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Volumn 42, Issue 1, 2010, Pages 24-44

UGT genomic diversity: Beyond gene duplication

Author keywords

Alternative splicing; Copy number variation; Epigenetics; Glucuronosyltransferase; Pharmacogenomics; Polymorphisms; UGT

Indexed keywords

BILIRUBIN; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 2B28; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; MESSENGER RNA; SEX HORMONE; UNCLASSIFIED DRUG;

EID: 74549134800     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602530903210682     Document Type: Review
Times cited : (118)

References (135)
  • 1
    • 35448997854 scopus 로고    scopus 로고
    • Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identifcation of apoptotic genes as targets for demethylation
    • Al-Romaih, K., Somers, G. R., Bayani, J., Hughes, S., Prasad, M., Cutz, J. C., et al. (2007). Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: identifcation of apoptotic genes as targets for demethylation. Cancer Cell Int 7:14.
    • (2007) Cancer Cell Int , vol.7 , pp. 14
    • Al-Romaih, K.1    Somers, G.R.2    Bayani, J.3    Hughes, S.4    Prasad, M.5    Cutz, J.C.6
  • 2
    • 58149299918 scopus 로고    scopus 로고
    • Serial analysis of gene expression (SAGE): 13 years of application in research
    • Anisimov, S. V. (2008). Serial analysis of gene expression (SAGE): 13 years of application in research. Curr Pharm Biotechnol 9:338-350.
    • (2008) Curr Pharm Biotechnol , vol.9 , pp. 338-350
    • Anisimov, S.V.1
  • 3
    • 0028904620 scopus 로고
    • Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome
    • Aono, S., Adachi, Y., Uyama, E., Yamada, Y., Keino, H., Nanno, T., et al. (1995). Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Lancet 345:958-959.
    • (1995) Lancet , vol.345 , pp. 958-959
    • Aono, S.1    Adachi, Y.2    Uyama, E.3    Yamada, Y.4    Keino, H.5    Nanno, T.6
  • 4
    • 0027739943 scopus 로고
    • Identifcation of defect in the genes for bilirubin UDP-glucuronosyl- transferase in a patient with Crigler-Najjar syndrome type II
    • Aono, S., Yamada, Y., Keino, H., Hanada, N., Nakagawa, T., Sasaoka, Y., et al. (1993). Identifcation of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun 197:1239-1244.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 1239-1244
    • Aono, S.1    Yamada, Y.2    Keino, H.3    Hanada, N.4    Nakagawa, T.5    Sasaoka, Y.6
  • 5
    • 38449087463 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3, and UGT1A4 mRNA in human livers
    • Aueviriyavit, S., Furihata, T., Morimoto, K., Kobayashi, K., Chiba, K. (2007). Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3, and UGT1A4 mRNA in human livers. Drug Metab Pharmacokinet 22:391-398.
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 391-398
    • Aueviriyavit, S.1    Furihata, T.2    Morimoto, K.3    Kobayashi, K.4    Chiba, K.5
  • 6
    • 0034007340 scopus 로고    scopus 로고
    • 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)
    • Barbier, O., Turgeon, D., Girard, C., Green, M. D., Tephly, T. R., Hum, D. W., et al. (2000). 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7). Drug Metab Dispos 28:497-502.
    • (2000) Drug Metab Dispos , vol.28 , pp. 497-502
    • Barbier, O.1    Turgeon, D.2    Girard, C.3    Green, M.D.4    Tephly, T.R.5    Hum, D.W.6
  • 7
    • 0029809062 scopus 로고    scopus 로고
    • Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids
    • Beaulieu, M., Levesque, E., Hum, D. W., Belanger, A. (1996). Isolation and characterization of a novel cDNA encoding a human UDP- glucuronosyltransferase active on C19 steroids. J Biol Chem 271:22855-22862.
    • (1996) J Biol Chem , vol.271 , pp. 22855-22862
    • Beaulieu, M.1    Levesque, E.2    Hum, D.W.3    Belanger, A.4
  • 10
    • 70349108450 scopus 로고    scopus 로고
    • Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine
    • Belanger, A.S., Caron, P., Harvey, M., Zimmerman, P.A., Mehlotra, R.K, Guillemette, C. (2009). Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos 37:1793-1796.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1793-1796
    • Belanger, A.S.1    Caron, P.2    Harvey, M.3    Zimmerman, P.A.4    Mehlotra, R.K.5    Guillemette, C.6
  • 13
    • 33847711077 scopus 로고    scopus 로고
    • Te role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice
    • Bonzo, J. A., Belanger, A., Tukey, R. H. (2007). Te role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice. Hepatology 45:349-360.
    • (2007) Hepatology , vol.45 , pp. 349-360
    • Bonzo, J.A.1    Belanger, A.2    Tukey, R.H.3
  • 14
    • 63849258680 scopus 로고    scopus 로고
    • Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome prolif-erator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2
    • [Epub 2009 Jan 14]
    • Buckley, D. B., Klaassen, C. D. (2009). Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome prolif-erator-activated receptor alpha, and nuclear factor erythroid 2-related factor 2. Drug Metab Dispos 37:847-856. [Epub 2009 Jan 14].
    • (2009) Drug Metab Dispos , vol.37 , pp. 847-856
    • Buckley, D.B.1    Klaassen, C.D.2
  • 15
    • 0030867709 scopus 로고    scopus 로고
    • Genetic and environmental factors associated with variation of human xenobiotic glu-curonidation and sulfation
    • Burchell, B., Coughtrie, M. W. (1997). Genetic and environmental factors associated with variation of human xenobiotic glu-curonidation and sulfation. Environ Health Perspect 105(Suppl 4):739-747.
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 4 , pp. 739-747
    • Burchell, B.1    Coughtrie, M.W.2
  • 17
    • 34247197937 scopus 로고    scopus 로고
    • Te nonsense-mediated decay RNA surveillance pathway
    • Chang, Y. F., Imam, J. S., Wilkinson, M. F. (2007). Te nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76:51-74.
    • (2007) Annu Rev Biochem , vol.76 , pp. 51-74
    • Chang, Y.F.1    Imam, J.S.2    Wilkinson, M.F.3
  • 19
    • 30144436526 scopus 로고    scopus 로고
    • Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases
    • Court, M. H. (2005). Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases. Meth Enzymol 400:104-116.
    • (2005) Meth Enzymol , vol.400 , pp. 104-116
    • Court, M.H.1
  • 20
    • 50449083633 scopus 로고    scopus 로고
    • Novel polymorphic human UDP-glucuronosyltransferase 2A3: Cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction
    • [Epub 2008 June 3]
    • Court, M. H., Hazarika, S., Krishnaswamy, S., Finel, M., Williams, J. A. (2008). Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Pharmacol 74:744-754. [Epub 2008 June 3].
