmann M.H., Hardy S., Archibald D., quart B., and MacNeil D.J. Sex difference in risk of torsade de pointes with d,l-sotalol. Circulation 94 10 (1996 Nov 15) 2535-2541
44. Han W., Chartier D., Li D., and Nattel S. Ionic remodeling of cardiac Purkinje cells by congestive heart failure. Circulation 104 17 (2001 Oct 23) 2095-2100
45. Knight B.P. Atrial fibrillation in patients with congestive heart failure. Pacing Clin. Electrophysiol. 26 7 Pt 2 (2003 Jul) 1620-1623
46. Wijffels M.C., Kirchhof C.J., Dorland R., and Allessie M.A. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 92 7 (1995 Oct 1) 1954-1968
47. Li D., Melnyk P., Feng J., Wang Z., Petrecca K., Shrier A., et al. Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 101 22 (2000 Jun 6) 2631-2638
48. Estes III N.A., Halperin J.L., Calkins H., Ezekowitz M.D., Gitman P., Go A.S., et al. ACC/AHA/Physician Consortium 2008 clinical performance measures for adults with nonvalvular atrial fibrillation or atrial flutter: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures and the Physician Consortium for Performance Improvement (Writing Committee to Develop Clinical Performance Measures for Atrial Fibrillation): developed in collaboration with the Heart Rhythm Society. Circulation 117 8 (2008 Feb 26) 1101-1120
49. Wright M., Haissaguerre M., Knecht S., Matsuo S., O'Neill M.D., Nault I., et al. State of the art: catheter ablation of atrial fibrillation. J. Cardiovasc. Electrophysiol. 19 6 (2008 Jun) 583-592
50. Savelieva I., and Camm J. Update on atrial fibrillation: Part I. Clin. Cardiol. 31 2 (2008 Feb) 55-62
51. Savelieva I., and Camm J. Update on atrial fibrillation: Part II. Clin. Cardiol. 31 3 (2008 Mar) 102-108
52. Biffi M., Boriani G., Bartolotti M., Bacchi Reggiani L., Zannoli R., and Branzi A. Atrial fibrillation recurrence after internal cardioversion: prognostic importance of electrophysiological parameters. Heart 87 5 (2002 May) 443-448
53. Yue L., Feng J., Gaspo R., Li G.R., Wang Z., and Nattel S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ. Res. 81 4 (1997 Oct) 512-525
54. Ramirez R.J., Nattel S., and Courtemanche M. Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 279 4 (2000 Oct) H1767-1785
55. Skasa M., Jungling E., Picht E., Schondube F., and Luckhoff A. L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation. Basic Res. Cardiol. 96 2 (2001 Apr) 151-159
56. Workman A.J., Kane K.A., and Rankin A.C. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc. Res. 52 2 (2001 Nov) 226-235
57. Nattel S. New ideas about atrial fibrillation 50 years on. Nature 415 6868 (2002 Jan 10) 219-226
58. Yue L., Melnyk P., Gaspo R., Wang Z., and Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ. Res. 84 7 (1999 Apr 16) 776-784
59. Jaleel N., Nakayama H., Chen X., Kubo H., MacDonnell S., Zhang H., et al. Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circ. Res. 103 10 (2008 Nov 7) 1109-1119
60. Lee S.H., Yu W.C., Cheng J.J., Hung C.R., Ding Y.A., Chang M.S., et al. Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling. Circulation 101 2 (2000 Jan 18) 200-206
61. Fareh S., Benardeau A., Thibault B., and Nattel S. The T-type Ca(2+) channel blocker mibefradil prevents the development of a substrate for atrial fibrillation by tachycardia-induced atrial remodeling in dogs. Circulation 100 21 (1999 Nov 23) 2191-2197
62. Fareh S., Benardeau A., and Nattel S. Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs. Cardiovasc. Res. 49 4 (2001 Mar) 762-770
63. Schreieck J., Wang Y., Overbeck M., Schomig A., and Schmitt C. Altered transient outward current in human atrial myocytes of patients with reduced left ventricular function. J. Cardiovasc. Electrophysiol. 11 2 (2000 Feb) 180-192
64. Kumagai K., Akimitsu S., Kawahira K., Kawanami F., Yamanouchi Y., Hiroki T., et al. Electrophysiological properties in chronic lone atrial fibrillation. Circulation 84 4 (1991 Oct) 1662-1668
65. Sanders P., Morton J.B., Davidson N.C., Spence S.J., Vohra J.K., Sparks P.B., et al. Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation 108 12 (2003 Sep 23) 1461-1468
66. Shinagawa K., Shi Y.F., Tardif J.C., Leung T.K., and Nattel S. Dynamic nature of atrial fibrillation substrate during development and reversal of heart failure in dogs. Circulation 105 22 (2002 Jun 4) 2672-2678
67. Ohtani K., Yutani C., Nagata S., Koretsune Y., Hori M., and Kamada T. High prevalence of atrial fibrosis in patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. 25 5 (1995 Apr) 1162-1169
68. Kostin S., Klein G., Szalay Z., Hein S., Bauer E.P., and Schaper J. Structural correlate of atrial fibrillation in human patients. Cardiovasc. Res. 54 2 (2002 May) 361-379
