Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: Relationship to the discriminative stimulus effects of cocaine

Psychopharmacology

Volumn 142, Issue 4, 1999, Pages 399-407

  Mantsch, John R ^a,b   Goeders, Nick E ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Cocaine; Corticosterone; Drug discrimination; Ketoconazole; Reinstatement; Self administration; Stress

Indexed keywords

COCAINE; CORTICOSTERONE; KETOCONAZOLE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DISCRIMINATIVE STIMULUS; DRUG DEPENDENCE TREATMENT; ELECTRIC SHOCK; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; STRESS;

ANIMALS; ANTIFUNGAL AGENTS; COCAINE; CORTICOSTERONE; DISCRIMINATION LEARNING; KETOCONAZOLE; MALE; RATS; RATS, WISTAR; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; STRESS, PSYCHOLOGICAL;

EID: 0032893173     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050905     Document Type: Article

References (40)

1. Ahmed SH, Koob GF (1997) Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology 132:289-295
2. Bennett JE (1996) Antifungal agents. In: Hardman JG, Limbird LE (eds) Goodman & Gilman's the pharmacological basis of therapeutics, 9th edn. McGraw-Hill, New York, pp 1175-1190
3. Berger SP, Hall S, Mickalian JD, Reid MS, Crawford CA, Delucchi K, Carr K, Hall S (1996) Haloperidol antagonism of cueelicited cocaine craving. Lancet 347:504-508
4. 2 mediation of the discriminative stimulus properties of d-amphetamine and cocaine. Psychopharmacology 103:50-55
5. de Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75:134-143
6. Deroche V, Marinelli M, Le Moal M, Piazza PV (1997) Glucocorticoids and behavioral effects of psychostimulants. II: Cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J Pharmacol Exp Ther 281:1401-1407
7. Erb S, Shaham Y, Stewart J (1996) Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology 128:408-412
8. Erb S, Shaham Y, Stewart J (1998) The role of corticotropin-releasing factor and corticosterone in stress-and cocaine-induced relapse to cocaine seeking in rats. J Neurosci 18:5529-5536
9. Extance K, Goudie AJ (1981) Inter-animal olfactory cues in operant drug discrimination procedures in rats. Psychopharmacology 73:363-371
10. Fahey JM, Pritchard GA, von Moltke LL, Pratt JS, Grassi JM, Shader RI, Greenblatt DJ (1998) Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice. J Pharmacol Exp Ther 285:271-276
11. Gawin FH (1991) Cocaine addiction: psychology and neurophysiology. Science 251:1580-1586
12. Gawin FH, Kleber HD (1986) Abstinence symptomology and psychiatric diagnosis in cocaine abusers. Arch Gen Psychiatry 43:107-113
13. Gerber GJ, Stretch R (1975) Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol Biochem Behav 3:1055-1061
14. Gietzen K, Penka L, Eisenburger R (1996) Imidazole fungicides provoke histamine release from mast cells and induce airway contraction. Exp Toxicol Pathol 48:529-531
15. Goeders NE (1997) A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 22:237-259
16. Goeders NE, Guerin GF (1994) Non-contingent electric footshock facilitates the acquisition of intravenous cocaine self-administration. Psychopharmacology 114:63-70
17. Goeders NE, Peltier RL, Guerin GF (1998) Ketoconazole reduces low dose cocaine self-administration in rats. Drug Alcohol Depend 53:67-77
18. Koob GF, Goeders NE (1989) Neuroanatomical substrates of drug self-administration. In: Liebman JM, Cooper SJ (eds) Oxford reviews in psychopharmacology, vol 1, neuropharmacological basis of reward. Oxford University Press, London, pp 214-263
19. Lê AD, Quan B, Juzytch W, Fletcher PJ, Joharchi N, Shaham Y (1998) Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats. Psychopharmacology 135:169-174
20. Loli P, Berselli ME, Tagliaferri M (1986) Use of ketoconazole in the treatment of Cushing's syndrome. J Clin Endocrinol Metab 63:1365-1371
21. Loose DS, Stover EP, Feldman D (1983) Ketoconazole binds to glucocorticoid receptors and exhibits antagonist activity in cultures cells. J Clin Invest 72:404-408
22. Mantsch JR, Goeders NE (1998) Generalization of a restraint-induced discriminative stimulus to cocaine in rats. Psychopharmacology 135:423-426
23. Mantsch JR, Saphier D, Goeders NE (1998) Corticosterone facilitates the acquisition of cocaine self-administration in rats: opposite effects of the type II glucocorticoid receptor agonist, dexamethasone. J Pharmacol Exp Ther 287:72-80
24. Miczek KA, Mutschler NH (1996) Activational effects of social stress on IV cocaine self-administration in rats. Psychopharmacology 128:256-264
25. Murphy BEP, Dhar V, Ghadirian AM, Chouinard G, Keller R (1991) Response to steroid suppression in major depression resistant to antidepressant therapy. J Clin Psychopharmacol 11:121-126
26. Piazza PV, Le Moal M (1996) Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol 36:359-378
27. Piazza PV, Le Moal M (1998) The role of stress in drug self-administration. Trends Pharmacol Sci 19:67-74
28. Ramsey NF, Van Ree JM (1993) Emotional but not physical stress enhances intravenous cocaine self-administration in drug-naive rats. Brain Res 608:216-222
29. Shaham Y, Stewart J (1995) Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology 119:334-341
30. Shaham Y, Stewart J (1996) Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology 125:385-391
31. Shaham Y, Erb S, Leung S, Buczek Y, Stewart J (1998) CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine-and heroin-trained rats. Psychopharmacology 137:184-190
32. Simar MR, Saphier D, Goeders NE (1996) Differential neuroendocrine and behavioral responses to cocaine in Lewis and Fischer rats. Neuroendocrinology 63:91-100
33. Sinha R, Catapano D, O'Malley S (1999) Stress-induced craving and stress response in cocaine dependent individuals. Psychopharmacology 142:343-351
34. Slikker Jr W, Brocco MJ, Killam Jr KF (1984) Reinstatement of responding maintained by cocaine or thiamylal. J Pharmacol Exp Ther 228:43-52
35. Sonino N (1987) The use of ketoconazole as an inhibitor of steroid production. N Engl J Med 317:812-818
36. Stewart J, de Wit H, Eikelboom R (1984) Role of unconditioned and conditioned drug effects in the self-administration of opioids and stimulants. Psychol Rev 91:251-268
37. Thakore JH, Dinan TG (1995) Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression. Biol Psychiatry 37:364-368
38. Tidey JW, Miczek KA (1997) Acquisition of cocaine self-administration after social stress: role of accumbens dopamine. Psychopharmacology 130:203-212
39. Tiffany ST (1990) A cognitive model of drug urges and drug-use behavior: role of autonomic and nonautonomic processes. Psychol Rev 97:147-168
40. Ward AS, Collins ED, Haney M, Foltin RW, Fischman MW (1998) Ketoconazole attenuates the cortisol response but not the subjective effects of smoked cocaine in humans. Behav Pharmacol (in press)