CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats

Psychopharmacology

Volumn 137, Issue 2, 1998, Pages 184-190

  Shaham, Yavin ^a,b   Erb, Suzanne ^c   Leung, Shirley ^a   Buczek, Yvona ^a   Stewart, Jane ^c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c and Applied Physiology   (Canada)

Author keywords

Cocaine; Corticotropin releasing factor; CRF receptor; Drug self administration; Heroin; Reinstatement; Relapse; Stress

Indexed keywords

BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; COCAINE; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR; DIAMORPHINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE; SHOCK; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ANIMALS; COCAINE; CORTICOTROPIN-RELEASING HORMONE; HEROIN; MALE; PYRIMIDINES; PYRROLES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; SELF ADMINISTRATION; STRESS, PSYCHOLOGICAL; SUCROSE;

EID: 0031960095     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050608     Document Type: Article

References (41)

1. Ahmed SH, Koob GF (1997) Cocaine-but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology 132:289-296
2. Ahmed SH, Epping-Jordan MP, Griffin PS, Markou SC, Heinrichs SC, De Souza EB, Rivier J, Koob GF (1996) Maintenance of cocaine self-administration is not affected by pharmacological blockade of brain CRF receptors. Soc Neurosci Abstr 22:925
3. Ambrosio E, Sharpe L, Pilotte N (1997) Regional binding to corticotropin releasing factor receptors in brain of rats exposed to chronic cocaine and cocaine withdrawal. Synapse 25:272-276
4. Behan DP, Grigoriadis DE, Lovenberg T, Chalmers D, Heinrichs S, Liaw C, De Souza EB (1996) Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders. Mol Psychiatry 1:265-277
5. Carroll ME, Comer SD (1996) Animal models of relapse. Exp Clin Psychopharmacol 4:11-18
6. 1 receptor antagonist. J Med Chem 40: 1749-1754
7. Comer SD, Lae ST, Wyvell CL, Curtis LK, Carroll ME (1995) Food deprivation affects extinction and reinstatement of responding in rats. Psychopharmacology 121:150-157
8. de Souza EB (1985) Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution. J Neurosci 7:88-100
9. de Souza EB (1995) Corticotropin-releasing factor receptors: physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 20: 789-819
10. de Wit H (1996) Priming effects with drugs and other reinforcers. Exp Clin Psychopharmacol 4:5-10
11. de Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75:134-143
12. de Wit H, Stewart J (1983) Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology 79:29-31
13. Dunn AJ, Berridge CM (1990) Physiological and behavioral responses to corticotropin-releasing factor: is CRF a mediator of anxiety or stress responses? Brain Res Rev 15:71-100
14. Erb S, Shaham Y, Stewart J (1996) Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology 128:408-412
15. 12 41 on footshock-and cocaine-induced reinstatement of cocaine seeking in rats. Soc Neurosci Abstr 23:2146
16. Gerber GJ, Stretch R (1975) Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol Biochem Behav 3:1055-1061
17. Heinrichs S, Menzaghi F, Schulteis G, Koob G, Stinus L (1995) Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal. Behav Pharmacol 6:74-80
18. Jaffe JH (1990) Drug addiction and drug abuse. In: Gilman AG, Rall TW, Nies AS, Taylor P (eds) Goodman & Gilman's the pharmacological basis of therapeutics. Pergamon Press, New York, pp 522-573
19. Jaffe JH, Cascell NG, Kumor KM, Sherer MA (1989) Cocaine-induced cocaine craving. Psychopharmacology 97:59-64
20. Joseph S, Knigge K (1983) Corticotropin releasing factor: immunocytochemical localization in rat brain. Neurosci Lett 35: 135-141
21. Koob GF (1996) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16:893-896
22. Kosten TR, Rounsaville BJ, Kleber HD (1986) A 2.5-year follow-up of depression, life crises, and treatment effects on abstinence among opioid addicts. Arch Gen Psychiatry 43:733-739
23. Lê AD, Quan B, Juzytch W, Fletcher PJ, Joharchi N, Shaham Y (1998) Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats. Psychopharmacology 135:169-174
24. Lundkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau LJ (1996) A non-peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like effects. Eur J Pharmacol 309: 195-200
25. 1 receptor antagonist. Eur J Pharmacol 323:21-26
26. Menzaghi F, Heinrichs SC, Merlo Pich E, Weiss F, Kooh GF (1993) The role of limbic and hypothalamic corticotropin-releasing factor in behavioral response to stress. Ann NY Acad Sci 697:142-154
27. Menzaghi F, Rassnick S, Heinrichs S, Baldwin H, Merlo Pich M, Weiss F, Koob GF (1994) The role of corticotropin-releasing factor in the anxiogenic effects of ethanol withdrawal. Ann NY Acad Sci 739:176-184
28. Merlo Pich E, Lorang M, Yeganeh M, Rodriguez de Fonseca F, Raber J, Koob GF, Weiss F (1995) Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci 15: 5439-5447
29. Meyer RE, Mirin SM (1979) The heroin stimulus: implications for a theory of addiction. Plenum Press, New York
30. Nemeroff CB (1996) The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol Psychiatry 1:336-342
31. Sarnyai Z, Buri E, Gardi J, Vecsernyes M, Julesz J, Telegdy G (1995) Brain corticotropin-releasing factor mediates "anxiety-like" behavior induced by cocaine withdrawal in rats. Brain Res 657:89-97
32. Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley DF III, Winston EN, Chen YL, Heym J (1996) CP-154,526: a potent and selective non-peptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci USA 93:10477-10482
33. Shaham Y, Stewart J (1995) Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology 119:334-341
34. Shaham Y, Stewart J (1996) Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology 125:385-391
35. Shaham Y, Funk D, Erb S, Brown T, Walker C-D, Stewart J (1997) Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci 17:2605-2614
36. Shiffman S, Wills TA (1985) Coping and substance abuse. Academic Press, Orlando
37. Stewart J, de Wit H (1987) Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs. In: Bozarth MA (ed) Methods of assessing the reinforcing properties of abused drugs. Springer, New York, pp 211-227
38. Swanson L, Sawchenko P, Rivier J, Vale W (1983) Organization of ovine corticotropin releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36:165-186
39. Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394-1397
40. Whitehead CC (1974) Methadone pseudowithdrawal syndrome: paradigm for a psychopharmacological model of opiate addiction. Psychosom Med 36:189-198
41. Zhou Y, Spangler R, LaForge K, Maggos C, Ho A, Kreek MJ (1996) Corticotropin-releasing factor and type 1 corticotropin-releasing factor receptor messenger RNAs in rat brain and pituitary during "binge"-pattern cocaine administration and chronic withdrawal. J Pharmacol Exp Ther 279:351-358