High cell density fed-batch cultivation of Escherichia coli using exponential feeding combined with pH-stat

Bioprocess and Biosystems Engineering

Volumn 26, Issue 3, 2004, Pages 147-150

  Kim, Beom Soo ^a   Lee, Seung Chul ^a   Lee, Sang Yup ^a   Chang, Yong Keun ^a   Chang, Ho Nam ^a  

^a Chungbuk National University   (South Korea)

Author keywords

Escherichia coli; Exponential feeding; Fed batch; pH stat

Indexed keywords

ACETIC ACID; GLUCOSE; POLY(3 HYDROXYBUTYRIC ACID);

ANAEROBIC BACTERIUM; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CONTROLLED STUDY; ESCHERICHIA COLI K 12; FED BATCH CULTURE; NONHUMAN; PH; PRIORITY JOURNAL;

ACETIC ACID; AMMONIA; BACTERIOLOGICAL TECHNIQUES; CULTURE MEDIA; ESCHERICHIA COLI; GLUCOSE; HYDROGEN-ION CONCENTRATION; INDUSTRIAL MICROBIOLOGY;

ESCHERICHIA COLI;

EID: 2442704008     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-003-0347-8     Document Type: Article

References (16)

1. Yamane T, Shimizu S (1984) Fed-batch techniques in microbial processes. Adv Biochem Eng Biotechnol 30:147-194
2. Lee J, Lee SY, Park S, Middelberg APJ (1999) Control of fed-batch fermentations. Biotechnol Adv 17:29-48
3. Johnston W, Cord-Ruwisch R, Cooney MJ (2002) Industrial control of recombinant E coli fed-batch culture: new perspectives on traditional controlled variables. Bioprocess Biosyst Eng 25:111-120
4. Yim SC, Jeong KJ, Chang HN, Lee SY (2001) High-level secretory production of human granulocyte-colony stimulating factor by fed-batch culture of recombinant Escherichia coli. Bioprocess Biosyst Eng 24:249-254
5. Suzuki T, Yamane T, Shimizu S (1990) Phenomenological background and some preliminary trials of automated substrate supply in pH-stat modal fed-batch culture using a set-point high limit. J Ferment Bioeng 69:292-297
6. Yano T, Kobayashi T, Shimizu S (1978) Fed-batch culture of methanol-utilizing bacterium with DO-stat. J Ferment Technol 56:416-420
7. Kim BS, Lee SC, Lee SY, Chang HN, Chang YK, Woo SI (1994) Production of poly (3-hydroxybutyric acid) by fed-batch culture of Alcaligenes eutrophus with glucose concentration control. Biotechnol Bioeng 43:892-898
8. Lee SY (1996) High cell-density culture of Escherichia coli. Tibtech 14:98-105
9. Lee SY, Yim KS, Chang HN, Chang YK (1994) Construction of plasmids, estimation of plasmid stability, and use of stable plasmids for the production of poly(3-hydroxybutyric acid) in Escherichia coli. J Biotechnol 32:203-211
10. Braunegg G, Sonnleitner B, Lafferty RM (1978) A rapid gas chromatographic method for the determination of poly-β-hydroxybutyric acid in microbial biomass. Eur J Appl Microbiol Biotechnol 6:29-37
11. Luli GW, Strohl WR (1990) Comparison of growth, acetate production, and acetate inhibition of Escherichia coli strains in batch and fed-batch fermentations. Appl Environ Microbiol 56:1004-1011
12. Han K, Lim HC, Hong J (1992) Acetic acid formation in Escherichia coli fermentation. Biotechnol Bioeng 39:663-671
13. Pan JG, Rhee JS, Lebeault JM (1987) Physiological constraints in increasing biomass concentration of Escherichia coli in fed-batch culture. Biotechnol Lett 2:89-94
14. Brown SW, Meyer HP, Fiechter A (1985) Continuous production of human leukocyte interferon with Escherichia coli and continuous cell lysis in a two-stage chemostat. Appl Microbiol Biotechnol 23:5-9
15. Riesenberg D, Schulz V, Knorre WA, Pohl HD, Korz D, Sanders EA, Ro A, Deckwer WD (1991) High cell density cultivation of Escherichia coli at controlled specific growth rate. J Biotechnol 20:17-28
16. Slater S, Gallaher T, Dennis D (1992) Production of poly-(β- hydroxybutyrate-co-3-hydroxyvalerate) in a recombinant Escherichia coli strain. Appl Environ Microbiol 58:1089-1094