Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking

Brain Research

Volumn 1314, Issue , 2010, Pages 15-28

  Shalev, Uri ^a   Erb, Suzanne ^b   Shaham, Yavin ^c  

^a and Applied Physiology   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Conditioned place preference; Extinction; Neuropeptide; Reinstatement; Relapse; Self administration; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; DYNORPHIN; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE S; NEUROPEPTIDE Y; NOCICEPTIN; OREXIN; PEPTIDE YY [3-36]; UROCORTIN I; UROCORTIN II; UROCORTIN III; YOHIMBINE;

ARTICLE; BEHAVIOR; DRUG DEPENDENCE; DRUG WITHDRAWAL; FOOD DEPRIVATION; FOOTSHOCK; NONHUMAN; PRIORITY JOURNAL; RELAPSE; STRESS;

ANIMALS; BRAIN; CHRONIC DISEASE; COMORBIDITY; CORTICOTROPIN-RELEASING HORMONE; DISEASE MODELS, ANIMAL; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; NEUROPEPTIDES; RECURRENCE; STRESS, PSYCHOLOGICAL; SUBSTANCE-RELATED DISORDERS;

ANIMALIA;

EID: 75149130856     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.07.028     Document Type: Article

References (182)

1. Aghajanian G.K., and VanderMaelen C.P. Alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: Intracellular studies in vivo. Science 215 (1982) 1394-1396
2. Aguilar M.A., Rodriguez-Arias M., and Minarro J. Neurobiological mechanisms of the reinstatement of drug-conditioned place preference. Brain Res. Rev. 59 (2009) 253-277
3. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., and Flier J.S. Role of leptin in the neuroendocrine response to fasting. Nature 382 (1996) 250-252
4. Akil H., Watson S., Young E., Lewis M., Khachaturian H., and Walker J. Endogenous opioids: Biology and function. Annu. Rev. Neurosci. 7 (1984) 223-255
5. Allen Y.S., Adrian T.E., Allen J.M., Tatemoto K., Crow T.J., Bloom S.R., and Polak J.M. Neuropeptide Y distribution in the rat brain. Science 221 (1983) 877-879
6. Amit Z., and Galina H. Stress-induced analgesia: Adaptive pain suppression. Physiol. Rev. 66 (1986) 1091-1120
7. Baker T.B., Piper M.E., McCarthy D.E., Majeskie M.R., and Fiore M.C. Addiction motivation reformulated: An affective processing model of negative reinforcement. Psychol. Rev. 111 (2004) 33-51
8. Baldo B.A., Daniel R.A., Berridge C.W., and Kelley A.E. Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J. Comp. Neurol. 464 (2003) 220-237
9. Bale T., and Vale W. CRF and CRF receptors: Role in stress responsivity and other behaviors. Annu. Rev. Pharmacol. Toxicol. 44 (2004) 525-557
10. Bardo M.T., and Bevins R.A. Conditioned place preference: What does it add to our preclinical understanding of drug reward?. Psychopharmacology 153 (2000) 31-43
11. Batterham R.L., Cowley M.A., Small C.J., Herzog H., Cohen M.A., Dakin C.L., Wren A.M., Brynes A.E., Low M.J., Ghatei M.A., Cone R.D., and Bloom S.R. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418 (2002) 650-654
12. Batterham R.L., Cohen M.A., Ellis S.M., Le Roux C.W., Withers D.J., Frost G.S., Ghatei M.A., and Bloom S.R. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 349 (2003) 941-948
13. Beardsley P., Howard J., Shelton K., and Carroll F. Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats. Psychopharmacology 183 (2005) 118-126
14. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., Vale W., and Sawchenko P.E. The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization. J. Comp. Neurol. 319 (1992) 218-245
15. Boggiano M.M., Chandler P.C., Oswald K.D., Rodgers R.J., Blundell J.E., Ishii Y., Beattie A.H., Holch P., Allison D.B., Schindler M., Arndt K., Rudolf K., Mark M., Schoelch C., Joost H.G., Klaus S., Thone-Reineke C., Benoit S.C., Seeley R.J., Beck-Sickinger A.G., Koglin N., Raun K., Madsen K., Wulff B.S., Stidsen C.E., Birringer M., Kreuzer O.J., Deng X.Y., Whitcomb D.C., Halem H., Taylor J., Dong J., Datta R., Culler M., Ortmann S., Castaneda T.R., and Tschop M. PYY3-36 as an anti-obesity drug target. Obes. Rev. 6 (2005) 307-322
