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Volumn 173, Issue 8, 2004, Pages 5148-5155

CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12; MONOKINE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

EID: 6344241187     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.8.5148     Document Type: Article
Times cited : (97)

References (60)
  • 1
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709
    • Krieg, A.M.1
  • 2
    • 0142153984 scopus 로고    scopus 로고
    • Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates
    • Verthelyi, D., and D. M. Klinman. 2003. Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clin. Immunol. 109:64.
    • (2003) Clin. Immunol. , vol.109 , pp. 64
    • Verthelyi, D.1    Klinman, D.M.2
  • 4
    • 0026625208 scopus 로고
    • Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity
    • Yamamoto, S., T. Yamamoto, T. Kataoka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. J. Immunol. 148:4072.
    • (1992) J. Immunol. , vol.148 , pp. 4072
    • Yamamoto, S.1    Yamamoto, T.2    Kataoka, T.3    Kuramoto, E.4    Yano, O.5    Tokunaga, T.6
  • 5
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery, J. S., J. H. Chace, A. K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570.
    • (1996) J. Immunol. , vol.156 , pp. 4570
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.K.3    Krieg, A.M.4
  • 6
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840.
    • (1996) J. Immunol. , vol.157 , pp. 1840
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 7
    • 0026006734 scopus 로고
    • Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA
    • Messina, J. P., G. S. Gilkeson, and D. S. Pisetsky. 1991. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147:1759.
    • (1991) J. Immunol. , vol.147 , pp. 1759
    • Messina, J.P.1    Gilkeson, G.S.2    Pisetsky, D.S.3
  • 9
    • 0035865054 scopus 로고    scopus 로고
    • Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
    • Verthelyi, D., K. J. Ishii, M. Gursel, F. Takeshita, and D. M. Klinman. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166:2372.
    • (2001) J. Immunol. , vol.166 , pp. 2372
    • Verthelyi, D.1    Ishii, K.J.2    Gursel, M.3    Takeshita, F.4    Klinman, D.M.5
  • 10
    • 0036737398 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells
    • Gursel, M., D. Verthelyi, and D. M. Klinman. 2002. CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells. Eur. J. Immunol. 32:2617.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2617
    • Gursel, M.1    Verthelyi, D.2    Klinman, D.M.3
  • 13
    • 0036587573 scopus 로고    scopus 로고
    • Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide
    • Gursel, M., D. Verthelyi, I. Gursel, K. J. Ishii, and D. M. Klinman. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J. Leukocyte Biol. 71:813.
    • (2002) J. Leukocyte Biol. , vol.71 , pp. 813
    • Gursel, M.1    Verthelyi, D.2    Gursel, I.3    Ishii, K.J.4    Klinman, D.M.5
  • 14
    • 0030240062 scopus 로고    scopus 로고
    • Macrophages ingest and are activated by bacterial DNA
    • Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
    • (1996) J. Immunol. , vol.157 , pp. 2116
    • Stacey, K.J.1    Sweet, M.J.2    Hume, D.A.3
  • 17
    • 0034671061 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression
    • Takeshita, S., F. Takeshita, D. E. Haddad, K. J. Ishii, and D. M. Klinman. 2000. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell. Immunol. 206:101.
    • (2000) Cell. Immunol. , vol.206 , pp. 101
    • Takeshita, S.1    Takeshita, F.2    Haddad, D.E.3    Ishii, K.J.4    Klinman, D.M.5
  • 18
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ
    • Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ. Proc. Natl. Acad. Sci. USA 93:2879.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2879
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Krieg, A.M.5
  • 19
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623.
    • (1997) J. Exp. Med. , vol.186 , pp. 1623
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 21
    • 0033168959 scopus 로고    scopus 로고
    • Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway
    • Schwartz, D. A., C. L. Wohlford-Lenane, T. J. Quinn, and A. M. Krieg. 1999. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. J. Immunol. 163:224.
    • (1999) J. Immunol. , vol.163 , pp. 224
    • Schwartz, D.A.1    Wohlford-Lenane, C.L.2    Quinn, T.J.3    Krieg, A.M.4
  • 22
    • 0036719064 scopus 로고    scopus 로고
    • Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challenge
    • Pal, S., H. L. Davis, E. M. Peterson, and L. M. de la Maza. 2002. Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challenge. Infect. Immun. 70:4812.