69. Boldt A., Wetzel U., Lauschke J., Weigl J., Gummert J., Hindricks G., et al. Fibrosis in left atrial tissue of patients with atrial fibrillation with and without underlying mitral valve disease. Heart 90 4 (2004 Apr) 400-405
70. Li D., Fareh S., Leung T.K., and Nattel S. Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 100 1 (1999 Jul 6) 87-95
71. Akar F.G., and Tomaselli G.F. Ion channels as novel therapeutic targets in heart failure. Ann. Med. 37 1 (2005) 44-54
72. Cutler M.J., Rosenbaum D.S., and Dunlap M.E. Structural and electrical remodeling as therapeutic targets in heart failure. J. Electrocardiol. 40 6 Suppl (2007 Nov-Dec) S1-S7
73. Kaab S., Nuss H.B., Chiamvimonvat N., O'Rourke B., Pak P.H., Kass D.A., et al. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ. Res. 78 2 (1996 Feb) 262-273
74. Kaab S., Dixon J., Duc J., Ashen D., Nabauer M., Beuckelmann D.J., et al. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98 14 (1998 Oct 6) 1383-1393
75. O'Rourke B., Kass D.A., Tomaselli G.F., Kaab S., Tunin R., and Marban E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure: I. Experimental studies. Circ. Res. 84 5 (1999 Mar 19) 562-570
76. Houser S.R., Piacentino III V., and Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J. Mol. Cell. Cardiol. 32 9 (2000 Sep) 1595-1607
77. Wang Y., Tandan S., Cheng J., Yang C., Nguyen L., Sugianto J., et al. Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure. J. Biol. Chem. 283 37 (2008 Sep 12) 25524-25532
78. Undrovinas A.I., Maltsev V.A., and Sabbah H.N. Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current. Cell. Mol. Life Sci. 55 3 (1999 Mar) 494-505
79. Wang Y., Cheng J., Joyner R.W., Wagner M.B., and Hill J.A. Remodeling of early-phase repolarization: a mechanism of abnormal impulse conduction in heart failure. Circulation 113 15 (2006 Apr 18) 1849-1856
80. Akar F.G., and Rosenbaum D.S. Transmural electrophysiological heterogeneities underlying arrhythmogenesis in heart failure. Circ. Res. 93 7 (2003 Oct 3) 638-645
81. Li G.R., Lau C.P., Ducharme A., Tardif J.C., and Nattel S. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. Am. J. Physiol. Heart Circ. Physiol. 283 3 (2002 Sep) H1031-1041
82. Clancy C.E., and Kass R.S. Defective cardiac ion channels: from mutations to clinical syndromes. J. Clin. Invest. 110 8 (2002 Oct) 1075-1077
83. Brown A.M., Schwindt P.C., and Crill W.E. Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels. J. Neurophysiol. 71 6 (1994 Jun) 2562-2565
84. Belardinelli L., Shryock J.C., and Fraser H. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart 92 Suppl 4 (2006 Jul) iv6-iv14
85. Maltsev V.A., Sabbab H.N., and Undrovinas A.I. Down-regulation of sodium current in chronic heart failure: effect of long-term therapy with carvedilol. Cell. Mol. Life Sci. 59 9 (2002 Sep) 1561-1568
86. Jacques D., Bkaily G., Jasmin G., Menard D., and Proschek L. Early fetal like slow Na+ current in heart cells of cardiomyopathic hamster. Mol. Cell. Biochem. 176 1-2 (1997 Nov) 249-256
87. Huang B., El-Sherif T., Gidh-Jain M., Qin D., and El-Sherif N. Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium. J. Cardiovasc. Electrophysiol. 12 2 (2001 Feb) 218-225
88. Maltsev V.A., Silverman N., Sabbah H.N., and Undrovinas A.I. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur. J. Heart Fail. 9 3 (2007 Mar) 219-227
89. Maltsev V.A., Sabbah H.N., Higgins R.S., Silverman N., Lesch M., and Undrovinas A.I. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98 23 (1998 Dec 8) 2545-2552
90. Valdivia C.R., Chu W.W., Pu J., Foell J.D., Haworth R.A., Wolff M.R., et al. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J. Mol. Cell. Cardiol. 38 3 (2005 Mar) 475-483
91. Shieh C.C., Coghlan M., Sullivan J.P., and Gopalakrishnan M. Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol. Rev. 52 4 (2000 Dec) 557-594
92. Wulff H., Castle N.A., and Pardo L.A. Voltage-gated potassium channels as therapeutic targets. Nat. Rev. Drug Discov. 8 12 (2009 Dec) 982-1001
93. Patel S.P., and Campbell D.L. Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J. Physiol. 569 Pt 1 (2005 Nov 15) 7-39
94. Oudit G.Y., Kassiri Z., Sah R., Ramirez R.J., Zobel C., and Backx P.H. The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium. J. Mol. Cell. Cardiol. 33 5 (2001 May) 851-872
95. Kaab S., Dixon J., Duc J., Ashen D., Nabauer M., Beuckelmann D.J., et al. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98 14 (1998) 1383-1393 1998/10/06/
96. Rosati B., Pan Z., Lypen S., Wang H.S., Cohen I., Dixon J.E., et al. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J. Physiol. 533 Pt 1 (2001 May 15) 119-125
