Myocardial-directed overexpression of the human β1-adrenergic receptor in transgenic mice

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 5, 2000, Pages 817-830

  Bisognano, John D ^a,c   Weinberger, Howard D ^a   Bohlmeyer, Teresa J ^a   Pende, Aldo ^a,d   Raynolds, Mary V ^a   Sastravaha, Amornrate ^a   Roden, Robert ^a   Asano, Koji ^a   Blaxall, Burns C ^a,e   Wu, Steven C ^a   Communal, Catherine ^b   Singh, Krishna ^b   Colucci, Wilson ^b   Bristow, Michael R ^a   Port, David J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b BOSTON UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d UNIVERSITY OF GENOA   (Italy)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Beta adrenergic receptors; Heart failure; Transgenic mice

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; MYOSIN HEAVY CHAIN; NORADRENALIN; PROTEIN BAX;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOSELECTIVITY; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0033837640     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1123     Document Type: Article

References (75)

1. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
2. Adrenergic nervous system in heart failure
3. Adrenergic effects on the biology of the adult mammalian cardiocyte
4. Down-regulation of β-adrenergic receptors and receptor mRNA in heart cells chronically exposed to norepinephrine
5. 1 receptor messenger RNA abundance in the failing human heart
6. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts
7. 2-adrenergic receptors in human failing hearts
8. 1-adrenergic receptors in the failing human heart
9. Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium
10. Expression of β-arrestins and β-adrenergic receptor kinases in the failing human heart
11. Quantification of Gi-proteins in the failing and nonfailing human myocardium
12. The role of G-proteins in transduction of the beta-adrenergic response in heart failure
13. Altered expression of the α-subunit of G proteins in failing human heart
14. The beta-adrenergic receptor-adenylate cyclase complex as a target for therapeutic intervention in heart failure
15. Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium
16. Role of beta-adrenergic receptor down-regulation in the peak exercise response of patients with heart failure due to idiopathic dilated cardiomyopathy
17. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a βARK inhibitor
18. Improvement in cardiac myocyte function by biological effects of medical therapy: A new concept in the treatment of heart failure
19. Myocardial beta-adrenoceptor changes in heart failure: Concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease
20. Down-regulation of β-adrenergic receptors: Agonist-induced reduction in receptor mRNA levels
21. Turning off the signal: Desensitization of β-adrenergic receptor function
22. 2-adrenergic receptor
23. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of β-agonist stimulation
24. Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice
25. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators
26. β-adrenergic blockade in chronic heart failure
27. Carvedilol inhibits clinical progression in patients with mild symptoms of heart failure
28. The paradox of beta-adrenergic blockade for the management of congestive heart failure
29. The role of third-generation beta-blocking agents in chronic heart failure
30. Cloning of the cDNA for the human β-adrenergic receptor
31. 2-adrenergic receptors in Chinese hamster fibroblasts
32. 1-adrenergic receptor mRNA: Role of the 3' untranslated region
33. Studies on the intrinsic activity (efficacy) of human adrenergic receptors. Co-expression of beta i and beta 2 reveals a lower efficacy for the beta I receptor
34. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure
35. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes
36. Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells
37. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway
38. 1-adrenoceptors overexpressed in rat ventricular cardiac myocytes
39. 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors
40. Isolation and characterization of the mouse cardiac myosin heavy chain genes
41. Role of myocyte-specific enhancer-binding factor (MEF-2) in transcriptional regulation of the α-cardiac myosin heavy chain gene
42. Cardiomyopathy in transgenic myf5 mice
43. 2-adrenergic receptor phosphorylation and increases β-adrenergic responsiveness
44. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy
45. Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes
46. 1-adrenergic receptor
47. 1-adrenergic receptor
48. Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice
49. Apoptosis in myocytes in end-stage heart failure
50. Apoptosis in the failing human heart
51. Gi protein protects adult rat ventricular myocytes, from β-adrenergic receptor-stimulated apoptosis in vitro
52. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure
53. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart
54. Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
55. Myocardial expression of a constitutively active α1b-adrenergic receptor in transgenic mice induces cardiac hypertrophy
56. Conditional expression and signaling of a specifically designed Gi- coupled receptor in transgenic mice
57. Transgenic Gαq overexpression induces cardiac contractile failure in mice
58. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression
59. Cardiomyopathy induced by cardiac Gs alpha over-expression
60. Low- and high-level transgenic expression of b2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gaq-overexpressing mice
61. β-adrenergic uncoupling, ventricular dysfunction, and exercise intolerance in a transgenic mouse model of hypertrophic cardiomyopathy
62. 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation
63. 2-adrenergic receptor to different G proteins by protein kinase A
64. Ligand-directed differential coupling of b2-adrenergic receptor to G proteins in intact cardiomyocytes
65. Beta-adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
66. Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase
67. Quantification of beta-adrenoceptors and beta-adrenoceptor kinase on protein and mRNA levels in heart failure
68. 1-adrenergic receptor. Involvement of G-protein-coupled receptor kinases and cAMP-dependent protein kinase
69. Desensitization of the beta-adrenergic receptor: Distinct molecular determinants of phosphorylation by specific kinases
70. Overexpression of Gs alpha protein in the hearts of transgenic mice
71. Persistent stimulation of β-adrenergic signaling triggers degeneration and apoptosis of cardiomyocytes
72. Stoichiometry of receptor-Gs-adenylate cyclase interactions
73. Chronic β-adrenergic receptor blockade prevents the depression in cardiac function in older mice with cardiac Gsα overexpression
74. Gene transfer to spark a failing heart