16. Bonci A., and Borgland S. Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system. Neuropharmacology 56 Suppl. 1 (2009) 107-111
17. Borgland S., Taha S., Sarti F., Fields H., and Bonci A. Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49 (2006) 589-601
18. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., DeLeon J., Lagu B., Heurich R., Lichtblau H., Shaposhnik Z., Daniewska I., Blackburn T.P., Branchek T.A., Gerald C., Vaysse P.J., and Forray C. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 8 (2002) 825-830
19. Bossert J., Ghitza U., Lu L., Epstein D., and Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications. Eur. J. Pharmacol. 526 (2005) 36-50
20. Boutrel B., Kenny P., Specio S., Martin-Fardon R., Markou A., Koob G., and de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 19168-19173
21. Boutrel B. A neuropeptide-centric view of psychostimulant addiction. Br. J. Pharmacol. 154 (2008) 343-357
22. Boutrel B., and de Lecea L. Addiction and arousal: The hypocretin connection. Physiol. Behav. 93 (2008) 947-951
23. Brown Z., Tribe E., D'souza N., and Erb S. Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat. Psychopharmacology (Berl) 203 (2009) 121-130
24. Bruijnzeel, A., Prado, M., Isaac, S., 2009. Corticotropin-releasing factor-1 receptor activation mediates nicotine withdrawal-induced deficit in brain reward function and stress-induced relapse. Biol Psychiatry. in press.
25. Cannella, N., Economidou, D., Kallupi, M., Stopponi, S., Heilig, M., Massi, M., Ciccocioppo, R., 2009. Persistent increase of alcohol-seeking evoked by neuropeptide S: An effect mediated by the hypothalamic hypocretin system. Neuropsychopharmacology. in press.
26. Cannon W.B. The emergency function of the adrenal medulla in pain and the major emotions. Am. J. Physiol. 33 (1914) 356-372
27. Capriles N., Rodaros D., Sorge R.E., and Stewart J. A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats. Psychopharmacology 168 (2003) 66-74
28. Carey A., Borozny K., Aldrich J., and McLaughlin J. Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. Eur. J. Pharmacol. 569 (2007) 84-89
29. Carroll M.E., France C.P., and Meisch R.A. Food deprivation increases oral and intravenous drug intake in rats. Science 205 (1979) 319-321
30. Carroll M.E. The role of food deprivation in the maintenance and reinstatement of cocaine-seeking behavior in rats. Drug Alcohol Depend. 16 (1985) 95-109
31. Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., Ellis C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S., and Sarau H.M. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400 (1999) 261-265
32. Chavkin C., James I.F., and Goldstein A. Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science 215 (1982) 413-415
33. Chrousos G.P., and Gold P.W. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267 (1992) 1244-1452
34. Chung S., Hopf F.W., Nagasaki H., Li C.Y., Belluzzi J.D., Bonci A., and Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 6772-6777
35. Ciccocioppo R., Angeletti S., Panocka I., and Massi M. Nociceptin/orphanin FQ and drugs of abuse. Peptides 21 (2000) 1071-1080
36. Ciccocioppo R., Fedeli A., Economidou D., Policani F., Weiss F., and Massi M. The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ. J. Neurosci. 23 (2003) 9445-9451
37. Clark J.T., Kalra P.S., Crowley W.R., and Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115 (1984) 427-429