97. Rosati B., Grau F., Rodriguez S., Li H., Nerbonne J.M., and McKinnon D. Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J. Physiol. 548 Pt 3 (2003 May 1) 815-822
98. Kaprielian R., Wickenden A.D., Kassiri Z., Parker T.G., Liu P.P., and Backx P.H. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. J. Physiol. 517 Pt 1 (1999 May 15) 229-245
99. Beuckelmann D.J., Nabauer M., and Erdmann E. Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73 2 (1993 Aug) 379-385
100. Le Grand B.L., Hatem S., Deroubaix E., Couetil J.P., and Coraboeuf E. Depressed transient outward and calcium currents in dilated human atria. Cardiovasc. Res. 28 4 (1994 Apr) 548-556
101. Wang H.S., Dixon J.E., and McKinnon D. Unexpected and differential effects of Cl- channel blockers on the Kv4.3 and Kv4.2 K+ channels. Implications for the study of the I(to2) current. Circ. Res. 81 5 (1997 Nov) 711-718
102. Beuckelmann D.J., Nabauer M., Kruger C., and Erdmann E. Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure. Am. Heart J. 129 4 (1995 Apr) 684-689
103. Litovsky S.H., and Antzelevitch C. Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. J. Am. Coll. Cardiol. 14 4 (1989 Oct) 1053-1066
104. Zygmunt A.C., Robitelle D.C., and Eddlestone G.T. Ito1 dictates behavior of ICl(Ca) during early repolarization of canine ventricle. Am. J. Physiol. 273 3 Pt 2 (1997 Sep) H1096-1106
105. Volk T., Nguyen T.H., Schultz J.H., and Ehmke H. Relationship between transient outward K+ current and Ca2+ influx in rat cardiac myocytes of endo- and epicardial origin. J. Physiol. 519 Pt 3 (1999 Sep 15) 841-850
106. Greenstein J.L., Wu R., Po S., Tomaselli G.F., and Winslow R.L. Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ. Res. 87 11 (2000 Nov 24) 1026-1033
107. Sah R., Ramirez R.J., Kaprielian R., and Backx P.H. Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes. J. Physiol. 533 Pt 1 (2001 May 15) 201-214
108. Wang Y.G., Wagner M.B., Kumar R., Goolsby W.N., and Joyner R.W. Fast pacing facilitates discontinuous action potential propagation between rabbit atrial cells. Am. J. Physiol. Heart Circ. Physiol. 279 5 (2000 Nov) H2095-2103
109. Medina-Ravell V.A., Lankipalli R.S., Yan G.X., Antzelevitch C., Medina-Malpica N.A., Medina-Malpica O.A., et al. Effect of epicardial or biventricular pacing to prolong QT interval and increase transmural dispersion of repolarization: does resynchronization therapy pose a risk for patients predisposed to long QT or torsade de pointes?. Circulation 107 5 (2003 Feb 11) 740-746
110. Bristow M.R., Saxon L.A., Boehmer J., Krueger S., Kass D.A., De Marco T., et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N. Engl. J. Med. 350 21 (2004 May 20) 2140-2150
111. Tamargo J., Caballero R., Gomez R., Valenzuela C., and Delpon E. Pharmacology of cardiac potassium channels. Cardiovasc. Res. 62 1 (2004 Apr 1) 9-33
112. Roden D.M. Clinical practice. Long-QT syndrome. N. Engl. J. Med. 358 2 (2008 Jan 10) 169-176
113. Vandenberg J.I., Walker B.D., and Campbell T.J. HERG K+ channels: friend and foe. Trends. Pharmacol. Sci. 22 5 (2001 May) 240-246
114. Jurkiewicz N.K., and Sanguinetti M.C. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide. Circ. Res. 72 1 (1993 Jan) 75-83
115. Lengyel C., Iost N., Virag L., Varro A., Lathrop D.A., and Papp J.G. Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. Br. J. Pharmacol. 132 1 (2001 Jan) 101-110
116. Varro A., Balati B., Iost N., Takacs J., Virag L., Lathrop D.A., et al. The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization. J. Physiol. 523 Pt 1 (2000 Feb 15) 67-81
117. Tsuji Y., Opthof T., Kamiya K., Yasui K., Liu W., Lu Z., et al. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc. Res. 48 2 (2000 Nov) 300-309
118. Kleiman R.B., and Houser S.R. Outward currents in normal and hypertrophied feline ventricular myocytes. Am. J. Physiol. 256 5 Pt 2 (1989 May) H1450-1461
119. Furukawa T., Bassett A.L., Furukawa N., Kimura S., and Myerburg R.J. The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy. J. Clin. Invest. 91 4 (1993 Apr) 1521-1531
120. Volders P.G., Sipido K.R., Vos M.A., Spatjens R.L., Leunissen J.D., Carmeliet E., et al. Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 100 24 (1999 Dec 14) 2455-2461
121. Xu X., Rials S.J., Wu Y., Salata J.J., Liu T., Bharucha D.B., et al. Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits. Circulation 103 11 (2001 Mar 20) 1585-1590
122. Brooksby P., Levi A.J., and Jones J.V. The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J. Hypertens. 11 6 (1993 Jun) 611-622
123. Ryder K.O., Bryant S.M., and Hart G. Changes in cell length consequent on depolarization in single left ventricular myocytes from guinea-pigs with pressure-overload left ventricular hypertrophy. Proc. Biol. Sci. 253 1336 (1993 Jul 22) 35-42
