Targeting phospholamban by gene transfer in human heart failure

Circulation

Volumn 105, Issue 8, 2002, Pages 904-907

  Del Monte, Federica ^a   Harding, Sian E ^a   Dec, G William ^a   Gwathmey, Judith K ^a   Hajjar, Roger J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Calcium; Gene therapy; Heart failure

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; PHOSPHOLAMBAN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TRANSFER; HEART CONTRACTION; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SARCOPLASMIC RETICULUM;

ADENOVIRIDAE; CALCIUM; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; DNA, ANTISENSE; ENZYME ACTIVATION; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER, HORIZONTAL; GENES, REPORTER; GENETIC VECTORS; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HUMANS; ISOENZYMES; MYOCARDIAL CONTRACTION; MYOCARDIUM; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

EID: 0037176978     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0802.105564     Document Type: Article

References (16)

1. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure
2. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
3. Human heart failure: cAMP stimulation of SR Ca(2+)-ATPase activity and phosphorylation level of phospholamban
4. 2+-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts
5. 2+-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation
6. Phospholamban: A prominent regulator of myocardial contractility
7. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation
8. Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a
9. A simplified system for generating recombinant adenoviruses
10. Regulation of calcium transport in cardiac sarcoplasmic reticulum by cyclic AMP-dependent protein kinase
11. Chronic phospholambansarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
12. Hydroxyl radical inhibits sarcoplasmic reticulum Ca(2+)-ATPase function by direct attack on the ATP binding site
13. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure
14. Evidence against spare or uncoupled beta-adrenoceptors in the human heart
15. Spare receptors for betaadrenoceptor-mediated positive inotropic effects of catecholamines in the human heart
16. 2+-exchanger protein levels and diastolic function of failing human myocardium