Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a Type 2 diabetic rat model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 2, 2007, Pages

  Sakata, Susumu ^a,b   Lebeche, Djamel ^a   Sakata, Yuri ^a   Sakata, Naoya ^a   Chemaly, Elie R ^a   Liang, LiFan ^a   Nakajima Takenaka, Chikako ^b   Tsuji, Tsuyoshi ^a,b   Konishi, Noboru ^b   Del Monte, Federica ^a   Hajjar, Roger J ^a   Takaki, Miyako ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiomyocyte hypertrophy; Diabetes mellitus; Gene therapy; Heart failure

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA GALACTOSIDASE; CALCIUM; COLLAGEN; SARCOPLASMIC RETICULUM ADENOSINE TRIPHOSPHATASE (CALCIUM); UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CROSS CIRCULATION; DRUG INFUSION; GENE; GENE TRANSFER; HEART; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HEART WEIGHT; INFECTION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ADENOVIRIDAE; ANIMALS; CARDIOMEGALY; CELL SIZE; COLLAGEN; CORONARY CIRCULATION; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RANDOM ALLOCATION; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 33846964547     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00892.2006     Document Type: Article

References (17)

1. Abe T, Ohga Y, Tabayashi N, Kobayashi S, Sakata S, Misawa H, Tsuji T, Kohzuki H, Suga H, Taniguchi S, Takaki M. Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats. Am J Physiol Heart Circ Physiol 282: H138-H148, 2002.
2. Adachi T, Cohen RA. Decreased aortic glutathione levels may contribute to impaired nitric oxide-induced relaxation in hypercholesterolaemia. Br J Pharmacol 129: 1014-1020, 2000.
3. Adachi T, Weisbrod RM, Pimentel DR, Ying J, Sharov VS, Schöneich C, Cohen RA. S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat Med 10: 1200-1207, 2004.
4. 2+ influx. Circ Res 84: 210-219, 1999.
5. Del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci USA 101: 5622-5627, 2004.
6. Del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK, Lewandowski ED, Hajjar RJ. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2-ATPase in a rat model of heart failure. Circulation 104: 1424-1429, 2001.
7. Iwanaga Y, Hoshijima M, Gu Y, Iwatate M, Dieterle T, Ikeda Y, Date MO, Chrast J, Matsuzaki M, Peterson KL, Chien KR, Ross J Jr. Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. J Clin Invest 113: 727-736, 2004.
8. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41: 1422-1428, 1992.
9. 2+-ATPase and α-smooth muscle actin gene expression in aortas of normotensive and spontaneously hypertensive rats. Circ Res 72: 341-348, 1993.
10. Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T, Guerrero JL, Gwathmey JK, Rosenzweig A, Hajjar RJ. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA 97: 793-798, 2000.
11. Mizushige K, Yao L, Noma T, Kiyomoto H, Yu Y, Hosomi N, Ohmori K, Matsuo H. Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model. Circulation 101: 899-907, 2000.
12. Ohga Y, Sakata S, Takenaka C, Abe T, Tsuji T, Taniguchi S, Takaki M. Cardiac dysfunction in terms of left ventricular mechanical work and energetics in hypothyroid rats. Am J Physiol Heart Circ Physiol 283: H631-H641, 2002.
13. Olson EN, Williams RS. Calcineurin signaling and muscle remodeling. Cell 101: 689-692, 2000.
14. Pathak A, del Monte F, Zhao W, Schultz JE, Lorenz JN, Bodi I, Weiser D, Hahn H, Carr AN, Syed F, Mavila N, Jha L, Qian J, Marreez Y, Chen G, McGraw DW, Heist EK, Guerrero JL, DePaoli-Roach AA, Hajjar RJ, Kranias EG. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circ Res 96: 756-766, 2005.
15. Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ. Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther 13: 987-996, 2006.
16. 2+-ATPase. Circulation 101: 790-796, 2000.
17. Varagic J, Frohlich ED, Díez J, Susic D, Ahn J, González A, López B. Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR. Am J Physiol Heart Circ Physiol 290: H1503-H1509, 2006.