Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-α in the pig and the phenotype of the IFN-α producing cells

Veterinary Immunology and Immunopathology

Volumn 101, Issue 1-2, 2004, Pages 87-102

  Domeika, Kristina ^a   Magnusson, Mattias ^a   Eloranta, Maija Leena ^a   Fuxler, Lisbeth ^a   Alm, Gunnar V ^a   Fossum, Caroline ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

ADV; Aujeszky's disease virus; CpG DNA; CpG ODN; DC; DELFIA; dendritic cells; dissociation enhanced lanthanide fluoroimmunoassay; DNA containing unmethylated CpG dinucleotides; ds; oligodeoxyribonucleotides containing unmethylated CpG dinucleotides

Indexed keywords

ALPHA INTERFERON; CD14 ANTIGEN; CD2 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; CPG OLIGODEOXYRIBONUCLEOTIDE; CYTOSINE; DOUBLE STRANDED DNA; LIPOFECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; OLIGODEOXYRIBONUCLEOTIDE; PLASMID DNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL STIMULATION; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; IN SITU HYBRIDIZATION; INTERFERON PRODUCTION; METHYLATION; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PSEUDORABIES HERPETOVIRUS; SUBSTITUTION REACTION; SWINE; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CPG ISLANDS; DNA METHYLATION; FLOW CYTOMETRY; FLUOROIMMUNOASSAY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHATIDYLETHANOLAMINES; RNA, MESSENGER; SWINE;

ALEUTIAN MINK DISEASE PARVOVIRUS (STRAIN G); SUIDAE; SUS SCROFA;

EID: 3142585337     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2004.04.017     Document Type: Article

References (70)