    • (2002) Infect. Immun. , vol.70 , pp. 4812
    • Pal, S.1    Davis, H.L.2    Peterson, E.M.3    De La Maza, L.M.4
  • 27
    • 0033541515 scopus 로고    scopus 로고
    • Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murine gram-negative pneumonia
    • Standiford, T. J., J. M. Wilkowski, T. H. Sisson, N. Hattori, B. Mehrad, K. A. Bucknell, and T. A. Moore. 1999. Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murine gram-negative pneumonia. Hum. Gene Ther. 10:899.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 899
    • Standiford, T.J.1    Wilkowski, J.M.2    Sisson, T.H.3    Hattori, N.4    Mehrad, B.5    Bucknell, K.A.6    Moore, T.A.7
  • 28
    • 0041331715 scopus 로고    scopus 로고
    • Differential chemokine responses and homing patterns of murine TCR αβ NKT cell subsets
    • Johnston, B., C. H. Kim, D. Soler, M. Emoto, and E. C. Butcher. 2003. Differential chemokine responses and homing patterns of murine TCR αβ NKT cell subsets. J. Immunol. 171:2960.
    • (2003) J. Immunol. , vol.171 , pp. 2960
    • Johnston, B.1    Kim, C.H.2    Soler, D.3    Emoto, M.4    Butcher, E.C.5
  • 29
    • 0032521881 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
    • Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627.
    • (1998) J. Immunol. , vol.160 , pp. 3627
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6    Heeg, K.7
  • 30
    • 0032168355 scopus 로고    scopus 로고
    • CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
    • Krieg, A. M., L. Love-Homan, A. K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428.
    • (1998) J. Immunol. , vol.161 , pp. 2428
    • Krieg, A.M.1    Love-Homan, L.2    Yi, A.K.3    Harty, J.T.4
  • 31
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms
    • Walker, P. S., T. Scharton-Kersten, A. M. Krieg, L. Love-Homan, E. D. Rowton, M. C. Udey, and J. C. Vogel. 1999. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms. Proc. Natl. Acad. Sci. USA 96:6970.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6970
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6    Vogel, J.C.7
  • 32
    • 0032706198 scopus 로고    scopus 로고
    • Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection
    • Klinman, D. M., J. Conover, and C. Coban. 1999. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect. Immun. 67:5658.
    • (1999) Infect. Immun. , vol.67 , pp. 5658
    • Klinman, D.M.1    Conover, J.2    Coban, C.3
  • 33
    • 0035117252 scopus 로고    scopus 로고
    • Interleukin-12- and γ-interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice
    • Gramzinski, R. A., D. L. Doolan, M. Sedegah, H. L. Davis, A. M. Krieg, and S. L. Hoffman. 2001. Interleukin-12- and γ-interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect. Immun. 69:1643.
    • (2001) Infect. Immun. , vol.69 , pp. 1643
    • Gramzinski, R.A.1    Doolan, D.L.2    Sedegah, M.3    Davis, H.L.4    Krieg, A.M.5    Hoffman, S.L.6
  • 34
    • 0033558121 scopus 로고    scopus 로고
    • Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
    • Elkins, K. L., T. R. Rhinehart-Jones, S. Stibitz, J. S. Conover, and D. M. Klinman. 1999. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162:2291.
    • (1999) J. Immunol. , vol.162 , pp. 2291
    • Elkins, K.L.1    Rhinehart-Jones, T.R.2    Stibitz, S.3    Conover, J.S.4    Klinman, D.M.5
  • 35
    • 0033624828 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis
    • Freidag, B. L., G. B. Melton, F. Collins, D. M. Klinman, A. Cheever, L. Stobie, W. Suen, and R. A. Seder. 2000. CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect. Immun. 68:2948.
    • (2000) Infect. Immun. , vol.68 , pp. 2948
    • Freidag, B.L.1    Melton, G.B.2    Collins, F.3    Klinman, D.M.4    Cheever, A.5    Stobie, L.6    Suen, W.7    Seder, R.A.8
  • 39
    • 0034771721 scopus 로고    scopus 로고
    • Protection against pulmonary infection with Klebsiella pneumoniae in mice by Interferon-γ through activation of phagocytic cells and stimulation of production of other cytokines
    • Yoshida, K., T. Matsumoto, K. Tateda, K. Uchida, S. Tsujimoto, Y. Iwakurai, and K. Yamaguchi. 2001. Protection against pulmonary infection with Klebsiella pneumoniae in mice by Interferon-γ through activation of phagocytic cells and stimulation of production of other cytokines. J. Med. Microbiol. 50:959.
