Down-regulation of sodium current in chronic heart failure: Effect of long-term therapy with carvedilol

Cellular and Molecular Life Sciences

Volumn 59, Issue 9, 2002, Pages 1561-1568

  Maltsev, V A ^a   Sabbah, H N ^a   Undrovinas, A I ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Cardiomyocyte; Carvedilol; Heart failure; Patch clamp; Sodium channel

Indexed keywords

1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID TETRAACETOXYMETHYLESTER; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUFFER; CARVEDILOL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; SODIUM CHANNEL; SODIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL EMBOLISM; BETA ADRENERGIC RECEPTOR BLOCKING; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; DOG; DOWN REGULATION; DRUG MECHANISM; ENZYME ISOLATION; HEART CONDUCTION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE WALL; ISCHEMIC HEART DISEASE; LONG TERM CARE; NONHUMAN; PATCH CLAMP; SODIUM CURRENT; SODIUM TRANSPORT; STEADY STATE;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM; CARBAZOLES; CARDIAC OUTPUT, LOW; CHRONIC DISEASE; DOGS; DOWN-REGULATION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PROPANOLAMINES; SODIUM CHANNELS;

ANIMALIA; CANIS FAMILIARIS;

EID: 0036710581     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8529-0     Document Type: Article

References (39)