    • (2008) Mol Pharmacol , vol.74 , pp. 744-754
    • Court, M.H.1    Hazarika, S.2    Krishnaswamy, S.3    Finel, M.4    Williams, J.A.5
  • 21
    • 0033815033 scopus 로고    scopus 로고
    • Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa
    • Czernik, P. J., Little, J. M., Barone, G. W., Raufman, J. P., Radominska-Pandya, A. (2000). Glucuronidation of estrogens and retinoic acid and expression of UDP-glucuronosyltransferase 2B7 in human intestinal mucosa. Drug Metab Dispos 28:1210-1216.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1210-1216
    • Czernik, P.J.1    Little, J.M.2    Barone, G.W.3    Raufman, J.P.4    Radominska-Pandya, A.5
  • 22
    • 43249113835 scopus 로고    scopus 로고
    • Deep cap analysis gene expression (CAGE): Genome-wide identifcation of promoters, quantifcation of their expression, and network inference
    • de Hoon, M., Hayashizaki, Y. (2008). Deep cap analysis gene expression (CAGE): genome-wide identifcation of promoters, quantifcation of their expression, and network inference. Biotechniques 44:627-628, 630, 632.
    • (2008) Biotechniques , vol.44 , pp. 627-628
    • De Hoon, M.1    Hayashizaki, Y.2
  • 24
    • 38849197491 scopus 로고    scopus 로고
    • Te UDP-glucuronosyltransferases as oligomeric enzymes
    • Finel, M., Kurkela, M. (2008). Te UDP-glucuronosyltransferases as oligomeric enzymes. Curr Drug Metab 9:70-76.
    • (2008) Curr Drug Metab , vol.9 , pp. 70-76
    • Finel, M.1    Kurkela, M.2
  • 25
    • 0024579299 scopus 로고
    • Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyo-deoxycholic acid in cell culture
    • Fournel-Gigleux, S., Jackson, M. R., Wooster, R., Burchell, B. (1989). Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyo-deoxycholic acid in cell culture. FEBS Lett 243:119-122.
    • (1989) FEBS Lett , vol.243 , pp. 119-122
    • Fournel-Gigleux, S.1    Jackson, M.R.2    Wooster, R.3    Burchell, B.4
  • 26
    • 11244283497 scopus 로고    scopus 로고
    • Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4
    • [Epub 2004 Oct 14]
    • Fremont, J. J., Wang, R. W., King, C. D. (2005). Coimmunoprecipitation of UDP-glucuronosyltransferase isoforms and cytochrome P450 3A4. Mol Pharmacol 67:260-262. [Epub 2004 Oct 14].
    • (2005) Mol Pharmacol , vol.67 , pp. 260-262
    • Fremont, J.J.1    Wang, R.W.2    King, C.D.3
  • 27
    • 74549127724 scopus 로고    scopus 로고
    • Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes
    • Fujiwara, R., Nakajima, M., Oda, S., Yamanaka, H., Ikushiro, S. I., Sakaki, T., et al. (2009). Interactions between human UDP- glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes. J Pharm Sci 27:27.
    • (2009) J Pharm Sci , vol.27 , pp. 27
    • Fujiwara, R.1    Nakajima, M.2    Oda, S.3    Yamanaka, H.4    Ikushiro, S.I.5    Sakaki, T.6
  • 28
    • 34548097015 scopus 로고    scopus 로고
    • Interactions between human UGT1A1, UGT1A4, and UGT1A6 afect their enzymatic activities
    • [Epub 2007 Jul 9]
    • Fujiwara, R., Nakajima, M., Yamanaka, H., Katoh, M., and Yokoi, T. (2007a). Interactions between human UGT1A1, UGT1A4, and UGT1A6 afect their enzymatic activities. Drug Metab Dispos 35:1781-1787. [Epub 2007 Jul 9].
    • (2007) Drug Metab Dispos , vol.35 , pp. 1781-1787
    • Fujiwara, R.1    Nakajima, M.2    Yamanaka, H.3    Katoh, M.4    Yokoi, T.5
  • 29
    • 34247379533 scopus 로고    scopus 로고
    • Efects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms
    • [Epub 2007 Feb 9]
    • Fujiwara, R., Nakajima, M., Yamanaka, H., Nakamura, A., Katoh, M., Ikushiro, S., et al. (2007b). Efects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms. Drug Metab Dispos 35:747-757. [Epub 2007 Feb 9].
    • (2007) Drug Metab Dispos , vol.35 , pp. 747-757
    • Fujiwara, R.1    Nakajima, M.2    Yamanaka, H.3    Nakamura, A.4    Katoh, M.5    Ikushiro, S.6
  • 30
    • 0036765309 scopus 로고    scopus 로고
    • Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
    • Gagne, J. F., Montminy, V., Belanger, P., Journault, K., Gaucher, G., Guillemette, C. (2002). Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 62:608-617.
    • (2002) Mol Pharmacol , vol.62 , pp. 608-617
    • Gagne, J.F.1    Montminy, V.2    Belanger, P.3    Journault, K.4    Gaucher, G.5    Guillemette, C.6
  • 31
    • 33645658128 scopus 로고    scopus 로고
    • Irinotecan inactivation is modulated by epige-netic silencing of UGT1A1 in colon cancer
    • Gagnon, J. F., Bernard, O., Villeneuve, L., Tetu, B., Guillemette, C. (2006). Irinotecan inactivation is modulated by epige-netic silencing of UGT1A1 in colon cancer. Clin Cancer Res 12:1850-1858.
    • (2006) Clin Cancer Res , vol.12 , pp. 1850-1858
    • Gagnon, J.F.1    Bernard, O.2    Villeneuve, L.3    Tetu, B.4    Guillemette, C.5
  • 32
    • 0032838879 scopus 로고    scopus 로고
    • Diferential glucuronidation of bile acids, androgens, and estrogens by human UGT1A3 and 2B7
    • Gall, W. E., Zawada, G., Mojarrabi, B., Tephly, T. R., Green, M. D., Cofman, B. L., et al. (1999a). Diferential glucuronidation of bile acids, androgens, and estrogens by human UGT1A3 and 2B7. J Steroid Biochem Mol Biol 70(1-3):101-108.
    • (1999) J Steroid Biochem Mol Biol , vol.70 , Issue.1-3 , pp. 101-108
    • Gall, W.E.1    Zawada, G.2    Mojarrabi, B.3    Tephly, T.R.4    Green, M.D.5    Cofman, B.L.6
  • 33
    • 0032838879 scopus 로고    scopus 로고
    • Diferential glucuronidation of bile acids, androgens, and estrogens by human UGT1A3 and 2B7
    • Gall, W. E., Zawada, G., Mojarrabi, B., Tephly, T. R., Green, M. D., Cofman, B. L., et al. (1999b). Diferential glucuronidation of bile acids, androgens, and estrogens by human UGT1A3 and 2B7. J Steroid Biochem Mol Biol 70(1-3):101-108.
    • (1999) J Steroid Biochem Mol Biol , vol.70 , Issue.1-3 , pp. 101-108
    • Gall, W.E.1    Zawada, G.2    Mojarrabi, B.3    Tephly, T.R.4    Green, M.D.5    Cofman, B.L.6
  • 34
    • 52949099116 scopus 로고    scopus 로고
    • Te UGT2B17 gene deletion polymorphism and risk of prostate cancer: A case-control study in Caucasians
    • Gallagher, C. J., Kadlubar, F. F., Muscat, J. E., Ambrosone, C. B., Lang, N. P., Lazarus, P. (2008). Te UGT2B17 gene deletion polymorphism and risk of prostate cancer: a case-control study in Caucasians. Cancer Detect Prev 32:186-187.
