Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse

Biological Psychiatry

Volumn 63, Issue 2, 2008, Pages 152-157

  Dayas, Christopher V ^a   McGranahan, Tresa M ^a   Martin Fardon, Rémi ^a   Weiss, Friedbert ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Addiction; alcohol; arcuate; CART; orexin; relapse; reward

Indexed keywords

ALCOHOL; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; OREXIN; PROTEIN FOS;

ALCOHOL BLOOD LEVEL; ALCOHOLISM; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BRAIN MAPPING; BRAIN REGION; CELL LABELING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORPUS STRIATUM; ENVIRONMENTAL EXPOSURE; HYPOTHALAMUS NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RELAPSE; REWARD;

ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, OPERANT; ETHANOL; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; RATS; RATS, WISTAR;

EID: 37349004777     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.02.002     Document Type: Article

References (37)

1. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., and Wulff B.S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393 (1998) 72-76
2. Kelley A.E., Baldo B.A., and Pratt W.E. A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J Comp Neurol 493 (2005) 72-85
3. Kelley A.E. Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86 (2005) 773-795
4. Lambert P.D. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 29 (1998) 293-298
5. Saper C.B., Chou T.C., and Elmquist J.K. The need to feed: Homeostatic and hedonic control of eating. Neuron 36 (2002) 199-211
6. Vicentic A., and Jones D.C. The CART system in appetite and drug addiction. J Pharmacol Exp Ther 320 (2006) 499-506
7. Harris G.C., and Aston-Jones G. Arousal and reward: A dichotomy in orexin function. Trends Neurosci 29 (2006) 571-577
8. Harris G.C., Wimmer M., and Aston-Jones G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 (2005) 556-559
9. Jaworski J.N., and Jones D.C. The role of CART in the reward/reinforcing properties of psychostimulants. Peptides 27 (2006) 1993-2004
10. Kuhar M.J., and Dall Vechia S.E. CART peptides: Novel addiction- and feeding-related neuropeptides. Trends Neurosci 22 (1999) 316-320
11. Boutrel B. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A 102 (2005) 19168-19173
12. Lawrence A.J. The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148 (2006) 752-759
13. Parsons M.P., Li S., and Kirouac G.J. The paraventricular nucleus of the thalamus as an interface between the orexin and CART peptides and the shell of the nucleus accumbens. Synapse 59 (2006) 480-490
14. Kirouac G.J., Parsons M.P., and Li S. Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus. Brain Res 1059 (2005) 179-188
15. Kirouac G.J., Parsons M.P., and Li S. Innervation of the paraventricular nucleus of the thalamus from cocaine- and amphetamine-regulated transcript (CART) containing neurons of the hypothalamus. J Comp Neurol 497 (2006) 155-165
16. Bhatnagar S., and Dallman M. Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neuroscience 84 (1998) 1025-1039
17. Van der Werf Y.D., Witter M.P., and Groenewegen H.J. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Brain Res Rev 39 (2002) 107-140
18. Dayas C.V., Liu X., Simms J.A., and Weiss F. Distinct patterns of neural activation associated with ethanol seeking: Effects of naltrexone. Biol Psychiatry (2006) November 6 [Epub ahead of publication].
19. Sinha R. Psychological stress, drug-related cues and cocaine craving. Psychopharmacology 152 (2000) 140-148 (Berl)
20. Stormark K.M. Autonomic cued reactivity in alcoholics: The effect of olfactory stimuli. Addict Behav 20 (1995) 571-584
21. Peyron C. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18 (1998) 9996-10015
22. Couceyro P.R., Koylu E.O., and Kuhar M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 12 (1997) 229-241
23. Koylu E.O. Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9 (1997) 823-833
24. Dallvechia-Adams S., Kuhar M.J., and Smith Y. Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons. J Comp Neurol 448 (2002) 360-372
25. Vicentic A., Lakatos A., and Jones D. The CART receptors: Background and recent advances. Peptides 27 (2006) 1934-1937
26. Petrovich G.D., Holland P.C., and Gallagher M. Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eating. J Neurosci 25 (2005) 8295-8302
27. Mieda M. Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci 24 (2004) 10493-10501
28. Schroeder B.E., Binzak J.M., and Kelley A.E. A common profile of prefrontal cortical activation following exposure to nicotine- or chocolate-associated contextual cues. Neuroscience 105 (2001) 535-545
29. Marinelli P.W., Quirion R., and Gianoulakis C. An in vivo profile of beta-endorphin release in the arcuate nucleus and nucleus accumbens following exposure to stress or alcohol. Neuroscience 127 (2004) 777-784
30. Greenwell T.N. Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area. J Comp Neurol 454 (2002) 320-328
31. Balkan B. Effects of adrenalectomy on CART expression in the rat arcuate nucleus. Synapse 50 (2003) 14-19
32. Vrang N. Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids. Brain Res 965 (2003) 45-50
33. Ford G.K. Orexin expression and function: Glucocorticoid manipulation, stress, and feeding studies. Endocrinology 146 (2005) 3724-3731
34. DiLeone R.J., Georgescu D., and Nestler E.J. Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci 73 (2003) 759-768
35. Elias C.F. Characterization of CART neurons in the rat and human hypothalamus. J Comp Neurol 432 (2001) 1-19
36. Koylu E.O. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J Comp Neurol 391 (1998) 115-132
37. Nambu T. Distribution of orexin neurons in the adult rat brain. Brain Res 827 (1999) 243-260