Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

Journal of Clinical Investigation

Volumn 116, Issue 9, 2006, Pages 2510-2520

  Knollmann, Björn C ^a,g   Chopra, Nagesh ^a   Hlaing, Thinn ^b   Akin, Brandy ^c   Yang, Tao ^a   Ettensohn, Kristen ^d   Knollmann, Barbara E C ^e   Horton, Kenneth D ^b   Weissman, Neil J ^b   Holinstat, Izabela ^a   Zhang, Wei ^a   Roden, Dan M ^a   Jones, Larry R ^c   Franzini Armstrong, Clara ^f   Pfeifer, Karl ^d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON HOSPITAL CENTER   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALSEQUESTRIN; CATECHOLAMINE; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATECHOLAMINERGIC SYSTEM; CONTROLLED STUDY; DIASTOLE; GENE DELETION; GENE MUTATION; GENOTYPE; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE TACHYCARDIA; HOMOZYGOSITY; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SARCOPLASMIC RETICULUM; UPREGULATION;

ALLELES; ANIMALS; BASE SEQUENCE; CALCIUM; CALSEQUESTRIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CROSSES, GENETIC; DIASTOLE; DNA PRIMERS; ELECTROCARDIOGRAPHY; EXONS; HEART; HOMOZYGOTE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; POLYMORPHISM, GENETIC; RNA; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

EID: 33748292955     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI29128     Document Type: Article

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