    • (2008) Cancer Detect Prev , vol.32 , pp. 186-187
    • Gallagher, C.J.1    Kadlubar, F.F.2    Muscat, J.E.3    Ambrosone, C.B.4    Lang, N.P.5    Lazarus, P.6
  • 35
    • 47749111708 scopus 로고    scopus 로고
    • Liver-enriched transcription factors and their role in regulating UDP-glucuronosyltransferase gene expression
    • Gardner-Stephen, D. A., Mackenzie, P. I. (2008). Liver-enriched transcription factors and their role in regulating UDP-glucuronosyltransferase gene expression. Curr Drug Metab 9:439-452.
    • (2008) Curr Drug Metab , vol.9 , pp. 439-452
    • Gardner-Stephen, D.A.1    MacKenzie, P.I.2
  • 36
    • 0035834673 scopus 로고    scopus 로고
    • Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltrans-ferase-1 (UGT1A1) and its functional implications
    • Ghosh, S. S., Sappal, B. S., Kalpana, G. V., Lee, S. W., Chowdhury, J. R., Chowdhury, N. R. (2001). Homodimerization of human bilirubin-uridine- diphosphoglucuronate glucuronosyltrans-ferase-1 (UGT1A1) and its functional implications. J Biol Chem 276:42108-42115.
    • (2001) J Biol Chem , vol.276 , pp. 42108-42115
    • Ghosh, S.S.1    Sappal, B.S.2    Kalpana, G.V.3    Lee, S.W.4    Chowdhury, J.R.5    Chowdhury, N.R.6
  • 37
    • 0018263844 scopus 로고
    • Why genes in pieces?
    • Gilbert, W. (1978). Why genes in pieces? Nature 271:501.
    • (1978) Nature , vol.271 , pp. 501
    • Gilbert, W.1
  • 38
    • 38449095074 scopus 로고    scopus 로고
    • Genetic diversity at the UGT1 locus is amplifed by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glu-curonidation activity
    • Girard, H., Levesque, E., Bellemare, J., Journault, K., Caillier, B., Guillemette, C. (2007). Genetic diversity at the UGT1 locus is amplifed by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glu-curonidation activity. Pharmacogenet Genom 17:1077-1089.
    • (2007) Pharmacogenet Genom , vol.17 , pp. 1077-1089
    • Girard, H.1    Levesque, E.2    Bellemare, J.3    Journault, K.4    Caillier, B.5    Guillemette, C.6
  • 39
    • 0034966656 scopus 로고    scopus 로고
    • Tirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus
    • Gong, Q. H., Cho, J. W., Huang, T., Potter, C., Gholami, N., Basu, N. K., et al. (2001). Tirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 11:357-368.
    • (2001) Pharmacogenetics , vol.11 , pp. 357-368
    • Gong, Q.H.1    Cho, J.W.2    Huang, T.3    Potter, C.4    Gholami, N.5    Basu, N.K.6
  • 40
    • 53049087109 scopus 로고    scopus 로고
    • Genomic and epigenetic instability in colorectal cancer pathogenesis
    • [Epub 2008 Sep 4]
    • Grady, W. M., Carethers, J. M. (2008). Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology 135:1079-1099. [Epub 2008 Sep 4].
    • (2008) Gastroenterology , vol.135 , pp. 1079-1099
    • Grady, W.M.1    Carethers, J.M.2
  • 42
    • 0037819284 scopus 로고    scopus 로고
    • Pharmacogenomics of human UDP-glucuronosyltransferase enzymes
    • Guillemette, C. (2003). Pharmacogenomics of human UDP- glucuronosyltransferase enzymes. Pharmacogenomics J 3:136-158.
    • (2003) Pharmacogenomics J , vol.3 , pp. 136-158
    • Guillemette, C.1
  • 43
    • 7444258476 scopus 로고    scopus 로고
    • Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: An overview
    • [Epub 2004 Sep 27]
    • Guillemette, C., Belanger, A., Lepine, J. (2004). Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Res 6:246-254. [Epub 2004 Sep 27].
    • (2004) Breast Cancer Res , vol.6 , pp. 246-254
    • Guillemette, C.1    Belanger, A.2    Lepine, J.3
  • 44
    • 0028982018 scopus 로고
    • Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells
    • Hashimoto, S., Chiorazzi, N., Gregersen, P. K. (1995). Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. Mol Immunol 32:651-659.
    • (1995) Mol Immunol , vol.32 , pp. 651-659
    • Hashimoto, S.1    Chiorazzi, N.2    Gregersen, P.K.3
  • 45
    • 0031010059 scopus 로고    scopus 로고
    • Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes
    • Ikushiro, S., Emi, Y., Iyanagi, T. (1997). Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes. Biochemistry 36:7154-7161.
    • (1997) Biochemistry , vol.36 , pp. 7154-7161
    • Ikushiro, S.1    Emi, Y.2    Iyanagi, T.3
  • 46
    • 55749107288 scopus 로고    scopus 로고
    • Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene
    • Innocenti, F., Liu, W., Fackenthal, D., Ramirez, J., Chen, P., Ye, X., et al. (2008). Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene. Pharmacogenet Genomics 18:683-697.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 683-697
    • Innocenti, F.1    Liu, W.2    Fackenthal, D.3    Ramirez, J.4    Chen, P.5    Ye, X.6
  • 47
    • 0034752769 scopus 로고    scopus 로고
    • Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation
    • Ishii, Y., Miyoshi, A., Watanabe, R., Tsuruda, K., Tsuda, M., Yamaguchi-Nagamatsu, Y., et al. (2001). Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation. Mol Pharmacol 60:1040-1048.
    • (2001) Mol Pharmacol , vol.60 , pp. 1040-1048
    • Ishii, Y.1    Miyoshi, A.2    Watanabe, R.3    Tsuruda, K.4    Tsuda, M.5    Yamaguchi-Nagamatsu, Y.6
  • 48
    • 32544455635 scopus 로고    scopus 로고
    • Large diferences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
    • [Epub 2005 Dec 6]
    • Jakobsson, J., Ekstrom, L., Inotsume, N., Garle, M., Lorentzon, M., Ohlsson, C., et al. (2006). Large diferences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. J Clin Endocrinol Metab 91:687-693. [Epub 2005 Dec 6].
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 687-693
    • Jakobsson, J.1    Ekstrom, L.2    Inotsume, N.3    Garle, M.4    Lorentzon, M.5    Ohlsson, C.6
  • 49
    • 0033564554 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
    • Jedlitschky, G., Cassidy, A. J., Sales, M., Pratt, N., Burchell, B. (1999). Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase. Biochem J 340(Pt 3):837-843.
    • (1999) Biochem J , vol.340 , Issue.PART 3 , pp. 837-843
    • Jedlitschky, G.1    Cassidy, A.J.2    Sales, M.3    Pratt, N.4    Burchell, B.5
  • 50
    • 0027433317 scopus 로고
    • Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
    • Jin, C., Miners, J. O., Lillywhite, K. J., Mackenzie, P. I. (1993b). Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ter 264:475-479.
