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Volumn 121, Issue 6, 2010, Pages 822-830

Ca2+ cycling and new therapeutic approaches for heart failure

Author keywords

Calcium; Gene therapy; Heart failure; Receptors, adrenergic, beta; Sarcoplasmic reticulum

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOVIRUS VECTOR; ANTISENSE OLIGONUCLEOTIDE; BETA ADRENERGIC RECEPTOR; BINDING PROTEIN; CALCIUM ION; HS 1 ASSOCIATED PROTEIN X 1; PARVOVIRUS VECTOR; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR 1; S 107; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; CALCIUM;

EID: 77149123965     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.890954     Document Type: Review
Times cited : (112)

References (118)
  • 2
    • 0242637601 scopus 로고    scopus 로고
    • What is the role of beta-adrenergic signaling in heart failure?
    • Lohse MJ, Engelhardt S, Eschenhagen T. What is the role of beta-adrenergic signaling in heart failure? Circ Res. 2003;93:896-906.
    • (2003) Circ Res , vol.93 , pp. 896-906
    • Lohse, M.J.1    Engelhardt, S.2    Eschenhagen, T.3
  • 3
    • 0037059457 scopus 로고    scopus 로고
    • Calcium and cardiac rhythms: Physiological and pathophysiological
    • Bers DM. Calcium and cardiac rhythms: physiological and pathophysiological. Circ Res. 2002;90:14-17.
    • (2002) Circ Res , vol.90 , pp. 14-17
    • Bers, D.M.1
  • 5
    • 0001078987 scopus 로고    scopus 로고
    • Alterations of calcium-regulatory proteins in heart failure
    • DOI 10.1016/S0008-6363(97)00277-0, PII S0008636397002770
    • Hasenfuss G. Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res. 1998;37:279-289. (Pubitemid 28165990)
    • (1998) Cardiovascular Research , vol.37 , Issue.2 , pp. 279-289
    • Hasenfuss, G.1
  • 8
    • 0024599436 scopus 로고
    • Molecular cloning and characterization of a Ca2 + + Mg2 +-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum: Regulation of its expression by pressure overload and developmental stage
    • Komuro I, Kurabayashi M, Shibazaki Y, Takaku F, Yazaki Y. Molecular cloning and characterization of a Ca2 + + Mg2 +-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum: regulation of its expression by pressure overload and developmental stage. J Clin Invest. 1989;83:1102-1108.
    • (1989) J Clin Invest , vol.83 , pp. 1102-1108
    • Komuro, I.1    Kurabayashi, M.2    Shibazaki, Y.3    Takaku, F.4    Yazaki, Y.5
  • 10
    • 0038464639 scopus 로고    scopus 로고
    • Phospholamban: A crucial regulator of cardiac contractility
    • MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol. 2003;4:566-577.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 566-577
    • MacLennan, D.H.1    Kranias, E.G.2
  • 11
    • 0034093205 scopus 로고    scopus 로고
    • Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor
    • Tepe NM, Liggett SB. Functional receptor coupling to Gi is a mechanism of agonist-promoted desensitization of the beta2-adrenergic receptor. J Recept Signal Transduct Res. 2000;20:75-85.
    • (2000) J Recept Signal Transduct Res , vol.20 , pp. 75-85
    • Tepe, N.M.1    Liggett, S.B.2
  • 13
    • 0026568523 scopus 로고
    • The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrena-line-treated guinea-pigs and patients with cardiac failure
    • Brown LA, Harding SE. The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrena-line-treated guinea-pigs and patients with cardiac failure. Br J Pharmacol. 1992;106:115-122.
    • (1992) Br J Pharmacol , vol.106 , pp. 115-122
    • Brown, L.A.1    Harding, S.E.2
  • 18
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 1997;390:88-91.
    • (1997) Nature , vol.390 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 19
    • 0034705626 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis: Evidence for Gi-dependent activation
    • Communal C, Colucci WS, Singh K. p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta-adrenergic receptor-stimulated apoptosis: evidence for Gi-dependent activation. J Biol Chem. 2000;275:19395-19400.
    • (2000) J Biol Chem , vol.275 , pp. 19395-19400
    • Communal, C.1    Colucci, W.S.2    Singh, K.3
  • 20
    • 0037067463 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation
    • Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP. Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation. Circ Res. 2002;91:46-53.
