-
1
-
-
23944474100
-
Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells
-
Abel K., Wang Y., Fritts L., Sanchez E., Chung E., Fitzgerald-Bocarsly P., Krieg A.M., and Miller C.J. Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells. Clin. Diagn. Lab. Immunol. 12 (2005) 606-621
-
(2005)
Clin. Diagn. Lab. Immunol.
, vol.12
, pp. 606-621
-
-
Abel, K.1
Wang, Y.2
Fritts, L.3
Sanchez, E.4
Chung, E.5
Fitzgerald-Bocarsly, P.6
Krieg, A.M.7
Miller, C.J.8
-
3
-
-
0037446777
-
CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha
-
Blackwell S.E., and Krieg A.M. CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha. J. Immunol. 170 (2003) 4061-4068
-
(2003)
J. Immunol.
, vol.170
, pp. 4061-4068
-
-
Blackwell, S.E.1
Krieg, A.M.2
-
4
-
-
19944430901
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
-
Coban C., Ishii K.J., Kawai T., Hemmi H., Sato S., Uematsu S., Yamamoto M., Takeuchi O., Itagaki S., Kumar N., Horii T., and Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201 (2005) 19-25
-
(2005)
J. Exp. Med.
, vol.201
, pp. 19-25
-
-
Coban, C.1
Ishii, K.J.2
Kawai, T.3
Hemmi, H.4
Sato, S.5
Uematsu, S.6
Yamamoto, M.7
Takeuchi, O.8
Itagaki, S.9
Kumar, N.10
Horii, T.11
Akira, S.12
-
5
-
-
0001696087
-
Isolation of whole mononuclear cells from peripheral blood and cord blood
-
Coico R. Isolation of whole mononuclear cells from peripheral blood and cord blood. Curr. Protocols Immunol. 2 (1996) 7.1.1
-
(1996)
Curr. Protocols Immunol.
, vol.2
-
-
Coico, R.1
-
6
-
-
45949092349
-
Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers
-
Cooper C.L., Ahluwalia N.K., Efler S.M., Vollmer J., Krieg A.M., and Davis H.L. Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers. J. Immune Based Ther. Vac. 6 (2008) 3
-
(2008)
J. Immune Based Ther. Vac.
, vol.6
, pp. 3
-
-
Cooper, C.L.1
Ahluwalia, N.K.2
Efler, S.M.3
Vollmer, J.4
Krieg, A.M.5
Davis, H.L.6
-
7
-
-
43449086682
-
Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression
-
Dar A., Nichani A.K., Benjamin P., Lai K., Soita H., Krieg A.M., Potter A., Babiuk L.A., and Mutwiri G.K. Attenuated cytokine responses in porcine lymph node cells stimulated with CpG DNA are associated with low frequency of IFNalpha-producing cells and TLR9 mRNA expression. Vet. Immunol. Immunopathol. 123 (2008) 324-336
-
(2008)
Vet. Immunol. Immunopathol.
, vol.123
, pp. 324-336
-
-
Dar, A.1
Nichani, A.K.2
Benjamin, P.3
Lai, K.4
Soita, H.5
Krieg, A.M.6
Potter, A.7
Babiuk, L.A.8
Mutwiri, G.K.9
-
8
-
-
6344241187
-
CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection
-
Deng J.C., Moore T.A., Newstead M.W., Zeng X., Krieg A.M., and Standiford T.J. CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection. J. Immunol. 173 (2004) 5148-5155
-
(2004)
J. Immunol.
, vol.173
, pp. 5148-5155
-
-
Deng, J.C.1
Moore, T.A.2
Newstead, M.W.3
Zeng, X.4
Krieg, A.M.5
Standiford, T.J.6
-
9
-
-
3142585337
-
Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-alpha in the pig and the phenotype of the IFN-alpha producing cells
-
Domeika K., Magnusson M., Eloranta M.L., Fuxler L., Alm G.V., and Fossum C. Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-alpha in the pig and the phenotype of the IFN-alpha producing cells. Vet. Immunol. Immunopathol. 101 (2004) 87-102
-
(2004)
Vet. Immunol. Immunopathol.