    • (1993) J Pharmacol Exp ter , vol.264 , pp. 475-479
    • Jin, C.1    Miners, J.O.2    Lillywhite, K.J.3    MacKenzie, P.I.4
  • 51
    • 0027267719 scopus 로고
    • CDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily
    • Jin, C. J., Miners, J. O., Lillywhite, K. J., Mackenzie, P. I. (1993a). cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun 194:496-503.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 496-503
    • Jin, C.J.1    Miners, J.O.2    Lillywhite, K.J.3    MacKenzie, P.I.4
  • 52
    • 0347623371 scopus 로고    scopus 로고
    • Genomewide survey of human alternative pre-mRNA splicing with exon junction microarrays
    • Johnson, J. M., Castle, J., Garrett-Engele, P., Kan, Z., Loerch, P. M., Armour, C. D., et al. (2003). Genomewide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 302:2141-2144.
    • (2003) Science , vol.302 , pp. 2141-2144
    • Johnson, J.M.1    Castle, J.2    Garrett-Engele, P.3    Kan, Z.4    Loerch, P.M.5    Armour, C.D.6
  • 53
    • 33746177794 scopus 로고    scopus 로고
    • Gene-expression diferences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population
    • Joshi, N., Johnson, L. L., Wei, W. Q., Abnet, C. C., Dong, Z. W., Taylor, P. R., et al. (2006). Gene-expression diferences in normal esophageal mucosa associated with regression and progression of mild and moderate squamous dysplasia in a high-risk Chinese population. Cancer Res 66:6851-6860.
    • (2006) Cancer Res , vol.66 , pp. 6851-6860
    • Joshi, N.1    Johnson, L.L.2    Wei, W.Q.3    Abnet, C.C.4    Dong, Z.W.5    Taylor, P.R.6
  • 54
    • 0035041103 scopus 로고    scopus 로고
    • 13-hydroxy-and 13-oxooctadecadienoic acids: Novel substrates for human UDP-glucuronosyltransferases
    • Jude, A. R., Little, J. M., Bull, A. W., Podgorski, I., Radominska-Pandya, A. (2001). 13-hydroxy-and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases. Drug Metab Dispos 29:652-655.
    • (2001) Drug Metab Dispos , vol.29 , pp. 652-655
    • Jude, A.R.1    Little, J.M.2    Bull, A.W.3    Podgorski, I.4    Radominska-Pandya, A.5
  • 55
    • 12144287461 scopus 로고    scopus 로고
    • Novel RNAs identifed from an in-depth analysis of the transcriptome of human chromosomes 21 and 22
    • Kampa, D., Cheng, J., Kapranov, P., Yamanaka, M., Brubaker, S., Cawley, S., et al. (2004). Novel RNAs identifed from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res 14:331-342.
    • (2004) Genome Res , vol.14 , pp. 331-342
    • Kampa, D.1    Cheng, J.2    Kapranov, P.3    Yamanaka, M.4    Brubaker, S.5    Cawley, S.6
  • 56
    • 40949134240 scopus 로고    scopus 로고
    • Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate
    • Karypidis, A. H., Olsson, M., Andersson, S. O., Rane, A., Ekstrom, L. (2008). Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate. Pharmacogenomics J 8:147-151.
    • (2008) Pharmacogenomics J , vol.8 , pp. 147-151
    • Karypidis, A.H.1    Olsson, M.2    Andersson, S.O.3    Rane, A.4    Ekstrom, L.5
  • 58
    • 19344363974 scopus 로고    scopus 로고
    • Promoter usage and alternative splicing
    • Kornblihtt, A. R. (2005). Promoter usage and alternative splicing. Curr Opin Cell Biol 17:262-268.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 262-268
    • Kornblihtt, A.R.1
  • 59
    • 0037423299 scopus 로고    scopus 로고
    • Expression and characterization of recombinant human UDP- glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purifed as an active dimeric enzyme
    • [Epub 2002 Nov 14]
    • Kurkela, M., Garcia-Horsman, J. A., Luukkanen, L., Morsky, S., Taskinen, J., Baumann, M., et al. (2003). Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purifed as an active dimeric enzyme. J Biol Chem 278:3536-3544. [Epub 2002 Nov 14].
    • (2003) J Biol Chem , vol.278 , pp. 3536-3544
    • Kurkela, M.1    Garcia-Horsman, J.A.2    Luukkanen, L.3    Morsky, S.4    Taskinen, J.5    Baumann, M.6
  • 60
    • 8844283291 scopus 로고    scopus 로고
    • Te interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specifc, and may involve both monomers
    • Kurkela, M., Hirvonen, J., Kostiainen, R., Finel, M. (2004). Te interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specifc, and may involve both monomers. Biochem Pharmacol 68:2443-2450.
    • (2004) Biochem Pharmacol , vol.68 , pp. 2443-2450
    • Kurkela, M.1    Hirvonen, J.2    Kostiainen, R.3    Finel, M.4
  • 61
    • 33847043537 scopus 로고    scopus 로고
    • Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate afnity of UGT1A6
    • Kurkela, M., Patana, A. S., Mackenzie, P. I., Court, M. H., Tate, C. G., Hirvonen, J., et al. (2007). Interactions with other human UDP- glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate afnity of UGT1A6. Pharmacogenet Genom 17:115-126.
    • (2007) Pharmacogenet Genom , vol.17 , pp. 115-126
    • Kurkela, M.1    Patana, A.S.2    MacKenzie, P.I.3    Court, M.H.4    Tate, C.G.5    Hirvonen, J.6
  • 62
    • 6344248683 scopus 로고    scopus 로고
    • Specifcity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methox-yestrogen metabolites by human uridine diphospho-glucuron-osyltransferases expressed in endometrium
    • Lepine, J., Bernard, O., Plante, M., Tetu, B., Pelletier, G., Labrie, F., et al. (2004). Specifcity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methox-yestrogen metabolites by human uridine diphospho-glucuron-osyltransferases expressed in endometrium. J Clin Endocrinol Metab 89:5222-5232.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5222-5232
    • Lepine, J.1    Bernard, O.2    Plante, M.3    Tetu, B.4    Pelletier, G.5    Labrie, F.6
  • 63
    • 0030795936 scopus 로고    scopus 로고
    • Isolation and characterization of UGT2B15(Y85): A UDP- glucuronosyltransferase encoded by a polymorphic gene
    • Levesque, E., Beaulieu, M., Green, M. D., Tephly, T. R., Belanger, A., Hum, D. W. (1997). Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 7:317-325.
    • (1997) Pharmacogenetics , vol.7 , pp. 317-325
    • Levesque, E.1    Beaulieu, M.2    Green, M.D.3    Tephly, T.R.4    Belanger, A.5    Hum, D.W.6
  • 64
    • 0032812606 scopus 로고    scopus 로고
    • Characterization and substrate specifcity of UGT2B4 (E458): A UDP-glucuronosyltransferase encoded by a polymorphic gene
    • Levesque, E., Beaulieu, M., Hum, D. W., Belanger, A. (1999). Characterization and substrate specifcity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 9:207-216.