38. Cohen F., Horowitz M.J., Lazarus R.S., Moos R.H., Robbins L.N., Rose R.M., and Rutter M. Panel report on psychosocial and modifiers of stress. In: Eliott G.R., and Eisdorfer C. (Eds). Stress and human health (1982), Springer Publishing Co., New York 147-188
39. Cohen S., Evans G.W., Stokols D., and Krantz D.S. Behavior, Health, and Environmental Stress (1986), Plenum Press, New York
40. Corbett A.D., Henderson G., McKnight A.T., and Paterson S.J. 75 years of opioid research: The exciting but vain quest for the Holy Grail. Br. J. Pharmacol. 147 Suppl. 1 (2006) S153-S162
41. Crombag H., Bossert J.M., Koya E., and Shaham Y. Context-induced relapse to drug seeking: A review. Trans. R. Soc. Lond., B: Biol. Sci. 363 (2008) 3233-3243
42. Dallman M.F., Akana S.F., Levin N., Walker C.D., Bradbury M.J., Suemaru S., and Scribner K.S. Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. Ann. N.Y. Acad. Sci. 746 (1995) 22-31
43. David D.J., Klemenhagen K.C., Holick K.A., Saxe M.D., Mendez I., Santarelli L., Craig D.A., Zhong H., Swanson C.J., Hegde L.G., Ping X.I., Dong D., Marzabadi M.R., Gerald C.P., and Hen R. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphen yl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J. Pharmacol. Exp. Ther. 321 (2007) 237-248
44. Dayas C., McGranahan T., Martin-Fardon R., and Weiss F. Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol. Psychiatry 63 (2008) 152-157
45. de Lecea L., Kilduff T., Peyron C., Gao X., Foye P., Danielson P., Fukuhara C., Battenberg E., Gautvik V., Bartlett F.n., Frankel W., van den Pol A., Bloom F., Gautvik K., and Sutcliffe J. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 322-327
46. de Souza E.B. Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 20 (1995) 789-819
47. de Wit H., and Stewart J. Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75 (1981) 134-143
48. Dhawan B., Cesselin F., Raghubir R., Reisine T., Bradley P., Portoghese P., and Hamon M. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. 48 (1996) 567-592
49. Dunn A.J., and Berridge C.M. Physiological and behavioral responses to corticotropin-releasing factor: Is CRF a mediator of anxiety or stress responses?. Brain Res. Rev. 15 (1990) 71-100
50. Eberlein G.A., Eysselein V.E., Schaeffer M., Layer P., Grandt D., Goebell H., Niebel W., Davis M., Lee T.D., Shively J.E., et al. A new molecular form of PYY: Structural characterization of human PYY(3-36) and PYY(1-36). Peptides 10 (1989) 797-803
51. Economidou D., Hansson A.C., Weiss F., Terasmaa A., Sommer W.H., Cippitelli A., Fedeli A., Martin-Fardon R., Massi M., Ciccocioppo R., and Heilig M. Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat. Biol. Psychiatry 64 (2008) 211-218
52. Epstein D., Preston K., Stewart J., and Shaham Y. Toward a model of drug relapse: An assessment of the validity of the reinstatement procedure. Psychopharmacology 189 (2006) 1-16
53. Erb S., and Stewart J. A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking. J. Neurosci. 19 (1999) RC35
54. Erb S., Shaham Y., and Stewart J. Stress reinstates cocaine-seeking behavior after prolonged extinction and drug-free periods. Psychopharmacology 128 (1996) 408-412
55. Erb S., Shaham Y., and Stewart J. The role of corticotropin-releasing factor and corticosterone in stress- and cocaine-induced relapse to cocaine seeking in rats. J. Neurosci. 18 (1998) 5529-5536
56. Erb S., Hitchcott P.K., Rajabi H., Mueller D., Shaham Y., and Stewart J. Alpha-2 adrenergic agonists block stress-induced reinstatement of cocaine seeking. Neuropsychopharmacology 23 (2000) 138-150
57. Erb S., Salmaso N., Rodaros D., and Stewart J. A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl) 158 (2001) 360-365