    • (2002) Circ Res , vol.91 , pp. 46-53
    • Jo, S.H.1    Leblais, V.2    Wang, P.H.3    Crow, M.T.4    Xiao, R.P.5
  • 22
    • 0033535942 scopus 로고    scopus 로고
    • Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
    • Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA. 1999;96:7059-7064.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7059-7064
    • Engelhardt, S.1    Hein, L.2    Wiesmann, F.3    Lohse, M.J.4
  • 23
    • 0033854690 scopus 로고    scopus 로고
    • Functional consequences of altering myocardial adrenergic receptor signaling
    • Koch WJ, Lefkowitz RJ, Rockman HA. Functional consequences of altering myocardial adrenergic receptor signaling. Annu Rev Physiol. 2000;62:237-260.
    • (2000) Annu Rev Physiol , vol.62 , pp. 237-260
    • Koch, W.J.1    Lefkowitz, R.J.2    Rockman, H.A.3
  • 24
    • 0034636061 scopus 로고    scopus 로고
    • Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
    • Liggett SB, Tepe NM, Lorenz JN, Canning AM, Jantz TD, Mitarai S, Yatani A, Dorn GW II. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 2000;101:1707-1714.
    • (2000) Circulation , vol.101 , pp. 1707-1714
    • Liggett, S.B.1    Tepe, N.M.2    Lorenz, J.N.3    Canning, A.M.4    Jantz, T.D.5    Mitarai, S.6    Yatani, A.7    Dorn Gw, I.I.8
  • 26
    • 0032729995 scopus 로고    scopus 로고
    • 2-adrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein
    • 2-adrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein. Circulation. 1999;100:2210-2212.
    • (1999) Circulation , vol.100 , pp. 2210-2212
    • Communal, C.1    Singh, K.2    Sawyer, D.B.3    Colucci, W.S.4
  • 27
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    • Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci USA. 2001;98:1607-1612.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3    Lefkowitz, R.J.4    Kobilka, B.K.5    Xiao, R.P.6
  • 28
    • 0035656783 scopus 로고    scopus 로고
    • Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor
    • Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L. Early impairment of calcium handling and altered expression of junctin in hearts of mice overexpressing the beta1-adrenergic receptor. FASEB J. 2001;15:2718-2720.
    • (2001) FASEB J , vol.15 , pp. 2718-2720
    • Engelhardt, S.1    Boknik, P.2    Keller, U.3    Neumann, J.4    Lohse, M.J.5    Hein, L.6
  • 29
    • 1542409908 scopus 로고    scopus 로고
    • Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation
    • Engelhardt S, Hein L, Dyachenkow V, Kranias EG, Isenberg G, Lohse MJ. Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation. 2004;109: 1154-1160.
    • (2004) Circulation , vol.109 , pp. 1154-1160
    • Engelhardt, S.1    Hein, L.2    Dyachenkow, V.3    Kranias, E.G.4    Isenberg, G.5    Lohse, M.J.6
  • 30
    • 0037134401 scopus 로고    scopus 로고
    • + exchange prevents hypertrophy, fibrosis, and heart failure in -adrenergic receptor transgenic mice
    • + exchange prevents hypertrophy, fibrosis, and heart failure in -adrenergic receptor transgenic mice. Circ Res. 2002;90:814-819.
    • (2002) Circ Res , vol.90 , pp. 814-819
    • Engelhardt, S.1    Hein, L.2    Keller, U.3    Klambt, K.4    Lohse, M.J.5
  • 31
    • 0030030791 scopus 로고    scopus 로고
    • Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: Progressive reduction of beta 1-adrenergic receptor mRNA in heart failure
    • Engelhardt S, Bohm M, Erdmann E, Lohse MJ. Analysis of beta-adrenergic receptor mRNA levels in human ventricular biopsy specimens by quantitative polymerase chain reactions: progressive reduction of beta 1-adrenergic receptor mRNA in heart failure. J Am Coll Cardiol. 1996;27:146-154.
    • (1996) J Am Coll Cardiol , vol.27 , pp. 146-154
    • Engelhardt, S.1    Bohm, M.2    Erdmann, E.3    Lohse, M.J.4
  • 32
    • 0027497584 scopus 로고
    • Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart
    • Ungerer M, Bohm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation. 1993;87:454-463.
