Phospholamban: A prominent regulator of myocardial contractility

Circulation Research

Volumn 79, Issue 6, 1996, Pages 1059-1063

  Koss, Kimberly L ^a   Kranias, Evangelia G ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

cardiac contractility; phospholamban; sarcoplasmic reticulum

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA ADRENERGIC RECEPTOR; PHOSPHOLAMBAN;

AMINO ACID SEQUENCE; CALCIUM TRANSPORT; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HEART FAILURE; HEART MUSCLE CONTRACTILITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SARCOPLASMIC RETICULUM; STOICHIOMETRY;

EID: 0029830352     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.79.6.1059     Document Type: Review

References (42)

1. Tada M, Kirchberger MA, Repke DI, Katz AM. The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem. 1974;249:6174-6180.
2. Simmerman HK, Collins JH, Theibert JL, Wegener AD, Jones LR. Sequence analysis of phospholamban: identification of phosphorylation sites and two major structural domains. J Biol Chem. 1986;261:13333-13341.
3. Raeymaekers L, Hofmann F, Casteels R. Cyclic GMP-dependent protein kinase phosphoryJates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle. Biochem J. 1988;252:269-273.
4. Hicks MJ, Shigekawa M, Katz AM. Mechanism by which cyclic adenosine 3′5′-monophosphate-dependent protein kinase stimulates calcium transport in cardiac sarcoplasmic reticulum. Circ Res. 1979;44:384-391.
5. 2+ transport by cyclic 3′,5′-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum. Biochim Biophys Acta. 1985;844:193-199.
6. 2+-ATPase with phospholamban in phospholipid vesicles. J Biol Chem. 1990;265:1702-1709.
7. Kranias EG. Regulation of calcium transport by protein phosphatase activity associated with cardiac sarcoplasmic reticulum. J Biol Chem. 1985;260:11006-11010.
8. Wegener AD, Simmerman HK, Lindemann JP, Jones LR. Phospholamban phosphorylation in intact ventricles: phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J Biol Chem. 1989;264:11468-11474.
9. Talosi L, Edes I, Kranias EG. Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts. Am J Physiol. 1993;264:H791-H797.
10. Mortishire-Smith RJ, Pitzenberger SM, Burke CJ, Middaugh CR, Garsky VM, Johnson RG. Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure. Biochemistry. 1995;34:7603-7613.
11. 2+-ATPase. Biochem J. 1994;303:511-516.
12. 2+-pump ATPase. J Biol Chem. 1992;267:1674-1679.
13. 2+ pump and blocking of phospholamban phosphorylation and dephosphorylation by a phospholamban monoclonal antibody. J Biol Chem. 1986;261:7018-7023.
14. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem. 1994;269:3088-3094.
15. 2+ transport ATPase of cardiac sarcoplasmic reticulum. J Biol Chem. 1993;268:11486-11488.
16. Wegener AD, Simmerman HK, Liepnieks J, Jones LR. Proteolytic cleavage of phospholamban purified from canine cardiac sarcoplasmic reticulum vesicles: generation of a low resolution model of phospholamban structure. J Biol Chem. 1986;261:5154-5159.
17. Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Brunger AT, Engelman DM. Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J. 1994;13:4757-4764.
18. Simmerman HKB, Kobayashi YM, Autry JM, Jones LR. A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure. J Biol Chem. 1996;271:5941-5946.
19. 2+-selective channels in lipid bilayers. J Biol Chem. 1988;263:18364-18368.
20. Voss J, Jones LR, Thomas DD. The physical mechanism of calcium pump regulation in the heart. Biophys J. 1994;67:190-196.
21. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation. Circ Res. 1994;75:401-409.
22. Hoit BD, Khoury SF, Kranias EG, Ball N, Walsh RA. In vivo echo-cardiographic detection of enhanced left ventricular function in gene-targeted mice with phospholamban deficiency. Circ Res. 1995;77:632-637.
23. Wolska BM, Stojanovic MO, Luo W, Kranias EG, Solaro RJ. Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular calcium under basal conditions and during β-adrenergic stimulation. Am J Physiol. 1996;271:391-397.
24. Luo W, Wolska BM, Grupp IL, Harrer JM, Haghighi K, Ferguson DG, Slack JP, Grupp G, Doetschman T, Solaro RJ, Kranias EG. Phospholamban gene dosage effects in the mammalian heart. Circ Res. 1996;78:839-847.
25. Chu G, Luo W, Matlib MA, Sweet WE, Ferguson DG, Boivin GP, Slack JP, Moravec CS, Grupp IL, Kranias EG. Compensatory mechanisms in phospholamban knock-out mouse hearts. Biophys J. 1996;70:A56. Abstract.
26. Kadambi VJ, Ponniah S, Harrer J, Hoit B, Dorn GW, Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest. 1996;97:533-539.
27. 2+-ATPase activity in guinea pig ventricles. J Biol Chem. 1983;258:464-471.
28. Mundina de Weilenmann C, Vittone L, deCingolani G, Mattiazi A. Dissociation between contraction and relaxation: the possible role of phospholamban phosphorylation. Basic Res Cardiol. 1987;82:507-516.
29. Garvey JL, Kranias EG, Solaro RJ. Phosphorylation of C-protein. troponin I and phospholamban in isolated rabbit hearts. Biochem J. 1988;249:709-714.
30. Ganim JR, Luo W, Ponniah S, Grupp IL, Kim HW, Ferguson DG, Kadambi V, Neumann JC, Doetschman T, Kranias EG. Mouse phospholamban gene expression during development in vivo and in vitro. Circ Res. 1992;71:1021-1030.
31. Fujii J, Zarain-Herzberg A, Willard HF, Tada M, MacLennan DH. Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to chromosome 6. J Biol Chem. 1991;266:11669-11675.
32. Koss KL, Ponniah S, Jones WK, Grupp IL, Kranias EG. Differential phospholamban gene expression in murine cardiac compartments: molecular and physiological analyses. Circ Res. 1995;77:342-353.
33. Jiang MT, Moffat MP, Narayanan N. Age-related alterations in the phosphorylation of sarcoplasmic reticulum and myofibrillar proteins and diminished contractile response to isoproterenol in intact rat ventricle. Circ Res. 1993;72:102-111.
34. 2+-transport and myocardial relaxation. Circ Res. 1994;75:245-251.
35. Arai M, Otsu K, MacLennan DH, Alpert NR, Periasamy M. Effect of thyroid hormone on the expression of mRNA encoding sarcoplasmic reticulum proteins. Circ Res. 1991;69:266-276.
36. Arai M, Alpert NR, MacLennan DH, Barton P, Periasamy M. Alterations in sarcoplasmic reticulum gene expression in human heart failure: a possible mechanism for alterations in systolic and diastolic properties of the failing myocardium. Circ Res. 1993;72:463-469.
37. Feldman AM, Ray PE, Silan CM, Mercer JA, Minobe W, Bristow MR. Selective gene expression in failing human heart: quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction. Circulation. 1991;83:1866-1872.
38. Meyer M, Schillinger W, Pieske B, Holubarsch C, Heilmann C, Posival H, Kuwajima G, Mikoshiba K, Just H, Hasenfuss G. Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation. 1995;92:778-784.
39. 2+ transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium. Circulation. 1994;90:653-657.
40. 2+-ATPase in failing and nonfailing human hearts. Cardiovasc Res. 1996;31:625-632.
41. Böhm M, Reiger B, Schwinger RH, Erdmann E. cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium. Cardiovasc Res. 1994;28:1713-1719.
42. 2+-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation. 1995;92:3220-3228.