, vol.101
, pp. 87-102
-
-
Domeika, K.1
Magnusson, M.2
Eloranta, M.L.3
Fuxler, L.4
Alm, G.V.5
Fossum, C.6
-
10
-
-
0033558121
-
Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
-
Elkins K.L., Rhinehart-Jones T.R., Stibitz S., Conover J.S., and Klinman D.M. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162 (1999) 2291-2298
-
(1999)
J. Immunol.
, vol.162
, pp. 2291-2298
-
-
Elkins, K.L.1
Rhinehart-Jones, T.R.2
Stibitz, S.3
Conover, J.S.4
Klinman, D.M.5
-
11
-
-
33847190253
-
The effect of CpG-ODN on antigen presenting cells of the foal
-
Flaminio M.J., Borges A.S., Nydam D.V., Horohov D.W., Hecker R., and Matychak M.B. The effect of CpG-ODN on antigen presenting cells of the foal. J. Immune Based Ther. Vac. 5 (2007) 1
-
(2007)
J. Immune Based Ther. Vac.
, vol.5
, pp. 1
-
-
Flaminio, M.J.1
Borges, A.S.2
Nydam, D.V.3
Horohov, D.W.4
Hecker, R.5
Matychak, M.B.6
-
12
-
-
43249097514
-
A review of the role of CpG oligodeoxynucleotides as toll-like receptor 9 agonists in prophylactic and therapeutic vaccine development in infectious diseases
-
Gupta K., and Cooper C. A review of the role of CpG oligodeoxynucleotides as toll-like receptor 9 agonists in prophylactic and therapeutic vaccine development in infectious diseases. Drugs R D 9 (2008) 137-145
-
(2008)
Drugs R D
, vol.9
, pp. 137-145
-
-
Gupta, K.1
Cooper, C.2
-
13
-
-
0036587573
-
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
-
Gursel M., Verthelyi D., Gursel I., Ishii K.J., and Klinman D.M. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J. Leukoc. Biol. 71 (2002) 813-820
-
(2002)
J. Leukoc. Biol.
, vol.71
, pp. 813-820
-
-
Gursel, M.1
Verthelyi, D.2
Gursel, I.3
Ishii, K.J.4
Klinman, D.M.5
-
14
-
-
0037223705
-
A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection
-
Harandi A.M., Eriksson K., and Holmgren J. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol. 77 (2003) 953-962
-
(2003)
J. Virol.
, vol.77
, pp. 953-962
-
-
Harandi, A.M.1
Eriksson, K.2
Holmgren, J.3
-
15
-
-
0038236749
-
Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
-
Hartmann G., Battiany J., Poeck H., Wagner M., Kerkmann M., Lubenow N., Rothenfusser S., and Endres S. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur. J. Immunol. 33 (2003) 1633-1641
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 1633-1641
-
-
Hartmann, G.1
Battiany, J.2
Poeck, H.3
Wagner, M.4
Kerkmann, M.5
Lubenow, N.6
Rothenfusser, S.7
Endres, S.8
-
16
-
-
0034650517
-
Mechanism and function of a newly identified CpG DNA motif in human primary B cells
-
Hartmann G., and Krieg A.M. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164 (2000) 944-953
-
(2000)
J. Immunol.
, vol.164
, pp. 944-953
-
-
Hartmann, G.1
Krieg, A.M.2
-
17
-
-
0034142182
-
Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
-
Hartmann G., Weeratna R.D., Ballas Z.K., Payette P., Blackwell S., Suparto I., Rasmussen W.L., Waldschmidt M., Sajuthi D., Purcell R.H., Davis H.L., and Krieg A.M. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J. Immunol. 164 (2000) 1617-1624
-
(2000)
J. Immunol.
, vol.164
, pp. 1617-1624
-
-
Hartmann, G.1
Weeratna, R.D.2
Ballas, Z.K.3
Payette, P.4
Blackwell, S.5
Suparto, I.6
Rasmussen, W.L.7
Waldschmidt, M.8
Sajuthi, D.9
Purcell, R.H.10
Davis, H.L.11
Krieg, A.M.12
-
18
-
-
76849095722
-
Evaluating the immune responses stimulated by CpG oligodeoxynucleotides
-
Hayashi M., Kuwahara M., Ogata M., Miyao-Kurosaki N., Abel T., Ueki R., Yano M., Fujii M., Hartmann G., and Takaku H. Evaluating the immune responses stimulated by CpG oligodeoxynucleotides. Nucleic Acids Res. Suppl. 323 (2003) 4
-
(2003)
Nucleic Acids Res. Suppl.