124. Tomaselli G.F., and Marban E. Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc. Res. 42 2 (1999 May) 270-283
125. Tsuji Y., Zicha S., Qi X.Y., Kodama I., and Nattel S. Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 113 3 (2006 Jan 24) 345-355
126. Noma A. ATP-regulated K+ channels in cardiac muscle. Nature 305 5930 (1983 Sep 8-14) 147-148
127. Schwappach B., Zerangue N., Jan Y.N., and Jan L.Y. Molecular basis for K(ATP) assembly: transmembrane interactions mediate association of a K+ channel with an ABC transporter. Neuron 26 1 (2000 Apr) 155-167
128. Burke M.A., Mutharasan R.K., and Ardehali H. The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel. Circ. Res. 102 2 (2008 Feb 1) 164-176
129. Kane G.C., Liu X.K., Yamada S., Olson T.M., and Terzic A. Cardiac KATP channels in health and disease. J. Mol. Cell. Cardiol. 38 6 (2005 Jun) 937-943
130. Babenko A.P., Gonzalez G., Aguilar-Bryan L., and Bryan J. Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells. Circ. Res. 83 11 (1998 Nov 30) 1132-1143
131. Fujita A., and Kurachi Y. Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers. Pharmacol. Ther. 85 1 (2000 Jan) 39-53
132. Mannhold R. KATP channel openers: structure-activity relationships and therapeutic potential. Med. Res. Rev. 24 2 (2004 Mar) 213-266
133. Hodgson D.M., Zingman L.V., Kane G.C., Perez-Terzic C., Bienengraeber M., Ozcan C., et al. Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance. EMBO J. 22 8 (2003 Apr 15) 1732-1742
134. Miyazaki T., Moritani K., Miyoshi S., Asanagi M., Zhao L.S., Mitamura H., et al. Nicorandil augments regional ischemia-induced monophasic action potential shortening and potassium accumulation without serious proarrhythmia. J. Cardiovasc. Pharmacol. 26 6 (1995 Dec) 949-956
135. Ueda H., Nakayama Y., Tsumura K., Yoshimaru K., Hayashi T., and Yoshikawa J. Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction. Can. J. Cardiol. 20 6 (2004 May 1) 625-629
136. De Waard M., Gurnett C.A., and Campbell K.P. Structural and functional diversity of voltage-activated calcium channels. Ion Channels 4 (1996) 41-87
137. Walker D., and De Waard M. Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function. Trends Neurosci. 21 4 (1998 Apr) 148-154
138. Kamp T.J., and Hell J.W. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ. Res. 87 (2000) 1095-1102 2000///
139. Pitt G.S., Dun W., and Boyden P.A. Remodeled cardiac calcium channels. J. Mol. Cell. Cardiol. 41 3 (2006 Sep) 373-388
140. Tandan S., Wang Y., Wang T.T., Jiang N., Hall D.D., Hell J.W., et al. Physical and functional interaction between calcineurin and the cardiac L-type Ca2+ channel. Circ. Res. 105 1 (2009 Jul 2) 51-60
141. Wang H.S., and Cohen I.S. Calcium channel heterogeneity in canine left ventricular myocytes. J. Physiol. 547 Pt 3 (2003 Mar 15) 825-833
142. Pandit S.V., Clark R.B., Giles W.R., and Demir S.S. A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys. J. 81 6 (2001 Dec) 3029-3051
143. Wang Y, Tandan S, Cheng J, Yang C, Nguyen L, Sugianto J, et al. CaMKII-dependent remodeling of Ca2+ current in pressure-overload heart failure. J Biol Chem. 2008 Sept 12;283(37):25524-32.
144. Bryant S.M., Shipsey S.J., and Hart G. Regional differences in electrical and mechanical properties of myocytes from guinea-pig hearts with mild left ventricular hypertrophy. Cardiovasc. Res. 35 2 (1997 Aug) 315-323
145. Kleiman R.B., and Houser S.R. Calcium currents in normal and hypertrophied isolated feline ventricular myocytes. Am. J. Physiol. 255 6 Pt 2 (1988 Dec) H1434-1442
146. Ryder K.O., Bryant S.M., and Hart G. Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation. Cardiovasc. Res. 27 7 (1993 Jul) 1278-1287
147. Yellen G. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31 3 (1998 Aug) 239-295
148. Shirokov R., Levis R., Shirokova N., and Rios E. Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor. J. Gen. Physiol. 102 6 (1993 Dec) 1005-1030
149. Pelzer D., Pelzer S., and McDonald T.F. Properties and regulation of calcium channels in muscle cells. Rev. Physiol. Biochem. Pharmacol. 114 (1990) 107-207
150. Kubalova Z. Inactivation of L-type calcium channels in cardiomyocytes. Experimental and theoretical approaches. Gen. Physiol. Biophys. 22 4 (2003 Dec) 441-454
151. Piot C., Lemaire S., Albat B., Seguin J., Nargeot J., and Richard S. High frequency-induced upregulation of human cardiac calcium currents. Circulation 93 1 (1996 Jan 1) 120-128
152. Beuckelmann D.J., and Erdmann E. Ca(2+)-currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium. Basic. Res. Cardiol. 87 Suppl 1 (1992) 235-243
