Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2

Cardiovascular Research

Volumn 68, Issue 1, 2005, Pages 98-108

  Kirchhefer, Uwe ^a   Baba, Hideo A ^b   Bokník, Peter ^a   Breeden, Kristine M ^c   Mavila, Nirmala ^c   Brüchert, Nicole ^a   Justus, Isabel ^a   Matus, Marek ^a   Schmitz, Wilhelm ^a   DePaoli Roach, Anna A ^c   Neumann, Joachim ^d  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c INDIANA UNIVERSITY   (United States)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Contractility; Heart; Inhibitor 2; Protein phoshatase 1; Transgenic mouse

Indexed keywords

AMINO ACID; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; MESSENGER RNA; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CHEMICAL ANALYSIS; ENZYME ACTIVITY; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STATISTICAL SIGNIFICANCE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BLOTTING, NORTHERN; CALCIUM; CALCIUM CHANNELS; CARDIOMEGALY; GENETIC ENGINEERING; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERFUSION; PHOSPHOPROTEIN PHOSPHATASE; PROTEINS; SARCOPLASMIC RETICULUM;

EID: 24344499138     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.05.019     Document Type: Article

References (48)

1. J. Neumann, R. Maas, P. Boknik, L.R. Jones, N. Zimmermann, and H. Scholz Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts J Pharmacol Exp Ther 289 1999 188 193
2. A.N. Carr, A.G. Schmidt, Y. Suzuki, F. del Monte, Y. Sato, and C. Lanner Type 1 phosphatase, a negative regulator of cardiac function Mol Cell Biol 22 2002 4124 4135
3. A.A. DePaoli-Roach Protein phosphatase 1 binding proteins R.A. Bradshow E. Dennis Handbook of Cellular Signaling vol. 1 2003 613 619
4. S.O. Marx, S. Reiken, Y. Hisamatsu, M. Gaburjakova, J. Gaburjakova, and Y.M. Yang Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers J Cell Biol 4 2001 699 708
5. H. Brandt, E.Y.C. Lee, and S.D. Killilea A protein inhibitor of rabbit liver phosphorylase phosphatase Biochem Biophys Res Commun 63 1975 950 956
6. F.L. Huang, and W.H. Glinsmann Separation and characterization of two phosphorylase phosphatase inhibitors from rabbit skeletal muscle Eur J Biochem 70 1976 419 426
7. P. Roach, P.J. Roach, and A.A. DePaoli-Roach Phosphoprotein phosphatase inhibitor-2. Identification as a species of molecular weight 31,000 in rabbit muscle, liver, and other tissues J Biol Chem 260 1985 6314 6317
8. C.F.B. Holmes, D.G. Campbell, F.B. Caudwell, A. Aitken, and P. Cohen The protein phosphatases involved in cellular regulation. Primary structure of inhibitor-2 from rabbit skeletal muscle Eur J Biochem 155 1986 173 182
9. J. Neumann, R.C. Gupta, W. Schmitz, H. Scholz, A.C. Nairn, and A.M. Watanabe Evidence for isoproterenol-induced phosphorylation of phosphatase inhibitor-1 in the intact heart Circ Res 69 1991 1450 1457
10. R.C. Gupta, J. Neumann, A.M. Watanabe, M. Lesch, and H.N. Sabbah Evidence for presence and hormonal regulation of protein phosphatase inhibitor-1 in ventricular cardiomyocyte Am J Physiol 270 1996 H1159 H1164
11. R.C. Gupta, J. Neumann, A.M. Watanabe, and H.N. Sabbah Inhibition of type 1 protein phosphatase activity by activation of beta-adrenoceptors in ventricular myocardium Biochem Pharmacol 63 2002 1069 1076
12. S. Mishra, R.C. Gupta, N. Tiwari, V. Sharov, and H.N. Sabbah Molecular mechanisms of reduced sarcoplasmic reticulum Ca(2+) uptake in human failing left ventricular myocardium J Heart Lung Transplant 21 2002 366 373
13. J. Neumann, T. Eschenhagen, L.R. Jones, B. Linck, W. Schmitz, and H. Scholz Increased expression of cardiac phosphatases in patients with end-stage heart failure J Mol Cell Cardiol 29 1997 265 272
14. S. Bartel, B. Stein, T. Eschenhagen, U. Mende, J. Neumann, and W. Schmitz Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts Mol Cell Biochem 157 1996 171 179
15. R.H. Schwinger, G. Münch, B. Bolck, P. Karczewski, E.G. Krause, and E. Erdmann Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation J Mol Cell Cardiol 31 1999 479 491
16. G.S. Bodor, A.E. Oakeley, P.D. Allen, D.L. Crimmins, J.H. Ladenson, and P.A. Anderson Troponin I phosphorylation in the normal and failing adult human heart Circulation 96 1997 1495 1500
17. P. Boknik, M. Fockenbrock, S. Herzig, J. Knapp, B. Linck, and H. Luss Protein phosphatase activity is increased in a rat model of long-term beta-adrenergic stimulation Naunyn-Schmiedebergs Arch Pharmacol 262 2000 222 231
18. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
19. J. Gulick, A. Subramaniam, J. Neumann, and J. Robbins Isolation and characterization of the mouse cardiac myosin heavy chain genes J Biol Chem 266 1991 9180 9185
20. I. Gombosova, P. Boknik, U. Kirchhefer, J. Knapp, H. Lüss, and G. Hanske Postnatal changes in contractile time parameters, calcium regulatory proteins, and phosphatases Am J Physiol 274 1998 H2123 H2132