58. Erb S., Petrovic A., Yi D., and Kayyali H. Central injections of CRF reinstate cocaine seeking in rats after postinjection delays of up to 3 h: an influence of time and environmental context. Psychopharmacology (Berl) 187 (2006) 112-120
59. Fahey J.M., Pritchard G.A., Moltke L.L., Pratt J.S., Grassi J.M., Shader R.I., and Greenblatt D.J. Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice. J. Pharmacol. Exp. Ther. 285 (1998) 271-276
60. Figlewicz D., MacDonald Naleid A., and Sipols A. Modulation of food reward by adiposity signals. Physiol. Behav. 91 (2007) 473-478
61. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
62. Fulton S., Woodside B., and Shizgal P. Modulation of brain reward circuitry by leptin. Science 287 (2000) 125-128
63. Fulton S., Pissios P., Manchon R., Stiles L., Frank L., Pothos E., Maratos-Flier E., and Flier J. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51 (2006) 811-822
64. Georges F., and Aston-Jones G. Potent regulation of midbrain dopamine neurons by the bed nucleus of the stria terminalis. J. Neurosci. 21 (2001) RC160
65. Georges F., and Aston-Jones G. Activation of ventral tegmental area cells by the bed nucleus of the stria terminalis: A novel excitatory amino acid input to midbrain dopamine neurons. J. Neurosci. 22 (2002) 5173-5187
66. Georgescu D., Sears R.M., Hommel J.D., Barrot M., Bolanos C.A., Marsh D.J., Bednarek M.A., Bibb J.A., Maratos-Flier E., Nestler E.J., and DiLeone R.J. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J. Neurosci. 25 (2005) 2933-2940
67. Ghitza U., Gray S., Epstein D., Rice K., and Shaham Y. The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: A role of CRF1 receptors. Neuropsychopharmacology 31 (2006) 2188-2196
68. Ghitza U.E., Nair S.G., Golden S.A., Gray S.M., Uejima J.L., Bossert J.M., and Shaham Y. Peptide YY3-36 decreases reinstatement of high-fat food seeking during dieting in a rat relapse model. J. Neurosci. 27 (2007) 11522-11532
69. Gietzen K., Penka L., and Eisenburger R. Imidazole fungicides provoke histamine release from mast cells and induce airway contraction. Exp. Toxicol. Pathol. 48 (1996) 529-531
70. Goldstein A., and Naidu A. Multiple opioid receptors: Ligand selectivity profiles and binding sties signatures. Mol. Pharmacol. 36 (1989) 265-272
71. Hahn J., Hopf F.W., and Bonci A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J. Neurosci. 29 (2009) 6335-6344
72. Hamlin A.S., Newby J., and McNally G.P. The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol-seeking. Neuroscience 146 (2007) 525-536
73. Harris G., Wimmer M., Randall-Thompson J., and Aston-Jones G. Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward. Behav. Brain Res. 183 (2007) 43-51
74. Harris G.C., Wimmer M., and Jones G.A. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
75. Heckman W.R., Kane B.R., Pakyz R.E., and Cosentino M.J. The effect of ketoconazole on endocrine and reproductive parameters in male mice and rats. J. Androl. 13 (1992) 191-198
76. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides 38 (2004) 213-224
77. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides. 38 (2004) 213-224
78. Heilig M.A., and Koob G.F. A key role of corticotropin-releasing factor in alcohol dependence. Trends Neurosci. 30 (2007) 399-406
79. Hervieu G. Melanin-concentrating hormone functions in the nervous system: Food intake and stress. Expert. Opin. Ther. Targets 7 (2003) 495-511
80. Highfield D., Yap J., Grimm J., Shalev U., and Shaham Y. Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats. Neuropsychopharmacology 25 (2001) 320-331
81. Hommel J., Trinko R., Sears R., Georgescu D., Liu Z., Gao X., Thurmon J., Marinelli M., and Dileone R. Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51 (2006) 801-810