, vol.323
, pp. 4
-
-
Hayashi, M.1
Kuwahara, M.2
Ogata, M.3
Miyao-Kurosaki, N.4
Abel, T.5
Ueki, R.6
Yano, M.7
Fujii, M.8
Hartmann, G.9
Takaku, H.10
-
19
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5 (2004) 987-995
-
(2004)
Nat. Immunol.
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
21
-
-
4344658819
-
C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level
-
Jurk M., Schulte B., Kritzler A., Noll B., Uhlmann E., Wader T., Schetter C., Krieg A.M., and Vollmer J. C-Class CpG ODN: sequence requirements and characterization of immunostimulatory activities on mRNA level. Immunobiology 209 (2004) 141-154
-
(2004)
Immunobiology
, vol.209
, pp. 141-154
-
-
Jurk, M.1
Schulte, B.2
Kritzler, A.3
Noll, B.4
Uhlmann, E.5
Wader, T.6
Schetter, C.7
Krieg, A.M.8
Vollmer, J.9
-
22
-
-
33748192184
-
Protection of Balb/c mice against infection with FMDV by immunostimulation with CpG oligonucleotides
-
Kamstrup S., Frimann T.H., and Barfoed A.M. Protection of Balb/c mice against infection with FMDV by immunostimulation with CpG oligonucleotides. Antivir. Res. 72 (2006) 42-48
-
(2006)
Antivir. Res.
, vol.72
, pp. 42-48
-
-
Kamstrup, S.1
Frimann, T.H.2
Barfoed, A.M.3
-
23
-
-
0035952189
-
Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides
-
Kamstrup S., Verthelyi D., and Klinman D.M. Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet. Microbiol. 78 (2001) 353-362
-
(2001)
Vet. Microbiol.
, vol.78
, pp. 353-362
-
-
Kamstrup, S.1
Verthelyi, D.2
Klinman, D.M.3
-
24
-
-
0037407691
-
Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
-
Kerkmann M., Rothenfusser S., Hornung V., Towarowski A., Wagner M., Sarris A., Giese T., Endres S., and Hartmann G. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170 (2003) 4465-4474
-
(2003)
J. Immunol.
, vol.170
, pp. 4465-4474
-
-
Kerkmann, M.1
Rothenfusser, S.2
Hornung, V.3
Towarowski, A.4
Wagner, M.5
Sarris, A.6
Giese, T.7
Endres, S.8
Hartmann, G.9
-
25
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
26
-
-
0029984358
-
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
-
Klinman D.M., Yi A.K., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 93 (1996) 2879-2883
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2879-2883
-
-
Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
27
-
-
0033950421
-
CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12
-
Kranzer K., Bauer M., Lipford G.B., Heeg K., Wagner H., and Lang R. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12. Immunology 99 (2000) 170-178
-
(2000)
Immunology
, vol.99
, pp. 170-178
-
-
Kranzer, K.1
Bauer, M.2
Lipford, G.B.3
Heeg, K.4
Wagner, H.5
Lang, R.6
-
28
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20 (2002) 709-760
-
(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
29
-
-
7444242674
-
Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
-
Krieg A.M., Efler S.M., Wittpoth M., Al Adhami M.J., and Davis H.L. Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J. Immunother. 27 (2004) 460-471
-
(2004)
J. Immunother.
, vol.27
, pp. 460-471
-
-
Krieg, A.M.1
Efler, S.M.2
Wittpoth, M.3
Al Adhami, M.J.4
Davis, H.L.5
-
30
-
-
0032168355
-
CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
-
Krieg A.M., Love-Homan L., Yi A.K., and Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161 (1998) 2428-2434
-
(1998)