1. Agrawal S., Temsamani J., Galbraith W., Tang J. Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28:1995;7-16
2. Ahmad-Nejad P., Häcker H., Rutz M., Bauer S., Vabulas R.M., Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32:2002;1958-1968
3. Artursson K., Gobl A., Lindersson M., Johansson M., Alm G. Molecular cloning of a gene encoding porcine interferon-β J. Interferon Res. 12:1992;153-160
4. Artursson K., Lindersson M., Varela N., Scheynius A., Alm G.V. Interferon-α production and tissue localization of interferon-α/ β producing cells after intradermal administration of Aujeszky's disease virus-infected cells in pigs. Scand. J. Immunol. 41:1995;121-129
5. Asselin-Paturel C., Boonstra A., Dalod M., Durand I., Yessaad N., Dezutter-Dambuyant C., Vicari A., O'Garra A., Biron C., Briere F., Trinchieri G. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2:2001;1144-1150
6. Bauer S., Kirschning C.J., Häcker H., Redecke V., Hausmann S., Akira S., Wagner H., Lipford G.B. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9237-9242
7. Belardelli F., Ferrantini M. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol. 23:2002;201-208
8. Bennett C.F., Chiang M.Y., Chan H., Shoemaker J.E., Mirabelli C.K. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 41:1992;1023-1033
9. Biron C.A. Interferons α and β as immune regulators - a new look. Immunity. 14:2001;661-664
10. Björck P. The multifaceted murine plasmacytoid dendritic cell. Hum. Immunol. 63:2002;1094-1102
11. Cederblad B., Alm G.V. Infrequent but efficient interferon-α producing human mononuclear leukocytes induced by herpes simplex virus in vitro studied by immuno-plaque and limiting dilution assays. J. Interferon Res. 10:1990;65-73
12. Charley B., Lavenant L. Characterization of blood mononuclear cells producing IFN-α following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus). Res. Immunol. 141:1990;141-151
13. Cong Y.-P., Song S.S., Bhagat L., Pandey R.K., Yu D., Kandimalla E.R., Agrawal S. Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells. Biochem. Biophys. Res. Commun. 310:2003;1133-1139
14. Comeau M.R., Van der Vuurst de Vries A.R., Maliszewski C.R., Galibert L. CD123bright plasmacytoid predendritic cells: progenitors undergoing cell fate conversion? J. Immunol. 169:2002;75-83
15. Cull V.S., Broomfield S., Bartlett E.J., Brekalo N.L., James C.M. Coimmunisation with type I IFN genes enhances protective immunity against cytomegalovirus and myocarditis in gB DNA-vaccinated mice. Gene Ther. 9:2002;1369-1378
16. Dalpke A.H., Zimmermann S., Albrecht I., Heeg K. Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo. Immunology. 106:2002;102-112
17. Di Pucchio T., Lapenta C., Santini S.M., Logozzi M., Parlato S., Belardelli F. CD2+/CD14+ monocytes rapidly differentiate into CD83+ dendritic cells. Eur. J. Immunol. 33:2003;358-367
18. Diaz de Arce H., Artursson K., L'Haridon R., Perers A., La Bonnardiere C., Alm G.V. A sensitive immunoassay for porcine interferon-α Vet. Immunol. Immunopathol. 30:1992;319-327
19. Dzionek A., Fuchs A., Schmidt P., Cremer S., Zysk M., Miltenyi S., Buck D.W., Schmitz J. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165:2000;6037-6046
20. Endresz V., Burian K., Berencsi K., Gyulai Z., Kari L., Horton H., Virok D., Meric C., Plotkin S.A., Gonczol E. Optimization of DNA immunization against human cytomegalovirus. Vaccine. 19:2001;3972-3980
21. Filion M.C., Saha N., Gueddi M., Phillips N.C. Development of short non-CpG phosphodiester oligonucleotides as immune stimulatory agents. Vaccine. 21:2003;983-989
22. Hartmann G., Krug A., Bidlingmaier M., Hacker U., Eigler A., Albrecht R., Strasburger C.J., Endres S. Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes. J. Pharmacol. Exp. Ther. 285:1998;920-928
23. Hemmi H., Takeuchi O., Kawai T., Kaisho T., Sato S., Sanjo H., Matsumoto M., Hoshino K., Wagner H., Takeda K., Akira S. A Toll-like receptor recognizes bacterial DNA. Nature. 408:2000;740-745
24. Häcker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., Heeg K., Lipford G.B., Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:1998;6230-6240
25. Jarrossay D., Napolitani G., Colonna M., Sallusto F., Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31:2001;3388-3393
26. Johansson E., Domeika K., Berg M., Alm G.V., Fossum C. Characterisation of porcine monocyte-derived dendritic cells according to their cytokine profile. Vet. Immunol. Immunopathol. 91:2003;183-197
27. Johansson E., Wallgren P., Fuxler L., Domeika K., Lefevre F., Fossum C. The DNA vaccine vector pcDNA3 induces IFN-α production in pigs. Vet. Immunol. Immunopathol. 87:2002;29-40
28. Kadowaki N., Antonenko S., Liu Y.J. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J. Immunol. 166:2001a;2291-2295
29. Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:2001b;863-869
30. Kamstrup S., Verthelyi D., Klinman D.M. Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides. Vet. Microbiol. 78:2001;353-362
31. Kimura Y., Sonehara K., Kuramoto E., Makino T., Yamamoto S., Yamamoto T., Kataoka T., Tokunaga T. Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. J. Biochem. 116:1994;991-994
32. Klinman D.M., Conover J., Coban C. Repeated administration of synthetic oligodeoxynucleotides expressing CpG motifs provides long-term protection against bacterial infection. Infect. Immun. 67:1999;5658-5663
33. Klinman D.M., Yi A.K., Beaucage S.L., Conover J., Krieg A.M. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon-γ Proc. Natl. Acad. Sci. U.S.A. 93:1996;2879-2883
34. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:2002;709-760
35. Krug A., Rothenfusser S., Hornung V., Jahrsdorfer B., Blackwell S., Ballas Z.K., Endres S., Krieg A.M., Hartmann G. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31:2001a;2154-2163
36. Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., Giese T., Engelmann H., Endres S., Krieg A.M., Hartmann G. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:2001b;3026-3037
37. Lee, J., Chuang, T.H., Redecke, V., She, L., Pitha, P.M., Carson, D.A., Raz, E., Cottam, H.B., 2003. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 100, 6646-6651.
