Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences

Biotechnology Progress

Volumn 15, Issue 3, 1999, Pages 540-555

  Quick, D J ^a,b   Shuler, M L ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ENZYME KINETICS; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; IN VITRO STUDY; MODEL; NAPHTHALENE OXIDE; NAPHTHALENE; PHARMACOKINETICS; UNSPECIFIC MONOOXYGENASE;

BINDING ENERGY; BLOOD; CELL CULTURE; ENZYME KINETICS; MATHEMATICAL MODELS; METABOLITES; NAPHTHALENE; PHYSIOLOGY; PROBES; REACTION KINETICS; TISSUE; TOXICITY;

CELL CULTURE INCUBATION; GLUTATHIONE; MICE; RATS;

PHARMACOKINETICS;

ADIPOSE TISSUE; ANIMALS; BIOTECHNOLOGY; GLUTATHIONE; LIVER; LUNG; MICE; MODELS, BIOLOGICAL; NAPHTHALENES; RATS; SPECIES SPECIFICITY; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0033136567     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990057t     Document Type: Article

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