J. Immunol.
, vol.161
, pp. 2428-2434
-
-
Krieg, A.M.1
Love-Homan, L.2
Yi, A.K.3
Harty, J.T.4
-
31
-
-
3142683548
-
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
-
Krug A., French A.R., Barchet W., Fischer J.A., Dzionek A., Pingel J.T., Orihuela M.M., Akira S., Yokoyama W.M., and Colonna M. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21 (2004) 107-119
-
(2004)
Immunity
, vol.21
, pp. 107-119
-
-
Krug, A.1
French, A.R.2
Barchet, W.3
Fischer, J.A.4
Dzionek, A.5
Pingel, J.T.6
Orihuela, M.M.7
Akira, S.8
Yokoyama, W.M.9
Colonna, M.10
-
32
-
-
0034933019
-
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
-
Krug A., Rothenfusser S., Hornung V., Jahrsdorfer B., Blackwell S., Ballas Z.K., Endres S., Krieg A.M., and Hartmann G. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur. J. Immunol. 31 (2001) 2154-2163
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2154-2163
-
-
Krug, A.1
Rothenfusser, S.2
Hornung, V.3
Jahrsdorfer, B.4
Blackwell, S.5
Ballas, Z.K.6
Endres, S.7
Krieg, A.M.8
Hartmann, G.9
-
33
-
-
0037377990
-
CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells
-
Krug A., Rothenfusser S., Selinger S., Bock C., Kerkmann M., Battiany J., Sarris A., Giese T., Speiser D., Endres S., and Hartmann G. CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J. Immunol. 170 (2003) 3468-3477
-
(2003)
J. Immunol.
, vol.170
, pp. 3468-3477
-
-
Krug, A.1
Rothenfusser, S.2
Selinger, S.3
Bock, C.4
Kerkmann, M.5
Battiany, J.6
Sarris, A.7
Giese, T.8
Speiser, D.9
Endres, S.10
Hartmann, G.11
-
34
-
-
0034777579
-
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
-
Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., Giese T., Engelmann H., Endres S., Krieg A.M., and Hartmann G. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31 (2001) 3026-3037
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3026-3037
-
-
Krug, A.1
Towarowski, A.2
Britsch, S.3
Rothenfusser, S.4
Hornung, V.5
Bals, R.6
Giese, T.7
Engelmann, H.8
Endres, S.9
Krieg, A.M.10
Hartmann, G.11
-
35
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
36
-
-
10744221674
-
The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 gene and CpG sequence
-
Li J., Gao R., Wu M., Meng M., Tang M., Shen Y., Wang L., Wu X., Yin X., Xie H., and Liu S. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 gene and CpG sequence. Vet. Res. Commun. 28 (2004) 33-46
-
(2004)
Vet. Res. Commun.
, vol.28
, pp. 33-46
-
-
Li, J.1
Gao, R.2
Wu, M.3
Meng, M.4
Tang, M.5
Shen, Y.6
Wang, L.7
Wu, X.8
Yin, X.9
Xie, H.10
Liu, S.11
-
37
-
-
33846338137
-
Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken
-
Linghua Z., Xingshan T., and Fengzhen Z. Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Vet. Immunol. Immunopathol. 115 (2007) 216-222
-
(2007)
Vet. Immunol. Immunopathol.
, vol.115
, pp. 216-222
-
-
Linghua, Z.1
Xingshan, T.2
Fengzhen, Z.3
-
38
-
-
33644797214
-
Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo
-
Linghua Z., Yong G., Xingshan T., and Fengzhen Z. Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Dev. Comp. Immunol. 30 (2006) 589-596
-
(2006)
Dev. Comp. Immunol.
, vol.30
, pp. 589-596
-
-
Linghua, Z.1
Yong, G.2
Xingshan, T.3
Fengzhen, Z.4
-
39
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
-
Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
40
-
-
0038341916
-
Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions
-
Marshall J.D., Fearon K., Abbate C., Subramanian S., Yee P., Gregorio J., Coffman R.L., and Van Nest G. Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leukoc. Biol. 73 (2003) 781-792
-
(2003)
J. Leukoc. Biol.
, vol.73
, pp. 781-792
-
-
Marshall, J.D.1
Fearon, K.2
Abbate, C.3
Subramanian, S.4
Yee, P.5
Gregorio, J.6
Coffman, R.L.7
Van Nest, G.8
-
41
-
-
33846990935
-
Friendly and dangerous signals: is the tissue in control?
-
Matzinger P. Friendly and dangerous signals: is the tissue in control?. Nat. Immunol. 8 (2007) 11-13
-
(2007)
Nat. Immunol.
