Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

British Journal of Pharmacology

Volumn 154, Issue 2, 2008, Pages 406-416

  Nair, S G ^a   Golden, S A ^a   Shaham, Y ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Food priming; Hypocretin; Hypocretin 1 receptor; Orexin; Reinstatement; Relapse; SB 334867; Self administration; Yohimbine

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; OREXIN 1 RECEPTOR; OREXIN A; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; BODY POSTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; FEEDING; FOOD INTAKE; IMMOBILIZATION; LIPID DIET; MALE; NONHUMAN; PHARMACOLOGIC STRESS TESTING; PRIORITY JOURNAL; RAT; REINFORCEMENT;

EID: 43449109190     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.3     Document Type: Article

References (66)

1. Avena NM, Rada P, Hoebel BG (2008). Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32: 20–39.
2. Baptista MA, Martin‐Fardon R, Weiss F (2004). Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. J Neurosci 24: 4723–4727.
3. Boggiano MM, Artiga AI, Pritchett CE, Chandler‐Laney PC, Smith ML, Eldridge AJ (2007). High intake of palatable food predicts binge‐eating independent of susceptibility to obesity: an animal model of lean vs obese binge‐eating and obesity with and without binge‐eating. Int J Obes 31: 1357–1367.
4. Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006). Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49: 589–601.
5. Bossert JM, Poles GC, Sheffler‐Collins SI, Ghitza UE (2006). The mGluR2/3 agonist LY379268 attenuates context‐ and discrete cue‐induced reinstatement of sucrose seeking but not sucrose self‐administration in rats. Behav Brain Res 173: 148–152.
6. Boutrel B, Kenny PJ, Specio SE, Martin‐Fardon R, Markou A, Koob GF et al. (2005). Role for hypocretin in mediating stress‐induced reinstatement of cocaine‐seeking behavior. Proc Natl Acad Sci USA 102: 19168–19173.
7. Bremner JD, Krystal JH, Southwick SM, Charney DS (1996a). Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse 23: 28–38.
8. Bremner JD, Krystal JH, Southwick SM, Charney DS (1996b). Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 23: 39–51.
9. Brisbare‐Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S et al. (2007). Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13: 150–155.
10. Chang H, Saito T, Ohiwa N, Tateoka M, Deocaris CC, Fujikawa T et al. (2007). Inhibitory effects of an orexin‐2 receptor antagonist on orexin A‐ and stress‐induced ACTH responses in conscious rats. Neurosci Res 57: 462–466.
11. Colantuoni C, Rada P, McCarthy J, Patten C, Avena NM, Chadeayne A et al. (2002). Evidence that intermittent, excessive sugar intake causes endogenous opioid dependence. Obes Res 10: 478–488.
12. Corwin RL, Buda‐Levin A (2004). Behavioral models of binge‐type eating. Physiol Behav 82: 123–130.
13. Dayas CV, McGranahan TM, Martin‐Fardon R, Weiss F (2008). Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63: 152–157.
14. De Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE et al. (1998). The hypocretins: hypothalamus‐specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95: 322–327.
15. De Vries TJ, De Vries W, Janssen MC, Schoffelmeer AN (2005). Suppression of conditioned nicotine and sucrose seeking by the cannabinoid‐1 receptor antagonist SR141716A. Behav Brain Res 161: 164–168.
16. De Vries TJ, Shaham Y, Homberg JR, Crombag H, Schuurman K, Dieben J et al. (2001). A cannabinoid mechanism in relapse to cocaine seeking. Nat Med 7: 1151–1154.
17. De Vries TJ, Shippenberg TS (2002). Neural systems underlying opiate addiction. J Neurosci 22: 3321–3325.
18. Drewnowski A (1997). Taste preferences and food intake. Annu Rev Nutr 17: 237–253.
19. Elfhag K, Rossner S (2005). Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain. Obes Rev 6: 67–85.