    • (1993) Circulation , vol.87 , pp. 454-463
    • Ungerer, M.1    Bohm, M.2    Elce, J.S.3    Erdmann, E.4    Lohse, M.J.5
  • 33
    • 0037050009 scopus 로고    scopus 로고
    • Seven-transmembrane-spanning receptors and heart function
    • Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 2002;415:206-212.
    • (2002) Nature , vol.415 , pp. 206-212
    • Rockman, H.A.1    Koch, W.J.2    Lefkowitz, R.J.3
  • 36
    • 0037188629 scopus 로고    scopus 로고
    • Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart
    • Gong H, Sun H, Koch WJ, Rau T, Eschenhagen T, Ravens U, Heubach JF, Adamson DL, Harding SE. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002; 105:2497-2503.
    • (2002) Circulation , vol.105 , pp. 2497-2503
    • Gong, H.1    Sun, H.2    Koch, W.J.3    Rau, T.4    Eschenhagen, T.5    Ravens, U.6    Heubach, J.F.7    Adamson, D.L.8    Harding, S.E.9
  • 37
    • 4844228660 scopus 로고    scopus 로고
    • Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy
    • Ahmet I, Krawczyk M, Heller P, Moon C, Lakatta EG, Talan MI. Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation. 2004;110:1083-1090.
    • (2004) Circulation , vol.110 , pp. 1083-1090
    • Ahmet, I.1    Krawczyk, M.2    Heller, P.3    Moon, C.4    Lakatta, E.G.5    Talan, M.I.6
  • 39
    • 63849141619 scopus 로고    scopus 로고
    • Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology
    • Nicolaou P, Kranias EG. Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology. Front Biosci. 2009;14: 3571-3585.
    • (2009) Front Biosci , vol.14 , pp. 3571-3585
    • Nicolaou, P.1    Kranias, E.G.2
  • 42
    • 34547113756 scopus 로고    scopus 로고
    • Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes
    • Rodriguez P, Mitton B, Nicolaou P, Chen G, Kranias EG. Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2007;293:H762-H769.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Rodriguez, P.1    Mitton, B.2    Nicolaou, P.3    Chen, G.4    Kranias, E.G.5
  • 44
    • 33845611066 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy
    • Yamada M, Ikeda Y, Yano M, Yoshimura K, Nishino S, Aoyama H, Wang L, Aoki H, Matsuzaki M. Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. FASEB J. 2006;20:1197-1199.
    • (2006) FASEB J , vol.20 , pp. 1197-1199
    • Yamada, M.1    Ikeda, Y.2    Yano, M.3    Yoshimura, K.4    Nishino, S.5    Aoyama, H.6    Wang, L.7    Aoki, H.8    Matsuzaki, M.9
  • 45
    • 0030025596 scopus 로고    scopus 로고
    • CAMP compartmentation is responsible for a local activation of cardiac Ca2 + channels by beta-adrenergic agonists
    • Jurevicius J, Fischmeister R. cAMP compartmentation is responsible for a local activation of cardiac Ca2 + channels by beta-adrenergic agonists. Proc Natl Acad Sci USA. 1996;93:295-299.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 295-299
    • Jurevicius, J.1    Fischmeister, R.2
  • 46
    • 0036500494 scopus 로고    scopus 로고
    • Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
    • Zaccolo M, Pozzan T. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science. 2002; 295:1711-1715.
    • (2002) Science , vol.295 , pp. 1711-1715
    • Zaccolo, M.1    Pozzan, T.2
  • 47
    • 33750910207 scopus 로고    scopus 로고
    • Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling
    • Nikolaev VO, Bunemann M, Schmitteckert E, Lohse MJ, Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res. 2006;99:1084-1091.
    • (2006) Circ Res , vol.99 , pp. 1084-1091
    • Nikolaev, V.O.1    Bunemann, M.2    Schmitteckert, E.3    Lohse, M.J.4    Engelhardt, S.5
  • 50
    • 34250156365 scopus 로고    scopus 로고
    • CAMP and cGMP signaling cross-talk: Role of phosphodiesterases and implications for cardiac pathophysiology
    • Zaccolo M, Movsesian MA. cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology. Circ Res. 2007;100:1569-1578.