    • (2001) J. Med. Microbiol. , vol.50 , pp. 959
    • Yoshida, K.1    Matsumoto, T.2    Tateda, K.3    Uchida, K.4    Tsujimoto, S.5    Iwakurai, Y.6    Yamaguchi, K.7
  • 40
    • 0036841679 scopus 로고    scopus 로고
    • Divergent role of γ-interferon in a murine model of pulmonary versus systemic Klebsiella pneumoniae infection
    • Moore, T. A., M. L. Perry, A. G. Getsoian, M. W. Newstead, and T. J. Standiford. 2002. Divergent role of γ-interferon in a murine model of pulmonary versus systemic Klebsiella pneumoniae infection. Infect. Immun. 70:6310.
    • (2002) Infect. Immun. , vol.70 , pp. 6310
    • Moore, T.A.1    Perry, M.L.2    Getsoian, A.G.3    Newstead, M.W.4    Standiford, T.J.5
  • 41
    • 0018870443 scopus 로고
    • Early bacterial clearance from murine lungs: Species-dependent phagocyte response
    • Rehm, S. R., G. N. Gross, and A. K. Pierce. 1980. Early bacterial clearance from murine lungs: species-dependent phagocyte response. J. Clin. Invest. 66:194.
    • (1980) J. Clin. Invest. , vol.66 , pp. 194
    • Rehm, S.R.1    Gross, G.N.2    Pierce, A.K.3
  • 43
    • 0028980812 scopus 로고
    • Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ cells in vivo
    • Ferrick, D. A., M. D. Schrenzel, T. Mulvania, B. Hsieh, W. G. Ferlin, and H. Lepper. 1995. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ cells in vivo. Nature 373:255.
    • (1995) Nature , vol.373 , pp. 255
    • Ferrick, D.A.1    Schrenzel, M.D.2    Mulvania, T.3    Hsieh, B.4    Ferlin, W.G.5    Lepper, H.6
  • 44
    • 0029969393 scopus 로고    scopus 로고
    • Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by γ/δ T lymphocytes
    • Ladel, C. H., C. Blum, and S. H. Kaufmann. 1996. Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by γ/δ T lymphocytes. Infect. Immun. 64:1744.
    • (1996) Infect. Immun. , vol.64 , pp. 1744
    • Ladel, C.H.1    Blum, C.2    Kaufmann, S.H.3
  • 45
    • 0034284225 scopus 로고    scopus 로고
    • γδ-T cells are critical for survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia
    • Moore, T. A., B. B. Moore, M. W. Newstead, and T. J. Standiford. 2000. γδ-T cells are critical for survival and early proinflammatory cytokine gene expression during murine Klebsiella pneumonia. J. Immunol. 165:2643.
    • (2000) J. Immunol. , vol.165 , pp. 2643
    • Moore, T.A.1    Moore, B.B.2    Newstead, M.W.3    Standiford, T.J.4
  • 46
    • 0033588821 scopus 로고    scopus 로고
    • Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells
    • Cui, J., N. Watanabe, T. Kawano, M. Yamashita, T. Kamata, C. Shimizu, M. Kimura, E. Shimizu, J. Koike, H. Koseki, et al. 1999. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190:783.
    • (1999) J. Exp. Med. , vol.190 , pp. 783
    • Cui, J.1    Watanabe, N.2    Kawano, T.3    Yamashita, M.4    Kamata, T.5    Shimizu, C.6    Kimura, M.7    Shimizu, E.8    Koike, J.9    Koseki, H.10
  • 48
    • 0034596944 scopus 로고    scopus 로고
    • Natural killer T cell activation inhibits hepatitis B virus replication in vivo
    • Kakimi, K., L. G. Guidotti, Y. Koezuka, and F. V. Chisari. 2000. Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J. Exp. Med. 192:921.
