U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking

Psychopharmacology

Volumn 144, Issue 4, 1999, Pages 339-346

  Schenk, Susan ^a   Partridge, Brian ^a   Shippenberg, Toni S ^b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Cocaine; Drug abuse; Kappa opioid; Relapse; Self administration; U69593

Indexed keywords

AMPHETAMINE; COCAINE; FLUPENTIXOL; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; DRUG SELF ADMINISTRATION; DRUG SENSITIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

AMPHETAMINE; ANIMALS; BEHAVIOR, ADDICTIVE; BENZENEACETAMIDES; COCAINE-RELATED DISORDERS; DOPAMINE ANTAGONISTS; DOPAMINE UPTAKE INHIBITORS; FLUPENTHIXOL; MALE; PIPERAZINES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; SELF ADMINISTRATION;

EID: 0032982427     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051016     Document Type: Article

References (45)

1. Broadbent J, Gaspard TM, Dworkin SI (1995) Assessment of the discriminative stimulus effects of cocaine in the rat: lack of interaction with opioids. Pharmacol Biochem Behav 51:379-385
2. Caine SB, Koob GF (1994) Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. J Pharmacol Exp Ther 270:209-218
3. Crawford CA, McDougall SA, Bolanos CA, Hall S, Berger SP (1995) The effects of the kappa-opioid agonist, U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. Psychopharmacology 120:392-399
4. DeWit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75:134-143
5. De Wit H, Wise RA (1976) Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine. Can J Psychol 31:195
6. Di Chiara G (1995) The role of dopamine in drug abuse viewed from the perspective of motivation. Drug Alcohol Depend 38:345-348
7. Di Chiara G, Imperato A (1988a) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278
8. Di Chiara G, Imperato A (1988b) Opposite effects of mu and kappa-opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244:1067-1080
9. Glick SD, Maisonneuve IM, Raucci J, Archer S (1995) Kappa-opioid inhibition of morphine and cocaine self-administration in rats. Brain Res 681:147-152
10. Heidbreder CA, Babovic-Vuksanovic D, Shoaib M, Shippenberg TS (1995) Development of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists. J Pharmacol Exp Ther 275:150-163
11. Heidbreder CA, Thompson AC, Shippenberg TS (1996) Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine. J Pharmacol Exp Ther 278:490-502
12. Heidbreder CA, Schenk S, Partridge B, Shippenberg TS (1998) Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of selective K-opioid receptor agonist. Synapse 30:255-262
13. Horger B, Shelton K, Schenk S (1990) Preexposure sensitizes rats to the rewarding effects of cocaine. Pharmacol Biochem Behav 37:707-711
14. Jaffe JH, Cascella NG, Kumor KM, Sherer MA (1989) Cocaine-induced cocaine craving. Psychopharmacology 97:59-64
15. Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug-and stress-induced sensitization to motor activity. Brain Res Rev 16:223-244
16. Kelley PH, Iversen SD (1976) Selective 6-OHDA-induced destruction of mesolinibic dopamine neurons; abolition of psychostimulant-induced locomotor activity in rats. Eur J Pharmacol 40:45-56
17. Koob GF, Le HT, Creese I (1987) D-1 receptor antagonist SCH 23390 increases cocaine self-administration in the rat. Neurosci Lett 79:315-321
18. Kuzmin AV, Semenova S, Gerrits MAFM, Zvartau EE, Van Ree JM (1997) Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-na rats and mice. Eur J Pharmacol 321:265-271
19. 3H] U69593, a highly selective ligand for the κ-opioid receptor. Eur J Pharmacol 109:281-284
20. Lett BT (1989) Repeated exposures intensify rather than diminish the rewarding effects of amphetamine, morphine and cocaine. Psychopharmacology 98:357-362
21. Manzanares J, Lookingland KJ, Moore KE (1991) Kappa opioid receptor mediated regulation of dopaminergic neurons in the rat brain. J Pharmacol Exp Ther 265:500-505
22. Mello NK, Negus SS (1996) Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures. Neuropsychopharmacology 14:375-424
23. Mello NK, Negus SS (1998) Effects of kappa opioid agonists on cocaine-and food-maintained responding by rhesus monkeys. J Pharmacol Exp Ther 286:812-824
24. Negus SS, Mello NK, Portoghese PS, Lin CE (1997) Effects of kappa-opioids on cocaine self-administration by rhesus monkeys. J Pharmacol Exp Ther 282:44-55
25. Post RM, Rose H (1976) Increasing effects of repetitive cocaine administration on the rat. Nature 260:731-732
26. 3H-cocaine binding in brain is associated with serotonergic neurons. Mol Pharmacol 23:600-605
27. Riberdy A, Kantak KM, Spealman RD (1995) Modulation of the discriminative stimulus effects of cocaine by the kappa-opioid agonist, U-50,488. Soc Neurosci Abstr 21:718
28. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223
29. Ritz M, Lamb RJ, Goldberg SR, Kuhar MJ (1988) Cocaine self-administration appears to be mediated by dopamine uptake inhibition. Prog Neuro-Psychopharmacol Biol Psychiatry 12:233-239
30. Robinson TE, Berridge KC (1993) The neural basis of drug-craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291
31. Schenk S, Partridge B (1997) Sensitization and tolerance in psychostimulant self-administration. Pharmacol Biochem Behav 57:543-550
32. Shippenberg TS, Heidbreder CA (1995) Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal aspects. J Pharmacol Exp Ther 273:808-815
33. Shippenberg TS, LeFevour A, Heidbreder C (1996) Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine. J Pharmacol Exp Ther 276:545-554
34. Shippenberg TS, LeFevour A, Thompson AC (1998) Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the κ-opioid receptor agonist U69593. Eur J Pharmacol 345:27-34
35. Spanagel R., Herz A, Shippenberg TS (1990) The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study. J Neurochem 55:1734-1740
36. Spealman RD, Bergman J (1992) Modulation of the discriminative stimulus effects of cocaine by mu and kappa-opioids. J Pharmacol Exp Ther 261:607-615
37. Spealman RD, Bergman J (1994) Opioid modulation of the discriminative stimulus effects of cocaine: comparison of μ, κ and δ agonists in squirrel monkeys discriminating low doses of cocaine. Behav Pharmacol 5:21-31
38. Spencer DG, Emmett-Oglesby MW (1985) Parallel processing strategies in the application of microcomputers to the behavioral laboratory. Behav Res Meth Instrum 17:294-300
39. Stewart J, Badiani A (1993) Tolerance and sensitization to the behavioral effects of drugs. Behav Pharmacol 4:289-313
40. Weeks JR (1975) Environmental influences affecting the voluntary intake of drugs: an overview. Fed Proc 34:1755-1758
41. Weissenborn R, Deroche V, Koob GF, Weiss F (1996) Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus. Psychopharmacology 126:311-322
42. Werling LL, Frattali A, Portoghese PS, Takemori AE, Cox BM (1988) Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs. J Pharmacol Exp Ther 246:282-286
43. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492
44. Woolfolk DR, Holtzman SG (1997) μ-, δ-and κ-opioid receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats. Drug Alcohol Depend 48:209-220
45. Worley CM, Valadez A, Schenk S (1994) Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine. Pharmacol Biochem Behav 48:217-221