, vol.8
, pp. 11-13
-
-
Matzinger, P.1
-
42
-
-
0035229733
-
CpG DNA: security code for host defense
-
Medzhitov R. CpG DNA: security code for host defense. Nat. Immunol. 2 (2001) 15-16
-
(2001)
Nat. Immunol.
, vol.2
, pp. 15-16
-
-
Medzhitov, R.1
-
43
-
-
0034129629
-
Signaling and transcription in T helper development
-
Murphy K.M., Ouyang W., Farrar J.D., Yang J., Ranganath S., Asnagli H., Afkarian M., and Murphy T.L. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18 (2000) 451-494
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 451-494
-
-
Murphy, K.M.1
Ouyang, W.2
Farrar, J.D.3
Yang, J.4
Ranganath, S.5
Asnagli, H.6
Afkarian, M.7
Murphy, T.L.8
-
44
-
-
12244274967
-
Biological activity of immunostimulatory CpG DNA motifs in domestic animals
-
Mutwiri G., Pontarollo R., Babiuk S., Griebel P., den Hurk S., Mena A., Tsang C., Alcon V., Nichani A., Ioannou X., Gomis S., Townsend H., Hecker R., Potter A., and Babiuk L.A. Biological activity of immunostimulatory CpG DNA motifs in domestic animals. Vet. Immunol. Immunopathol. 91 (2003) 89-103
-
(2003)
Vet. Immunol. Immunopathol.
, vol.91
, pp. 89-103
-
-
Mutwiri, G.1
Pontarollo, R.2
Babiuk, S.3
Griebel, P.4
den Hurk, S.5
Mena, A.6
Tsang, C.7
Alcon, V.8
Nichani, A.9
Ioannou, X.10
Gomis, S.11
Townsend, H.12
Hecker, R.13
Potter, A.14
Babiuk, L.A.15
-
45
-
-
2442471894
-
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
-
Mutwiri G.K., Nichani A.K., Babiuk S., and Babiuk L.A. Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J. Control Release 97 (2004) 1-17
-
(2004)
J. Control Release
, vol.97
, pp. 1-17
-
-
Mutwiri, G.K.1
Nichani, A.K.2
Babiuk, S.3
Babiuk, L.A.4
-
46
-
-
0037144547
-
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
-
Nguyen K.B., Watford W.T., Salomon R., Hofmann S.R., Pien G.C., Morinobu A., Gadina M., O'Shea J.J., and Biron C.A. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297 (2002) 2063-2066
-
(2002)
Science
, vol.297
, pp. 2063-2066
-
-
Nguyen, K.B.1
Watford, W.T.2
Salomon, R.3
Hofmann, S.R.4
Pien, G.C.5
Morinobu, A.6
Gadina, M.7
O'Shea, J.J.8
Biron, C.A.9
-
47
-
-
33846222461
-
Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep
-
Nichani A.K., Dar M.A., Krieg A.M., Mirakhur K.K., Kaushik R.S., Griebel P.J., Manuja A., Townsend H.G., Babiuk L.A., and Mutwiri G.K. Systemic innate immune responses following intrapulmonary delivery of CpG oligodeoxynucleotides in sheep. Vet. Immunol. Immunopathol. 115 (2007) 357-368
-
(2007)
Vet. Immunol. Immunopathol.
, vol.115
, pp. 357-368
-
-
Nichani, A.K.1
Dar, M.A.2
Krieg, A.M.3
Mirakhur, K.K.4
Kaushik, R.S.5
Griebel, P.J.6
Manuja, A.7
Townsend, H.G.8
Babiuk, L.A.9
Mutwiri, G.K.10
-
48
-
-
12144287264
-
CpG oligodeoxynucleotide induction of antiviral effector molecules in sheep
-
Nichani A.K., Kaushik R.S., Mena A., Popowych Y., Dent D., Townsend H.G., Mutwiri G., Hecker R., Babiuk L.A., and Griebel P.J. CpG oligodeoxynucleotide induction of antiviral effector molecules in sheep. Cell. Immunol. 227 (2004) 24-37
-
(2004)
Cell. Immunol.