    • (1999) Pharmacogenetics , vol.9 , pp. 207-216
    • Levesque, E.1    Beaulieu, M.2    Hum, D.W.3    Belanger, A.4
  • 65
    • 33846442350 scopus 로고    scopus 로고
    • Regulation of the UGT1A1 bilirubin-conjugating pathway: Role of a new splicing event at the UGT1A locus
    • Levesque, E., Girard, H., Journault, K., Lepine, J., Guillemette, C. (2007). Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 45:128-138.
    • (2007) Hepatology , vol.45 , pp. 128-138
    • Levesque, E.1    Girard, H.2    Journault, K.3    Lepine, J.4    Guillemette, C.5
  • 67
    • 0035799361 scopus 로고    scopus 로고
    • Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase
    • Levesque, E., Turgeon, D., Carrier, J. S., Montminy, V., Beaulieu, M., Belanger, A. (2001). Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry 40:3869-3881.
    • (2001) Biochemistry , vol.40 , pp. 3869-3881
    • Levesque, E.1    Turgeon, D.2    Carrier, J.S.3    Montminy, V.4    Beaulieu, M.5    Belanger, A.6
  • 68
    • 67651171447 scopus 로고    scopus 로고
    • Using high-density exon arrays to profle gene expression in closely related species
    • Lin, L., Liu, S., Brockway, H., Seok, J., Jiang, P., Wong, W. H., et al. (2009). Using high-density exon arrays to profle gene expression in closely related species. Nucleic Acids Res 27:27.
    • (2009) Nucleic Acids Res , vol.27 , pp. 27
    • Lin, L.1    Liu, S.2    Brockway, H.3    Seok, J.4    Jiang, P.5    Wong, W.H.6
  • 69
    • 54249156408 scopus 로고    scopus 로고
    • Quantifcation of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant
    • Lincz, L. F., Mudge, L. M., Scorgie, F. E., Sakof, J. A., Hamilton, C. S., Seldon, M. (2008). Quantifcation of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. Neoplasia 10:1131-1137.
    • (2008) Neoplasia , vol.10 , pp. 1131-1137
    • Lincz, L.F.1    Mudge, L.M.2    Scorgie, F.E.3    Sakof, J.A.4    Hamilton, C.S.5    Seldon, M.6
  • 72
    • 24644510450 scopus 로고    scopus 로고
    • Polymorphic variations in the expression of the chemical detoxifying UDP-glucuronosyltransferases
    • Mackenzie, P. I., Gregory, P. A., Lewinsky, R. H., Yasmin, S. N., Height, T., McKinnon, R. A., et al. (2005). Polymorphic variations in the expression of the chemical detoxifying UDP-glucuronosyltransferases. Toxicol Appl Pharmacol 207(2 Suppl):77-83.
    • (2005) Toxicol Appl Pharmacol , vol.207 , Issue.2 SUPPL. , pp. 77-83
    • MacKenzie, P.I.1    Gregory, P.A.2    Lewinsky, R.H.3    Yasmin, S.N.4    Height, T.5    McKinnon, R.A.6
  • 73
    • 8544224973 scopus 로고    scopus 로고
    • Te UDP-glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
    • Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Bairoch, A., Belanger, A., et al. (1997). Te UDP-glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255-269.
    • (1997) Pharmacogenetics , vol.7 , pp. 255-269
    • MacKenzie, P.I.1    Owens, I.S.2    Burchell, B.3    Bock, K.W.4    Bairoch, A.5    Belanger, A.6
  • 74
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and pro-teome expansion in metazoans
    • Maniatis, T., Tasic, B. (2002). Alternative pre-mRNA splicing and pro-teome expansion in metazoans. Nature 418:236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 76
    • 33645502893 scopus 로고    scopus 로고
    • A dominant-negative human growth hormone-releasing hormone (GHRH) receptor splice variant inhibits GHRH binding
    • McElvaine, A. T., Mayo, K. E. (2006). A dominant-negative human growth hormone-releasing hormone (GHRH) receptor splice variant inhibits GHRH binding. Endocrinology 147:1884-1894.
    • (2006) Endocrinology , vol.147 , pp. 1884-1894
    • McElvaine, A.T.1    Mayo, K.E.2
  • 77
    • 0030778114 scopus 로고    scopus 로고
    • Structure and function of urid-ine diphosphate glucuronosyltransferases
    • Meech, R., Mackenzie, P. I. (1997a). Structure and function of urid-ine diphosphate glucuronosyltransferases. Clin Exp Pharmacol Physiol 24:907-915.
    • (1997) Clin Exp Pharmacol Physiol , vol.24 , pp. 907-915
    • Meech, R.1    MacKenzie, P.I.2
  • 78
    • 0030846868 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase, the role of the amino terminus in dimerization
    • Meech, R., Mackenzie, P. I. (1997b). UDP-glucuronosyltransferase, the role of the amino terminus in dimerization. J Biol Chem 272:26913-26917.
    • (1997) J Biol Chem , vol.272 , pp. 26913-26917
    • Meech, R.1    MacKenzie, P.I.2
  • 79
    • 0032147023 scopus 로고    scopus 로고
    • Determinants of UDP glucuro nosyltransferase membrane association and residency in the endoplasmic reticulum
    • Meech, R., Mackenzie, P. I. (1998). Determinants of UDP glucuro nosyltransferase membrane association and residency in the endoplasmic reticulum. Arch Biochem Biophys 356:77-85.
    • (1998) Arch Biochem Biophys , vol.356 , pp. 77-85
    • Meech, R.1    MacKenzie, P.I.2
  • 80
    • 69549121731 scopus 로고    scopus 로고
    • Copy-number variations of the human sex steroid metabolizing genes, UGT2B17 and UGT2B28, along with their associations with a UGT2B15 functional polymorphism
    • Menard, V., Eap, O., Harvey, M., Guillemette, C., Lévesque, E. (2009). Copy-number variations of the human sex steroid metabolizing genes, UGT2B17 and UGT2B28, along with their associations with a UGT2B15 functional polymorphism. Hum Mutat 30:1310-1319.
    • (2009) Hum Mutat , vol.30 , pp. 1310-1319
    • Menard, V.1    Eap, O.2    Harvey, M.3    Guillemette, C.4    Lévesque, E.5
  • 81
    • 60149110358 scopus 로고    scopus 로고
    • Pre-mRNA processing reaches back to transcription and ahead to translation
    • Moore, M. J., Proudfoot, N. J. (2009). Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 136:688-700.
    • (2009) Cell , vol.136 , pp. 688-700
    • Moore, M.J.1    Proudfoot, N.J.2
  • 82
    • 0038190942 scopus 로고    scopus 로고
    • A human minor his-tocompatibility antigen resulting from diferential expression due to a gene deletion
    • Murata, M., Warren, E. H., Riddell, S. R. (2003). A human minor his-tocompatibility antigen resulting from diferential expression due to a gene deletion. J Exp Med 197:1279-1289.
