A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection

Journal of Virology

Volumn 77, Issue 2, 2003, Pages 953-962

  Harandi, Ali M ^a   Eriksson, Kristina ^a   Holmgren, Jan ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CPG OLIGONUCLEOTIDE; GAMMA INTERFERON; IMMUNOLOGIC AGENT; INTERLEUKIN 12; INTERLEUKIN 18; RANTES; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEATH; DISEASE COURSE; FEMALE; GENITAL HERPES; GENITAL SYSTEM; HERPES SIMPLEX VIRUS 2; IMMUNITY; IMMUNOSTIMULATION; LETHAL DOSE; MOUSE; MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; T LYMPHOCYTE; VAGINA DISCHARGE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CPG ISLANDS; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; HERPES GENITALIS; IMMUNOLOGIC MEMORY; LYMPH NODES; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES;

EID: 0037223705     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.2.953-962.2003     Document Type: Article

References (58)

1. Adler, H., J. L. Beland, N. C. Del-Pan, L. Kobzik, R. A. Sobel, and I. J. Rimm. 1999. In the absence of T-cells, natural killer cells protect from mortality due to HSV-1 encephalitis. J. Neuroimmunol. 93:208-213.
2. Ban, E., L. Dupre, E. Hermann, W. Rohn, C. Vendeville, B. Quatannens, P. Ricciardi-Castagnoli, A. Capron, and G. Riveau. 2000. CpG motifs induce Langerhans cell migration in vivo. Int. Immunol. 12:737-745.
3. Bernstein, D. I., and L. R. Stanberry. 1999. Herpes simplex virus vaccines. Vaccine 17:1681-1689.
4. Biron, C. A., G. Sonnenfeld, and R. M. Welsh. 1984. Interferon induces natural killer cell blastogenesis in vivo. J. Leukoc. Biol. 35:31-37.
5. Bohle, B., B. Jahn-Schmid, D. Maurer, D. Kraft, and C. Ebner. 1999. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 29:2344-2353.
6. Chen, C. Y., R. C. Ballard, C. M. Beek-Sague, Y. Dangor, F. Radebe, S. Schmid, J. B. Weiss, V. Tshabalala, G. Fehler, Y. Htun, and S. A. Morse. 2000. Human immunodeficiency virus infection and genital ulcer disease in South Africa: The herpetic connection. Sex. Transm. Dis. 27:21-29.
7. Corey, L., A. G. Langenberg, R. Ashley, R. E. Sekulovich, A. E. Izu, J. M. J. Douglas, H. H. Handsfield, T. Warren, L. Marr, S. Tyring, R. DiCarlo, A. A. Adimora, P. Leone, C. L. Dekker, R. L. Burke, W. P. Leong, and S. E. Straus. 1999. Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection. Two randomized controlled trials. JAMA 282:331-340.
8. Dalton, D. K., S. Pitt-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739.
9. De Clercq, E. 2000. Guanosine analogues as anti-herpesvirus agents. Nucleosides Nucleotides Nucleic Acids 19:1531-1541.
10. De Stasio, P. R., and M. W. Taylor. 1990. Specific effect of interferon on the herpes simplex virus type 1 transactivation event. J. Virol. 64:2588-2593.
11. Dieu, M., B. Vanbervliet, A. Vicari, J. Bridon, E. Oldham, S. Ait-Yahia, F. Briere, A. Zlotnik, S. Lebecque, and C. Caux. 1998. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188:373-386.
12. Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. 1986. Induction by IL 1 and interferon-γ: Tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245-254.
13. Elkins, K., T. Rhinehart-Jones, S. Stibitz, J. Conover, and D. Klinman. 1999. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol. 162:2291-2298.
14. Gramzinski, R., D. Doolan, M. Sedegah, H. Davis, A. Krieg, and S. Hoffman. 2001. Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect. Immun. 69:1643-1649.
15. Gwanzura, L., W. McFarland, D. Alexander, R. L. Burke, and D. Katzenstein. 1998. Association between human immunodeficiency virus and herpes simplex virus type 2 seropositivity among male factory workers in Zimbabwe. J. Infect. Dis. 177:481-484.
16. Harandi, A., B. Svennerholm, J. Holmgren, and K. Eriksson. 2001. Protective vaccination against genital herpes simplex virus type 2 (HSV-2) infection in mice is associated with a rapid induction of local IFN-gamma-dependent RANTES production following a vaginal viral challenge. Am. J. Reprod. Immunol. 46:420-424.
17. Harandi, A. M., B. Svennerholm, J. Holmgren, and K. Eriksson. 2001. Differential roles of B-cells and IFN-γ-secreting CD4+ T-cells in innate and adaptive immune control of genital HSV-2 infection in mice. J. Gen. Virol. 82:845-853.
18. Harandi, A. M., B. Svennerholm, J. Holmgren, and K. Eriksson. 2001. Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity. J. Virol. 75:6705-6709.
19. Hemmi, H., O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740-745.
20. Jeansson, S., M. Forsgren, and B. Svennerholm. 1983. Evaluation of solubilized herpes simplex virus membrane antigen by enzyme-linked immunosorbent assay. J. Clin. Microbiol. 18:1160-1166.
21. Johansson, E. L., C. Rask, M. Fredriksson, K. Eriksson, C. Czerkinsky, and J. Holmgren. 1998. Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates. Infect. Immun. 66:514-520.
22. Kinghorn, G. R. 1994. Epidemiology of genital herpes. J. Int. Med. Res. 22:14A-23A.
23. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426.