82. IUPHAR, 2008. Opioid receptors: Introduction. Vol., ed.^eds. IUPHAR data base.
83. Jaffe J.H. Drug addiction and drug abuse. In: Gilman A.G., Rall T.W., Nies A.S., and Taylor P. (Eds). Goodman & Gilman's the Pharmacological Basis of Therapeutics(8) (1990), Pergamon Press, New York 522-573
84. Johanson C.E., Woolverton W.L., and Schuster C.R. Evaluating laboratory models of drug dependence. In: Meltzer H.Y. (Ed). Psychopharmacology: The third generation of progress (1987), Raven Press, New York 1617-1626
85. Kalivas P.W., and McFarland K. Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology 168 (2003) 44-56
86. Kalivas P.W., and Volkow N.D. The neural basis of addiction: A pathology of motivation and choice. Am. J. Psychiatry 162 (2005) 1403-1413
87. Kask A., Harro J., von Horsten S., Redrobe J.P., Dumont Y., and Quirion R. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci. Biobehav. Rev. 26 (2002) 259-283
88. Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., and Baker B.I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 305 (1983) 321-323
89. Koob G.F. A role for brain stress systems in addiction. Neuron 59 (2008) 11-34
90. Kreibich A., Reyes B.A., Curtis A.L., Ecke L., Chavkin C., Van Bockstaele E.J., and Valentino R.J. Presynaptic inhibition of diverse afferents to the locus coeruleus by kappa-opiate receptors: A novel mechanism for regulating the central norepinephrine system. J. Neurosci. 28 (2008) 6516-6525
91. Kreibich A.S., and Blendy J.A. cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement. J. Neurosci. 24 (2004) 6686-6692
92. Land B., Bruchas M., Lemos J., Xu M., Melief E., and Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J. Neurosci. 28 (2008) 407-414
93. Larhammar D., and Salaneck E. Molecular evolution of NPY receptor subtypes. Neuropeptides 38 (2004) 141-151
94. Lawrence A.J., Cowen M.S., Yang H.J., Chen F., and Oldfield B. The orexin system regulates alcohol-seeking in rats. Br. J. Pharmacol. 148 (2006) 752-759
95. Le A., Harding S., Juzytsch W., Watchus J., Shalev U., and Shaham Y. The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats. Psychopharmacology (Berl) 150 (2000) 317-324
96. Le A., Harding S., Juzytsch W., Fletcher P., and Shaham Y. The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. J. Neurosci. 22 (2002) 7844-7849
97. Lee B., Tiefenbacher S., Platt D.M., and Spealman R.D. Pharmacological blockade of alpha(2)-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys. Neuropsychopharmacology 29 (2004) 686-693
98. Leibowitz S.F. Brain peptides and obesity: Pharmacologic treatment. Obes. Res. 3 Suppl. 4 (1995) 573S-589S
99. Lembo P.M., Grazzini E., Cao J., Hubatsch D.A., Pelletier M., Hoffert C., St-Onge S., Pou C., Labrecque J., Groblewski T., O'Donnell D., Payza K., Ahmad S., and Walker P. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat. Cell Biol. 1 (1999) 267-271
100. Leri F., Tremblay A., Sorge R., and Stewart J. Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use. Neuropsychopharmacology 29 (2004) 1312-1320
101. Liu X., and Weiss F. Additive effect of stress and drug cues on reinstatement of ethanol seeking: Exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J. Neurosci. 22 (2002) 7856-7861
102. Lu L., Ceng X., and Huang M. Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats. Neuroreport 11 (2000) 2373-2378
103. Lu L., Liu D., and Ceng X. Corticotropin-releasing factor receptor type 1 mediates stress-induced relapse to cocaine-conditioned place preference in rats. Eur. J. Pharmacol. 415 (2001) 203-208
104. Lu L., Shepard J.D., Scott Hall F., and Shaham Y. Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: A review. Neurosci. Biobehav. Rev. 27 (2003) 457-491
105. Mantsch J.R., and Goeders N.E. Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: Relationship to the discriminative stimulus effects of cocaine. Psychopharmacology 142 (1999) 399-407
106. Maric T., Tobin S., Quinn T., and Shalev U. Food deprivation-like effects of neuropeptide Y on heroin self-administration and reinstatement of heroin seeking in rats. Behav. Brain Res. 194 (2008) 39-43