153. Mewes T., and Ravens U. L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium. J. Mol. Cell. Cardiol. 26 10 (1994 Oct) 1307-1320
154. Ouadid H., Albat B., and Nargeot J. Calcium currents in diseased human cardiac cells. J. Cardiovasc. Pharmacol. 25 2 (1995 Feb) 282-291
155. Schroder F., Handrock R., Beuckelmann D.J., Hirt S., Hullin R., Priebe L., et al. Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation 98 10 (1998 Sep 8) 969-976
156. Rasmussen R.P., Minobe W., and Bristow M.R. Calcium antagonist binding sites in failing and nonfailing human ventricular myocardium. Biochem. Pharmacol. 39 4 (1990 Feb 15) 691-696
157. Schmidt U., Schwinger R.H., Bohm S., Uberfuhr P., Kreuzer E., Reichart B., et al. Evidence for an interaction of halothane with the L-type Ca2+ channel in human myocardium. Anesthesiology 79 2 (1993 Aug) 332-339
158. Gruver E.J., Morgan J.P., Stambler B.S., and Gwathmey J.K. Uniformity of calcium channel number and isometric contraction in human right and left ventricular myocardium. Basic Res Cardiol. 89 2 (1994 Mar-Apr) 139-148
159. Schwinger R.H., Hoischen S., Reuter H., and Hullin R. Regional expression and functional characterization of the L-type Ca2+-channel in myocardium from patients with end-stage heart failure and in non-failing human hearts. J. Mol. Cell. Cardiol. 31 1 (1999 Jan) 283-296
160. Takahashi T., Allen P.D., Lacro R.V., Marks A.R., Dennis A.R., Schoen F.J., et al. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J. Clin. Invest. 90 3 (1992 Sep) 927-935
161. Yang Y., Chen X., Margulies K., Jeevanandam V., Pollack P., Bailey B.A., et al. L-type Ca2+ channel alpha 1c subunit isoform switching in failing human ventricular myocardium. J. Mol. Cell. Cardiol. 32 6 (2000 Jun) 973-984
162. Studer R., Reinecke H., Bilger J., Eschenhagen T., Bohm M., Hasenfuss G., et al. Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circ. Res. 75 3 (1994 Sep) 443-453
163. Flesch M., Schwinger R.H., Schiffer F., Frank K., Sudkamp M., Kuhn-Regnier F., et al. Evidence for functional relevance of an enhanced
164. Reinecke H., Studer R., Vetter R., Holtz J., and Drexler H. Cardiac Na+/Ca2+ exchange activity in patients with end-stage heart failure. Cardiovasc. Res. 31 1 (1996 Jan) 48-54
165. Wang Z., Nolan B., Kutschke W., and Hill J.A. Na+-Ca2+ exchanger remodeling in pressure overload cardiac hypertrophy. J. Biol. Chem. 276 21 (2001 May 25) 17706-17711
166. Schillinger W., Fiolet J.W., Schlotthauer K., and Hasenfuss G. Relevance of Na+-Ca2+ exchange in heart failure. Cardiovasc. Res. 57 4 (2003 Mar 15) 921-933
167. Pogwizd S.M., Qi M., Yuan W., Samarel A.M., and Bers D.M. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ. Res. 85 11 (1999 Nov 26) 1009-1019
168. Pogwizd S.M., Schlotthauer K., Li L., Yuan W., and Bers D.M. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ. Res. 88 11 (2001 Jun 8) 1159-1167
169. Reuter H., Pott C., Goldhaber J.I., Henderson S.A., Philipson K.D., and Schwinger R.H. Na(+)-Ca2+ exchange in the regulation of cardiac excitation-contraction coupling. Cardiovasc. Res. 67 2 (2005 Aug 1) 198-207
170. Diedrichs H., Frank K., Schneider C.A., Burst V., Hagemeister J., Zobel C., et al. Increased functional importance of the Na,Ca-exchanger in contracting failing human myocardium but unchanged activity in isolated vesicles. Int. Heart J. 48 6 (2007 Nov) 755-766
171. Schwinger R.H., Wang J., Frank K., Muller-Ehmsen J., Brixius K., McDonough A.A., et al. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation 99 16 (1999 Apr 27) 2105-2112
172. Reuter H., Henderson S.A., Han T., Mottino G.A., Frank J.S., Ross R.S., et al. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium 34 1 (2003 Jul) 19-26
173. Dhalla N.S., Dixon I.M., Rupp H., and Barwinsky J. Experimental congestive heart failure due to myocardial infarction: sarcolemmal receptors and cation transporters. Basic Res. Cardiol. 86 Suppl 3 (1991) 13-23
174. Yao A., Su Z., Nonaka A., Zubair I., Spitzer K.W., Bridge J.H., et al. Abnormal myocyte Ca2+ homeostasis in rabbits with pacing-induced heart failure. Am. J. Physiol. 275 4 Pt 2 (1998 Oct) H1441-1448
175. Winslow R.L., Rice J., Jafri S., Marban E., and O'Rourke B. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure: II. Model studies. Circ. Res. 84 5 (1999 Mar 19) 571-586
176. Janvier N.C., and Boyett M.R. The role of Na-Ca exchange current in the cardiac action potential. Cardiovasc. Res. 32 1 (1996 Jul) 69-84
177. Nagy Z.A., Virag L., Toth A., Biliczki P., Acsai K., Banyasz T., et al. Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed after depolarization in canine heart. Br. J. Pharmacol. 143 7 (2004 Dec) 827-831