    • (2007) Circ Res , vol.100 , pp. 1569-1578
    • Zaccolo, M.1    Movsesian, M.A.2
  • 53
    • 0025020589 scopus 로고
    • Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure
    • Morgan JP, Erny RE, Allen PD, Grossman W, Gwathmey JK. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation. 1990;81(suppl):III-21-III-32.
    • (1990) Circulation , vol.81 , Issue.SUPPL.
    • Morgan, J.P.1    Erny, R.E.2    Allen, P.D.3    Grossman, W.4    Gwathmey, J.K.5
  • 56
    • 0017835354 scopus 로고
    • Subcellular basis of cardiac contractile failure
    • Dhalla NS, Das PK, Sharma GP. Subcellular basis of cardiac contractile failure. J Mol Cell Cardiol. 1978;10:363-385.
    • (1978) J Mol Cell Cardiol , vol.10 , pp. 363-385
    • Dhalla, N.S.1    Das, P.K.2    Sharma, G.P.3
  • 59
    • 4544365484 scopus 로고    scopus 로고
    • Expression of the sarco/endoplasmic reticulum calcium ATPase type 2 and 3 isoforms in normal skin and Darier's disease
    • Tavadia S, Authi KS, Hodgins MB, Munro CS. Expression of the sarco/endoplasmic reticulum calcium ATPase type 2 and 3 isoforms in normal skin and Darier's disease. Br J Dermatol. 2004;151:440-445.
    • (2004) Br J Dermatol , vol.151 , pp. 440-445
    • Tavadia, S.1    Authi, K.S.2    Hodgins, M.B.3    Munro, C.S.4
  • 61
    • 0033105384 scopus 로고    scopus 로고
    • Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation
    • Schwinger RH, Munch G, Bolck B, Karczewski P, Krause EG, Erdmann E. Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation. J Mol Cell Cardiol. 1999;31:479-491.
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 479-491
    • Schwinger, R.H.1    Munch, G.2    Bolck, B.3    Karczewski, P.4    Krause, E.G.5    Erdmann, E.6
  • 64
    • 4444326728 scopus 로고    scopus 로고
    • Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy
    • Haghighi K, Gregory KN, Kranias EG. Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy. Biochem Biophys Res Commun. 2004;322:1214-1222.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 1214-1222
    • Haghighi, K.1    Gregory, K.N.2    Kranias, E.G.3
  • 67
    • 0032561337 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice
    • Sato Y, Ferguson DG, Sako H, Dorn GW II, Kadambi VJ, Yatani A, Hoit BD, Walsh RA, Kranias EG. Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J Biol Chem. 1998;273: 28470-28477.
    • (1998) J Biol Chem , vol.273 , pp. 28470-28477
    • Sato, Y.1    Ferguson, D.G.2    Sako, H.3    Dorn Gw, I.I.4    Kadambi, V.J.5    Yatani, A.6    Hoit, B.D.7    Walsh, R.A.8    Kranias, E.G.9
  • 71
    • 0030770826 scopus 로고    scopus 로고
    • Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor: Proteins of the cardiac junctional sarcoplasmic reticulum membrane
    • Zhang L, Kelley J, Schmeisser G, Kobayashi YM, Jones LR. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor: proteins of the cardiac junctional sarcoplasmic reticulum membrane. J Biol Chem. 1997;272:23389-23397.
    • (1997) J Biol Chem , vol.272 , pp. 23389-23397
    • Zhang, L.1    Kelley, J.2    Schmeisser, G.3    Kobayashi, Y.M.4    Jones, L.R.5
  • 78
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
    • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell. 2000;101:365-376.
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.O.1    Reiken, S.2    Hisamatsu, Y.3    Jayaraman, T.4    Burkhoff, D.5    Rosemblit, N.6    Marks, A.R.7
  • 80
    • 3042716226 scopus 로고    scopus 로고
    • Cardiac ryanodine receptor function and regulation in heart disease
    • Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004;1015:144-159.
    • (2004) Ann N y Acad Sci , vol.1015 , pp. 144-159
    • Lehnart, S.E.1    Wehrens, X.H.2    Kushnir, A.3    Marks, A.R.4
  • 81
    • 31444432542 scopus 로고    scopus 로고
    • Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression
    • Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci USA. 2006;103:511-518.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 511-518
    • Wehrens, X.H.1    Lehnart, S.E.2    Reiken, S.3    Vest, J.A.4    Wronska, A.5    Marks, A.R.6
  • 84
    • 35449001639 scopus 로고    scopus 로고
    • Regulation of ryanodine receptors in the heart
    • Lehnart S, Marks AR. Regulation of ryanodine receptors in the heart. Circ Res. 2007;101:746-749.