, vol.227
, pp. 24-37
-
-
Nichani, A.K.1
Kaushik, R.S.2
Mena, A.3
Popowych, Y.4
Dent, D.5
Townsend, H.G.6
Mutwiri, G.7
Hecker, R.8
Babiuk, L.A.9
Griebel, P.J.10
-
49
-
-
33645802206
-
Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding
-
Nichani A.K., Mena A., Kaushik R.S., Mutwiri G.K., Townsend H.G., Hecker R., Krieg A.M., Babiuk L.A., and Griebel P.J. Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpesvirus-1 shedding. Oligonucleotides 16 (2006) 58-67
-
(2006)
Oligonucleotides
, vol.16
, pp. 58-67
-
-
Nichani, A.K.1
Mena, A.2
Kaushik, R.S.3
Mutwiri, G.K.4
Townsend, H.G.5
Hecker, R.6
Krieg, A.M.7
Babiuk, L.A.8
Griebel, P.J.9
-
50
-
-
1142285586
-
In vivo immunostimulatory effects of CpG oligodeoxynucleotide in cattle and sheep
-
Nichani A.K., Mena A., Popowych Y., Dent D., Townsend H.G., Mutwiri G.K., Hecker R., Babiuk L.A., and Griebel P.J. In vivo immunostimulatory effects of CpG oligodeoxynucleotide in cattle and sheep. Vet. Immunol. Immunopathol. 98 (2004) 17-29
-
(2004)
Vet. Immunol. Immunopathol.
, vol.98
, pp. 17-29
-
-
Nichani, A.K.1
Mena, A.2
Popowych, Y.3
Dent, D.4
Townsend, H.G.5
Mutwiri, G.K.6
Hecker, R.7
Babiuk, L.A.8
Griebel, P.J.9
-
51
-
-
0036828062
-
Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs
-
Olbrich A.R., Schimmer S., Heeg K., Schepers K., Schumacher T.N., and Dittmer U. Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs. J. Virol. 76 (2002) 11397-11404
-
(2002)
J. Virol.
, vol.76
, pp. 11397-11404
-
-
Olbrich, A.R.1
Schimmer, S.2
Heeg, K.3
Schepers, K.4
Schumacher, T.N.5
Dittmer, U.6
-
52
-
-
0029989339
-
Immune and inflammatory responses in TNF alpha-deficient mice. A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
-
Pasparakis M., Alexopoulou L., Episkopou V., and Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice. A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184 (1996) 1397-1411
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1397-1411
-
-
Pasparakis, M.1
Alexopoulou, L.2
Episkopou, V.3
Kollias, G.4
-
53
-
-
0032526030
-
Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons
-
Pfeffer L.M., Dinarello C.A., Herberman R.B., Williams B.R., Borden E.C., Bordens R., Walter M.R., Nagabhushan T.L., Trotta P.P., and Pestka S. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 58 (1998) 2489-2499
-
(1998)
Cancer Res.
, vol.58
, pp. 2489-2499
-
-
Pfeffer, L.M.1
Dinarello, C.A.2
Herberman, R.B.3
Williams, B.R.4
Borden, E.C.5
Bordens, R.6
Walter, M.R.7
Nagabhushan, T.L.8
Trotta, P.P.9
Pestka, S.10
-
54
-
-
11144353781
-
Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
-
Poeck H., Wagner M., Battiany J., Rothenfusser S., Wellisch D., Hornung V., Jahrsdorfer B., Giese T., Endres S., and Hartmann G. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 103 (2004) 3058-3064
-
(2004)
Blood
, vol.103
, pp. 3058-3064
-
-
Poeck, H.1
Wagner, M.2
Battiany, J.3
Rothenfusser, S.4
Wellisch, D.5
Hornung, V.6
Jahrsdorfer, B.7
Giese, T.8
Endres, S.9
Hartmann, G.10
-
55
-
-
0032519405
-
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
-
Qin S., Rottman J.B., Myers P., Kassam N., Weinblatt M., Loetscher M., Koch A.E., Moser B., and Mackay C.R. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J. Clin. Invest. 101 (1998) 746-754
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 746-754
-
-
Qin, S.1
Rottman, J.B.2
Myers, P.3
Kassam, N.4
Weinblatt, M.5