178. Armoundas A.A., Hobai I.A., Tomaselli G.F., Winslow R.L., and O'Rourke B. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ. Res. 93 1 (2003 Jul 11) 46-53
179. Pogwizd S.M., Sipido K.R., Verdonck F., and Bers D.M. Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis. Cardiovasc. Res. 57 4 (2003 Mar 15) 887-896
180. Sipido K.R., Bito V., Antoons G., Volders P.G., and Vos M.A. Na/Ca exchange and cardiac ventricular arrhythmias. Ann. N.Y. Acad. Sci. 1099 (2007 Mar) 339-348
181. Lab M.J. Monophasic action potentials and the detection and significance of mechanoelectric feedback in vivo. Prog. Cardiovasc. Dis. 34 1 (1991 Jul-Aug) 29-35
182. Taggart P. Mechano-electric feedback in the human heart. Cardiovasc. Res. 32 1 (1996 Jul) 38-43
183. Lab M.J., Taggart P., and Sachs F. Mechano-electric feedback. Cardiovasc. Res. 32 1 (1996 Jul) 1-2
184. Franz M.R., Cima R., Wang D., Profitt D., and Kurz R. Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias. Circulation 86 3 (1992 Sep) 968-978
185. Nazir S.A., and Lab M.J. Mechanoelectric feedback and atrial arrhythmias. Cardiovasc. Res. 32 1 (1996 Jul) 52-61
186. Zeng T., Bett G.C., and Sachs F. Stretch-activated whole cell currents in adult rat cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 278 2 (2000 Feb) H548-557
187. Song Y.D., Yang X.C., and Liu T.F. Gu ZW. Nonselective cation current in rabbit ventricular myocytes. Methods Find Exp. Clin. Pharmacol. 27 6 (2005 Jul-Aug) 377-383
188. Hu H., and Sachs F. Mechanically activated currents in chick heart cells. J. Membr. Biol. 154 3 (1996 Dec) 205-216
189. Sasaki N., Mitsuiye T., and Noma A. Effects of mechanical stretch on membrane currents of single ventricular myocytes of guinea-pig heart. Jpn. J. Physiol. 42 6 (1992) 957-970
190. Taggart P., and Lab M. Cardiac mechano-electric feedback and electrical restitution in humans. Prog. Biophys. Mol. Biol. 97 2-3 (2008 Jun-Jul) 452-460
191. Nishimura S., Seo K., Nagasaki M., Hosoya Y., Yamashita H., Fujita H., et al. Responses of single-ventricular myocytes to dynamic axial stretching. Prog. Biophys. Mol. Biol. 97 2-3 (2008 Jun-Jul) 282-297
192. Riemer T.L., Sobie E.A., and Tung L. Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models. Am. J. Physiol. 275 2 Pt 2 (1998 Aug) H431-442
193. Wang Y., Joyner R.W., Wagner M.B., Cheng J., Lai D., and Crawford B.H. Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 296 5 (2009 May) H1227-1235
194. Fotopoulos G.D., Mason M.J., Walker S., Jepson N.S., Patel D.J., Mitchell A.G., et al. Stabilisation of medically refractory ventricular arrhythmia by intra-aortic balloon counterpulsation. Heart 82 1 (1999 Jul) 96-100
195. Guerrero P.A., Schuessler R.B., Davis L.M., Beyer E.C., Johnson C.M., Yamada K.A., et al. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J. Clin. Invest. 99 8 (1997 Apr 15) 1991-1998
196. Thomas S.A., Schuessler R.B., Berul C.I., Beardslee M.A., Beyer E.C., Mendelsohn M.E., et al. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation 97 7 (1998 Feb 24) 686-691
197. Coppen S.R., Dupont E., Rothery S., and Severs N.J. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ. Res. 82 2 (1998 Feb 9) 232-243
198. Bukauskas F.F., Elfgang C., Willecke K., and Weingart R. Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. Biophys. J. 68 6 (1995 Jun) 2289-2298
199. Gourdie R.G., Severs N.J., Green C.R., Rothery S., Germroth P., and Thompson R.P. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J. Cell. Sci. 105 Pt 4 (1993 Aug) 985-991
200. Gros D., Jarry-Guichard T., Ten Velde I., de Maziere A., van Kempen M.J., Davoust J., et al. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circ. Res. 74 5 (1994 May) 839-851
201. Smith J.H., Green C.R., Peters N.S., Rothery S., and Severs N.J. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy. Am. J. Pathol. 139 4 (1991 Oct) 801-821
202. Peters N.S., Coromilas J., Severs N.J., and Wit A.L. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation 95 4 (1997 Feb 18) 988-996
203. Patel V.B., Siddiq T., Sherwood R., Richardson P.J., and Preedy V.R. Effects of the dihydropyridine calcium channel blocker amlodipine on ventricular and atrial protein synthesis in an aortic constriction model of hypertension and, following chronic treatment, in the left ventricle of SHR rats. Int. J. Cardiol. 58 3 (1997 Feb) 241-255
204. Matsushita T., Oyamada M., Fujimoto K., Yasuda Y., Masuda S., Wada Y., et al. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Circ. Res. 85 11 (1999 Nov 26) 1046-1055