    • (2003) J Exp Med , vol.197 , pp. 1279-1289
    • Murata, M.1    Warren, E.H.2    Riddell, S.R.3
  • 83
    • 34548055967 scopus 로고    scopus 로고
    • Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phe- nylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: Efects of UGT-UGT interactions
    • [Epub 2007 Jun 18]
    • Nakajima, M., Yamanaka, H., Fujiwara, R., Katoh, M., Yokoi, T. (2007). Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phe-nylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: efects of UGT-UGT interactions. Drug Metab Dispos 35:1679-1686. [Epub 2007 Jun 18].
    • (2007) Drug Metab Dispos , vol.35 , pp. 1679-1686
    • Nakajima, M.1    Yamanaka, H.2    Fujiwara, R.3    Katoh, M.4    Yokoi, T.5
  • 84
    • 0028786765 scopus 로고
    • Multiple alternative splice isoforms of parathyroid hormone-related peptide mRNA in human cell lines
    • Nakamura, M., Hashimoto, T., Furuyama, J., Kakudo, K. (1995a). Multiple alternative splice isoforms of parathyroid hormone-related peptide mRNA in human cell lines. J Mol Endocrinol 15:245-249.
    • (1995) J Mol Endocrinol , vol.15 , pp. 245-249
    • Nakamura, M.1    Hashimoto, T.2    Furuyama, J.3    Kakudo, K.4
  • 87
    • 33947527347 scopus 로고    scopus 로고
    • Oligomerization of the UDP-glucuronosyltransferase 1A proteins: Homo-and heterodimeri-zation analysis by fuorescence resonance energy transfer and co-immunoprecipitation
    • Operana, T. N., Tukey, R. H. (2007). Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo-and heterodimeri-zation analysis by fuorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem 282:4821-4829.
    • (2007) J Biol Chem , vol.282 , pp. 4821-4829
    • Operana, T.N.1    Tukey, R.H.2
  • 88
    • 0033615624 scopus 로고    scopus 로고
    • An internal signal sequence mediates the targeting and retention of the human UDP-glucuronosyl transferase 1A6 to the endoplasmic reticulum
    • Ouzzine, M., et al. (1999). An internal signal sequence mediates the targeting and retention of the human UDP-glucuronosyl transferase 1A6 to the endoplasmic reticulum. J Biol Chem 274:31401-31409.
    • (1999) J Biol Chem , vol.274 , pp. 31401-31409
    • Ouzzine, M.1
  • 89
    • 0347623265 scopus 로고    scopus 로고
    • Te human UDP-glucuronosyltransferases: Structural aspects and drug glucuronidation
    • Ouzzine, M., Barre, L., Netter, P., Magdalou, J., Fournel-Gigleux, S. (2003). Te human UDP-glucuronosyltransferases: structural aspects and drug glucuronidation. Drug Metab Rev 35:287-303.
    • (2003) Drug Metab Rev , vol.35 , pp. 287-303
    • Ouzzine, M.1    Barre, L.2    Netter, P.3    Magdalou, J.4    Fournel-Gigleux, S.5
  • 90
    • 30144437158 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases: Gene structures of UGT1 and UGT2 families
    • Owens, I. S., Basu, N. K., Banerjee, R. (2005). UDP- glucuronosyltransferases: gene structures of UGT1 and UGT2 families. Meth Enzymol 400:1-22.
    • (2005) Meth Enzymol , vol.400 , pp. 1-22
    • Owens, I.S.1    Basu, N.K.2    Banerjee, R.3
  • 91
    • 33748057111 scopus 로고    scopus 로고
    • Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African-American and Caucasian men
    • Park, J., Chen, L., Ratnashinge, L., Sellers, T. A., Tanner, J. P., Lee, J. H., et al. (2006). Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African-American and Caucasian men. Cancer Epidemiol Biomark Prev 15:1473-1478.
    • (2006) Cancer Epidemiol Biomark Prev , vol.15 , pp. 1473-1478
    • Park, J.1    Chen, L.2    Ratnashinge, L.3    Sellers, T.A.4    Tanner, J.P.5    Lee, J.H.6
  • 92
    • 2442631680 scopus 로고    scopus 로고
    • Asp85tyr polymorphism in the UDP-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer
    • Park, J., Chen, L., Shade, K., Lazarus, P., Seigne, J., Patterson, S., et al. (2004). Asp85tyr polymorphism in the UDP-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. J Urol 171(6 Pt 1):2484-2488.
    • (2004) J Urol , vol.171 , Issue.6 PART 1 , pp. 2484-2488
    • Park, J.1    Chen, L.2    Shade, K.3    Lazarus, P.4    Seigne, J.5    Patterson, S.6
  • 94
    • 59149088381 scopus 로고    scopus 로고
    • Te impact of micro-RNAs and alternative splicing in pharmacogenomics
    • Passetti, F., Ferreira, C. G., Costa, F. F. (2009). Te impact of micro-RNAs and alternative splicing in pharmacogenomics. Pharmacogenom J 9:1-13.
    • (2009) Pharmacogenom J , vol.9 , pp. 1-13
    • Passetti, F.1    Ferreira, C.G.2    Costa, F.F.3
  • 95
    • 34548356391 scopus 로고    scopus 로고
    • Te human UDP-glucuronosyltransferase: Identifcation of key residues within the nucleotide-sugar binding site
    • [Epub 2007 Jun 19]
    • Patana, A. S., Kurkela, M., Goldman, A., Finel, M. (2007). Te human UDP-glucuronosyltransferase: identifcation of key residues within the nucleotide-sugar binding site. Mol Pharmacol 72:604-611. [Epub 2007 Jun 19].
    • (2007) Mol Pharmacol , vol.72 , pp. 604-611
    • Patana, A.S.1    Kurkela, M.2    Goldman, A.3    Finel, M.4
  • 96
    • 0027431814 scopus 로고
    • Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4
    • Pillot, T., Ouzzine, M., Fournel-Gigleux, S., Lafaurie, C., Radominska, A., Burchell, B., et al. (1993). Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4. J Biol Chem 268:25636-25642.
    • (1993) J Biol Chem , vol.268 , pp. 25636-25642
    • Pillot, T.1    Ouzzine, M.2    Fournel-Gigleux, S.3    Lafaurie, C.4    Radominska, A.5    Burchell, B.6
  • 99
    • 40949130482 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9, and UGT2B7 mRNA expression in human liver
    • [Epub 2007 Apr 17]
    • Ramirez, J., Mirkov, S., Zhang, W., Chen, P., Das, S., Liu, W., et al. (2008). Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9, and UGT2B7 mRNA expression in human liver. Pharmacogenom J 8:152-161. [Epub 2007 Apr 17].
    • (2008) Pharmacogenom J , vol.8 , pp. 152-161
    • Ramirez, J.1    Mirkov, S.2    Zhang, W.3    Chen, P.4    Das, S.5    Liu, W.6
  • 101
    • 0034050743 scopus 로고    scopus 로고
    • Genomic organization of the UGT2b gene cluster on human chromosome 4q13
    • Riedy, M., Wang, J. Y., Miller, A. P., Buckler, A., Hall, J., Guida, M. (2000). Genomic organization of the UGT2b gene cluster on human chromosome 4q13. Pharmacogenetics 10:251-260.
