Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation

Cancer Cell International

Volumn 7, Issue , 2007, Pages

  Al Romaih, Khaldoun ^a,b   Somers, Gino R ^a,c   Bayani, Jane ^b   Hughes, Simon ^f   Prasad, Mona ^b   Cutz, Jean Claude ^e   Xue, Hui ^d   Zielenska, Maria ^a,c   Wang, Yuzhuo ^d,g   Squire, Jeremy A ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d BRITISH COLUMBIA CANCER AGENCY   (Canada)

^e MCMASTER UNIVERSITY   (Canada)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN A9B; I KAPPA B KINASE ALPHA; PROGRAMMED CELL DEATH PROTEIN 5; PROTEIN; PROTEIN PAWR; PROTEIN PDCD5; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MATRIX; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROARRAY ANALYSIS; MITOSIS INHIBITION; MOUSE; NICK END LABELING; NONHUMAN; OSTEOSARCOMA; OSTEOSARCOMA CELL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR DIFFERENTIATION; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION;

EID: 35448997854     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-7-14     Document Type: Article

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