21. U. Kirchhefer, J. Neumann, D.M. Bers, I.B. Buchwalow, L. Fabritz, and G. Hanske Impaired relaxation in transgenic mice overexpressing junctin Cardiovasc Res 59 2003 369 379
22. K.T. Tokuyasu A study of positive staining of ultrathin frozen sections J Ultrastruct Res 63 1978 287 307
23. S.T. Rapundalo, R.J. Solaro, and E.G. Kranias Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins Circ Res 64 1989 104 111
24. J. Neumann, P. Boknik, S. Herzig, W. Schmitz, H. Scholz, and R.C. Gupta Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid Am J Physiol 265 1993 H257 H266
25. A.J. Zhang, G. Bai, S. Deans-Zirattu, M.F. Browner, and E.Y.C. Lee Expression of the catalytic subunit of phosphorylase phosphatase (protein phosphatase-1) in Escherichia coli J Biol Chem 267 1992 1484 1490
26. U. Kirchhefer, J. Neumann, H.A. Baba, F. Begrow, Y.M. Kobayashi, and U. Reinke Cardiac hypertrophy and impaired relaxation in transgenic mice overexpressing triadin 1 J Biol Chem 276 2001 4142 4149
27. M.A. Porzio, and A.M. Pearson Improved resolution of myofibrillar proteins with sodium dodecyl sulfate-polyacrylamide gel electrophoresis Biochim Biophys Acta 490 1977 27 34
28. 1-adrenergic receptor transgenic mice Proc Natl Acad Sci U S A 96 1999 7059 7064
29. I. Park, and A.A. DePaoli-Roach Domains of phosphatase inhibitor-2 involved in the control of the ATP-Mg-dependent protein phosphatase J Biol Chem 269 1994 28919 28928
30. J. Yang, T.D. Hurley, and A.A. DePaoli-Roach Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif J Biol Chem 275 2000 22635 22644
31. A. Pathak, F. del Monte, W. Zhao, J.E. Schultz, J.N. Lorenz, and I. Bodi Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1 Circ Res 96 2005 756 766
32. W.G. Aschenbach, Y. Suzuki, K. Breeden, C. Prats, M.F. Hirshman, and S.D. Dufresne The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise J Biol Chem 276 2001 39959 39967
33. Y. Suzuki, C. Lanner, J.-H. Kim, P.G. Vilardo, H. Zhang, and J. Yang Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL Mol Cell Biol 21 2001 2683 2694
34. M. Delibegovic, C.G. Armstrong, L. Dobbie, P.W. Watt, A.J. Smith, and P.T. Cohen Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance Diabetes 52 2003 596 604
35. L.K. MacDougall, L.R. Jones, and P. Cohen Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban Eur J Biochem 196 1991 725 734
36. G. Chu, J.W. Lester, K.B. Young, W. Luo, J. Zhai, and E.G. Kranias A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac response to β-agonists J Biol Chem 275 2000 38938 38943
37. J.C. Braz, K. Gregory, A. Pathak, W. Zhao, B. Sahin, and R. Klevitsky PKC-alpha regulates cardiac contractility and propensity toward heart failure Nat Med 10 2004 248 254
38. B. Linck, P. Boknik, J. Knapp, F.U. Muller, J. Neumann, and W. Schmitz Effects of cantharidin on force of contraction and phosphatase activity in nonfailing and failing human hearts Br J Pharmacol 119 1996 545 550
39. J.A. Lee, A. Takai, and D.G. Allen Okadaic acid, a protein phosphatase inhibitor, increases the calcium transients in isolated ferret ventricular muscle Exp Physiol 76 1991 281 284
40. P. Boknik, S. Khorchidi, G.S. Bodor, S. Huke, J. Knapp, and B. Linck Role of protein phosphatases in regulation of cardiac inotropy and relaxation Am J Physiol 280 2001 H786 H794
41. A. El-Armouche, T. Pamminger, D. Ditz, O. Zolk, and T. Eschenhagen Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts Cardiovasc Res 61 2004 87 93
42. A. El-Armouche, T. Rau, O. Zolk, D. Ditz, T. Pamminger, and W.H. Zimmermann Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes FASEB J 17 2003 437 439
43. B.J. Wilkins, and J.D. Molkentin Calcineurin and cardiac hypertrophy: where have we been? Where are we going? J Physiol 541 2002 1 8
44. G. Chu, A.N. Carr, K.B. Young, J.W. Lester, A. Yatani, and A. Sanbe Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure Cardiovasc Res 54 2002 105 116
45. C.B. Klee, H. Ren, and X. Wang Regulation of the calmodulin-stimulated protein phosphatase, calcineurin J Biol Chem 273 1998 13367 13370
46. L.J. DeWindt, H.W. Lim, O.F. Bueno, Q. Liang, U. Delling, and J.C. Braz Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo Proc Natl Acad Sci U S A 98 2001 3322 3327
47. B.A. Rothermel, T.A. McKinsey, R.B. Vega, R.L. Nicol, P. Mammen, and J. Yang Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo Proc Natl Acad Sci U S A 98 2001 3328 3333
48. W.F. Lubbe, T. Podzuweit, and L.H. Opie Potential arrhythmogenic role of cyclic adenosine monophosphate (AMP) and cytosolic calcium overload: implications for prophylactic effects of beta-blockers in myocardial infarction and proarrhythmic effects of phosphodiesterase inhibitors J Am Coll Cardiol 19 1992 1622 1633