205. Uzzaman M., Honjo H., Takagishi Y., Emdad L., Magee A.I., Severs N.J., et al. Remodeling of gap junctional coupling in hypertrophied right ventricles of rats with monocrotaline-induced pulmonary hypertension. Circ. Res. 86 8 (2000 Apr 28) 871-878
206. Emdad L., Uzzaman M., Takagishi Y., Honjo H., Uchida T., Severs N.J., et al. Gap junction remodeling in hypertrophied left ventricles of aortic-banded rats: prevention by angiotensin II type 1 receptor blockade. J. Mol. Cell. Cardiol. 33 2 (2001 Feb) 219-231
207. Dupont E., Matsushita T., Kaba R.A., Vozzi C., Coppen S.R., Khan N., et al. Altered connexin expression in human congestive heart failure. J. Mol. Cell. Cardiol. 33 2 (2001 Feb) 359-371
208. Ai X., and Pogwizd S.M. Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A. Circ. Res. 96 1 (2005 Jan 7) 54-63
209. Akar F.G., Spragg D.D., Tunin R.S., Kass D.A., and Tomaselli G.F. Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy. Circ. Res. 95 7 (2004 Oct 1) 717-725
210. Poelzing S., and Rosenbaum D.S. Altered connexin43 expression produces arrhythmia substrate in heart failure. Am. J. Physiol. Heart Circ. Physiol. 287 4 (2004 Oct) H1762-1770
211. Liu F., and Gutstein D.E. The cardiac gap junction: a potential therapeutic target in the treatment of heart disease. Mt. Sinai J. Med. 69 6 (2002 Nov) 421-424
212. Chung C.Y., Bien H., and Entcheva E. The role of cardiac tissue alignment in modulating electrical function. J. Cardiovasc. Electrophysiol. 18 12 (2007 Dec) 1323-1329
213. Koller M.L., Maier S.K., Gelzer A.R., Bauer W.R., Meesmann M., and Gilmour Jr. R.F. Altered dynamics of action potential restitution and alternans in humans with structural heart disease. Circulation 112 11 (2005 Sep 13) 1542-1548
214. Sukhareva M., Morrissette J., and Coronado R. Mechanism of chloride-dependent release of Ca2+ in the sarcoplasmic reticulum of rabbit skeletal muscle. Biophys. J. 67 2 (1994 Aug) 751-765
215. McPherson P.S., and Campbell K.P. The ryanodine receptor/Ca2+ release channel. J. Biol. Chem. 268 19 (1993 Jul 5) 13765-13768
216. Tarroni P., Rossi D., Conti A., and Sorrentino V. Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells. J. Biol. Chem. 272 32 (1997 Aug 8) 19808-19813
217. Marx S.O., Reiken S., Hisamatsu Y., Jayaraman T., Burkhoff D., Rosemblit N., et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101 4 (2000 May 12) 365-376
218. Bultynck G., Vermassen E., Szlufcik K., De Smet P., Fissore R.A., Callewaert G., et al. Calcineurin and intracellular Ca2+-release channels: regulation or association?. Biochem. Biophys. Res. Commun. 311 4 (2003 Nov 28) 1181-1193
219. Nimer L.R., Needleman D.H., Hamilton S.L., Krall J., and Movsesian M.A. Effect of ryanodine on sarcoplasmic reticulum Ca2+ accumulation in nonfailing and failing human myocardium. Circulation 92 9 (1995 Nov 1) 2504-2510
220. Meyer M., Schillinger W., Pieske B., Holubarsch C., Heilmann C., Posival H., et al. Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation 92 4 (1995 Aug 15) 778-784
221. Sainte Beuve C., Allen P.D., Dambrin G., Rannou F., Marty I., Trouve P., et al. Cardiac calcium release channel (ryanodine receptor) in control and cardiomyopathic human hearts: mRNA and protein contents are differentially regulated. J. Mol. Cell. Cardiol. 29 4 (1997 Apr) 1237-1246
222. Go L.O., Moschella M.C., Watras J., Handa K.K., Fyfe B.S., and Marks A.R. Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. J. Clin. Invest. 95 2 (1995 Feb) 888-894
223. Borlak J., and Thum T. Hallmarks of ion channel gene expression in end-stage heart failure. FASEB J. 17 12 (2003 Sep) 1592-1608
224. Zhang T., Maier L.S., Dalton N.D., Miyamoto S., Ross Jr. J., Bers D.M., et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ. Res. 92 8 (2003 May 2) 912-919
225. Bers D.M. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem. J. 396 1 (2006 May 15) e1-3
226. Kohlhaas M., Zhang T., Seidler T., Zibrova D., Dybkova N., Steen A., et al. Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ. Res. 98 2 (2006 Feb 3) 235-244
227. Ai X., Curran J.W., Shannon T.R., Bers D.M., and Pogwizd S.M. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ. Res. 97 12 (2005 Dec 9) 1314-1322
228. Curran J., Hinton M.J., Rios E., Bers D.M., and Shannon T.R. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ. Res. 100 3 (2007 Feb 16) 391-398
229. Engelender S., and De Meis L. Pharmacological differentiation between intracellular calcium pump isoforms. Mol. Pharmacol. 50 5 (1996 Nov) 1243-1252
230. Verboomen H., Wuytack F., De Smedt H., Himpens B., and Casteels R. Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban. Biochem. J. 286 Pt 2 (1992 Sep 1) 591-595
231. Koss K.L., and Kranias E.G. Phospholamban: a prominent regulator of myocardial contractility. Circ. Res. 79 6 (1996 Dec) 1059-1063