38. Lee S.W., Song M.K., Baek K.H., Park Y., Kim J.K., Lee C.H., Cheong H.K., Cheong C., Sung Y.C. Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials. J. Immunol. 165:2000;3631-3639
39. Lefevre F., L'Haridon R., Borras-Cuesta F., La Bonnardiere C. Production, purification and biological properties of an Escherichia coli-derived recombinant porcine α-interferon. J. Gen. Virol. 71:1990;1057-1063
40. Magnusson M., Johansson E., Berg M., Eloranta M.-L., Fuxler L., Fossum C. The plasmid pcDNA3 differently induces production of interferon-α and interleukin-6 in cultures of porcine leukocytes. Vet. Immunol. Immunopathol. 78:2001a;45-56
41. Magnusson M., Magnusson S., Vallin H., Rönnblom L., Alm G.V. Importance of CpG dinucleotides in activation of natural IFN-α producing cells by a lupus-related oligodeoxynucleotide. Scand. J. Immunol. 54:2001b;543-550
42. Nowacki W., Charley B. Enrichment of coronavirus-induced interferon-producing blood leukocytes increases the interferon yield per cell: a study with pig leukocytes. Res. Immunol. 144:1993;111-120
43. Pearson A.M., Rich A., Krieger M. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J. Biol. Chem. 268:1993;3546-3554
44. Pisetsky D.S. Immune activation by bacterial DNA: a new genetic code. Immunity. 5:1996;303-310
45. Pisetsky D.S., Reich C.F. III The influence of lipofectin on the in vitro stimulation of murine spleen cells by bacterial DNA and plasmid DNA vectors. J. Interferon Cytokine Res. 19:1999;1219-1226
46. Riffault S., Carrat C., Besnardeau L., La Bonnardiere C., Charley B. In vivo induction of interferon-α in pig by non-infectious coronavirus: tissue localization and in situ phenotypic characterization of interferon-α producing cells. J. Gen. Virol. 78:1997;2483-2487
47. Riffault S., Carrat C., van Reeth K., Pensaert M., Charley B. Interferon-α producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Vet. Res. 32:2001;71-79
48. Rissoan M.C., Duhen T., Bridon J.M., Bendriss-Vermare N., Peronne C., de Saint Vis B., Briere F., Bates E.E. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood. 100:2002;3295-3303
49. Rizza P., Ferrantini M., Capone I., Belardelli F. Cytokines as natural adjuvants for vaccines: where are we now? Trends Immunol. 23:2002;381-383
50. Salmon H., Johnson I., Germana S., Haller G.W., Sachs D.H., Leguern C. Dendritic cells enriched from swine thymus co-express CD1, CD2 and major histocompatibility complex class II and actively stimulate alloreactive T lymphocytes. Scand. J. Immunol. 52:2000;164-172
51. Samuel C.E. Antiviral actions of interferons. Clin. Microbiol. Rev. 14:2001;778-809
52. Sandberg K., Eloranta M.-L., Campbell I.L. Expression of alpha/beta interferons (IFN-α/β) and their relationship to IFN-α/β- induced genes in lymphocytic choriomeningitis. J. Virol. 68:1994;7358-7366
53. Sato Y., Miyata M., Nishimaki T., Kochi H., Kasukawa R. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J. Rheumatol. 26:1999;294-301
54. Schotte R., Rissoan M.-C., Bendriss-Vermare N., Bridon J.-M., Duhen T., Weijer K., Briere F., Spits H. The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Blood. 101:2003;1015-1023
55. Segal B.M., Chang J.T., Shevach E.M. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J. Immunol. 164:2000;5683-5688
56. Siegal F.P., Kadowaki N., Shodell M., Fitzgerald-Bocarsly P.A., Shah K., Ho S., Antonenko S., Liu Y.J. The nature of the principal type 1 interferon-producing cells in human blood. Science. 284:1999;1835-1837
57. Summerfield A., McCullough K.C. Porcine bone marrow myeloid cells: phenotype and adhesion molecule expression. J. Leukoc. Biol. 62:1997;176-185
58. Summerfield A., Guzylack-Piriou L., Schaub A., Carrasco C.P., Tâche V., Charley B., McCullough K.C. Porcine peripheral bood dendritic cells and natural interferon-producing cells. Immunology. 110:2003;440-449
59. Svensson H., Johannisson A., Nikkilä T., Alm G.V., Cederblad B. The cell surface phenotype of human natural interferon-α producing cells as determined by flow cytometry. Scand. J. Immunol. 44:1996;164-172
60. Takeshita F., Leifer C.A., Gursel I., Ishii K.J., Takeshita S., Gursel M., Klinman D.M. Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167:2001;3555-3558
61. Thacker E., Summerfield A., McCullough K., Ezquerra A., Dominguez J., Alonso F., Lunney J., Sinkora J., Haverson K. Summary of workshop findings for porcine myelomonocytic markers. Vet. Immunol. Immunopathol. 80:2001;93-109
62. Thierry A.R., Dritschilo A. Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acids Res. 20:1992;5691-5698
63. Tudor D., Riffault S., Carrat C., Lefevre F., Bernoin M., Charley B. Type I IFN modulates the immune response induced by DNA vaccination to pseudorabies virus glycoprotein C. Virology. 286:2001;197-205
64. Tüting T., Wilson C.C., Martin D.M., Kasamon Y.L., Rowles J., Ma D.I., Slingluff C.L. Jr., Wagner S.N., van der Bruggen P., Baar J., Lotze M.T., Storkus W.J. Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-α J. Immunol. 160:1998;1139-1147
65. Van der Stede Y., Verdonck F., Vancaeneghem S., Cox E., Goddeeris B.M. CpG-oligodinucleotides as an effective adjuvant in pigs for intramuscular immunizations. Vet. Immunol. Immunopathol. 86:2002;31-41
66. Verthelyi D., Ishii K.J., Gursel M., Takeshita F., Klinman D.M. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J. Immunol. 166:2001;2372-2377
67. Wattrang E., Wallgren P., Fossum C. Actinobacillus pleuropneumoniae serotype 2-effects on the interferon-α production of porcine leukocytes in vivo and in vitro. Comp. Immunol. Microbiol. Infect. Dis. 21:1998;135-154
68. Yamamoto S., Yamamoto T., Nojima Y., Umemori K., Phalen S., McMurray D.N., Kuramoto E., Iho S., Takauji R., Sato Y., Yamada T., Ohara N., Matsumoto S., Goto Y., Matsuo K., Tokunaga T. Discovery of immunostimulatory CpG-DNA and its application to tuberculosis vaccine development. Jpn. J. Infect. Dis. 55:2002;37-44
69. Yang H., Parkhouse R.M. Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues. Immunology. 89:1996;76-83
70. Zhao Q., Matson S., Herrera C.J., Fisher E., Yu H., Krieg A.M. Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methylphosphonate oligonucleotides. Antisense Res. Dev. 3:1993;53-66