Changes in sinus node function in a rabbit model of heart failure with ventricular arrhythmias and sudden death

Circulation

Volumn 101, Issue 25, 2000, Pages 2975-2980

  Opthof, Tobias ^a   Coronel, Ruben ^b   Rademaker, Han M E ^b   Vermeulen, Jessica T ^b   Wilms Schopman, Francien J G ^b   Janse, Michiel J ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NONE

Author keywords

Acetylcholine; Arrhythmia; Death, sudden; Heart failure; Nervous system, autonomic; Norepinephrine; Sinoatrial node

Indexed keywords

ACETYLCHOLINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATECHOLAMINE RELEASE; CONTROLLED STUDY; HEART CYCLE; HEART FAILURE; HEART RATE VARIABILITY; HEART VENTRICLE ARRHYTHMIA; HOLTER MONITORING; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RABBIT; SINUS NODE; SUDDEN DEATH; VAGUS NERVE;

EID: 0034720825     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.101.25.2975     Document Type: Article

References (22)

1. Kannel WB, Ho K, Thom T. Changing epidemiological features of cardiac failure. Br Heart J. 1994;72(suppl):S3-S9.
2. Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991;325:303-310.
3. Luu M, Stevenson WG, Stevenson LW, et al. Diverse mechanisms of unexpected cardiac arrest in advanced heart failure. Circulation. 1989; 80:1675-1680.
4. Bayés de Luna A, Coumel P, Leclercq JF. Ambulatory sudden death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J. 1989;117:151-159.
5. Coumel P, Leenhardt A, Houven X, et al. New insights into the mechanisms of sudden cardiac death gained by noninvasive means. In: Allessie MA, Fromer M, eds. Atrial and Ventricular Fibrillation: Mechanisms and Device Therapy. Armonk NY: Futura Publishing Co; 1997:37-51.
6. Copie X, Hnatkova K, Staunton A, et al. Predictive power of increased heart rate versus depressed left ventricular ejection fraction and heart rate variability for risk stratification after myocardial infarction: results of a two-year follow-up study. J Am Coll Cardiol. 1996;27:270-276.
7. Floras N. Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure. J Am Coll Cardiol. 1993;4:72A-84A.
8. Eckberg DL, Drabinsky M, Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. N Engl J Med. 1971;285:877-883.
9. Schwartz PJ, LaRovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death: experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85(suppl I):I-177-I-191.
10. Vermeulen JT, McGuire MA, Opthof T, et al. Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts. Cardiovasc Res. 1994;28:1547-1554.
11. Opthof T, DeJonge B, Mackaay AJC, et al. Functional and morphological organization of the guinea-pig sinoatrial node compared with the rabbit sinoatrial node. J Mol Cell Cordial. 1985;17:549-564,
12. Opthof T, Mackaay AJC, Bleeker WK, et al. Cycle length dependence of the chronotropic effects of adrenaline and acetylcholine in the rabbit sinoatrial node. J Auton Nerv Syst. 1983;8:193-204.
13. Opthof T. The mammalian sinoatrial node. Cardiovasc Drugs Ther. 1988;1:573-597.
14. Jafri SM, Khaja F, McFarland T, et al. Efficacy of propranolol therapy after acute myocardial infarction related to coronary arterial anatomy and left ventricular function. Am J Cardiol. 1987;60:976-980.
15. Jose AD, Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res. 1970;4:160-167.
16. Opthof T. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc Res. 2000;45:177-184.
17. Jose AD, Taylor RR. Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man. J Clin Invest. 1969;48: 2019-2031.
18. Vatner SF, Higgins CB. Braunwald E. Sympathetic and parasympathetic components of reflex tachycardia induced by hypotension in conscious dogs with and without heart failure. Cardiovasc Res. 1974;8:153-161.
19. White CW. Abnormalities in baroreflex control of heart rate in canine heart failure. Am J Physiol. 1981;240:H793-H799.
20. Beau SL, Hand DE, Schuessler RB, et al. Relative densities of muscarinic cholinergic and β-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity. Circ Res. 1995;77:957-963.
21. Schmitz W, Boknik P, Linck B, et al. Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure. Mol Cell Biochem. 1996;157:251-258.
22. Ryu KH, Tanaka N, Ross J. Effects of a sinus node inhibitor on the normal and failing rabbit heart. Basic Res Cardiol. 1996;91:131-139.