20. Epstein DH, Preston KL, Stewart J, Shaham Y (2006). Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology 189: 1–16.
21. Fedoroff I, Polivy J, Herman CP (2003). The specificity of restrained versus unrestrained eaters' responses to food cues: general desire to eat, or craving for the cued food ? Appetite 41: 7–13.
22. Feltenstein MW, See RE (2006). Potentiation of cue‐induced reinstatement of cocaine‐seeking in rats by the anxiogenic drug yohimbine. Behav Brain Res 174: 1–8.
23. Figlewicz DP, MacDonald Naleid A, Sipols AJ (2007). Modulation of food reward by adiposity signals. Physiol Behav 91: 473–478.
24. Ghitza UE, Gray SM, Epstein DH, Rice KC, Shaham Y (2006). The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF(1) receptors. Neuropsychopharmacology 31: 2188–2196.
25. Ghitza UE, Nair SG, Golden SA, Gray SM, Uejima JL, Bossert JM et al. (2007). Peptide YY3–36 decreases reinstatement of high‐fat food seeking during dieting in a rat relapse model. J Neurosci 27: 11522–11532.
26. Grilo CM, Shiffman S, Wing RR (1989). Relapse crises and coping among dieters. J Consult Clin Psychol 57: 488–495.
27. Hagan MM, Chandler PC, Wauford PK, Rybak RJ, Oswald KD (2003). The role of palatable food and hunger as trigger factors in an animal model of stress induced binge eating. Int J Eat Disord 34: 183–197.
28. Hagan MM, Wauford PK, Chandler PC, Jarrett LA, Rybak RJ, Blackburn K (2002). A new animal model of binge eating: key synergistic role of past caloric restriction and stress. Physiol Behav 77: 45–54.
29. Hamlin AS, Blatchford KE, McNally GP (2006). Renewal of an extinguished instrumental response: neural correlates and the role of D1 dopamine receptors. Neuroscience 143: 25–38.
30. Hamlin AS, Newby J, McNally GP (2007). The neural correlates and role of D1 dopamine receptors in renewal of extinguished alcohol‐seeking. Neuroscience 146: 525–536.
31. Harris GC, Aston‐Jones G (2006). Arousal and reward: a dichotomy in hypocretin function. Trends Neurosci 29: 571–577.
32. Harris GC, Wimmer M, Aston‐Jones G (2005). A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437: 556–559.
33. Harris GC, Wimmer M, Randall‐Thompson JF, Aston‐Jones G (2007). Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward. Behav Brain Res 183: 43–51.
34. Haynes AC, Chapman H, Taylor C, Moore GB, Cawthorne MA, Tadayyon M et al. (2002). Anorectic, thermogenic and anti‐obesity activity of a selective orexin‐1 receptor antagonist in ob/ob mice. Regul Pept 104: 153–159.
35. Haynes AC, Jackson B, Chapman H, Tadayyon M, Johns A, Porter RA et al. (2000). A selective orexin‐1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96: 45–51.
36. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M et al. (1999). Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20: 1099–1105.
37. Herman CP, Polivy J (1975). Anxiety, restraint, and eating behavior. J Abnorm Psychol 84: 66–72.
38. Ishii Y, Blundell JE, Halford JC, Upton N, Porter R, Johns A et al. (2005a). Anorexia and weight loss in male rats 24 h following single dose treatment with orexin‐1 receptor antagonist SB‐334867. Behav Brain Res 157: 331–341.
39. Ishii Y, Blundell JE, Halford JC, Upton N, Porter R, Johns A et al. (2005b). Satiety enhancement by selective orexin‐1 receptor antagonist SB‐334867: influence of test context and profile comparison with CCK‐8S. Behav Brain Res 160: 11–24.
40. Kalivas PW, Volkow ND (2005). The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162: 1403–1413.
41. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B (2006). The orexin system regulates alcohol‐seeking in rats. Br J Pharmacol 148: 752–759.
42. Le AD, Harding S, Juzytsch W, Funk D, Shaham Y (2005). Role of alpha‐2 adrenoceptors in stress‐induced reinstatement of alcohol seeking and alcohol self‐administration in rats. Psychopharmacology 179: 366–373.
