Persistent Increase of Alcohol-Seeking Evoked by Neuropeptide S: An Effect Mediated by the Hypothalamic Hypocretin System

Neuropsychopharmacology

Volumn 34, Issue 9, 2009, Pages 2125-2134

  Cannella, Nazzareno ^a   Economidou, Daina ^a   Kallupi, Marsida ^a   Stopponi, Serena ^a   Heilig, Markus ^b   Massi, Maurizio ^a   Ciccocioppo, Roberto ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Addiction; Alcohol; Hypocretin 1 orexinA; Neuropeptide S; Rat; Relapse

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; ALCOHOL; NEUROPEPTIDE RECEPTOR; NEUROPEPTIDE S; OREXIN A;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN NERVE CELL; CONDITIONED REFLEX; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; INSTRUMENTAL CONDITIONING; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; PAIRED ASSOCIATE LEARNING; PRIORITY JOURNAL; RAT; REINFORCEMENT; STIMULUS RESPONSE;

ALCOHOL DRINKING; ANALYSIS OF VARIANCE; ANIMALS; BENZOXAZOLES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CONDITIONING, CLASSICAL; CUES; DISEASE MODELS, ANIMAL; ETHANOL; HYPOTHALAMUS; MALE; NEUROPEPTIDES; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SELF ADMINISTRATION; SUBSTANCE-RELATED DISORDERS; UREA;

EID: 67651089809     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2009.37     Document Type: Article

References (30)

1. Adinoff B, Junghanns K, Kiefer F, Krishnan-Sarin S (2005). Suppression of the HPA axis stress-response: implications for relapse. Alcohol Clin Exp Res 29: 1351-1355.
2. Badia-Elder NE, Henderson AN, Bertholomey ML, Dodge NC, Stewart RB (2008). The effects of neuropeptide S on ethanol drinking and other related behaviors in alcohol-preferring and -nonpreferring rats. Alcohol Clin Exp Res 32: 1380-1387.
3. Beck B, Fernette B, Stricker-Krongrad A (2005). Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats. Biochem Biophys Res Commun 332: 859-865.
4. Boutrel B, Kenny PJ, Specio SE, Martin-Far don R, Markou A, Koob GF et al (2005). Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci USA 102: 19168-19173.
5. Ciccocioppo R, Angeletti S, Weiss F (2001). Long-lasting resistance to extinction of response reinstatement induced by ethanol-related stimuli: role of genetic ethanol preference. Alcohol Clin Exp Res 25: 1414-1419.
6. Ciccocioppo R, Kallupi M, Cannella N, Braconi S, Stopponi S, Economidou D (2007). Neuropeptide S system activation facilitate conditioned reinstatement of cocaine seeking in the rat. Society for Neuroscience 2007, San Diego, pp. 271.18/Z1. Ref Type: Abstract.
7. Cippitelli A, Cannella N, Braconi S, Duranti A, Tontini A, Bilbao A et al (2008). Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology 198: 449-460.
8. Cleck JN, Blendy JA (2008). Making a bad thing worse: adverse effects of stress on drug addiction. J Clin Invest 118: 454-461.
9. Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F (2008). Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry 63: 152-157.
10. de Lecea L, Kilduff TS, Peyron C, Gao XB, Foye PE, Danielson PE et al (1998). The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95: 322-327.
11. de Lecea L, Sutcliffe JG (2005). The hypocretins and sleep. FEBS J 272: 5675-5688.
12. Economidou D, Mattioli L, Cifani C, Perfumi M, Massi M, Cuomo V et al (2006). Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats. Psychopharmacology (Berl) 183: 394-403.
13. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S et al (1999). Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96: 10911-10916.
14. Harris GC, Wimmer M, Aston-Jones G (2005). A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437: 556-559.
15. Heilig M, Koob GF (2007). A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406.
16. Jungling K, Seidenbecher T, Sosulina L, Lesting J, Sangha S, Clark SD et al (2008). Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala. Neuron 59: 298-310.
17. Katner SN, Magalong JG, Weiss F (1999). Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology 20: 471-479.
18. Kotz CM, Wang C, Teske JA, Thorpe AJ, Novak CM, Kiwaki K et al (2006). Orexin A mediation of time spent moving in rats: neural mechanisms. Neuroscience 142: 29-36.
19. Lawrence AJ, Cowen MS, Yang HJ, Chen F, Oldfield B (2006). The orexin system regulates alcohol-seeking in rats. Br J Pharmacol 148: 752-759.
20. Le A, Shaham Y (2002). Neurobiology of relapse to alcohol in rats. Pharmacol Ther 94: 137-156.
21. Le AD, Harding S, Juzytsch W, Funk D, Shaham Y (2005). Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psycho-pharmacology 179: 366-373.
22. Niimi M (2006). Centrally administered neuropeptide S activates orexin-containing neurons in the hypothalamus and stimulates feeding in rats. Endocrine 30: 75-79.
23. Reinscheid RK, Xu YL, Civelli O (2005). Neuropeptide S: a new player in the modulation of arousal and anxiety. Mol Interv 5: 42-46.
24. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H et al (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
25. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG (2007). Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin Exp Res 31: 1858-1865.
26. Smith KL, Patterson M, Dhillo WS, Patel SR, Semjonous NM, Gardiner JV et al (2006). Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake. Endocrinology 147: 3510-3518.
27. Stewart RB, Gatto GJ, Lumeng L, Li TK, Murphy JM (1993). Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10: 1-10.
28. Vitale G, Filaferro M, Ruggieri V, Pennella S, Frigeri C, Rizzi A et al (2008). Anxiolytic-like effect of neuropeptide S in the rat defensive burying. Peptides 12: 2286-2291.
29. Xu YL, Gall CM, Jackson VR, Civelli O, Reinscheid RK (2007). Distribution of neuropeptide S receptor mRNA and neurochem-ical characteristics of neuropeptide S-expressing neurons in the rat brain. J Comp Neurol 500: 84-102.
30. Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang ZW, Lin SH et al (2004). Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43: 487-497.