    • (2000) J. Exp. Med. , vol.192 , pp. 921
    • Kakimi, K.1    Guidotti, L.G.2    Koezuka, Y.3    Chisari, F.V.4
  • 49
    • 0034746796 scopus 로고    scopus 로고
    • + natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans
    • + natural killer T cells by α-galactosylceramide results in development of Th1 response and local host resistance in mice infected with Cryptococcus neoformans. Infect. Immun. 69:213.
    • (2001) Infect. Immun. , vol.69 , pp. 213
    • Kawakami, K.1    Kinjo, Y.2    Yara, S.3    Koguchi, Y.4    Uezu, K.5    Nakayama, T.6    Taniguchi, M.7    Saito, A.8
  • 50
    • 0038228956 scopus 로고    scopus 로고
    • The regulatory role of Vα14 NKT cells in innate and acquired immune response
    • Taniguchi, M., M. Harada, S. Kojo, T. Nakayama, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21:483.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 483
    • Taniguchi, M.1    Harada, M.2    Kojo, S.3    Nakayama, T.4    Wakao, H.5
  • 53
    • 0344177198 scopus 로고    scopus 로고
    • Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: Focus on γδ cells
    • Ferrero, E., P. Biswas, K. Vettoretto, M. Ferrarini, M. Uguccioni, L. Piali, B. E. Leone, B. Moser, C. Rugarli, and R. Pardi. 2003. Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on γδ cells. Immunology 108:365.
    • (2003) Immunology , vol.108 , pp. 365
    • Ferrero, E.1    Biswas, P.2    Vettoretto, K.3    Ferrarini, M.4    Uguccioni, M.5    Piali, L.6    Leone, B.E.7    Moser, B.8    Rugarli, C.9    Pardi, R.10
  • 54
    • 12144291406 scopus 로고    scopus 로고
    • Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1 infected patients: Competition by HIV-1 TAT
    • Poggi, A., R. Carosio, D. Fenoglio, S. Brenci, G. Murdaca, M. Setti, F. Indiveri, S. Scabini, E. Ferrero, and M. R. Zocchi. 2004. Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1 infected patients: competition by HIV-1 TAT. Blood 103:2205.
    • (2004) Blood , vol.103 , pp. 2205
    • Poggi, A.1    Carosio, R.2    Fenoglio, D.3    Brenci, S.4    Murdaca, G.5    Setti, M.6    Indiveri, F.7    Scabini, S.8    Ferrero, E.9    Zocchi, M.R.10
  • 55
    • 0032921241 scopus 로고    scopus 로고
    • CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines
    • Oxenius, A., M. M. Martinic, H. Hengartner, and P. Klenerman. 1999. CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines. J. Virol. 73:4120.
    • (1999) J. Virol. , vol.73 , pp. 4120
    • Oxenius, A.1    Martinic, M.M.2    Hengartner, H.3    Klenerman, P.4
  • 56
    • 0035860575 scopus 로고    scopus 로고
    • CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV)
    • Hancock, G. E., K. M. Heers, J. D. Smith, C. A. Scheuer, A. R. Ibraghimov, and K. S. Pryharski. 2001. CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV). Vaccine 19:4874.
    • (2001) Vaccine , vol.19 , pp. 4874
    • Hancock, G.E.1    Heers, K.M.2    Smith, J.D.3    Scheuer, C.A.4    Ibraghimov, A.R.5    Pryharski, K.S.6
  • 57
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice
    • Agrawal, S., J. Temsamani, and J. Y. Tang. 1991. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88:7595.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7595
    • Agrawal, S.1    Temsamani, J.2    Tang, J.Y.3
  • 59
    • 0027298897 scopus 로고
    • Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application within the central nervous system
    • Whitesell, L., D. Geselowitz, C. Chavany, B. Fahmy, S. Walbridge, J. R. Alger, and L. M. Neckers. 1993. Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proc. Natl. Acad. Sci. USA 90:4665.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4665
    • Whitesell, L.1    Geselowitz, D.2    Chavany, C.3    Fahmy, B.4    Walbridge, S.5    Alger, J.R.6    Neckers, L.M.7
  • 60
    • 0022780091 scopus 로고
    • Oligodeoxynucleotide stability in subcellular extracts and culture media
    • Wickstrom, E. 1986. Oligodeoxynucleotide stability in subcellular extracts and culture media. J. Biochem. Biophys. Methods 13:97.
    • (1986) J. Biochem. Biophys. Methods , vol.13 , pp. 97
    • Wickstrom, E.1


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