1. Ufret-Vincenty C. A., Baro D. J., Lederer W. J., Rockman H. A., Quinones L. E. and Santana L. F. (2001) Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. J. Biol. Chem. 276: 28197-28203
2. Yue L., Melnyk P., Gaspo R., Wang Z. and Nattel S. (1999) Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ. Res. 84: 776-784
3. Pu J. and Boyden P. A. (1997) Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart: A possible ionic mechanism for reduced excitability and postrepolarization refractoriness. Circ. Res. 81: 110-119
4. Tan H. L., Bink-Boelkens M. T., Bezzina C. R., Viswanathan P. C., Beaufort-Krol G. C., Tintelen P. J. van et al. (2001) A sodium-channel mutation causes isolated cardiac conduction disease. Nature 409: 1043-1047
5. Pinto J. M. and Boyden P. A. (1999) Electrical remodeling in ischemia and infarction. Cardiovasc. Res. 42: 284-297
6. Spooner P. M., Albert C., Benjamin E. J., Boineau R., Elston, R. C., George A. L. Jr et al. (2001) Sudden cardiac death, genes, and arrhythmogenesis: Consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part I. Circulation. 103: 2361-2364
7. Spooner P. M., Albert C., Benjamin E. J., Boineau R., Elston R. C., George A. L. Jr et al. (2001) Sudden cardiac death, genes, and arrhythmogenesis: Consideration of new population and mechanistic approaches from a national heart, lung, and blood institute workshop, part ii. Circulation 103: 2447-2452.
8. Breithardt O. A., Stellbrink C., Franke A., Balta O., Diem B. H., Bakker P. et al. (2002) Acute effects of cardiac resynchronization therapy on left ventricular Doppler indices in patients with congestive heart failure. Am. Heart J. 143: 34-44
9. Poole-Wilson P. A., Cleland J. G., Di Lenarda A., Hanrath P., Komajda M., Metra M. et al. (2002) Rationale and design of the carvedilol or metoprolol European trial in patients with chronic heart failure: COMET. Eur. J. Heart Fail. 4: 321-329
10. Doggrell S. A. and Brown L. (2002) Present and future pharmacotherapy for heart failure. Expert Opin. Pharmacother. 3: 915-930
11. Kajiwara K., Yanagita T., Nakashima Y., Wada A., Izumi F. and Yanagihara N. (2002) Differential effects of short and prolonged exposure to carvedilol on voltage-dependent Na(+) channels in cultured bovine adrenal medullary cells. J. Pharmacol. Exp. Ther. 302: 212-218
12. Sabbah H. N., Stein P. D., Kono T., Gheorghiade M., Levine T. B., Jafri S. et al. (1991) A canine model of chronic heart failure produced by multiple sequential coronary microembolizations. Am. J. Physiol. 260: H1379-H1384
13. Sabbah H. N., Goldberg A. D., Schoels W., Kono T., Webb C., Brachmann J. et al. (1992) Spontaneous and inducible ventricular arrhythmias in a canine model of chronic heart failure: Relation to haemodynamics and sympathoadrenergic activation. Eur. Heart J. 13: 1562-1572
14. Sakmann B. F., Spindler A. J., Bryant S. M., Linz K. W. and Noble D. (2000) Distribution of a persistent sodium current across the ventricular wall in guinea pigs. Circ. Res. 87: 910-914
15. Maltsev V. A., Sabbah H. N., Higgins R. S. D., Silverman N., Lesch M. and Undrovinas A. I. (1998) Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98: 2545-2552
16. Volz A., Piper H. M., Siegmund B. and Schwartz P. (1991) Longevity of adult ventricular rat heart muscle cells in serumfree primary culture. J. Mol. Cell. Cardiol. 23: 161-173
17. Maltsev V. A. and Undrovinas A. I. (1997) Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel. Am. J. Physiol. 273: H1832-H1840
18. Chiamvimonvat N., Kargacin M. E., Clark R. B. and Duff H. J. (1995) Effects of intracellular calcium on sodium current density in cultured neonatal rat cardiac myocytes. J. Physiol. 483: 307-318
19. Kaab S., Dixon J., Duc J., Ashen D., Nabauer M., Beuckelmann D. J. et al. (1998) Molecular basis of transient outward potassium current downregulation in human heart failure: A decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 98: 1383-1393
20. De Mello W. C. (1999) Cell coupling and impulse propagation in the failing heart. J. Cardiovasc. Electrophysiol. 10: 1409-1420
21. Maltsev V. A., Sabbah H. N. and Undrovinas A. I. (2001) Late sodium current is a novel target for amiodarone: Studies in failing human myocardium. J. Mol. Cell. Cardiol. 33: 923-932
22. Teerlink J. R. and Massie B. M. (2000) The role of beta-blockers in preventing sudden death in heart failure. J. Card Fail. 6: 25-33
23. Stellbrink C., Breithardt O. A., Franke A., Sack S,. Bakker P., Auricchio A. et al. (2001) Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances. J. Am. Coll. Cardiol. 38: 1957-1965
24. Sabbah H. N. (1999) The cellular and physiologic effects of beta blockers in heart failure. Clin. Cardiol. 22: V16-V20
25. Beuckelmann D. J. and Erdmann E. (1992) Ca(2+)-currents and intracellular [Ca2+]i-transients in single ventricular myocytes isolated from terminally failing human myocardium. Basic Res. Cardiol. 87: 235-243
26. Gengo P. J., Sabbah H. N., Steffen R. P., Sharpe J. K., Kono T., Stein P. D. et al. (1992) Myocardial beta adrenoceptor and voltage sensitive calcium channel changes in a canine model of chronic heart failure. J. Mol. Cell. Cardiol. 24: 1361-1369
27. Pogwizd S. M., Schlotthauer K., Li L., Yuan W. and Bers D. M. (2001) Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ. Res. 88: 1159-1167
28. Schroder F., Handrock R., Beuckelmann D. J., Hirt S., Hullin R., Priebe L. et al. (1998) Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle. Circulation 98: 969-976
29. 2+ transient in cardiomyocytes of dogs with chronic heart failure. Cell. Mol. Life Sci. 54: 597-605
30. Duff H. J., Offord J., West J. and Catterall W. A. (1992) Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle. Mol. Pharmacol. 42: 570-574
31. 2+-sensitive isoforms in the failing human heart. Circulation 99: 384-391
32. + channel inactivation gate is required for modulation by protein, kinase C. J. Gen. Physiol. 108: 375-379
33. + channels. J. Membr. Biol. 130: 183-190
34. Hein S., Kostin S., Heling A., Maeno Y. and Schaper J. (2000) The role of the cytoskeleton in heart failure. Cardiovasc. Res. 45: 273-278
35. Undrovinas A. I., Shander G. S. and Makielski J. C. (1995) Cytoskeleton modulates gating of voltage-dependent sodium channel in heart. Am. J. Physiol. 269: H203-H214
36. Kubo H., Margulies K. B., Piacentino V. 3rd, Gaughan J. P. and Houser S. R. (2001) Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation 104: 1012-1018
37. Reiken S., Gaburjakova M., Gaburjakova J., He K. K., Prieto A., Becker E. et al. (2001) beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure. Circulation 104: 2843-2848
38. Gupta R. C., Undrovinas A. I., Mishra S., Maltsev V. A., Tiwari N., Goldstein S. et al. (2001) Chronic therapy with carvedilol improves sarcoplasmic reticulum function and cardiomyocyte contractility in dogs with heart failure. Circulation 104: 11-366
39. Book W. M. (2002) Carvedilol: A nonselective beta blocking agent with antioxidant properties. Congest. Heart Fail. 8: 173-177