43. Lee B, Tiefenbacher S, Platt DM, Spealman RD (2004). Pharmacological blockade of alpha(2)‐adrenoceptors induces reinstatement of cocaine‐seeking behavior in squirrel monkeys. Neuropsychopharmacology 29: 686–693.
44. Marinelli PW, Funk D, Juzytsch W, Harding S, Rice KC, Shaham Y et al. (2007). The CRF(1) receptor antagonist antalarmin attenuates yohimbine‐induced increases in operant alcohol self‐administration and reinstatement of alcohol seeking in rats. Psychopharmacology 195: 345–355.
45. Nair SG, Gray SM, Ghitza UE (2006). Role of food type in yohimbine‐ and pellet‐priming‐induced reinstatement of food seeking. Physiol Behav 88: 559–566.
46. Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M et al. (2006). Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26: 398–405.
47. Paxinos G, Watson C (2005). The Rat Brain in Stereotaxic Coordinates. Elsevier Academic Press: Amsterdam.
48. Peterson CB, Mitchell JE (1999). Psychosocial and pharmacological treatment of eating disorders: a review of research findings. J Clin Psychol 55: 685–697.
49. Peyron C, Tighe DK, Van Den Pol AN, De Lecea L, Heller HC, Sutcliffe JG et al. (1998). Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996–10015.
50. Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR et al. (2001). SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of hypocretin‐A in rats. Eur J Neurosci 13: 1444–1452.
51. Rodgers RJ, Ishii Y, Halford JC, Blundell JE (2002). Orexins and appetite regulation. Neuropeptides 36: 303–325.
52. Sakai RR, Ma LY, He PF, Fluharty SJ (1995). Intracerebroventricular administration of angiotensin type 1 (AT1) receptor antisense oligonucleotides attenuate thirst in the rat. Regul Pept 59: 183–192.
53. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H et al. (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein‐coupled receptors that regulate feeding behavior. Cell 92: 573–585.
54. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003). The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168: 3–20.
55. Shalev U, Finnie PS, Quinn T, Tobin S, Wahi P (2006). A role for corticotropin‐releasing factor, but not corticosterone, in acute food‐deprivation‐induced reinstatement of heroin seeking in rats. Psychopharmacology 187: 376–384.
56. Shalev U, Grimm JW, Shaham Y (2002). Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacol Rev 54: 1–42.
57. Shalev U, Marinelli M, Baumann MH, Piazza PV, Shaham Y (2003). The role of corticosterone in food deprivation‐induced reinstatement of cocaine seeking in the rat. Psychopharmacology 168: 170–176.
58. Shalev U, Yap J, Shaham Y (2001). Leptin attenuates food deprivation‐induced relapse to heroin seeking. J Neurosci 21: RC129.
59. Shepard JD, Bossert JM, Liu SY, Shaham Y (2004). The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse. Biol Psychiatry 55: 1082–1089.
60. Smart D, Jerman JC, Brough SJ, Neville WA, Jewitt F, Porter RA (2000). The orexins are weak agonists at recombinant human orexin‐1 and orexin‐2 receptors. Br J Pharmacol 129: 1289–1291.
61. Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F et al. (1999). Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR. Br J Pharmacol 128: 1–3.
62. Stewart J (2000). Pathways to relapse: the neurobiology of drug‐ and stress‐induced relapse to drug‐taking. J Psychiatry Neurosci 25: 125–136.
63. Sutcliffe JG, De Lecea L (2002). The hypocretins: setting the arousal threshold. Nat Rev Neurosci 3: 339–349.
64. Van Den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB (1998). Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 18: 7962–7971.
65. White CL, Ishii Y, Mendoza T, Upton N, Stasi LP, Bray GA et al. (2005). Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary‐induced obesity. Peptides 26: 2331–2338.
66. Zheng H, Patterson LM, Berthoud HR (2007). Orexin signaling in the ventral tegmental area is required for high‐fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 27: 11075–11082.