Loetscher, M.6
Koch, A.E.7
Moser, B.8
Mackay, C.R.9
-
56
-
-
12144290582
-
CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro
-
Rothenfusser S., Hornung V., Ayyoub M., Britsch S., Towarowski A., Krug A., Sarris A., Lubenow N., Speiser D., Endres S., and Hartmann G. CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood 103 (2004) 2162-2169
-
(2004)
Blood
, vol.103
, pp. 2162-2169
-
-
Rothenfusser, S.1
Hornung, V.2
Ayyoub, M.3
Britsch, S.4
Towarowski, A.5
Krug, A.6
Sarris, A.7
Lubenow, N.8
Speiser, D.9
Endres, S.10
Hartmann, G.11
-
57
-
-
0035660704
-
Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta
-
Rothenfusser S., Hornung V., Krug A., Towarowski A., Krieg A.M., Endres S., and Hartmann G. Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. Eur. J. Immunol. 31 (2001) 3525-3534
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3525-3534
-
-
Rothenfusser, S.1
Hornung, V.2
Krug, A.3
Towarowski, A.4
Krieg, A.M.5
Endres, S.6
Hartmann, G.7
-
58
-
-
0038814164
-
Recent advances in immunostimulatory CpG oligonucleotides
-
Rothenfusser S., Tuma E., Wagner M., Endres S., and Hartmann G. Recent advances in immunostimulatory CpG oligonucleotides. Curr. Opin. Mol. Ther. 5 (2003) 98-106
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, pp. 98-106
-
-
Rothenfusser, S.1
Tuma, E.2
Wagner, M.3
Endres, S.4
Hartmann, G.5
-
59
-
-
40449127141
-
Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques
-
Stewart V.A., McGrath S., Krieg A.M., Larson N.S., Angov E., Smith C.L., Brewer T.G., and Heppner Jr. D.G. Activation of innate immunity in healthy Macaca mulatta macaques by a single subcutaneous dose of GMP CpG 7909: safety data and interferon-inducible protein-10 kinetics for humans and macaques. Clin. Vac. Immunol. 15 (2008) 221-226
-
(2008)
Clin. Vac. Immunol.
, vol.15
, pp. 221-226
-
-
Stewart, V.A.1
McGrath, S.2
Krieg, A.M.3
Larson, N.S.4
Angov, E.5
Smith, C.L.6
Brewer, T.G.7
Heppner Jr., D.G.8
-
60
-
-
3242749617
-
CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells
-
Teleshova N., Kenney J., Jones J., Marshall J., Van Nest G., Dufour J., Bohm R., Lifson J.D., Gettie A., and Pope M. CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells. J. Immunol. 173 (2004) 1647-1657
-
(2004)
J. Immunol.
, vol.173
, pp. 1647-1657
-
-
Teleshova, N.1
Kenney, J.2
Jones, J.3
Marshall, J.4
Van Nest, G.5
Dufour, J.6
Bohm, R.7
Lifson, J.D.8
Gettie, A.9
Pope, M.10
-
61
-
-
0037435878
-
Reduced faecal excretion of F4+-E coli by the intramuscular immunisation of suckling piglets by the addition of 1alpha, 25-dihydroxyvitamin D3 or CpG-oligodeoxynucleotides
-
Van der Stede Y., Cox E., Verdonck F., Vancaeneghem S., and Goddeeris B.M. Reduced faecal excretion of F4+-E coli by the intramuscular immunisation of suckling piglets by the addition of 1alpha, 25-dihydroxyvitamin D3 or CpG-oligodeoxynucleotides. Vaccine 21 (2003) 1023-1032
-
(2003)
Vaccine
, vol.21
, pp. 1023-1032
-
-
Van der Stede, Y.1
Cox, E.2
Verdonck, F.3
Vancaeneghem, S.4
Goddeeris, B.M.5
-
62
-
-
0036215167
-
CpG-oligodinucleotides as an effective adjuvant in pigs for intramuscular immunizations
-
Van der Stede Y., Verdonck F., Vancaeneghem S., Cox E., and Goddeeris B.M. CpG-oligodinucleotides as an effective adjuvant in pigs for intramuscular immunizations. Vet. Immunol. Immunopathol. 86 (2002) 31-41
-
(2002)
Vet. Immunol. Immunopathol.