107. Marinelli P., Funk D., Juzytsch W., Harding S., Rice K., Shaham Y., and Le A. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl) 195 (2007) 345-355
108. Martin-Fardon R., Ciccocioppo R., Massi M., and Weiss F. Nociceptin prevents stress-induced ethanol- but not cocaine-seeking behavior in rats. Neuroreport 11 (2000) 1939-1943
109. McFarland K., Davidge S.B., Lapish C.C., and Kalivas P.W. Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J. Neurosci. 24 (2004) 1551-1560
110. Meil W.M., and See R.E. Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: An animal model of relapse. Behav. Pharmacol. 7 (1996) 754-763
111. Meunier J., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J., Guillemot J., Ferrara P., and Monsarrat B. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 (1995) 532-535
112. Moran T.H., Smedh U., Kinzig K.P., Scott K.A., Knipp S., and Ladenheim E.E. Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 (2005) R384-348
113. Murphy K.G., Dhillo W.S., and Bloom S.R. Gut peptides in the regulation of food intake and energy homeostasis. Endocr. Rev. 27 (2006) 719-727
114. Nair S., Golden S., and Shaham Y. Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats. Br. J. Pharmacol. 154 (2008) 406-416
115. Nair S., Adams-Deustch T., Pickens C., Smith D., and Shaham Y. Effect of the melanin concentrating hormone receptor 1 antagonist SNAP 94847 on food self-administration and relapse to food seeking in rats. Psychopharmacology 205 (2009) 129-140
116. Nair S.G., Adams-Deustch T., Epstein D.H., and Shaham Y. The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking. Prog. Neurobiol. 89 (2009) 18-45
117. Narita M., Nagumo Y., Hashimoto S., Narita M., Khotib J., Miyatake M., Sakurai T., Yanagisawa M., Nakamachi T., Shioda S., and Suzuki T. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J. Neurosci. 26 (2006) 398-405
118. O'Brien C.P. A range of research-based pharmacotherapies for addiction. Science 278 (1997) 66-70
119. Paneda C., Huitron-Resendiz S., Frago L., Chowen J., Picetti R., de Lecea L., and Roberts A. Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. J. Neurosci. 29 (2009) 4155-4161
120. Peyron C., Tighe D., van den Pol A., de Lecea L., Heller H., Sutcliffe J., and Kilduff T. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18 (1998) 9996-10015
121. Piazza P.V., and Le Moal M. The role of stress in drug self-administration. Trends Pharmacol. Sci. 19 (1998) 67-74
122. Pissios P., Bradley R.L., and Maratos-Flier E. Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions. Endocr. Rev. 27 (2006) 606-620
123. Redila V., and Chavkin C. Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology (Berl). 200 (2008) 59-70
124. Redmond D.E.J., and Huang Y.H. Locus coeruleus and anxiety. Life Sci. 25 (1979) 2149-2162
125. Reinscheid R., Nothacker H., Bourson A., Ardati A., Henningsen R., Bunzow J., Grandy D., Langen H., Monsma F.J., and Civelli O. Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor. Science 270 (1995) 792-794
126. Ribeiro Do Couto B., Aguilar M.A., Manzanedo C., Rodriguez-Arias M., Armario A., and Minarro J. Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice. Psychopharmacology (Berl) 185 (2006) 459-470
127. Richards J., Simms J., Steensland P., Taha S., Borgland S., Bonci A., and Bartlett S. Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl) 199 (2008) 109-117
128. Rodaros D., Caruana D.A., Amir S., and Stewart J. Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience 150 (2007) 8-13
129. Rodi D., Zucchini S., Simonato M., Cifani C., Massi M., and Polidori C. Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: Evidence for involvement of the bed nucleus of the stria terminalis. Psychopharmacology (Berl) 196 (2008) 523-531
130. Saito Y., Cheng M., Leslie F.M., and Civelli O. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J. Comp. Neurol. 435 (2001) 26-40
131. Sakanaka M., Shibasaki T., and Lederis K. Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex. Brain Res. 382 (1986) 213-238
132. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R., Tanaka H., Williams S., Richarson J., Kozlowski G., Wilson S., Arch J., Buckingham R., Haynes A., Carr S., Annan R., McNulty D., Liu W., Terrett J., Elshourbagy N., Bergsma D., and Yanagisawa M. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 1 page following 696
133. Sakurai T. The neural circuit of orexin (hypocretin): Maintaining sleep and wakefulness. Nat. Rev. Neurosci. 8 (2007) 171-181
134. Sanchez C.J., and Sorg B.A. Conditioned fear stimuli reinstate cocaine-induced conditioned place preference. Brain Res. 908 (2001) 86-92
135. Sanchez C.J., Bailie T.M., Wu W.R., Li N., and Sorg B.A. Manipulation of dopamine d1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior. Neuroscience 119 (2003) 497-505
136. Sarnyai Z., Shaham Y., and Heinrichs S. The role of corticotropin-releasing factor in drug addiction. Pharmacol. Rev. 53 (2001) 209-243
137. Schenk S., Partridge B., and Shippenberg T. U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking. Psychopharmacology (Berl) 144 (1999) 339-346
138. Schenk S., Partridge B., and Shippenberg T. Reinstatement of extinguished drug-taking behavior in rats: Effect of the kappa-opioid receptor agonist, U69593. Psychopharmacology (Berl) 151 (2000) 85-90
139. Self D.W., Barnhart W.J., Lehman D.A., and Nestler E.J. Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists. Science 271 (1996) 1586-1589
140. Selye H. A syndrome produced by diverse nocuous agents. Nature 138 (1936) 32-36
141. Shaham Y., and Stewart J. Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal. Psychopharmacology 119 (1995) 334-341
142. Shaham Y. Effect of stress on opioid-seeking behavior: Evidence from studies with rats. Ann. Behav. Med. 18 (1996) 255-263
143. Shaham Y., Rajabi H., and Stewart J. Relapse to heroin-seeking under opioid maintenance: The effects of opioid withdrawal, heroin priming and stress. J. Neurosci. 16 (1996) 1957-1963
144. Shaham Y., and Stewart J. Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology (Berl) 125 (1996) 385-391
145. Shaham Y., Funk D., Erb S., Brown T., Walker C., and Stewart J. Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J. Neurosci. 17 (1997) 2605-2614
146. Shaham Y., Erb S., Leung S., Buczek Y., and Stewart J. CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats. Psychopharmacology (Berl) 137 (1998) 184-190
147. Shaham Y., Erb S., and Stewart J. Stress-induced relapse to heroin and cocaine seeking in rats: A review. Brain Res. Rev. 33 (2000) 13-33
148. Shaham Y., Highfield D., Delfs J.M., Leung S., and Stewart J. Clonidine blocks stress-induced reinstatement of heroin seeking in rats: An effect independent of the locus coeruleus noradrenergic neurons. Eur. J. Neurosci. 12 (2000) 292-302
149. Shaham Y., Shalev U., Lu L., De Wit H., and Stewart J. The reinstatement model of drug relapse: History, methodology and major findings. Psychopharmacology 168 (2003) 3-20
150. Shalev U., Highfield D., Yap J., and Shaham Y. Stress and relapse to drug seeking in rats: Studies on the generality of the effect. Psychopharmacology 150 (2000) 337-346
151. Shalev U., Yap J., and Shaham Y. Leptin attenuates acute food deprivation-induced relapse to heroin seeking. J. Neurosci. 21 (2001) RC129
152. Shalev U., Grimm J.W., and Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: A review. Pharmacol. Rev. 54 (2002) 1-42
153. Shalev U., Marinelli M., Baumann M.H., Piazza P.V., and Shaham Y. The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat. Psychopharmacology 168 (2003) 170-176
154. Shalev U., Finnie P., Quinn T., Tobin S., and Wahi P. A role for corticotropin-releasing factor, but not corticosterone, in acute food-deprivation-induced reinstatement of heroin seeking in rats. Psychopharmacology (Berl) 187 (2006) 376-384
155. Shelton K.L., and Beardsley P.M. Interaction of extinguished cocaine-conditioned stimuli and footshock on reinstatement in rats. Int. J. Comp. Psychol. 18 (2005) 154-166
156. Shepard J., Bossert J., Liu S., and Shaham Y. The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse. Biol. Psychiatry 55 (2004) 1082-1089
157. Shippenberg T., Zapata A., and Chefer V. Dynorphin and the pathophysiology of drug addiction. Pharmacol. Ther. 116 (2007) 306-321