    • (2000) Pharmacogenetics , vol.10 , pp. 251-260
    • Riedy, M.1    Wang, J.Y.2    Miller, A.P.3    Buckler, A.4    Hall, J.5    Guida, M.6
  • 102
    • 0034534895 scopus 로고    scopus 로고
    • Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions
    • Ritter, J. K. (2000). Roles of glucuronidation and UDP- glucuronosyltransferases in xenobiotic bioactivation reactions. Chem Biol Interact 129(1-2):171-193.
    • (2000) Chem Biol Interact , vol.129 , Issue.1-2 , pp. 171-193
    • Ritter, J.K.1
  • 103
    • 34250329999 scopus 로고    scopus 로고
    • Intestinal UGTs as potential modifers of pharma-cokinetics and biological responses to drugs and xenobiotics
    • Ritter, J. K. (2007). Intestinal UGTs as potential modifers of pharma-cokinetics and biological responses to drugs and xenobiotics. Expert Opin Drug Metab Toxicol 3:93-107.
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 93-107
    • Ritter, J.K.1
  • 104
    • 0026591504 scopus 로고
    • Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log diferences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
    • Ritter, J. K., Chen, F., Sheen, Y. Y., Lubet, R. A., Owens, I. S. (1992a). Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log diferences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives. Biochemistry 31:3409-3414.
    • (1992) Biochemistry , vol.31 , pp. 3409-3414
    • Ritter, J.K.1    Chen, F.2    Sheen, Y.Y.3    Lubet, R.A.4    Owens, I.S.5
  • 105
    • 0026701911 scopus 로고
    • A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini
    • Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T., et al. (1992b). A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261.
    • (1992) J Biol Chem , vol.267 , pp. 3257-3261
    • Ritter, J.K.1    Chen, F.2    Sheen, Y.Y.3    Tran, H.M.4    Kimura, S.5    Yeatman, M.T.6
  • 106
    • 0026008487 scopus 로고
    • Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells
    • Ritter, J. K., Crawford, J. M., Owens, I. S. (1991). Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266:1043-1047.
    • (1991) J Biol Chem , vol.266 , pp. 1043-1047
    • Ritter, J.K.1    Crawford, J.M.2    Owens, I.S.3
  • 107
    • 34547678535 scopus 로고    scopus 로고
    • In-depth query of large genomes using tiling arrays
    • Samanta, M. P., Tongprasit, W., Stolc, V. (2007). In-depth query of large genomes using tiling arrays. Meth Mol Biol 377:163-174.
    • (2007) Meth Mol Biol , vol.377 , pp. 163-174
    • Samanta, M.P.1    Tongprasit, W.2    Stolc, V.3
  • 108
    • 47549084086 scopus 로고    scopus 로고
    • Doping test results dependent on genotype of uridine diphospho- glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation
    • Schulze, J. J., Lundmark, J., Garle, M., Skilving, I., Ekstrom, L., Rane, A. (2008). Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation. J Clin Endocrinol Metab 93:2500-2506.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2500-2506
    • Schulze, J.J.1    Lundmark, J.2    Garle, M.3    Skilving, I.4    Ekstrom, L.5    Rane, A.6
  • 109
    • 33847421803 scopus 로고    scopus 로고
    • Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidi-nylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation
    • [Epub 2006 Dec 6]
    • Senekeo-Efenberger, K., Chen, S., Brace-Sinnokrak, E., Bonzo, J. A., Yueh, M. F., Argikar, U., et al. (2007). Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidi-nylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos 35:419-427. [Epub 2006 Dec 6].
    • (2007) Drug Metab Dispos , vol.35 , pp. 419-427
    • Senekeo-Efenberger, K.1    Chen, S.2    Brace-Sinnokrak, E.3    Bonzo, J.A.4    Yueh, M.F.5    Argikar, U.6
  • 111
    • 33846631884 scopus 로고    scopus 로고
    • Common genetic variants account for differences in gene expression among ethnic groups
    • Spielman, R. S., Bastone, L. A., Burdick, J. T., Morley, M., Ewens, W. J., Cheung, V. G. (2007). Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet 39:226-231.
    • (2007) Nat Genet , vol.39 , pp. 226-231
    • Spielman, R.S.1    Bastone, L.A.2    Burdick, J.T.3    Morley, M.4    Ewens, W.J.5    Cheung, V.G.6
  • 112
    • 38349085591 scopus 로고    scopus 로고
    • Regulation of alternative splicing by reversible protein phosphorylation
    • Stamm, S. (2008). Regulation of alternative splicing by reversible protein phosphorylation. J Biol Chem 283:1223-1227.
    • (2008) J Biol Chem , vol.283 , pp. 1223-1227
    • Stamm, S.1
  • 113
    • 41749096772 scopus 로고    scopus 로고
    • Identifcation of UDP-glucuronosyltransferase 1A10 in nonmalignant and malignant human breast tissues
    • Starlard-Davenport, A., Lyn-Cook, B., Radominska-Pandya, A. (2008). Identifcation of UDP-glucuronosyltransferase 1A10 in nonmalignant and malignant human breast tissues. Steroids 73:611-620.
    • (2008) Steroids , vol.73 , pp. 611-620
    • Starlard-Davenport, A.1    Lyn-Cook, B.2    Radominska-Pandya, A.3
  • 114
    • 55949120786 scopus 로고    scopus 로고
    • Variability and function of family 1 uridine-5'-diphosphate glucuronosyltrans-ferases (UGT1A)
    • Strassburg, C. P., Kalthof, S., Ehmer, U. (2008). Variability and function of family 1 uridine-5'-diphosphate glucuronosyltrans-ferases (UGT1A). Crit Rev Clin Lab Sci 45:485-530.
    • (2008) Crit Rev Clin Lab Sci , vol.45 , pp. 485-530
    • Strassburg, C.P.1    Kalthof, S.2    Ehmer, U.3
  • 115
    • 0032502764 scopus 로고    scopus 로고
    • Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identifcation and characterization of the novel extrahepatic UGT1A8
    • Strassburg, C. P., Manns, M. P., Tukey, R. H. (1998). Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identifcation and characterization of the novel extrahepatic UGT1A8. J Biol Chem 273:8719-8726.
    • (1998) J Biol Chem , vol.273 , pp. 8719-8726
    • Strassburg, C.P.1    Manns, M.P.2    Tukey, R.H.3
  • 116
    • 0031756678 scopus 로고    scopus 로고
    • Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium
    • Strassburg, C. P., Nguyen, N., Manns, M. P., Tukey, R. H. (1998). Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol 54:647-654.
    • (1998) Mol Pharmacol , vol.54 , pp. 647-654
    • Strassburg, C.P.1    Nguyen, N.2    Manns, M.P.3    Tukey, R.H.4
  • 117
    • 30144438495 scopus 로고    scopus 로고
    • Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor
    • DOI 10.1016/S0076-6879(05)00006-6, PII S0076687905000066, 6, Phase II Conjugation Enzymes and Transport Systems
    • Sugatani, J., Sueyoshi, T., Negishi, M., Miwa, M. (2005). Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocor-ticoid receptor. Methods Enzymol 400:92-104. (Pubitemid 43052417)
    • (2005) Methods in Enzymology , vol.400 , pp. 92-104
    • Sugatani, J.1    Sueyoshi, T.2    Negishi, M.3    Miwa, M.4
  • 118
    • 68549110517 scopus 로고    scopus 로고
    • A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: A putative link to stress-induced heart disease
    • Sztainberg, Y., Kuperman, Y., Issler, O., Gil, S., Vaughan, J., Rivier, J., et al. (2009). A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease. FASEB J.
