In vitro evaluation of human xenobiotic toxicity: Scientific concepts and the novel Integrated Discrete Multiple Cell Co-culture (IdMOC) technology

Altex

Volumn 25, Issue 1, 2008, Pages 43-49

  Li, Albert P ^a  

^a In Vitro ADMET Laboratories LLC   (United States)

Author keywords

Alternative methods; Cytotoxicity screening; Drug development; Human drug toxicity; IdMOC; In vitro toxicity

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 9 AMINOCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CYCLOPHOSPHAMIDE; DIOXIN; FENOFIBRATE; NSC 603071; NSC 629971; POLYBROMINATED BIPHENYL; RIFAMPICIN; TAMOXIFEN; TOPOTECAN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; CYTOCHROME P450; ISOENZYME;

CANCER CELL; CELL CULTURE; COCULTURE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RESEARCH; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; REVIEW; SPECIES DIFFERENCE; SYSTEMIC CIRCULATION; TARGET CELL; TOXICITY TESTING; ARTICLE; CULTURE TECHNIQUE; DRUG EFFECT; METABOLISM; METHODOLOGY; ORGAN CULTURE TECHNIQUE;

CELL CULTURE TECHNIQUES; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; ORGAN CULTURE TECHNIQUES; TAMOXIFEN; XENOBIOTICS;

EID: 48949105651     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: 10.14573/altex.2008.1.43     Document Type: Review

References (48)