24. Kohka, H., T. Yoshini, H. Iwagaki, I. Sakuma, T. Tanimoto, Y. Matsuo, M. Kurimoto, K. Orita, T. Akagi, and N. Tanaka. 1998. Interleukin-18/interferon-gamma-inducing factor, a novel cytokine, up-regulates ICAM-1 (CD54) expression in KG-1 cells. J. Leukoc. Biol. 64:519-527.
25. Krieg, A., and H. Davis. 2001. Enhancing vaccine with immune stimulatory CpG DNA. Curr. Opin. Mol. Ther. 3:15-24.
26. Krieg, A., L. Love-Homan, A. Yi, and J. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428-2434.
27. Krieg, A., A. Yi, S. Matson, T. Waldschmidt, G. Bishop, R. Teasdale, G. Koretzky, and D. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549.
28. Lillard, J. W., P. N. Boyaka, D. D. Taub, and J. R. McGhee. 2001. RANTES potentiates antigen-specific mucosal immune responses. J. Immunol. 166:162-169.
29. Lipford, G., T. Sparwasser, M. Bauer, S. Zimmermann, E. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420-3426.
30. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4:471-481.
31. Munder, M., M. Mallo, K. Eichmann, and M. Modolell. 1998. Murine macrophages secrete interferon-gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J. Exp. Med. 187:2103-2108.
32. Naesens, L., and E. De Clercq. 2001. Recent developments in herpesvirus therapy. Herpes 8:12-16.
33. Nahmias, A. J., F. K. Lee, and S. Beckman-Nahmias. 1990. Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world. Scand. J. Infect. Dis. Suppl. 69:19-36.
34. Rollins, B. J. 1997. Chemokines. Blood 90:909-928.
35. Roman, M., E. Martin-Orozco, J. Goodman, M. Nguyen, Y. Sato, A. Ronaghy, R. Kornbluth, D. Richman, D. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849-854.
36. Saparwasser, T., L. Hultner, E. Koch, A. Luz, G. Lipford, and H. Wagner. 1999. Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J. Immunol. 162:2368-2374.
37. Schindler, H., M. B. Lutz, M. Röllinghoff, and C. Bogdan. 2001. The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J. Immunol. 166:3075-3082.
38. Schwartz, D., C. Wohlford-Lenane, T. Quinn, and A. Krieg. 1999. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. J. Immunol. 163:224-231.
39. Seth, P., W. E. Rawls, R. Duff, F. Rap, E. Adam, and J. L. Melnick. 1974. Antigenic differences between isolates of herpesvirus type 2. Intervirology 3:1-14.
40. Sozzani, S., W. Luini, A. Borsatti, N. Polentarutti, D. Zhou, L. Piemonti, G. D. Amico, C. A. Power, T. N. Wells, M. Gobbi, et al. 1993. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. Immunol. 159:1993-2000.
41. Sparwasser, T., E. S. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, G. B. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045-2054.
42. Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Hacker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336-337.
43. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock. Eur. J. Immunol. 27:1671-1679.
44. Stephenson, J. 2000. Genital herpes vaccine shows limited promise. JAMA. 284:1913-1914.
45. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383-390.
46. Takeshita, S., F. Takeshita, D. Haddad, K. Ishii, and D. Klinman. 2000. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell. Immunol. 206:101-106.
47. Taub, D. D., T. J. Sayers, C. R. Carter, and J. R. Ortaldo. 1995. Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. J. Immunol. 155:3877-3888.
48. Tomura, M., X. Zhou, S. Maruo, H. Ahn, T. Hamaoka, H. Okamura, K. Nakanishi, T. Tanimoto, M. Kurimoto, and H. Fujiwara. 1998. A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells. J. Immunol. 160:4738-4746.
49. Wagner, H. 2002. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr. Opin. Immunol. 5:62-69.
50. Walker, P., T. Scharton-Kersten, A. Krieg, L. Love-Homan, E. Rowton, M. Udey, and J. Vogel. 1999. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc. Natl. Acad. Sci. USA 96:6970-6975.
51. Whitley, R. J. 1991. Perinatal herpes simplex virus infections. Rev. Med. Virol. 1:101-110.
52. Wolf, S., P. Temple, M. Kobayashi, D. Young, M. Dielg, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, and R. Hewick. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074-3081.
53. Yamamoto, S., T. Yamamoto, T. Kataoka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN-gamma and augment IFN-gamma-mediated natural killer activity. J. Immunol. 148:4072-4076.
54. Yamamoto, S., T. Yamamoto, S. Shimada, E. Kuramoto, O. Yano, T. Kataoka, and T. Tokunaga. 1992. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immunol. 36:983-997.
55. Yi, A., D. Klinman, T. Martin, S. Matson, and A. Krieg. 1996. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J. Immunol. 157:5394-5402.
56. Yi, A.-K., M. Chang, D. Peckham, A. Krieg, and R. Ashman. 1998. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote ceii cycle entry. J. Immunol. 160:5898-5906.
57. Yoshimoto, T., K. Takeda, T. Tanaka, K. Ohkusu, S. Kashiwamura, H. Okamura, S. Akira, and K. Nakanishi. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production. J. Immunol. 161:3400-3407.
58. Zimmermann, S., O. Egeter, S. Hausmann, G. Lipford, M. Röcken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627-3630.