    • (2007) Circ Res , vol.101 , pp. 746-749
    • Lehnart, S.1    Marks, A.R.2
  • 85
    • 3042763171 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor
    • 2+/calmodulin- dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004;94:e61-e70.
    • (2004) Circ Res , vol.94
    • Wehrens, X.H.1    Lehnart, S.E.2    Reiken, S.R.3    Marks, A.R.4
  • 87
    • 33747431210 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes
    • 2+/calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res. 2006;99: 398-406.
    • (2006) Circ Res , vol.99 , pp. 398-406
    • Guo, T.1    Zhang, T.2    Mestril, R.3    Bers, D.M.4
  • 89
    • 0037332597 scopus 로고    scopus 로고
    • Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II
    • Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. J Clin Invest. 2003;111: 617-625.
    • (2003) J Clin Invest , vol.111 , pp. 617-625
    • Zhu, W.Z.1    Wang, S.Q.2    Chakir, K.3    Yang, D.4    Zhang, T.5    Brown, J.H.6    Devic, E.7    Kobilka, B.K.8    Cheng, H.9    Xiao, R.P.10
  • 92
    • 0037264473 scopus 로고    scopus 로고
    • Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2 +-ATPase in mice lacking the CREM gene
    • Muller FU, Lewin G, Matus M, Neumann J, Riemann B, Wistuba J, Schutz G, Schmitz W. Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2 +-ATPase in mice lacking the CREM gene. FASEB J. 2003;17:103-105.
    • (2003) FASEB J , vol.17 , pp. 103-105
    • Muller, F.U.1    Lewin, G.2    Matus, M.3    Neumann, J.4    Riemann, B.5    Wistuba, J.6    Schutz, G.7    Schmitz, W.8
  • 97
    • 50649097202 scopus 로고    scopus 로고
    • The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: A potent target for cardiovascular diseases
    • Kawase Y, Hajjar RJ. The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nat Clin Pract Cardiovasc Med. 2008;5:554-565.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 554-565
    • Kawase, Y.1    Hajjar, R.J.2
  • 98
    • 0035908945 scopus 로고    scopus 로고
    • Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure
    • del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED, Hajjar RJ. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation. 2001;104: 1424-1429.
    • (2001) Circulation , vol.104 , pp. 1424-1429
    • Del Monte, F.1    Williams, E.2    Lebeche, D.3    Schmidt, U.4    Rosenzweig, A.5    Gwathmey, J.K.6    Lewandowski, E.D.7    Hajjar, R.J.8
  • 100
    • 24744448691 scopus 로고    scopus 로고
    • Sarco/endoplasmic reticulum Ca2 +-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat
    • Lipskaia L, del Monte F, Capiod T, Yacoubi S, Hadri L, Hours M, Hajjar RJ, Lompre AM. Sarco/endoplasmic reticulum Ca2 +-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat. Circ Res. 2005;97:488-495.
    • (2005) Circ Res , vol.97 , pp. 488-495
    • Lipskaia, L.1    Del Monte, F.2    Capiod, T.3    Yacoubi, S.4    Hadri, L.5    Hours, M.6    Hajjar, R.J.7    Lompre, A.M.8
  • 104
    • 62649133817 scopus 로고    scopus 로고
    • Greenberg B, Borow K, Dittrich H, Zsebo KM, Hajjar RJ. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial
    • Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B, Borow K, Dittrich H, Zsebo KM, Hajjar RJ. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase 1/2 clinical trial. J Card Fail. 2009;15: 171-181.
    • (2009) J Card Fail , vol.15 , pp. 171-181
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3    Cappola, T.P.4    Pauly, D.F.5
  • 112
    • 33947157690 scopus 로고    scopus 로고
    • Novel targets for treating heart and muscle disease: Stabilizing ryanodine receptors and preventing intracellular calcium leak
    • Lehnart SE. Novel targets for treating heart and muscle disease: stabilizing ryanodine receptors and preventing intracellular calcium leak. Curr Opin Pharmacol. 2007;7:225-232.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 225-232
    • Lehnart, S.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.