158. Sinha R. How does stress increase risk of drug abuse and relapse?. Psychopharmacology 158 (2001) 343-359
159. Smith D.G., Hegde L.G., Wolinsky T.D., Miller S., Papp M., Ping X., Edwards T., Gerald C.P., and Craig D.A. The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents. Behav. Brain Res. 197 (2009) 284-291
160. Sorge R., Rajabi H., and Stewart J. Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement. Neuropsychopharmacology 30 (2005) 1681-1692
161. Spealman R.D., Barrett-Larimore R.L., Rowlett J.K., Platt D.M., and Khroyan T.V. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol. Biochem. Behav. 64 (1999) 327-336
162. Stewart J. Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area. Pharmacol. Biochem. Behav. 20 (1984) 917-923
163. Sutcliffe J., and de Lecea L. The hypocretins: Setting the arousal threshold. Nat. Rev. Neurosci. 3 (2002) 339-349
164. Swanson L.W., Sawchenko P.E., Rivier J., and Vale W.W. Organization of bovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study. Neuroendocrinology 36 (1983) 165-186
165. Tatemoto K., Carlquist M., and Mutt V. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296 (1982) 659-660
166. Valdez G., Platt D., Rowlett J., Ruedi-Bettschen D., and Spealman R. Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: A role for opioid and stress-related mechanisms. J. Pharmacol. Exp. Ther. 323 (2007) 525-533
167. Vale W., Spiess J., Rivier C., and Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213 (1981) 1394-1397
168. Valentino R.J., and Van Bockstaele E. Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur. J. Pharmacol. 583 (2008) 194-203
169. Van Pett K., Viau V., Bittencourt J.C., Chan R.K., Li H.Y., Arias C., Prins G.S., Perrin M., Vale W., and Sawchenko P.E. Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J. Comp. Neurol. 428 (2000) 191-212
170. Vertes R.P., Fortin W.J., and Crane A.M. Projections of the median raphe nucleus in the rat. J. Comp. Neurol. 407 (1999) 555-582
171. Wang B., Shaham Y., Zitzman D., Azari S., Wise R., and You Z. Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: A role in stress-induced relapse to drug seeking. J. Neurosci. 25 (2005) 5389-5396
172. Wang B., You Z., Rice K., and Wise R. Stress-induced relapse to cocaine seeking: Roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) 193 (2007) 283-294
173. Wang B., You Z., and Wise R. Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: Independence from the local corticotropin-releasing factor network. Biol. Psychiatry 65 (2009) 857-862
174. Wang J., Fang Q., Liu Z., and Lu L. Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats. Psychopharmacology (Berl) 185 (2006) 19-28
175. Weiss F., Maldonado-Vlaar C.S., Parsons L.H., Kerr T.M., Smit D.L., and Ben-Shahar O. Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4321-4326
176. Wikler A. Dynamics of drug dependence, implication of a conditioning theory for research and treatment. Arch. Gen. Psychiatry 28 (1973) 611-616
177. Winsky-Sommerer R., Yamanaka A., Diano S., Borok E., Roberts A.J., Sakurai T., Kilduff T.S., Horvath T.L., and de Lecea L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response. J. Neurosci. 24 (2004) 11348-11439
178. Winsky-Sommerer R., Boutrel B., and de Lecea L. Stress and arousal: The corticotrophin-releasing factor/hypocretin circuitry. Mol. Neurobiol. 32 (2005) 285-494
179. Xu Y., Reinscheid R., Huitron-Resendiz S., Clark S., Wang Z., Lin S., Brucher F., Zeng J., Ly N., Henriksen S., de Lecea L., and Civelli O. Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43 (2004) 487-497
180. Zamir N., Skofitsch G., and Jacobowitz D.M. Distribution of immunoreactive melanin-concentrating hormone in the central nervous system of the rat. Brain Res. 373 1-2 (1986) 240-245
181. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
182. Zislis G., Desai T., Prado M., Shah H., and Bruijnzeel A. Effects of the CRF receptor antagonist D-Phe CRF(12-41) and the alpha2-adrenergic receptor agonist clonidine on stress-induced reinstatement of nicotine-seeking behavior in rats. Neuropharmacology 53 (2007) 958-966