    • (2009) FASEB J
    • Sztainberg, Y.1    Kuperman, Y.2    Issler, O.3    Gil, S.4    Vaughan, J.5    Rivier, J.6
  • 119
    • 63849272821 scopus 로고    scopus 로고
    • Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: Evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction
    • [Epub 2009 Jan 21]
    • Takeda, S., Ishii, Y., Iwanaga, M., Nurrochmad, A., Ito, Y., Mackenzie, P I., et al. (2009). Interaction of cytochrome P450 3A4 and UDP- glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction. Mol Pharmacol 75:956-964. [Epub 2009 Jan 21].
    • (2009) Mol Pharmacol , vol.75 , pp. 956-964
    • Takeda, S.1    Ishii, Y.2    Iwanaga, M.3    Nurrochmad, A.4    Ito, Y.5    MacKenzie, P.I.6
  • 120
    • 0036266930 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1-alpha is a causal factor responsible for interindividual diferences in the expression of UDP-glucuronosyltransferase 2B7 mRNA in human livers
    • Toide, K., Takahashi, Y., Yamazaki, H., Terauchi, Y., Fujii, T., Parkinson, A., et al. (2002). Hepatocyte nuclear factor-1-alpha is a causal factor responsible for interindividual diferences in the expression of UDP-glucuronosyltransferase 2B7 mRNA in human livers. Drug Metab Dispos 30:613-615.
    • (2002) Drug Metab Dispos , vol.30 , pp. 613-615
    • Toide, K.1    Takahashi, Y.2    Yamazaki, H.3    Terauchi, Y.4    Fujii, T.5    Parkinson, A.6
  • 121
    • 33751007567 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver
    • Trottier, J., Verreault, M., Grepper, S., Monte, D., Belanger, J., Kaeding, J., et al. (2006). Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 44:1158-1170.
    • (2006) Hepatology , vol.44 , pp. 1158-1170
    • Trottier, J.1    Verreault, M.2    Grepper, S.3    Monte, D.4    Belanger, J.5    Kaeding, J.6
  • 122
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey, R. H., Strassburg, C. P. (2000). Human UDP- glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 123
    • 0035115599 scopus 로고    scopus 로고
    • Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    • Tukey, R. H., Strassburg, C. P. (2001). Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405-414.
    • (2001) Mol Pharmacol , vol.59 , pp. 405-414
    • Tukey, R.H.1    Strassburg, C.P.2
  • 124
    • 0037403749 scopus 로고    scopus 로고
    • Glucuronidation activity of the UGT2B17 enzyme toward xeno-biotics
    • Turgeon, D., Carrier, J. S., Chouinard, S., Belanger, A. (2003). Glucuronidation activity of the UGT2B17 enzyme toward xeno-biotics. Drug Metab Dispos 31:670-676.
    • (2003) Drug Metab Dispos , vol.31 , pp. 670-676
    • Turgeon, D.1    Carrier, J.S.2    Chouinard, S.3    Belanger, A.4
  • 125
    • 0034695410 scopus 로고    scopus 로고
    • Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
    • Turgeon, D., Carrier, J. S., Levesque, E., Beatty, B. G., Belanger, A., Hum, D. W. (2000). Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. J Mol Biol 295:489-504.
    • (2000) J Mol Biol , vol.295 , pp. 489-504
    • Turgeon, D.1    Carrier, J.S.2    Levesque, E.3    Beatty, B.G.4    Belanger, A.5    Hum, D.W.6
  • 126
    • 0035103197 scopus 로고    scopus 로고
    • Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members
    • Turgeon, D., Carrier, J. S., Levesque, E., Hum, D. W., Belanger, A. (2001). Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology 142:778-787.
    • (2001) Endocrinology , vol.142 , pp. 778-787
    • Turgeon, D.1    Carrier, J.S.2    Levesque, E.3    Hum, D.W.4    Belanger, A.5
  • 127
    • 33747040567 scopus 로고    scopus 로고
    • Te liver X-receptor alpha controls hepatic expression of the human bile acid-glucuroni-dating UGT1A3 enzyme in human cells and transgenic mice
    • Verreault, M., Senekeo-Efenberger, K., Trottier, J., Bonzo, J. A., Belanger, J., Kaeding, J., et al. (2006). Te liver X-receptor alpha controls hepatic expression of the human bile acid-glucuroni-dating UGT1A3 enzyme in human cells and transgenic mice. Hepatology 44:368-378.
    • (2006) Hepatology , vol.44 , pp. 368-378
    • Verreault, M.1    Senekeo-Efenberger, K.2    Trottier, J.3    Bonzo, J.A.4    Belanger, J.5    Kaeding, J.6
  • 128
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., et al. (2008). Alternative isoform regulation in human tissue transcriptomes. Nature 456:470-476.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3    Khrebtukova, I.4    Zhang, L.5    Mayr, C.6
  • 129
    • 34548337281 scopus 로고    scopus 로고
    • Te p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    • Wang, W., Kwok, A. M., Chan, J. Y. (2007). Te p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription. J Biol Chem 282:24670-24678.
    • (2007) J Biol Chem , vol.282 , pp. 24670-24678
    • Wang, W.1    Kwok, A.M.2    Chan, J.Y.3
  • 130
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang, Z., Gerstein, M., Snyder, M. (2009). RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10:57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 133
    • 50949113663 scopus 로고    scopus 로고
    • Adaptive evolution of UGT2B17 copy-number variation
    • Xue, Y., Sun, D., Daly, A., Yang, F., Zhou, X., Zhao, M., et al. (2008). Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet 83:337-346.
    • (2008) Am J Hum Genet , vol.83 , pp. 337-346
    • Xue, Y.1    Sun, D.2    Daly, A.3    Yang, F.4    Zhou, X.5    Zhao, M.6
  • 134
    • 57149123783 scopus 로고    scopus 로고
    • Genome-wide copy-number-variation study identi-fed a susceptibility gene, UGT2B17, for osteoporosis
    • [Epub 2008 Nov 6]
    • Yang, T. L., Chen, X. D., Guo, Y., Lei, S. F., Wang, J. T., Zhou, Q., et al. (2008). Genome-wide copy-number-variation study identi-fed a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet 83:663-674. [Epub 2008 Nov 6].
    • (2008) Am J Hum Genet , vol.83 , pp. 663-674
    • Yang, T.L.1    Chen, X.D.2    Guo, Y.3    Lei, S.F.4    Wang, J.T.5    Zhou, Q.6
  • 135
    • 35048858890 scopus 로고    scopus 로고
    • Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice
    • [Epub 2007 Jul 26]
    • Yuan, J. H., Li, Y. Q., Yang, X. Y. (2007). Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. Pharmacology 80:269-278. [Epub 2007 Jul 26]
    • (2007) Pharmacology , vol.80 , pp. 269-278
    • Yuan, J.H.1    Li, Y.Q.2    Yang, X.Y.3


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