232. Movsesian M.A., Nishikawa M., and Adelstein R.S. Phosphorylation of phospholamban by calcium-activated, phospholipid-dependent protein kinase. Stimulation of cardiac sarcoplasmic reticulum calcium uptake. J. Biol. Chem. 259 13 (1984 Jul 10) 8029-8032
233. Simmerman H.K., Collins J.H., Theibert J.L., Wegener A.D., and Jones L.R. Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains. J. Biol. Chem. 261 28 (1986 Oct 5) 13333-13341
234. Wegener A.D., Simmerman H.K., Lindemann J.P., and Jones L.R. Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J. Biol. Chem. 264 19 (1989 Jul 5) 11468-11474
235. Talosi L., Edes I., and Kranias E.G. Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts. Am. J. Physiol. 264 3 Pt 2 (1993 Mar) H791-797
236. Kranias E.G. Regulation of Ca2+ transport by cyclic 3′,5′-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochim. Biophys. Acta 844 2 (1985 Feb 21) 193-199
237. Tada M., Inui M., Yamada M., Kadoma M., Kuzuya T., Abe H., et al. Effects of phospholamban phosphorylation catalyzed by adenosine 3′:5′-monophosphate- and calmodulin-dependent protein kinases on calcium transport ATPase of cardiac sarcoplasmic reticulum. J. Mol. Cell. Cardiol. 15 5 (1983 May) 335-346
238. Davis B.A., Schwartz A., Samaha F.J., and Kranias E.G. Regulation of cardiac sarcoplasmic reticulum calcium transport by calcium-calmodulin-dependent phosphorylation. J. Biol. Chem. 258 22 (1983 Nov 25) 13587-13591
239. Jackson W.A., and Colyer J. Translation of Ser16 and Thr17 phosphorylation of phospholamban into Ca 2+-pump stimulation. Biochem. J. 316 Pt 1 (1996 May 15) 201-207
240. Le Peuch C.J., Haiech J., and Demaille J.G. Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations. Biochemistry 18 23 (1979 Nov 13) 5150-5157
241. Raeymaekers L., Hofmann F., and Casteels R. Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle. Biochem. J. 252 1 (1988 May 15) 269-273
242. Colyer J., and Wang J.H. Dependence of cardiac sarcoplasmic reticulum calcium pump activity on the phosphorylation status of phospholamban. J. Biol. Chem. 266 26 (1991 Sep 15) 17486-17493
243. Chu G., Lester J.W., Young K.B., Luo W., Zhai J., and Kranias E.G. A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta-agonists. J. Biol. Chem. 275 49 (2000 Dec 8) 38938-38943
244. MacDougall L.K., Jones L.R., and Cohen P. Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban. Eur. J. Biochem. 196 3 (1991 Mar 28) 725-734
245. Dash R., Frank K.F., Carr A.N., Moravec C.S., and Kranias E.G. Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium. J. Mol. Cell. Cardiol. 33 7 (2001 Jul) 1345-1353
246. Hasenfuss G., Reinecke H., Studer R., Meyer M., Pieske B., Holtz J., et al. Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium. Circ. Res. 75 3 (1994 Sep) 434-442
247. Schwinger R.H., Bohm M., Schmidt U., Karczewski P., Bavendiek U., Flesch M., et al. Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation 92 11 (1995 Dec 1) 3220-3228
248. Frank K., Bolck B., Bavendiek U., and Schwinger R.H. Frequency dependent force generation correlates with sarcoplasmic calcium ATPase activity in human myocardium. Basic Res. Cardiol. 93 5 (1998 Oct) 405-411
249. Movsesian M.A., Karimi M., Green K., and Jones L.R. Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium. Circulation 90 2 (1994 Aug) 653-657
250. MacLennan D.H., and Kranias E.G. Phospholamban: a crucial regulator of cardiac contractility. Nat. Rev. Mol. Cell Biol. 4 7 (2003 Jul) 566-577
251. Heineke J., and Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7 8 (2006 Aug) 589-600
252. Nakayama H., Chen X., Baines C.P., Klevitsky R., Zhang X., Zhang H., et al. Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J. Clin. Invest. 117 9 (2007 Sep) 2431-2444
253. Nakayama H., Bodi I., Correll R.N., Chen X., and Lorenz J. Houser SR, et al. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J. Clin. Invest. 119 12 (2009 Dec) 3787-3796
254. Wickenden A.D., Lee P., Sah R., Huang Q., Fishman G.I., and Backx P.H. Targeted expression of a dominant-negative K(v)4.2 K(+) channel subunit in the mouse heart. Circ. Res. 85 11 (1999 Nov 26) 1067-1076
255. Kassiri Z., Zobel C., Nguyen T.T., Molkentin J.D., and Backx P.H. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circ. Res. 90 5 (2002 Mar 22) 578-585
256. Wang Y., Cheng J., Tandan S., Jiang M., McCloskey D.T., and Hill J.A. Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart. J. Cardiovasc. Electrophysiol. 17 3 (2006 Mar) 298-304
257. Go A.S., Hylek E.M., Phillips K.A., Chang Y., Henault L.E., Selby J.V., et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 285 18 (2001 May 9) 2370-2375