Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca2+ leak through ryanodine receptor in heart failure

Circulation

Volumn 102, Issue 17, 2000, Pages 2131-2136

  Yano, Masafumi ^a   Ono, Kaoru ^a   Ohkusa, Tomoko ^a   Suetsugu, Masae ^a   Kohno, Masateru ^a   Hisaoka, Takayuki ^a   Kobayashi, Shigeki ^a   Hisamatsu, Yuji ^a   Yamamoto, Takeshi ^a   Kohno, Michihiro ^a   Noguchi, Naoya ^b   Takasawa, Shin ^b   Okamoto, Hiroshi ^b   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium; Heart failure; Ion channels; Sarcoplasmic reticulum

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM CHANNEL; CALCIUM ION; FK 506 BINDING PROTEIN; ION CHANNEL; RYANODINE RECEPTOR; TACROLIMUS; TRITIUM;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; HEART FAILURE; HEART LEFT VENTRICLE; HEART PACING; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; STOICHIOMETRY;

EID: 0034711171     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.17.2131     Document Type: Article

References (24)

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3. Role of ryanodine receptors
4. Structure and function of ryanodine receptors
5. FK506-binding protein associated with the calcium release channel (ryanodine receptor)
6. Intracellular calcium-release channels: Regulators of cell life and death
7. Stabilization of calcium release channel (ryanodine receptor) function by FK 506-binding protein
8. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor
9. Selective binding of FKBP12.6 by the cardiac ryanodine receptor
10. Inhibition of calcineurin by a novel FK-506-binding protein
11. 2+-release channels from cardiac muscle
12. 2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure
13. 2+ from islet microsomes
14. 2+ release from cardiac sarcoplasmic reticulum
15. Characterization of cyclic 3':5'-AMP-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium
16. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
17. The calcium release channel of sarcoplasmic reticulum is modulated by FK-506-binding protein: Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum
18. 2+ release from sarcoplasmic reticulum
19. Role of calcium feed back in excitation-contraction coupling in isolated triads
20. 2+ release from sarcoplasmic reticulum
21. 2+, adenine nucleotide, and calmodulin
22. Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506
23. Cardiac defects and altered ryanodine receptor function in mice lacking FKBP 12
24. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts