Both β2- and β1-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of fallot infants, consistent with selective coupling of β2-adrenergic receptors to G(s)-protein

Circulation

Volumn 102, Issue 15, 2000, Pages 1814-1821

  Molenaar, Peter ^a,b,c   Bartel, Sabine ^d   Cochrane, Andrew ^e   Vetter, Donathe ^d   Jalali, Homayoun ^a   Pohlner, Peter ^a   Burrell, Kylie ^c   Karczewski, Peter ^d   Krause, Ernst Georg ^d   Kaumann, Alberto ^f,g  

^a THE PRINCE CHARLES HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

^f BABRAHAM INSTITUTE   (United Kingdom)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Catecholamines; Myocardial contraction; Receptors, Adrenergic, Beta; Tetralogy of Fallot

Indexed keywords

ADRENALIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; GUANOSINE TRIPHOSPHATE; NORADRENALIN; PHOSPHOLAMBAN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TROPONIN I;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FALLOT TETRALOGY; FEMALE; HEART MUSCLE RELAXATION; HEART RIGHT VENTRICLE OUTFLOW TRACT; HEART VENTRICLE CONTRACTION; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; INFANT; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR DENSITY;

EID: 0034633833     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.15.1814     Document Type: Article

References (35)

1. 2-adrenoceptors in human atrium
2. 2-Adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium
3. 2-adrenoceptors in single myocytes from human ventricle
4. 2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I and C protein in ventricular myocardium from patients with terminal heart failure
5. 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force
6. Phospholamban: A prominent regulator of myocardial contractility
7. Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation
8. The molecular basis for distinct β-adrenergic receptor subtype actions in cardiomyocytes
9. 2-adrenergic signal transduction
10. 2-adrenoceptors of human heart: Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by ( - )-noradrenaline and ( - )-adrenaline
11. 2-Adrenoceptor-mediated positive inotropic effects of adrenaline in human ventricular myocardium: Quantitative discrepancies between binding and adenylate cyclase stimulation
12. 2-Adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium
13. 2-adrenergic receptors display subtype-selective coupling to G(s)
14. 2-adrenergic receptors
15. Right ventricular infundibular β-adrenoceptor complex in tetralogy of Fallot patients
16. Grading the severity of congestive heart failure in infants
17. Convenient apparatus for recording contractions of isolated muscle
18. Differential sensitivity to isoproterenol of troponin 1 and phospholamban phosphorylation in isolated rat heart
19. Discrimination between two sites of phosphorylation on adjacent amino acids by phosphorylation site-specific antibodies to phospholamban
20. 2-adrenoceptors
21. Increase of myocardial G(i)-proteins in human heart failure
22. Increase in the 40,000-mol wt pertussis toxin substrate (G-protein) in the failing human heart
23. Increased messenger RNA level of the inhibitory G-protein α-subunit G(iα2) in human end-stage heart failure
24. Distribution of myocardial beta-adrenoceptor subtypes and coupling to the adenylate cyclase in children with congenital heart disease and implication for treatment
25. A quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity binding states of the receptor by computer modelling of ligand binding data
26. Transgenic approaches to define the functional role of dual site phospholamban phosphorylation
27. 2+ and contraction following β-adrenergic stimulation of rat heart
28. Ser 16 prevails over Thr 17 phospholamban phosphorylation in the β-adrenergic regulation of cardiac relaxation
29. 2+ current in cardiac myocytes
30. L-type calcium current in human ventricular myocytes at a physiological temperature from children with tetralogy of Fallot
31. Hamodynamische Untersuchungen mit Isoprenalin und β-Rezeptorenblockern bei Kindern mit Fallotscher Tetralogie
32. Relief of dyspnoeic attacks in Fallot's tetralogy with propranolol
33. From the bedside to the basic science laboratory: Arrhythmias in Fallot's tetralogy
34. 2-adrenoceptors mediate catecholamine-evoked arrhythmias in isolated human right atrium
35. 2-adrenergic stimulation in animals susceptible to sudden death