1. Abboud, G., Kaplowitz, N. (2007). Drug-induced liver injury. Drug Saf. 30(4), 277-294.
2. Bakand, S., Winder, C., Hayes, A. (2007). Comparative in vitro cytotoxicity assessment of selected gaseous compounds in human alveolar epithelial cells. Toxicol. In Vitro (in press). (Pubitemid 350026240)
3. Dambach, D. M., Andrews, B. A., Moulin, F. (2005). New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol. Pathol. 33(1), 17-26. (Pubitemid 40216800)
4. Deldar, A., Stevens, C. E. (1993). Development and application of in vitro models of hematopoiesis to drug development. Toxicol. Pathol. 21(2), 231-240. (Pubitemid 23241717)
5. Dietrich, D. R., O'Brien, E., Stack, M. E., Heussner, A. H. (2001). Species- and sex-specific renal cytotoxicity of ochratoxin A and B in vitro. Exp. Toxicol. Pathol. 53(2-3), 215-225. (Pubitemid 32625766)
6. DiMasi, J. A., Hansen, R. W., Grabowski, H. G. (2003). The price of innovation: new estimates of drug development costs. J. Health Econ. 22(2), 151-185. (Pubitemid 36279392)
7. Easterbrook, J., Fackett, D., Li, A. P. (2001). A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in Phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4′-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. Chem. Biol. Interact. 134(3), 243-249. (Pubitemid 32406147)
8. Erickson-Miller, C. L., May, R. D., Tomaszewski, J. et al. (1997). Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro. Cancer Chemother. Pharmacol. 39(5), 467-472. (Pubitemid 27078134)
9. FDA (2006). Drug interaction studies-study design, data analysis, and implications for dosing and labeling. http://www.fda.gov/cder/guidance/2635fnl. pdf
10. Guengerich, F. P. (2006). Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J. 8(1), E101-111.
11. Guizzetti, M., Pathak, S., Giordano, G., Costa, L. G. (2005). Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 215(3), 182-190. (Pubitemid 41446320)
12. Hasinoff, B. B., Patel, D., Wu, X. (2007). The cytotoxicity of celecoxib towards cardiac myocytes is cyclooxygenase-2 independent. Cardiovasc. Toxicol. 7(1), 19-27. (Pubitemid 47338488)
13. Hengstler, J. G., Van der Burg, B., Steinberg, P., Oesch, F. (1999). Interspecies differences in cancer susceptibility and toxicity. Drug Metab. Rev. 31(4), 917-970.
14. Han, S. G., Castranova, V., Vallyathan, V. (2007). Comparative cytotoxicity of cadmium and mercury in a human bronchial epithelial cell line (BEAS-2B) and its role in oxidative stress and induction of heat shock protein 70. J. Toxicol. Environ. Health A. 70(10), 852-860. (Pubitemid 46633966)
15. Handschin, C., Meyer, U. A. (2003). Induction of drug metabolism: the role of nuclear receptors. Pharmacol. Rev. 55(4), 649-673. (Pubitemid 37504978)
16. Harlan, J. M., Harker, L. A., Striker, G. E., Weaver, L. J. (1983). Effects of lipopolysaccharide on human endothelial cells in culture. Thromb. Res. 29(1), 15-26.
17. Kim, M. K., Kim, K. S., Chung, J. H. et al. (2007). Environmental metabolite, 1,2-diacetylbenzene, produces cytotoxicity through ROS generation in HUVEC cells. J. Toxicol. Environ. Health A. 70(15-16), 1336-1343.
18. Kola, I., Landis, J. (2004). Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3, 711-715. (Pubitemid 39173511)
19. Lewis, D. F., Ioannides, C., Parke, D. V. (1998). Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ. Health Perspect. 106(10), 633-641. (Pubitemid 29002676)
20. Li, A. P. (1986). An in vitro lung epithelial cell system for evaluating the potential toxicity of inhalable materials. Food Chem. Toxicol. 24(6-7), 527-534.
21. Li, A. P. (2001). Screening for human ADME/Tox drug properties in drug discovery. Drug Discov. Today 6(7), 357-366. (Pubitemid 32208650)
22. Li, A. P. (2002). A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity. Chem. Biol. Interact. 142(1-2), 7-23.
23. Li, A. P. (2004a). In vitro approaches to evaluate ADMET drug properties. Curr. Top. Med. Chem. 4(7), 701-706. (Pubitemid 38842586)
24. Li, A. P. (2004b). An integrated, multidisciplinary approach for drug safety assessment. Drug Discov. Today 9(16), 687-693 (Pubitemid 39070278)
25. Li, A. P. (2005). Cell culture tool and method. U. S. Patent 20050101010.
26. Li, A. P. (2007). Human hepatocytes: isolation, cryopreservation and applications in drug development. Chem. Biol. Interact. 168(1), 16-29. (Pubitemid 46659921)
27. Li, A. P., Myers, C. A. (1988). In vitro evaluation of the cytotoxic potential of a novel man-made fiber, calcium sodium metaphosphate fiber (Phosphate Fiber). Fundam. Appl. Toxicol. 11(1), 21-28. (Pubitemid 18198218)
28. Li, A. P., Lu, C., Brent, J. A. et al. (1999). Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem. Biol. Interact. 121(1), 17-35. (Pubitemid 29240667)
29. Li, A. P., Bode, C., Sakai, Y. (2004). A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells. Chem. Biol. Interact. 150(1), 129-136. (Pubitemid 39441299)
30. Li, W., Lam, M., Choy, D. et al. (2006). Human primary renal cells as a model for toxicity assessment of chemo-therapeutic drugs. Toxicol. In Vitro 20(5), 669-676. (Pubitemid 43816247)
31. Liu, C. L., Huang, J. K., Cheng, S. P. et al. (2006). Fatty liver and transaminase changes with adjuvant tamoxifen therapy. Anticancer Drugs 17(6), 709-713.
32. Lock, E. A., Reed, C. J., McMillan, J. M. et al. (2007). Lack of formic acid production in rat hepatocytes and human renal proximal tubule cells exposed to chloral hydrate or trichloroacetic acid. Toxicology 230(2-3), 234-243. (Pubitemid 46109141)
33. Lu, C., Li, A. P. (2001). Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chem. Biol. Interact. 134(3), 271-281. (Pubitemid 32406149)
34. Ma, X., Shah, Y., Cheung, C. et al. (2007). The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab. Dispos. 35(2), 194-200. (Pubitemid 46148730)
35. Matzno, S., Tazuya-Murayama, K., Tanaka, H. et al. (2003). Evaluation of the synergistic adverse effects of concomitant therapy with statins and fibrates on rhabdomyolysis. J. Pharm. Pharmacol. 55(6), 795-802. (Pubitemid 36752723)
36. McClay, E. F., McClay, M. T., Monroe, L. et al. (2001). A phase II study of high dose tamoxifen and weekly cisplatin in patients with metastatic melanoma. Melanoma Res. 11(3), 309-313. (Pubitemid 32578819)
37. Merrill, J. C., Beck, D. J., Kaminski, D. A., Li, A. P. (1995). Polybrominated biphenyl induction of cytochrome P450 mixed function oxidase activity in primary rat and human hepatocytes. Toxicology 99(3), 147-152.
38. Rich, I. N., Hall, K. M. (2005). Validation and development of a predictive paradigm for hemotoxicology using a multifunctional bioluminescence colony-forming proliferation assay. Toxicol. Sci. 87(2), 427-441. (Pubitemid 41300690)
39. Rodriguez-Antona, C., Donato, M. T., Boobis, A. et al. (2002). Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 32(6), 505-520. (Pubitemid 34743622)
40. Sayes, C. M., Reed, K. L., Warheit, D. B. (2007). Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles. Toxicol. Sci. 97(1), 163-180. (Pubitemid 47072165)
41. Silkworm, J. B., Koganti, A., Illouz, K. et al. (2005). Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells. Toxicol. Sci. 87(2), 508-519.
42. Stair, E. L., Reddy, G., Ritchey, J. W. et al. (2005). Effects of 1,3,5-Trinitrobenzene on cytotoxicity and metabolic activity of type I astrocytes of rats. Int. J. Toxicol. 24(1), 51-57. (Pubitemid 40504494)
43. Stanley, L. A., Horsburgh, B. C., Ross, J. et al. (2006). PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab. Rev. 38(3), 515-597. (Pubitemid 44167200)
44. Schwartz, A. L., Fridovich, S. E., Knowles, B. B., Lodish, H. F. (1981). Characterization of the asialoglycoprotein receptor in a continuous hepatoma line. J. Biol. Chem. 256(17), 8878-8881.
45. Westerink, W. M., Schoonen, W. G. (2007). Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro (in press).
46. Wilkening, S., Stahl, F., Bader, A. (2003). Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties. Drug Metab. Dispos. 31(8), 1035-1042. (Pubitemid 36975674)
47. Xu, L., Li, A. P., Kaminski, D. L., Ruh, M. F. (2000). 2,3,7,8 Tetrachlorodi..benzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chem. Biol. Interact. 124(3), 173-189. (Pubitemid 30072751)
48. Yang, Q., Nagano, T., Shah, Y. et al. (2007). The PPARα-humanized Mouse: a Model to Investigate Species Differences in Liver Toxicity Mediated by PPARα. Toxicol Sci. (in press).