, vol.86
, pp. 31-41
-
-
Van der Stede, Y.1
Verdonck, F.2
Vancaeneghem, S.3
Cox, E.4
Goddeeris, B.M.5
-
63
-
-
18744410092
-
Porcine-specific CpG-oligodeoxynucleotide activates B-cells and increases the expression of MHC-II molecules on lymphocytes
-
Van der Stede Y., Verdonck F., Verfaillie T., Goddeeris B.M., and Cox E. Porcine-specific CpG-oligodeoxynucleotide activates B-cells and increases the expression of MHC-II molecules on lymphocytes. Vet. Immunol. Immunopathol. 105 (2005) 115-124
-
(2005)
Vet. Immunol. Immunopathol.
, vol.105
, pp. 115-124
-
-
Van der Stede, Y.1
Verdonck, F.2
Verfaillie, T.3
Goddeeris, B.M.4
Cox, E.5
-
64
-
-
0035865054
-
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
-
Verthelyi D., Ishii K.J., Gursel M., Takeshita F., and Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166 (2001) 2372-2377
-
(2001)
J. Immunol.
, vol.166
, pp. 2372-2377
-
-
Verthelyi, D.1
Ishii, K.J.2
Gursel, M.3
Takeshita, F.4
Klinman, D.M.5
-
65
-
-
2342470820
-
CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques
-
Verthelyi D., Wang V.W., Lifson J.D., and Klinman D.M. CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques. Aids 18 (2004) 1003-1008
-
(2004)
Aids
, vol.18
, pp. 1003-1008
-
-
Verthelyi, D.1
Wang, V.W.2
Lifson, J.D.3
Klinman, D.M.4
-
66
-
-
9144238063
-
Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
-
Vollmer J., Weeratna R., Payette P., Jurk M., Schetter C., Laucht M., Wader T., Tluk S., Liu M., Davis H.L., and Krieg A.M. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur. J. Immunol. 34 (2004) 251-262
-
(2004)
Eur. J. Immunol.
, vol.34
, pp. 251-262
-
-
Vollmer, J.1
Weeratna, R.2
Payette, P.3
Jurk, M.4
Schetter, C.5
Laucht, M.6
Wader, T.7
Tluk, S.8
Liu, M.9
Davis, H.L.10
Krieg, A.M.11
-
67
-
-
20844455173
-
Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration
-
von Beust B.R., Johansen P., Smith K.A., Bot A., Storni T., and Kundig T.M. Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration. Eur. J. Immunol. 35 (2005) 1869-1876
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 1869-1876
-
-
von Beust, B.R.1
Johansen, P.2
Smith, K.A.3
Bot, A.4
Storni, T.5
Kundig, T.M.6
-
68
-
-
33745809515
-
Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides
-
Wilson H.L., Dar A., Napper S.K., Marianela Lopez A., Babiuk L.A., and Mutwiri G.K. Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides. Int. Rev. Immunol. 25 (2006) 183-213
-
(2006)
Int. Rev. Immunol.
, vol.25
, pp. 183-213
-
-
Wilson, H.L.1
Dar, A.2
Napper, S.K.3
Marianela Lopez, A.4
Babiuk, L.A.5
Mutwiri, G.K.6
-
69
-
-
3042521095
-
Regulating effects of porcine interleukin-6 gene and CpG motifs on immune responses to porcine trivalent vaccines in mice
-
Wu M., Gao R., Meng M., Li J., Tan M., Shen Y., Wang L., Yin X., Wu X., Xie H., and Liu S. Regulating effects of porcine interleukin-6 gene and CpG motifs on immune responses to porcine trivalent vaccines in mice. Res. Vet. Sci. 77 (2004) 49-57
-
(2004)
Res. Vet. Sci.
, vol.77
, pp. 49-57
-
-
Wu, M.1
Gao, R.2
Meng, M.3
Li, J.4
Tan, M.5
Shen, Y.6
Wang, L.7
Yin, X.8
Wu, X.9
Xie, H.10
Liu, S.11
-
70
-
-
0030589385
-
Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
-
Yi A.K., Klinman D.M., Martin T.L., Matson S., and Krieg A.M. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. 157 (1996) 5394-5402
-
(1996)
J. Immunol.
, vol.157
, pp. 5394-5402
-
-
Yi, A.K.1
Klinman, D.M.2
Martin, T.L.3
Matson, S.4
Krieg, A.M.5
|